7YCX

The structure of INTAC-PEC complex

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
1	0000287	molecular_function	magnesium ion binding
1	0000428	cellular_component	DNA-directed RNA polymerase complex
1	0000974	cellular_component	Prp19 complex
1	0001055	molecular_function	RNA polymerase II activity
1	0001172	biological_process	RNA-templated transcription
1	0003677	molecular_function	DNA binding
1	0003723	molecular_function	RNA binding
1	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
1	0003968	molecular_function	RNA-dependent RNA polymerase activity
1	0005515	molecular_function	protein binding
1	0005634	cellular_component	nucleus
1	0005654	cellular_component	nucleoplasm
1	0005665	cellular_component	RNA polymerase II, core complex
1	0005694	cellular_component	chromosome
1	0005730	cellular_component	nucleolus
1	0005737	cellular_component	cytoplasm
1	0006351	biological_process	DNA-templated transcription
1	0006353	biological_process	DNA-templated transcription termination
1	0006355	biological_process	regulation of DNA-templated transcription
1	0006366	biological_process	transcription by RNA polymerase II
1	0008270	molecular_function	zinc ion binding
1	0016787	molecular_function	hydrolase activity
1	0019900	molecular_function	kinase binding
1	0031625	molecular_function	ubiquitin protein ligase binding
1	0031981	cellular_component	nuclear lumen
1	0032991	cellular_component	protein-containing complex
1	0033120	biological_process	positive regulation of RNA splicing
1	0034062	molecular_function	5'-3' RNA polymerase activity
1	0046872	molecular_function	metal ion binding
1	0050436	molecular_function	microfibril binding
1	1990841	molecular_function	promoter-specific chromatin binding
2	0000428	cellular_component	DNA-directed RNA polymerase complex
2	0001055	molecular_function	RNA polymerase II activity
2	0003677	molecular_function	DNA binding
2	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
2	0005665	cellular_component	RNA polymerase II, core complex
2	0006351	biological_process	DNA-templated transcription
2	0006366	biological_process	transcription by RNA polymerase II
2	0016779	molecular_function	nucleotidyltransferase activity
2	0032549	molecular_function	ribonucleoside binding
2	0046872	molecular_function	metal ion binding
3	0003677	molecular_function	DNA binding
3	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
3	0006351	biological_process	DNA-templated transcription
3	0046983	molecular_function	protein dimerization activity
4	0001054	molecular_function	RNA polymerase I activity
4	0001055	molecular_function	RNA polymerase II activity
4	0001056	molecular_function	RNA polymerase III activity
4	0003677	molecular_function	DNA binding
4	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
4	0005634	cellular_component	nucleus
4	0005665	cellular_component	RNA polymerase II, core complex
4	0005666	cellular_component	RNA polymerase III complex
4	0005736	cellular_component	RNA polymerase I complex
4	0006351	biological_process	DNA-templated transcription
4	0006360	biological_process	transcription by RNA polymerase I
4	0006366	biological_process	transcription by RNA polymerase II
4	0006383	biological_process	transcription by RNA polymerase III
4	0016591	cellular_component	RNA polymerase II, holoenzyme
5	0000428	cellular_component	DNA-directed RNA polymerase complex
5	0001650	cellular_component	fibrillar center
5	0003677	molecular_function	DNA binding
5	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
5	0005634	cellular_component	nucleus
5	0005654	cellular_component	nucleoplasm
5	0005665	cellular_component	RNA polymerase II, core complex
5	0005666	cellular_component	RNA polymerase III complex
5	0005736	cellular_component	RNA polymerase I complex
5	0006351	biological_process	DNA-templated transcription
5	0006366	biological_process	transcription by RNA polymerase II
6	0000428	cellular_component	DNA-directed RNA polymerase complex
6	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
6	0005634	cellular_component	nucleus
6	0005665	cellular_component	RNA polymerase II, core complex
6	0006351	biological_process	DNA-templated transcription
7	0000428	cellular_component	DNA-directed RNA polymerase complex
7	0001193	biological_process	maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II
7	0003676	molecular_function	nucleic acid binding
