7Y60

Cryo-EM structure of human CAF1LC bound right-handed Di-tetrasome

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000786	cellular_component	nucleosome
A	0003677	molecular_function	DNA binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005694	cellular_component	chromosome
A	0006325	biological_process	chromatin organization
A	0006334	biological_process	nucleosome assembly
A	0010467	biological_process	gene expression
A	0016020	cellular_component	membrane
A	0030527	molecular_function	structural constituent of chromatin
A	0032200	biological_process	telomere organization
A	0032991	cellular_component	protein-containing complex
A	0040029	biological_process	epigenetic regulation of gene expression
A	0043229	cellular_component	intracellular organelle
A	0045296	molecular_function	cadherin binding
A	0046982	molecular_function	protein heterodimerization activity
A	0070062	cellular_component	extracellular exosome
B	0000781	cellular_component	chromosome, telomeric region
B	0000786	cellular_component	nucleosome
B	0003677	molecular_function	DNA binding
B	0003723	molecular_function	RNA binding
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005694	cellular_component	chromosome
B	0006325	biological_process	chromatin organization
B	0006334	biological_process	nucleosome assembly
B	0016020	cellular_component	membrane
B	0030527	molecular_function	structural constituent of chromatin
B	0032200	biological_process	telomere organization
B	0032991	cellular_component	protein-containing complex
B	0043505	cellular_component	CENP-A containing nucleosome
B	0045653	biological_process	negative regulation of megakaryocyte differentiation
B	0046982	molecular_function	protein heterodimerization activity
B	0061644	biological_process	protein localization to CENP-A containing chromatin
B	0070062	cellular_component	extracellular exosome
C	0000786	cellular_component	nucleosome
C	0003677	molecular_function	DNA binding
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005694	cellular_component	chromosome
C	0006325	biological_process	chromatin organization
C	0006334	biological_process	nucleosome assembly
C	0010467	biological_process	gene expression
C	0016020	cellular_component	membrane
C	0030527	molecular_function	structural constituent of chromatin
C	0032200	biological_process	telomere organization
C	0032991	cellular_component	protein-containing complex
C	0040029	biological_process	epigenetic regulation of gene expression
C	0043229	cellular_component	intracellular organelle
C	0045296	molecular_function	cadherin binding
C	0046982	molecular_function	protein heterodimerization activity
C	0070062	cellular_component	extracellular exosome
D	0000781	cellular_component	chromosome, telomeric region
D	0000786	cellular_component	nucleosome
D	0003677	molecular_function	DNA binding
D	0003723	molecular_function	RNA binding
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005694	cellular_component	chromosome
D	0006325	biological_process	chromatin organization
D	0006334	biological_process	nucleosome assembly
D	0016020	cellular_component	membrane
D	0030527	molecular_function	structural constituent of chromatin
D	0032200	biological_process	telomere organization
D	0032991	cellular_component	protein-containing complex
D	0043505	cellular_component	CENP-A containing nucleosome
D	0045653	biological_process	negative regulation of megakaryocyte differentiation
D	0046982	molecular_function	protein heterodimerization activity
D	0061644	biological_process	protein localization to CENP-A containing chromatin
D	0070062	cellular_component	extracellular exosome
E	0000786	cellular_component	nucleosome
E	0003677	molecular_function	DNA binding
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005694	cellular_component	chromosome
E	0006325	biological_process	chromatin organization
E	0006334	biological_process	nucleosome assembly
E	0010467	biological_process	gene expression
E	0016020	cellular_component	membrane
E	0030527	molecular_function	structural constituent of chromatin
E	0032200	biological_process	telomere organization
E	0032991	cellular_component	protein-containing complex
E	0040029	biological_process	epigenetic regulation of gene expression
E	0043229	cellular_component	intracellular organelle
E	0045296	molecular_function	cadherin binding
E	0046982	molecular_function	protein heterodimerization activity
E	0070062	cellular_component	extracellular exosome
F	0000781	cellular_component	chromosome, telomeric region
F	0000786	cellular_component	nucleosome
F	0003677	molecular_function	DNA binding
F	0003723	molecular_function	RNA binding
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005694	cellular_component	chromosome
F	0006325	biological_process	chromatin organization
F	0006334	biological_process	nucleosome assembly
F	0016020	cellular_component	membrane
F	0030527	molecular_function	structural constituent of chromatin
F	0032200	biological_process	telomere organization
F	0032991	cellular_component	protein-containing complex
F	0043505	cellular_component	CENP-A containing nucleosome
F	0045653	biological_process	negative regulation of megakaryocyte differentiation
F	0046982	molecular_function	protein heterodimerization activity
F	0061644	biological_process	protein localization to CENP-A containing chromatin
F	0070062	cellular_component	extracellular exosome
G	0000786	cellular_component	nucleosome
G	0003677	molecular_function	DNA binding
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005694	cellular_component	chromosome
G	0006325	biological_process	chromatin organization
G	0006334	biological_process	nucleosome assembly
G	0010467	biological_process	gene expression
G	0016020	cellular_component	membrane
G	0030527	molecular_function	structural constituent of chromatin
G	0032200	biological_process	telomere organization
G	0032991	cellular_component	protein-containing complex
G	0040029	biological_process	epigenetic regulation of gene expression
G	0043229	cellular_component	intracellular organelle
G	0045296	molecular_function	cadherin binding
G	0046982	molecular_function	protein heterodimerization activity
G	0070062	cellular_component	extracellular exosome
H	0000781	cellular_component	chromosome, telomeric region
H	0000786	cellular_component	nucleosome
H	0003677	molecular_function	DNA binding
H	0003723	molecular_function	RNA binding
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005694	cellular_component	chromosome
H	0006325	biological_process	chromatin organization
H	0006334	biological_process	nucleosome assembly
H	0016020	cellular_component	membrane
H	0030527	molecular_function	structural constituent of chromatin
H	0032200	biological_process	telomere organization
H	0032991	cellular_component	protein-containing complex
H	0043505	cellular_component	CENP-A containing nucleosome
H	0045653	biological_process	negative regulation of megakaryocyte differentiation
H	0046982	molecular_function	protein heterodimerization activity
H	0061644	biological_process	protein localization to CENP-A containing chromatin
H	0070062	cellular_component	extracellular exosome
L	0006335	biological_process	DNA replication-dependent chromatin assembly

