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7YSV

GluK1-1a extracellular domain captured in SYM2081 bound desensitized state

Functional Information from GO Data
ChainGOidnamespacecontents
A0000149molecular_functionSNARE binding
A0003333biological_processamino acid transmembrane transport
A0004970molecular_functionglutamate-gated receptor activity
A0005216molecular_functionmonoatomic ion channel activity
A0005234molecular_functionextracellularly glutamate-gated ion channel activity
A0005313molecular_functionL-glutamate transmembrane transporter activity
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0007268biological_processchemical synaptic transmission
A0007399biological_processnervous system development
A0008328cellular_componentionotropic glutamate receptor complex
A0014051biological_processgamma-aminobutyric acid secretion
A0014054biological_processpositive regulation of gamma-aminobutyric acid secretion
A0014069cellular_componentpostsynaptic density
A0015276molecular_functionligand-gated monoatomic ion channel activity
A0015277molecular_functionkainate selective glutamate receptor activity
A0015813biological_processL-glutamate transmembrane transport
A0016020cellular_componentmembrane
A0016595molecular_functionglutamate binding
A0019722biological_processcalcium-mediated signaling
A0022849molecular_functionglutamate-gated calcium ion channel activity
A0030425cellular_componentdendrite
A0030534biological_processadult behavior
A0032229biological_processnegative regulation of synaptic transmission, GABAergic
A0032230biological_processpositive regulation of synaptic transmission, GABAergic
A0032983cellular_componentkainate selective glutamate receptor complex
A0034220biological_processmonoatomic ion transmembrane transport
A0035235biological_processionotropic glutamate receptor signaling pathway
A0035249biological_processsynaptic transmission, glutamatergic
A0035725biological_processsodium ion transmembrane transport
A0038023molecular_functionsignaling receptor activity
A0042391biological_processregulation of membrane potential
A0042734cellular_componentpresynaptic membrane
A0042802molecular_functionidentical protein binding
A0043025cellular_componentneuronal cell body
A0043195cellular_componentterminal bouton
A0043235cellular_componentreceptor complex
A0045202cellular_componentsynapse
A0045211cellular_componentpostsynaptic membrane
A0048167biological_processregulation of synaptic plasticity
A0048172biological_processregulation of short-term neuronal synaptic plasticity
A0048266biological_processbehavioral response to pain
A0050804biological_processmodulation of chemical synaptic transmission
A0051649biological_processestablishment of localization in cell
A0051899biological_processmembrane depolarization
A0051932biological_processsynaptic transmission, GABAergic
A0051967biological_processnegative regulation of synaptic transmission, glutamatergic
A0060079biological_processexcitatory postsynaptic potential
A0060080biological_processinhibitory postsynaptic potential
A0071805biological_processpotassium ion transmembrane transport
A0097110molecular_functionscaffold protein binding
A0098815biological_processmodulation of excitatory postsynaptic potential
A0098839cellular_componentpostsynaptic density membrane
A0098978cellular_componentglutamatergic synapse
A0099171biological_processpresynaptic modulation of chemical synaptic transmission
A0099505biological_processregulation of presynaptic membrane potential
A0099507molecular_functionligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
A1901363molecular_functionheterocyclic compound binding
A1904315molecular_functiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
B0000149molecular_functionSNARE binding
B0003333biological_processamino acid transmembrane transport
B0004970molecular_functionglutamate-gated receptor activity
B0005216molecular_functionmonoatomic ion channel activity
B0005234molecular_functionextracellularly glutamate-gated ion channel activity
B0005313molecular_functionL-glutamate transmembrane transporter activity
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0007268biological_processchemical synaptic transmission
B0007399biological_processnervous system development
B0008328cellular_componentionotropic glutamate receptor complex
B0014051biological_processgamma-aminobutyric acid secretion
B0014054biological_processpositive regulation of gamma-aminobutyric acid secretion
B0014069cellular_componentpostsynaptic density
B0015276molecular_functionligand-gated monoatomic ion channel activity
B0015277molecular_functionkainate selective glutamate receptor activity
B0015813biological_processL-glutamate transmembrane transport
B0016020cellular_componentmembrane
B0016595molecular_functionglutamate binding
B0019722biological_processcalcium-mediated signaling
B0022849molecular_functionglutamate-gated calcium ion channel activity
B0030425cellular_componentdendrite
B0030534biological_processadult behavior
B0032229biological_processnegative regulation of synaptic transmission, GABAergic
B0032230biological_processpositive regulation of synaptic transmission, GABAergic
B0032983cellular_componentkainate selective glutamate receptor complex
B0034220biological_processmonoatomic ion transmembrane transport
B0035235biological_processionotropic glutamate receptor signaling pathway
B0035249biological_processsynaptic transmission, glutamatergic
B0035725biological_processsodium ion transmembrane transport
B0038023molecular_functionsignaling receptor activity
B0042391biological_processregulation of membrane potential
B0042734cellular_componentpresynaptic membrane
B0042802molecular_functionidentical protein binding
B0043025cellular_componentneuronal cell body
B0043195cellular_componentterminal bouton
B0043235cellular_componentreceptor complex
B0045202cellular_componentsynapse
B0045211cellular_componentpostsynaptic membrane
B0048167biological_processregulation of synaptic plasticity
B0048172biological_processregulation of short-term neuronal synaptic plasticity
B0048266biological_processbehavioral response to pain
B0050804biological_processmodulation of chemical synaptic transmission
B0051649biological_processestablishment of localization in cell
B0051899biological_processmembrane depolarization
B0051932biological_processsynaptic transmission, GABAergic
B0051967biological_processnegative regulation of synaptic transmission, glutamatergic
B0060079biological_processexcitatory postsynaptic potential
B0060080biological_processinhibitory postsynaptic potential
B0071805biological_processpotassium ion transmembrane transport
B0097110molecular_functionscaffold protein binding
B0098815biological_processmodulation of excitatory postsynaptic potential
B0098839cellular_componentpostsynaptic density membrane
B0098978cellular_componentglutamatergic synapse
B0099171biological_processpresynaptic modulation of chemical synaptic transmission
B0099505biological_processregulation of presynaptic membrane potential
B0099507molecular_functionligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
B1901363molecular_functionheterocyclic compound binding
B1904315molecular_functiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
C0000149molecular_functionSNARE binding