7	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
7	0005634	cellular_component	nucleus
7	0005654	cellular_component	nucleoplasm
7	0005665	cellular_component	RNA polymerase II, core complex
7	0005730	cellular_component	nucleolus
7	0006283	biological_process	transcription-coupled nucleotide-excision repair
7	0006351	biological_process	DNA-templated transcription
7	0006366	biological_process	transcription by RNA polymerase II
7	0006367	biological_process	transcription initiation at RNA polymerase II promoter
7	0008270	molecular_function	zinc ion binding
7	0016591	cellular_component	RNA polymerase II, holoenzyme
7	0046872	molecular_function	metal ion binding
8	0000428	cellular_component	DNA-directed RNA polymerase complex
8	0001054	molecular_function	RNA polymerase I activity
8	0001055	molecular_function	RNA polymerase II activity
8	0001056	molecular_function	RNA polymerase III activity
8	0003677	molecular_function	DNA binding
8	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
8	0005634	cellular_component	nucleus
8	0005654	cellular_component	nucleoplasm
8	0005665	cellular_component	RNA polymerase II, core complex
8	0005666	cellular_component	RNA polymerase III complex
8	0005736	cellular_component	RNA polymerase I complex
8	0006351	biological_process	DNA-templated transcription
8	0006360	biological_process	transcription by RNA polymerase I
8	0006366	biological_process	transcription by RNA polymerase II
8	0008270	molecular_function	zinc ion binding
8	0042797	biological_process	tRNA transcription by RNA polymerase III
8	0046872	molecular_function	metal ion binding
9	0000428	cellular_component	DNA-directed RNA polymerase complex
9	0001055	molecular_function	RNA polymerase II activity
9	0003677	molecular_function	DNA binding
9	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
9	0005634	cellular_component	nucleus
9	0005665	cellular_component	RNA polymerase II, core complex
9	0006351	biological_process	DNA-templated transcription
9	0006366	biological_process	transcription by RNA polymerase II
9	0016591	cellular_component	RNA polymerase II, holoenzyme
9	0046983	molecular_function	protein dimerization activity
A	0001832	biological_process	blastocyst growth
A	0001833	biological_process	inner cell mass cell proliferation
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0007566	biological_process	embryo implantation
A	0016020	cellular_component	membrane
A	0016180	biological_process	snRNA processing
A	0031965	cellular_component	nuclear membrane
A	0032039	cellular_component	integrator complex
A	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
A	0034474	biological_process	U2 snRNA 3'-end processing
A	0043066	biological_process	negative regulation of apoptotic process
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0016020	cellular_component	membrane
B	0016180	biological_process	snRNA processing
B	0031965	cellular_component	nuclear membrane
B	0032039	cellular_component	integrator complex
B	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
B	0034472	biological_process	snRNA 3'-end processing
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005730	cellular_component	nucleolus
D	0016180	biological_process	snRNA processing
D	0032039	cellular_component	integrator complex
D	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0016020	cellular_component	membrane
E	0016180	biological_process	snRNA processing
E	0031965	cellular_component	nuclear membrane
E	0032039	cellular_component	integrator complex
E	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
E	0034472	biological_process	snRNA 3'-end processing
F	0004888	molecular_function	transmembrane signaling receptor activity
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0015629	cellular_component	actin cytoskeleton
F	0016180	biological_process	snRNA processing
F	0032039	cellular_component	integrator complex
F	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
F	0034472	biological_process	snRNA 3'-end processing
G	0000077	biological_process	DNA damage checkpoint signaling
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005694	cellular_component	chromosome
G	0005737	cellular_component	cytoplasm
G	0006974	biological_process	DNA damage response
G	0016180	biological_process	snRNA processing
G	0016604	cellular_component	nuclear body