Functional Information from PROSITE/UniProt

site_id	PS00047
Number of Residues	5
Details	HISTONE_H4 Histone H4 signature. GAKRH

Chain	Residue	Details
H	GLY14-HIS18

---

site_id	PS00322
Number of Residues	7
Details	HISTONE_H3_1 Histone H3 signature 1. KAPRKQL

Chain	Residue	Details
G	LYS14-LEU20

---

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. MASAsvDnTAIIWDV

Chain	Residue	Details
L	MET144-VAL158

---

site_id	PS00959
Number of Residues	9
Details	HISTONE_H3_2 Histone H3 signature 2. PFqRLVREI

Chain	Residue	Details
G	PRO66-ILE74

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
L	THR394
F	LYS16-LYS20
D	LYS16-LYS20
B	LYS16-LYS20

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231

Chain	Residue	Details
L	SER409
F	SER1
D	SER1
B	SER1

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163

Chain	Residue	Details
L	THR419
F	ARG3
D	ARG3
B	ARG3

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
K	SER803
F	LYS5
D	LYS5
B	LYS5

---

site_id	SWS_FT_FI5
Number of Residues	12
Details	MOD_RES: N6-propionyllysine; alternate => ECO:0000269|PubMed:17267393

Chain	Residue	Details
H	LYS8
B	LYS8
B	LYS16
B	LYS44
H	LYS16
H	LYS44
F	LYS8
F	LYS16
F	LYS44
D	LYS8
D	LYS16
D	LYS44

---

site_id	SWS_FT_FI6
Number of Residues	16
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000269|PubMed:22389435

Chain	Residue	Details
H	LYS12
D	LYS31
D	LYS77
D	LYS91
B	LYS12
B	LYS31
B	LYS77
B	LYS91
H	LYS31
H	LYS77
H	LYS91
F	LYS12
F	LYS31
F	LYS77
F	LYS91
D	LYS12

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:12086618, ECO:0000269|PubMed:15964846, ECO:0000269|PubMed:17967882, ECO:0000269|PubMed:27338793