C0003333biological_processamino acid transmembrane transport
C0004970molecular_functionglutamate-gated receptor activity
C0005216molecular_functionmonoatomic ion channel activity
C0005234molecular_functionextracellularly glutamate-gated ion channel activity
C0005313molecular_functionL-glutamate transmembrane transporter activity
C0005515molecular_functionprotein binding
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0007268biological_processchemical synaptic transmission
C0007399biological_processnervous system development
C0008328cellular_componentionotropic glutamate receptor complex
C0014051biological_processgamma-aminobutyric acid secretion
C0014054biological_processpositive regulation of gamma-aminobutyric acid secretion
C0014069cellular_componentpostsynaptic density
C0015276molecular_functionligand-gated monoatomic ion channel activity
C0015277molecular_functionkainate selective glutamate receptor activity
C0015813biological_processL-glutamate transmembrane transport
C0016020cellular_componentmembrane
C0016595molecular_functionglutamate binding
C0019722biological_processcalcium-mediated signaling
C0022849molecular_functionglutamate-gated calcium ion channel activity
C0030425cellular_componentdendrite
C0030534biological_processadult behavior
C0032229biological_processnegative regulation of synaptic transmission, GABAergic
C0032230biological_processpositive regulation of synaptic transmission, GABAergic
C0032983cellular_componentkainate selective glutamate receptor complex
C0034220biological_processmonoatomic ion transmembrane transport
C0035235biological_processionotropic glutamate receptor signaling pathway
C0035249biological_processsynaptic transmission, glutamatergic
C0035725biological_processsodium ion transmembrane transport
C0038023molecular_functionsignaling receptor activity
C0042391biological_processregulation of membrane potential
C0042734cellular_componentpresynaptic membrane
C0042802molecular_functionidentical protein binding
C0043025cellular_componentneuronal cell body
C0043195cellular_componentterminal bouton
C0043235cellular_componentreceptor complex
C0045202cellular_componentsynapse
C0045211cellular_componentpostsynaptic membrane
C0048167biological_processregulation of synaptic plasticity
C0048172biological_processregulation of short-term neuronal synaptic plasticity
C0048266biological_processbehavioral response to pain
C0050804biological_processmodulation of chemical synaptic transmission
C0051649biological_processestablishment of localization in cell
C0051899biological_processmembrane depolarization
C0051932biological_processsynaptic transmission, GABAergic
C0051967biological_processnegative regulation of synaptic transmission, glutamatergic
C0060079biological_processexcitatory postsynaptic potential
C0060080biological_processinhibitory postsynaptic potential
C0071805biological_processpotassium ion transmembrane transport
C0097110molecular_functionscaffold protein binding
C0098815biological_processmodulation of excitatory postsynaptic potential
C0098839cellular_componentpostsynaptic density membrane
C0098978cellular_componentglutamatergic synapse
C0099171biological_processpresynaptic modulation of chemical synaptic transmission
C0099505biological_processregulation of presynaptic membrane potential
C0099507molecular_functionligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
C1901363molecular_functionheterocyclic compound binding
C1904315molecular_functiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
D0000149molecular_functionSNARE binding
D0003333biological_processamino acid transmembrane transport
D0004970molecular_functionglutamate-gated receptor activity
D0005216molecular_functionmonoatomic ion channel activity
D0005234molecular_functionextracellularly glutamate-gated ion channel activity
D0005313molecular_functionL-glutamate transmembrane transporter activity
D0005515molecular_functionprotein binding
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0007268biological_processchemical synaptic transmission
D0007399biological_processnervous system development
D0008328cellular_componentionotropic glutamate receptor complex
D0014051biological_processgamma-aminobutyric acid secretion
D0014054biological_processpositive regulation of gamma-aminobutyric acid secretion
D0014069cellular_componentpostsynaptic density
D0015276molecular_functionligand-gated monoatomic ion channel activity
D0015277molecular_functionkainate selective glutamate receptor activity
D0015813biological_processL-glutamate transmembrane transport
D0016020cellular_componentmembrane
D0016595molecular_functionglutamate binding
D0019722biological_processcalcium-mediated signaling
D0022849molecular_functionglutamate-gated calcium ion channel activity
D0030425cellular_componentdendrite
D0030534biological_processadult behavior
D0032229biological_processnegative regulation of synaptic transmission, GABAergic
D0032230biological_processpositive regulation of synaptic transmission, GABAergic
D0032983cellular_componentkainate selective glutamate receptor complex
D0034220biological_processmonoatomic ion transmembrane transport
D0035235biological_processionotropic glutamate receptor signaling pathway
D0035249biological_processsynaptic transmission, glutamatergic
D0035725biological_processsodium ion transmembrane transport
D0038023molecular_functionsignaling receptor activity
D0042391biological_processregulation of membrane potential
D0042734cellular_componentpresynaptic membrane
D0042802molecular_functionidentical protein binding
D0043025cellular_componentneuronal cell body
D0043195cellular_componentterminal bouton
D0043235cellular_componentreceptor complex
D0045202cellular_componentsynapse
D0045211cellular_componentpostsynaptic membrane
D0048167biological_processregulation of synaptic plasticity
D0048172biological_processregulation of short-term neuronal synaptic plasticity
D0048266biological_processbehavioral response to pain
D0050804biological_processmodulation of chemical synaptic transmission
D0051649biological_processestablishment of localization in cell
D0051899biological_processmembrane depolarization
D0051932biological_processsynaptic transmission, GABAergic
D0051967biological_processnegative regulation of synaptic transmission, glutamatergic
D0060079biological_processexcitatory postsynaptic potential
D0060080biological_processinhibitory postsynaptic potential
D0071805biological_processpotassium ion transmembrane transport
D0097110molecular_functionscaffold protein binding
D0098815biological_processmodulation of excitatory postsynaptic potential
D0098839cellular_componentpostsynaptic density membrane
D0098978cellular_componentglutamatergic synapse
D0099171biological_processpresynaptic modulation of chemical synaptic transmission
D0099505biological_processregulation of presynaptic membrane potential
D0099507molecular_functionligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
D1901363molecular_functionheterocyclic compound binding
D1904315molecular_functiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues240
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
AASP543-ALA563
DASP543-ALA563
DILE620-LEU640
DILE801-GLY821
AILE620-LEU640
AILE801-GLY821
BASP543-ALA563
BILE620-LEU640
BILE801-GLY821
CASP543-ALA563
CILE620-LEU640
CILE801-GLY821