G	0032039	cellular_component	integrator complex
G	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
G	0034472	biological_process	snRNA 3'-end processing
G	0071479	biological_process	cellular response to ionizing radiation
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0016180	biological_process	snRNA processing
H	0032039	cellular_component	integrator complex
H	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
H	0034472	biological_process	snRNA 3'-end processing
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005829	cellular_component	cytosol
I	0016180	biological_process	snRNA processing
I	0030512	biological_process	negative regulation of transforming growth factor beta receptor signaling pathway
I	0032039	cellular_component	integrator complex
I	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
I	0034472	biological_process	snRNA 3'-end processing
K	0004521	molecular_function	RNA endonuclease activity
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0016180	biological_process	snRNA processing
K	0016787	molecular_function	hydrolase activity
K	0032039	cellular_component	integrator complex
K	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
K	0072562	cellular_component	blood microparticle
P	0000159	cellular_component	protein phosphatase type 2A complex
P	0000775	cellular_component	chromosome, centromeric region
P	0004722	molecular_function	protein serine/threonine phosphatase activity
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005694	cellular_component	chromosome
P	0005737	cellular_component	cytoplasm
P	0005739	cellular_component	mitochondrion
P	0005829	cellular_component	cytosol
P	0005886	cellular_component	plasma membrane
P	0007059	biological_process	chromosome segregation
P	0007143	biological_process	female meiotic nuclear division
P	0015630	cellular_component	microtubule cytoskeleton
P	0016020	cellular_component	membrane
P	0016328	cellular_component	lateral plasma membrane
P	0019888	molecular_function	protein phosphatase regulator activity
P	0030425	cellular_component	dendrite
P	0035331	biological_process	negative regulation of hippo signaling
P	0035556	biological_process	intracellular signal transduction
P	0040008	biological_process	regulation of growth
P	0042995	cellular_component	cell projection
P	0043005	cellular_component	neuron projection
P	0043025	cellular_component	neuronal cell body
P	0043029	biological_process	T cell homeostasis
P	0045202	cellular_component	synapse
P	0045595	biological_process	regulation of cell differentiation
P	0046982	molecular_function	protein heterodimerization activity
P	0051232	biological_process	meiotic spindle elongation
P	0051306	biological_process	mitotic sister chromatid separation
P	0051754	biological_process	meiotic sister chromatid cohesion, centromeric
P	0051898	biological_process	negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
P	0065003	biological_process	protein-containing complex assembly
P	0070062	cellular_component	extracellular exosome
P	0090443	cellular_component	FAR/SIN/STRIPAK complex
P	0098978	cellular_component	glutamatergic synapse
P	1903538	biological_process	regulation of meiotic cell cycle process involved in oocyte maturation
P	1990405	molecular_function	protein antigen binding
P	2001241	biological_process	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
Q	0000159	cellular_component	protein phosphatase type 2A complex
Q	0000278	biological_process	mitotic cell cycle
Q	0000775	cellular_component	chromosome, centromeric region
Q	0000922	cellular_component	spindle pole
Q	0001932	biological_process	regulation of protein phosphorylation
Q	0004721	molecular_function	phosphoprotein phosphatase activity
Q	0004722	molecular_function	protein serine/threonine phosphatase activity
Q	0004725	molecular_function	protein tyrosine phosphatase activity
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005694	cellular_component	chromosome
Q	0005737	cellular_component	cytoplasm
Q	0005739	cellular_component	mitochondrion
Q	0005829	cellular_component	cytosol
Q	0005856	cellular_component	cytoskeleton
Q	0005886	cellular_component	plasma membrane
Q	0006470	biological_process	protein dephosphorylation
Q	0007498	biological_process	mesoderm development
Q	0008287	cellular_component	protein serine/threonine phosphatase complex
Q	0010288	biological_process	response to lead ion
