7XHN

Structure of human inner kinetochore CCAN-DNA complex

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0000278	biological_process	mitotic cell cycle
C	0000775	cellular_component	chromosome, centromeric region
C	0000776	cellular_component	kinetochore
C	0000779	cellular_component	condensed chromosome, centromeric region
C	0000939	cellular_component	inner kinetochore
C	0003677	molecular_function	DNA binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005694	cellular_component	chromosome
C	0005721	cellular_component	pericentric heterochromatin
C	0005829	cellular_component	cytosol
C	0007059	biological_process	chromosome segregation
C	0016604	cellular_component	nuclear body
C	0019237	molecular_function	centromeric DNA binding
C	0030496	cellular_component	midbody
C	0042802	molecular_function	identical protein binding
C	0051301	biological_process	cell division
C	0051315	biological_process	attachment of mitotic spindle microtubules to kinetochore
C	0051382	biological_process	kinetochore assembly
C	0051455	biological_process	spindle attachment to meiosis I kinetochore
H	0000775	cellular_component	chromosome, centromeric region
H	0000776	cellular_component	kinetochore
H	0000939	cellular_component	inner kinetochore
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005694	cellular_component	chromosome
H	0005730	cellular_component	nucleolus
H	0005829	cellular_component	cytosol
H	0007052	biological_process	mitotic spindle organization
H	0007059	biological_process	chromosome segregation
H	0043515	molecular_function	kinetochore binding
H	0051382	biological_process	kinetochore assembly
H	0051383	biological_process	kinetochore organization
I	0000070	biological_process	mitotic sister chromatid segregation
I	0000775	cellular_component	chromosome, centromeric region
I	0000776	cellular_component	kinetochore
I	0000939	cellular_component	inner kinetochore
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005694	cellular_component	chromosome
I	0005829	cellular_component	cytosol
I	0007059	biological_process	chromosome segregation
I	0007548	biological_process	sex differentiation
I	0016604	cellular_component	nuclear body
I	0034080	biological_process	CENP-A containing chromatin assembly
I	0034508	biological_process	centromere complex assembly
K	0000070	biological_process	mitotic sister chromatid segregation
K	0000775	cellular_component	chromosome, centromeric region
K	0000776	cellular_component	kinetochore
K	0000939	cellular_component	inner kinetochore
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005694	cellular_component	chromosome
K	0005829	cellular_component	cytosol
K	0007059	biological_process	chromosome segregation
K	0051382	biological_process	kinetochore assembly
L	0000775	cellular_component	chromosome, centromeric region
L	0000939	cellular_component	inner kinetochore
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005694	cellular_component	chromosome
L	0005829	cellular_component	cytosol
L	0007059	biological_process	chromosome segregation
M	0000775	cellular_component	chromosome, centromeric region
M	0000776	cellular_component	kinetochore
M	0000939	cellular_component	inner kinetochore
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0005694	cellular_component	chromosome
M	0005737	cellular_component	cytoplasm
M	0005829	cellular_component	cytosol
M	0007059	biological_process	chromosome segregation
N	0000775	cellular_component	chromosome, centromeric region
N	0000776	cellular_component	kinetochore
N	0000939	cellular_component	inner kinetochore
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0005694	cellular_component	chromosome
N	0005829	cellular_component	cytosol
N	0007059	biological_process	chromosome segregation
N	0034080	biological_process	CENP-A containing chromatin assembly
O	0000775	cellular_component	chromosome, centromeric region
O	0000776	cellular_component	kinetochore
O	0000939	cellular_component	inner kinetochore
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005694	cellular_component	chromosome
O	0005829	cellular_component	cytosol
O	0007059	biological_process	chromosome segregation
O	0016604	cellular_component	nuclear body
O	0031511	cellular_component	Mis6-Sim4 complex
O	0034508	biological_process	centromere complex assembly
P	0000775	cellular_component	chromosome, centromeric region
P	0000939	cellular_component	inner kinetochore
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005694	cellular_component	chromosome
P	0005730	cellular_component	nucleolus
P	0005829	cellular_component	cytosol
P	0007059	biological_process	chromosome segregation
P	0034080	biological_process	CENP-A containing chromatin assembly
Q	0000775	cellular_component	chromosome, centromeric region
Q	0000939	cellular_component	inner kinetochore
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005654	cellular_component	nucleoplasm
Q	0005694	cellular_component	chromosome
Q	0005829	cellular_component	cytosol
Q	0007059	biological_process	chromosome segregation
Q	0015629	cellular_component	actin cytoskeleton
Q	0051310	biological_process	metaphase chromosome alignment
Q	1905342	biological_process	positive regulation of protein localization to kinetochore
R	0000775	cellular_component	chromosome, centromeric region
R	0000776	cellular_component	kinetochore
R	0000939	cellular_component	inner kinetochore
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005694	cellular_component	chromosome
R	0005737	cellular_component	cytoplasm
R	0005829	cellular_component	cytosol
R	0006355	biological_process	regulation of DNA-templated transcription
R	0006915	biological_process	apoptotic process
R	0007059	biological_process	chromosome segregation
R	0007155	biological_process	cell adhesion
R	0007165	biological_process	signal transduction
R	0016020	cellular_component	membrane
R	0034080	biological_process	CENP-A containing chromatin assembly
R	0050679	biological_process	positive regulation of epithelial cell proliferation
R	0051301	biological_process	cell division
R	1904036	biological_process	negative regulation of epithelial cell apoptotic process
