7Y5K

Crystal structure of human CAF-1 core complex in spacegroup C2221

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0006335	biological_process	DNA replication-dependent chromatin assembly
C	0000118	cellular_component	histone deacetylase complex
C	0000122	biological_process	negative regulation of transcription by RNA polymerase II
C	0000781	cellular_component	chromosome, telomeric region
C	0000785	cellular_component	chromatin
C	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005694	cellular_component	chromosome
C	0005829	cellular_component	cytosol
C	0006260	biological_process	DNA replication
C	0006325	biological_process	chromatin organization
C	0006334	biological_process	nucleosome assembly
C	0006335	biological_process	DNA replication-dependent chromatin assembly
C	0006338	biological_process	chromatin remodeling
C	0006355	biological_process	regulation of DNA-templated transcription
C	0007420	biological_process	brain development
C	0008094	molecular_function	ATP-dependent activity, acting on DNA
C	0008285	biological_process	negative regulation of cell population proliferation
C	0016581	cellular_component	NuRD complex
C	0016589	cellular_component	NURF complex
C	0030336	biological_process	negative regulation of cell migration
C	0030512	biological_process	negative regulation of transforming growth factor beta receptor signaling pathway
C	0031492	molecular_function	nucleosomal DNA binding
C	0032991	cellular_component	protein-containing complex
C	0033186	cellular_component	CAF-1 complex
C	0035098	cellular_component	ESC/E(Z) complex
C	0042393	molecular_function	histone binding
C	0042659	biological_process	regulation of cell fate specification
C	0042826	molecular_function	histone deacetylase binding
C	0045892	biological_process	negative regulation of DNA-templated transcription
C	0045893	biological_process	positive regulation of DNA-templated transcription
C	0070822	cellular_component	Sin3-type complex
C	1902455	biological_process	negative regulation of stem cell population maintenance
C	1902459	biological_process	positive regulation of stem cell population maintenance
C	1904949	cellular_component	ATPase complex
C	2000736	biological_process	regulation of stem cell differentiation

Functional Information from PROSITE/UniProt

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. MASAsvDnTAIIWDV

Chain	Residue	Details
C	LEU289-LEU303
B	MET144-VAL158
C	LEU193-ILE207
C	LEU333-LEU347

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
B	THR394

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231

Chain	Residue	Details
B	SER409

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163

Chain	Residue	Details
B	THR419

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0000250|UniProtKB:Q60972

Chain	Residue	Details
C	LYS160

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site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
C	SER355

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site_id	SWS_FT_FI6
Number of Residues	1
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate

Chain	Residue	Details
C	LYS4

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site_id	SWS_FT_FI7
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:28112733

Chain	Residue	Details
C	LYS160

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