Q	0010719	biological_process	negative regulation of epithelial to mesenchymal transition
Q	0015630	cellular_component	microtubule cytoskeleton
Q	0016020	cellular_component	membrane
Q	0016787	molecular_function	hydrolase activity
Q	0017018	molecular_function	myosin phosphatase activity
Q	0035331	biological_process	negative regulation of hippo signaling
Q	0035556	biological_process	intracellular signal transduction
Q	0035970	biological_process	peptidyl-threonine dephosphorylation
Q	0040008	biological_process	regulation of growth
Q	0043029	biological_process	T cell homeostasis
Q	0045121	cellular_component	membrane raft
Q	0045202	cellular_component	synapse
Q	0045595	biological_process	regulation of cell differentiation
Q	0046872	molecular_function	metal ion binding
Q	0046982	molecular_function	protein heterodimerization activity
Q	0048156	molecular_function	tau protein binding
Q	0050811	molecular_function	GABA receptor binding
Q	0051321	biological_process	meiotic cell cycle
Q	0051898	biological_process	negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Q	0070062	cellular_component	extracellular exosome
Q	0070262	biological_process	peptidyl-serine dephosphorylation
Q	0071902	biological_process	positive regulation of protein serine/threonine kinase activity
Q	0090443	cellular_component	FAR/SIN/STRIPAK complex
Q	1900227	biological_process	positive regulation of NLRP3 inflammasome complex assembly
Q	1904526	biological_process	regulation of microtubule binding
Q	1904528	biological_process	positive regulation of microtubule binding
Q	1904539	biological_process	negative regulation of glycolytic process through fructose-6-phosphate
Q	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
a	0003677	molecular_function	DNA binding
a	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
a	0005634	cellular_component	nucleus
a	0005665	cellular_component	RNA polymerase II, core complex
a	0005666	cellular_component	RNA polymerase III complex
a	0005736	cellular_component	RNA polymerase I complex
a	0006351	biological_process	DNA-templated transcription
a	0006366	biological_process	transcription by RNA polymerase II
a	0008270	molecular_function	zinc ion binding
a	0046872	molecular_function	metal ion binding
e	0003682	molecular_function	chromatin binding
e	0005515	molecular_function	protein binding
e	0005634	cellular_component	nucleus
e	0005654	cellular_component	nucleoplasm
e	0005829	cellular_component	cytosol
e	0016604	cellular_component	nuclear body
e	0031401	biological_process	positive regulation of protein modification process
e	0032021	cellular_component	NELF complex
e	0034244	biological_process	negative regulation of transcription elongation by RNA polymerase II
e	0045944	biological_process	positive regulation of transcription by RNA polymerase II
e	0060090	molecular_function	molecular adaptor activity
f	0003723	molecular_function	RNA binding
f	0005515	molecular_function	protein binding
f	0005634	cellular_component	nucleus
f	0005654	cellular_component	nucleoplasm
f	0005737	cellular_component	cytoplasm
f	0008283	biological_process	cell population proliferation
f	0032021	cellular_component	NELF complex
f	0034244	biological_process	negative regulation of transcription elongation by RNA polymerase II
f	0045892	biological_process	negative regulation of DNA-templated transcription
f	0048863	biological_process	stem cell differentiation
f	2000737	biological_process	negative regulation of stem cell differentiation
g	0003723	molecular_function	RNA binding
g	0005515	molecular_function	protein binding
g	0005634	cellular_component	nucleus
g	0005654	cellular_component	nucleoplasm
g	0016020	cellular_component	membrane
g	0032021	cellular_component	NELF complex
g	0034244	biological_process	negative regulation of transcription elongation by RNA polymerase II
g	0045892	biological_process	negative regulation of DNA-templated transcription
h	0000122	biological_process	negative regulation of transcription by RNA polymerase II
h	0000785	cellular_component	chromatin
h	0003676	molecular_function	nucleic acid binding
h	0003682	molecular_function	chromatin binding
h	0003723	molecular_function	RNA binding
h	0003729	molecular_function	mRNA binding
h	0005515	molecular_function	protein binding
h	0005634	cellular_component	nucleus
h	0005654	cellular_component	nucleoplasm