Chain	Residue	Details
H	LYS20
F	LYS20
D	LYS20
B	LYS20

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	MOD_RES: Phosphoserine; by PAK2 => ECO:0000269|PubMed:21724829, ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
H	SER47
F	SER47
D	SER47
B	SER47

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:15592455, ECO:0007744|PubMed:20068231

Chain	Residue	Details
H	TYR51
F	TYR51
D	TYR51
B	TYR51

---

site_id	SWS_FT_FI10
Number of Residues	4
Details	MOD_RES: N6-glutaryllysine; alternate => ECO:0000269|PubMed:31542297

Chain	Residue	Details
H	LYS59
F	LYS59
D	LYS59
B	LYS59
C	LYS14
C	LYS56
A	LYS14
A	LYS56

---

site_id	SWS_FT_FI11
Number of Residues	4
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P62806

Chain	Residue	Details
H	LYS79
F	LYS79
D	LYS79
B	LYS79

---

site_id	SWS_FT_FI12
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P62806

Chain	Residue	Details
H	THR80
F	THR80
D	THR80
B	THR80
C	LYS18
C	LYS64
A	LYS18
A	LYS64

---

site_id	SWS_FT_FI13
Number of Residues	4
Details	MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
H	TYR88
F	TYR88
D	TYR88
B	TYR88

---

site_id	SWS_FT_FI14
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:25218447

Chain	Residue	Details
H	LYS12
F	LYS12
D	LYS12
B	LYS12

---

site_id	SWS_FT_FI15
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000269|PubMed:19818714

Chain	Residue	Details
G	LYS27
H	LYS91
C	LYS27
F	LYS91
D	LYS91
B	LYS91

---

site_id	SWS_FT_FI16
Number of Residues	12
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733

Chain	Residue	Details
H	LYS20
B	LYS20
B	LYS59
B	LYS79
H	LYS59
H	LYS79
F	LYS20
F	LYS59
F	LYS79
D	LYS20
D	LYS59
D	LYS79

---

site_id	SWS_FT_FI17
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1); alternate => ECO:0000269|PubMed:30886146

Chain	Residue	Details
H	LYS31
F	LYS31
D	LYS31
B	LYS31

---

site_id	SWS_FT_FI18
Number of Residues	4
Details	MOD_RES: N6-methyllysine => ECO:0000269|PubMed:15983376

Chain	Residue	Details
G	LYS37
E	LYS37
C	LYS37
A	LYS37

---

site_id	SWS_FT_FI19
Number of Residues	4
Details	MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:19783980

Chain	Residue	Details
G	TYR41
E	TYR41
C	TYR41
A	TYR41

---

site_id	SWS_FT_FI20
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:20850016

Chain	Residue	Details
G	SER57
E	SER57
C	SER57
A	SER57

---

site_id	SWS_FT_FI21
Number of Residues	4
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000269|PubMed:22389435, ECO:0000269|PubMed:29211711

Chain	Residue	Details
G	LYS79
E	LYS79
C	LYS79
A	LYS79

---

site_id	SWS_FT_FI22
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0000269|PubMed:20850016

Chain	Residue	Details
G	THR80
E	THR80
C	THR80
A	THR80

---

site_id	SWS_FT_FI23
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P84243

Chain	Residue	Details
G	SER86
E	SER86
C	SER86
A	SER86

---

site_id	SWS_FT_FI24
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
G	THR107
E	THR107
C	THR107
A	THR107

---

site_id	SWS_FT_FI25
Number of Residues	4
Details	MOD_RES: N6-glutaryllysine; alternate => ECO:0000269|PubMed:31542297

Chain	Residue	Details
G	LYS115
E	LYS115
C	LYS115
A	LYS115

---

site_id	SWS_FT_FI26
Number of Residues	4
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000269|PubMed:22389435, ECO:0000269|PubMed:27436229

Chain	Residue	Details
G	LYS122
E	LYS122
C	LYS122
A	LYS122

---

site_id	SWS_FT_FI27
Number of Residues	4
Details	LIPID: N6-decanoyllysine => ECO:0000269|PubMed:35939806

Chain	Residue	Details
G	LYS18
E	LYS18
C	LYS18
A	LYS18

---