7Y45

Cryo-EM structure of the Na+,K+-ATPase in the E2.2K+ state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0005215	molecular_function	transporter activity
A	0005391	molecular_function	P-type sodium:potassium-exchanging transporter activity
A	0005524	molecular_function	ATP binding
A	0005886	cellular_component	plasma membrane
A	0005890	cellular_component	sodium:potassium-exchanging ATPase complex
A	0006813	biological_process	potassium ion transport
A	0006814	biological_process	sodium ion transport
A	0006883	biological_process	intracellular sodium ion homeostasis
A	0008556	molecular_function	P-type potassium transmembrane transporter activity
A	0010248	biological_process	establishment or maintenance of transmembrane electrochemical gradient
A	0016020	cellular_component	membrane
A	0016887	molecular_function	ATP hydrolysis activity
A	0030007	biological_process	intracellular potassium ion homeostasis
A	0036376	biological_process	sodium ion export across plasma membrane
A	0042383	cellular_component	sarcolemma
A	0046872	molecular_function	metal ion binding
A	1902600	biological_process	proton transmembrane transport
A	1990573	biological_process	potassium ion import across plasma membrane
B	0001671	molecular_function	ATPase activator activity
B	0005886	cellular_component	plasma membrane
B	0005890	cellular_component	sodium:potassium-exchanging ATPase complex
B	0006813	biological_process	potassium ion transport
B	0006814	biological_process	sodium ion transport
B	0006883	biological_process	intracellular sodium ion homeostasis
B	0030007	biological_process	intracellular potassium ion homeostasis
B	0036376	biological_process	sodium ion export across plasma membrane
B	1990573	biological_process	potassium ion import across plasma membrane
C	0000166	molecular_function	nucleotide binding
C	0005215	molecular_function	transporter activity
C	0005391	molecular_function	P-type sodium:potassium-exchanging transporter activity
C	0005524	molecular_function	ATP binding
C	0005886	cellular_component	plasma membrane
C	0005890	cellular_component	sodium:potassium-exchanging ATPase complex
C	0006813	biological_process	potassium ion transport
C	0006814	biological_process	sodium ion transport
C	0006883	biological_process	intracellular sodium ion homeostasis
C	0008556	molecular_function	P-type potassium transmembrane transporter activity
C	0010248	biological_process	establishment or maintenance of transmembrane electrochemical gradient
C	0016020	cellular_component	membrane
C	0016887	molecular_function	ATP hydrolysis activity
C	0030007	biological_process	intracellular potassium ion homeostasis
C	0036376	biological_process	sodium ion export across plasma membrane
C	0042383	cellular_component	sarcolemma
C	0046872	molecular_function	metal ion binding
C	1902600	biological_process	proton transmembrane transport
C	1990573	biological_process	potassium ion import across plasma membrane
D	0001671	molecular_function	ATPase activator activity
D	0005886	cellular_component	plasma membrane
D	0005890	cellular_component	sodium:potassium-exchanging ATPase complex
D	0006813	biological_process	potassium ion transport
D	0006814	biological_process	sodium ion transport
D	0006883	biological_process	intracellular sodium ion homeostasis
D	0030007	biological_process	intracellular potassium ion homeostasis
D	0036376	biological_process	sodium ion export across plasma membrane
D	1990573	biological_process	potassium ion import across plasma membrane
E	0016020	cellular_component	membrane
E	0043269	biological_process	regulation of monoatomic ion transport
E	0099106	molecular_function	ion channel regulator activity
G	0016020	cellular_component	membrane
G	0043269	biological_process	regulation of monoatomic ion transport
G	0099106	molecular_function	ion channel regulator activity

Functional Information from PROSITE/UniProt

site_id	PS01310
Number of Residues	14
Details	FXYD FXYD family signature. ErFtYDyyRLRvvG

Chain	Residue	Details
E	GLU10-GLY23

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site_id	PS00390
Number of Residues	21
Details	ATPASE_NA_K_BETA_1 Sodium and potassium ATPases beta subunits signature 1. WkkFlWDsekkefLGRTgssW

Chain	Residue	Details
D	TRP13-TRP33

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site_id	PS00391
Number of Residues	16
Details	ATPASE_NA_K_BETA_2 Sodium and potassium ATPases beta subunits signature 2. KkaCRfsrmwLknCSG

Chain	Residue	Details
D	LYS147-GLY162

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site_id	PS00154
Number of Residues	7
Details	ATPASE_E1_E2 E1-E2 ATPases phosphorylation site. DKTGTLT

Chain	Residue	Details
C	ASP376-THR382

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