h	0005694	cellular_component	chromosome
h	0005886	cellular_component	plasma membrane
h	0006355	biological_process	regulation of DNA-templated transcription
h	0016604	cellular_component	nuclear body
h	0031401	biological_process	positive regulation of protein modification process
h	0032021	cellular_component	NELF complex
h	0034244	biological_process	negative regulation of transcription elongation by RNA polymerase II
h	0045944	biological_process	positive regulation of transcription by RNA polymerase II
h	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
i	0000122	biological_process	negative regulation of transcription by RNA polymerase II
i	0000993	molecular_function	RNA polymerase II complex binding
i	0005515	molecular_function	protein binding
i	0005634	cellular_component	nucleus
i	0005654	cellular_component	nucleoplasm
i	0006355	biological_process	regulation of DNA-templated transcription
i	0006368	biological_process	transcription elongation by RNA polymerase II
i	0008270	molecular_function	zinc ion binding
i	0032044	cellular_component	DSIF complex
i	0032785	biological_process	negative regulation of DNA-templated transcription, elongation
i	0032786	biological_process	positive regulation of DNA-templated transcription, elongation
i	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
i	0034244	biological_process	negative regulation of transcription elongation by RNA polymerase II
i	0045944	biological_process	positive regulation of transcription by RNA polymerase II
i	0046872	molecular_function	metal ion binding
i	0046982	molecular_function	protein heterodimerization activity
i	0140673	biological_process	transcription elongation-coupled chromatin remodeling
j	0000122	biological_process	negative regulation of transcription by RNA polymerase II
j	0003682	molecular_function	chromatin binding
j	0003723	molecular_function	RNA binding
j	0003729	molecular_function	mRNA binding
j	0005515	molecular_function	protein binding
j	0005634	cellular_component	nucleus
j	0005654	cellular_component	nucleoplasm
j	0006354	biological_process	DNA-templated transcription elongation
j	0006357	biological_process	regulation of transcription by RNA polymerase II
j	0006368	biological_process	transcription elongation by RNA polymerase II
j	0016239	biological_process	positive regulation of macroautophagy
j	0019899	molecular_function	enzyme binding
j	0032044	cellular_component	DSIF complex
j	0032784	biological_process	regulation of DNA-templated transcription elongation
j	0032785	biological_process	negative regulation of DNA-templated transcription, elongation
j	0032786	biological_process	positive regulation of DNA-templated transcription, elongation
j	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
j	0045944	biological_process	positive regulation of transcription by RNA polymerase II
j	0046982	molecular_function	protein heterodimerization activity
j	0140673	biological_process	transcription elongation-coupled chromatin remodeling
k	0000428	cellular_component	DNA-directed RNA polymerase complex
k	0000932	cellular_component	P-body
k	0003676	molecular_function	nucleic acid binding
k	0003697	molecular_function	single-stranded DNA binding
k	0003727	molecular_function	single-stranded RNA binding
k	0005634	cellular_component	nucleus
k	0005665	cellular_component	RNA polymerase II, core complex
k	0006351	biological_process	DNA-templated transcription
k	0006352	biological_process	DNA-templated transcription initiation
k	0006367	biological_process	transcription initiation at RNA polymerase II promoter
k	0031369	molecular_function	translation initiation factor binding
k	0045948	biological_process	positive regulation of translational initiation
k	0060213	biological_process	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
l	0000166	molecular_function	nucleotide binding
l	0000428	cellular_component	DNA-directed RNA polymerase complex
l	0005634	cellular_component	nucleus
l	0005665	cellular_component	RNA polymerase II, core complex
l	0006352	biological_process	DNA-templated transcription initiation
l	0006367	biological_process	transcription initiation at RNA polymerase II promoter
l	0030880	cellular_component	RNA polymerase complex
l	0031369	molecular_function	translation initiation factor binding
l	0044237	biological_process	cellular metabolic process