site_idSWS_FT_FI2
Number of Residues220
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
AARG564-GLY619
BARG564-GLY619
CARG564-GLY619
DARG564-GLY619

site_idSWS_FT_FI3
Number of Residues636
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
ATHR641-ASN800
BTHR641-ASN800
CTHR641-ASN800
DTHR641-ASN800

site_idSWS_FT_FI4
Number of Residues16
DetailsBINDING: BINDING => ECO:0000269|PubMed:15710405, ECO:0007744|PDB:1YCJ
ChainResidueDetails
CTHR499
CSER670
CTHR671
DPRO497
DTHR499
DSER670
DTHR671
CPRO497
ATHR499
ASER670
ATHR671
BSER670
BTHR671
APRO497
BPRO497
BTHR499

site_idSWS_FT_FI5
Number of Residues8
DetailsBINDING: BINDING => ECO:0000269|PubMed:15710405, ECO:0000269|PubMed:15721240, ECO:0007744|PDB:1YCJ
ChainResidueDetails
AARG504
AGLU719
BARG504
BGLU719
CARG504
CGLU719
DARG504
DGLU719

site_idSWS_FT_FI6
Number of Residues4
DetailsMOD_RES: Phosphoserine; by PKC => ECO:0000255
ChainResidueDetails
ASER691
BSER691
CSER691
DSER691

site_idSWS_FT_FI7
Number of Residues4
DetailsMOD_RES: Phosphothreonine; by PKC => ECO:0000255
ChainResidueDetails
ATHR727
BTHR727
CTHR727
DTHR727

site_idSWS_FT_FI8
Number of Residues36
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN34
BASN34
BASN40
BASN242
BASN345
BASN394
BASN405
BASN412
BASN527
BASN732
CASN34
AASN40
CASN40
CASN242
CASN345
CASN394
CASN405
CASN412
CASN527
CASN732
DASN34
DASN40
AASN242
DASN242
DASN345
DASN394
DASN405
DASN412
DASN527
DASN732
AASN345
AASN394
AASN405
AASN412
AASN527
AASN732

221051

PDB entries from 2024-06-12

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