Functional Information from PROSITE/UniProt

site_id	PS01112
Number of Residues	10
Details	RNA_POL_N_8KD RNA polymerases N / 8 Kd subunits signature. IIPVrCFTCG

Chain	Residue	Details
8	ILE2-GLY11

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site_id	PS01166
Number of Residues	13
Details	RNA_POL_BETA RNA polymerases beta chain signature. GdKFASrHGQKGT

Chain	Residue	Details
2	GLY932-THR944

---

site_id	PS00019
Number of Residues	10
Details	ACTININ_1 Actinin-type actin-binding domain signature 1. QPeTYYKWDN

Chain	Residue	Details
A	GLN620-ASN629

---

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YVCTAPH

Chain	Residue	Details
7	TYR112-HIS118

---

site_id	PS00466
Number of Residues	38
Details	ZF_TFIIS_1 Zinc finger TFIIS-type signature. CqkCghkeavffqSHSARaEDAmrlyyvCtaph.CghrW

Chain	Residue	Details
7	CYS86-TRP123

---

site_id	PS01030
Number of Residues	27
Details	RNA_POL_M_15KD RNA polymerases M / 15 Kd subunits signature. FCqECNNMLypkedkenrillyaCrnC

Chain	Residue	Details
7	PHE16-CYS42

---

site_id	PS00125
Number of Residues	6
Details	SER_THR_PHOSPHATASE Serine/threonine specific protein phosphatases signature. LRGNHE

Chain	Residue	Details
Q	LEU114-GLU119

---

site_id	PS00115
Number of Residues	7
Details	RNA_POL_II_REPEAT Eukaryotic RNA polymerase II heptapeptide repeat. YSPTSPA

Chain	Residue	Details
1	TYR1593-ALA1599
1	TYR1615-SER1621
1	TYR1622-SER1628
1	TYR1629-ASN1635
1	TYR1636-SER1642
1	TYR1643-SER1649
1	TYR1650-SER1656
1	TYR1657-SER1663
1	TYR1664-SER1670
1	TYR1671-SER1677
1	TYR1678-SER1684
1	TYR1685-SER1691
1	TYR1692-SER1698
1	TYR1706-SER1712
1	TYR1713-SER1719
1	TYR1720-SER1726
1	TYR1727-SER1733
1	TYR1734-SER1740
1	TYR1741-ASN1747
1	TYR1748-ASN1754
1	TYR1755-SER1761
1	TYR1762-SER1768
1	TYR1769-ASN1775
1	TYR1776-ASN1782
1	TYR1783-SER1789
1	TYR1790-SER1796
1	TYR1797-SER1803
1	TYR1818-SER1824
1	TYR1825-SER1831
1	TYR1839-SER1845
1	TYR1867-LYS1873
1	TYR1874-THR1880
1	TYR1888-THR1894
1	TYR1902-LYS1908
1	TYR1909-THR1915
1	TYR1916-LYS1922
1	TYR1923-THR1929
1	TYR1930-LYS1936
1	TYR1947-THR1953

---

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DNDPSDYVEqdDI

Chain	Residue	Details
3	ASP136-ILE148

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site_id	PS00446
Number of Residues	41
Details	RNA_POL_D_30KD RNA polymerases D / 30 to 40 Kd subunits signature. NSIRRvfiaevpiiAidwVqidaNsSvlhDEfIAhRLGLIP

Chain	Residue	Details
3	ASN32-PRO72

---

site_id	PS01111
Number of Residues	15
Details	RNA_POL_K_14KD RNA polymerases K / 14 to 18 Kd subunits signature. TkYErARvLGtRAlQ

Chain	Residue	Details
5	THR58-GLN72

---

site_id	PS00039
Number of Residues	9
Details	DEAD_ATP_HELICASE DEAD-box subfamily ATP-dependent helicases signature. MIDEADEfV

Chain	Residue	Details
F	MET627-VAL635

---

site_id	PS01154
Number of Residues	32
Details	RNA_POL_L_13KD RNA polymerases L / 13 to 16 Kd subunits signature. InkEdHTLgNiIksqLlkdpqVlfagYkvpHP

Chain	Residue	Details
9	ILE35-PRO66

---

site_id	PS01110
Number of Residues	14
Details	RNA_POL_H_23KD RNA polymerases H / 23 Kd subunits signature. HELVPEHvvMtkEE

Chain	Residue	Details
4	HIS142-GLU155

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
h	SER249
G	SER809
E	VAL930-LEU950
1	ASP499
1	ARG1416
1	ARG1421
I	LYS58

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: N-acetylserine => ECO:0007744|PubMed:19413330

Chain	Residue	Details
1	CYS154
1	CYS184
1	ASN493
1	ASP495
j	SER36
i	CYS33
i	CYS36
1	CYS111
1	CYS114
E	SER2

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18691976

Chain	Residue	Details
7	CYS39
7	CYS42
7	CYS20
E	SER279

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
h	GLU374
E	SER1010
j	ARG696
h	GLU172

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
j	SER804
j	SER686
j	SER789

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Symmetric dimethylarginine; by PRMT5; alternate => ECO:0000269|PubMed:12718890

Chain	Residue	Details
j	ARG698

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:O55201

Chain	Residue	Details
j	LYS718
h	SER185

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	MOD_RES: Phosphothreonine; by CDK9 => ECO:0000269|PubMed:10757782

Chain	Residue	Details
j	THR775
j	THR784

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
j	THR791
1	THR1912
1	THR1915
1	THR1919
1	THR1926
1	THR1929
1	THR1933
j	THR806
1	THR1870
1	THR1877

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
h	THR274
j	THR1034

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25218447, ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:28112733

Chain	Residue	Details
1	UNK1861
1	SER1875
j	LYS143
1	UNK1857

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
h	SER353
j	LYS1037

---

site_id	SWS_FT_FI13
Number of Residues	1
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733

Chain	Residue	Details
h	LYS78

---

site_id	SWS_FT_FI14
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
h	LYS82
1	SER1850

---

site_id	SWS_FT_FI15
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:19690332

Chain	Residue	Details
1	THR1854

---

site_id	SWS_FT_FI16
Number of Residues	4
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:26566685

Chain	Residue	Details
1	LYS1866
1	LYS1873
1	LYS1887
1	UNK1859

---

site_id	SWS_FT_FI17
Number of Residues	5
Details	MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:26566685

Chain	Residue	Details
1	TYR1881
1	TYR1916
1	TYR1930
1	UNK1860
1	TYR1867

---

site_id	SWS_FT_FI18
Number of Residues	1
Details	MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:26566685, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:24275569

Chain	Residue	Details
1	TYR1874

---

site_id	SWS_FT_FI19
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:26566685, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163

Chain	Residue	Details
1	SER1878
1	SER1882

---

site_id	SWS_FT_FI20
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
1	THR1885

---

site_id	SWS_FT_FI21
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P08775

Chain	Residue	Details
1	THR1894

---

site_id	SWS_FT_FI22
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648

Chain	Residue	Details
1	SER1896

---

site_id	SWS_FT_FI23
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163

Chain	Residue	Details
1	SER1899

---

site_id	SWS_FT_FI24
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
1	SER1906

---

site_id	SWS_FT_FI25
Number of Residues	1
Details	MOD_RES: N6,N6-dimethyllysine => ECO:0000250|UniProtKB:P08775

Chain	Residue	Details
1	LYS1908

---

site_id	SWS_FT_FI26
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:26566685, ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:24275569

Chain	Residue	Details
1	TYR1909
1	TYR1923

---

site_id	SWS_FT_FI27
Number of Residues	3
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:26566685, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163

Chain	Residue	Details
1	SER1927
1	SER1913
1	SER1920

---

site_id	SWS_FT_FI28
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:26566685, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:21406692

Chain	Residue	Details
1	SER1931
1	SER1917

---

site_id	SWS_FT_FI29
Number of Residues	2
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000305|PubMed:26566685

Chain	Residue	Details
1	LYS1936
1	LYS1922

---

site_id	SWS_FT_FI30
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163

Chain	Residue	Details
1	SER1934

---

site_id	SWS_FT_FI31
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); by NEDD4 => ECO:0000269|PubMed:32142649, ECO:0000305|PubMed:32142654

Chain	Residue	Details
1	LYS1268

---