S	0000712	biological_process	resolution of meiotic recombination intermediates
S	0000775	cellular_component	chromosome, centromeric region
S	0000776	cellular_component	kinetochore
S	0000785	cellular_component	chromatin
S	0000939	cellular_component	inner kinetochore
S	0003677	molecular_function	DNA binding
S	0003682	molecular_function	chromatin binding
S	0003690	molecular_function	double-stranded DNA binding
S	0005515	molecular_function	protein binding
S	0005634	cellular_component	nucleus
S	0005654	cellular_component	nucleoplasm
S	0005694	cellular_component	chromosome
S	0005829	cellular_component	cytosol
S	0006281	biological_process	DNA repair
S	0006974	biological_process	DNA damage response
S	0007059	biological_process	chromosome segregation
S	0031297	biological_process	replication fork processing
S	0031398	biological_process	positive regulation of protein ubiquitination
S	0036297	biological_process	interstrand cross-link repair
S	0043240	cellular_component	Fanconi anaemia nuclear complex
S	0046982	molecular_function	protein heterodimerization activity
S	0051301	biological_process	cell division
S	0071821	cellular_component	FANCM-MHF complex
T	0000278	biological_process	mitotic cell cycle
T	0000775	cellular_component	chromosome, centromeric region
T	0000776	cellular_component	kinetochore
T	0000939	cellular_component	inner kinetochore
T	0003677	molecular_function	DNA binding
T	0005515	molecular_function	protein binding
T	0005634	cellular_component	nucleus
T	0005654	cellular_component	nucleoplasm
T	0005694	cellular_component	chromosome
T	0005829	cellular_component	cytosol
T	0007059	biological_process	chromosome segregation
T	0016604	cellular_component	nuclear body
T	0046982	molecular_function	protein heterodimerization activity
T	0051276	biological_process	chromosome organization
T	0051301	biological_process	cell division
T	0051382	biological_process	kinetochore assembly
U	0000775	cellular_component	chromosome, centromeric region
U	0000776	cellular_component	kinetochore
U	0000939	cellular_component	inner kinetochore
U	0005515	molecular_function	protein binding
U	0005634	cellular_component	nucleus
U	0005654	cellular_component	nucleoplasm
U	0005694	cellular_component	chromosome
U	0005737	cellular_component	cytoplasm
U	0005829	cellular_component	cytosol
U	0007059	biological_process	chromosome segregation
U	0034451	cellular_component	centriolar satellite
U	0043009	biological_process	chordate embryonic development
W	0000278	biological_process	mitotic cell cycle
W	0000775	cellular_component	chromosome, centromeric region
W	0000776	cellular_component	kinetochore
W	0000939	cellular_component	inner kinetochore
W	0003677	molecular_function	DNA binding
W	0005515	molecular_function	protein binding
W	0005634	cellular_component	nucleus
W	0005654	cellular_component	nucleoplasm
W	0005694	cellular_component	chromosome
W	0005730	cellular_component	nucleolus
W	0007059	biological_process	chromosome segregation
W	0016363	cellular_component	nuclear matrix
W	0034080	biological_process	CENP-A containing chromatin assembly
W	0046982	molecular_function	protein heterodimerization activity
W	0051276	biological_process	chromosome organization
W	0051301	biological_process	cell division
W	0051382	biological_process	kinetochore assembly
X	0000712	biological_process	resolution of meiotic recombination intermediates
X	0000775	cellular_component	chromosome, centromeric region
X	0000776	cellular_component	kinetochore
X	0000785	cellular_component	chromatin
X	0000939	cellular_component	inner kinetochore
X	0003677	molecular_function	DNA binding
X	0003690	molecular_function	double-stranded DNA binding
X	0005515	molecular_function	protein binding
X	0005634	cellular_component	nucleus
X	0005654	cellular_component	nucleoplasm
X	0005694	cellular_component	chromosome
X	0005829	cellular_component	cytosol
X	0006281	biological_process	DNA repair
X	0007059	biological_process	chromosome segregation
X	0031297	biological_process	replication fork processing
X	0031398	biological_process	positive regulation of protein ubiquitination
X	0036297	biological_process	interstrand cross-link repair
X	0043240	cellular_component	Fanconi anaemia nuclear complex
X	0051301	biological_process	cell division
X	0051382	biological_process	kinetochore assembly
X	0071821	cellular_component	FANCM-MHF complex
c	0000278	biological_process	mitotic cell cycle
c	0000775	cellular_component	chromosome, centromeric region
c	0000776	cellular_component	kinetochore
c	0000779	cellular_component	condensed chromosome, centromeric region
c	0000939	cellular_component	inner kinetochore
c	0003677	molecular_function	DNA binding
c	0005515	molecular_function	protein binding
c	0005634	cellular_component	nucleus
c	0005654	cellular_component	nucleoplasm
c	0005694	cellular_component	chromosome
c	0005721	cellular_component	pericentric heterochromatin
c	0005829	cellular_component	cytosol
c	0007059	biological_process	chromosome segregation
c	0016604	cellular_component	nuclear body
c	0019237	molecular_function	centromeric DNA binding
c	0030496	cellular_component	midbody
c	0042802	molecular_function	identical protein binding
c	0051301	biological_process	cell division
c	0051315	biological_process	attachment of mitotic spindle microtubules to kinetochore
c	0051382	biological_process	kinetochore assembly
c	0051455	biological_process	spindle attachment to meiosis I kinetochore
o	0000775	cellular_component	chromosome, centromeric region
o	0000776	cellular_component	kinetochore
o	0000939	cellular_component	inner kinetochore
o	0005515	molecular_function	protein binding
o	0005634	cellular_component	nucleus
o	0005654	cellular_component	nucleoplasm
o	0005694	cellular_component	chromosome
o	0005829	cellular_component	cytosol
o	0007059	biological_process	chromosome segregation
o	0016604	cellular_component	nuclear body
o	0031511	cellular_component	Mis6-Sim4 complex
o	0034508	biological_process	centromere complex assembly

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: N-acetylmethionine => ECO:0007744|PubMed:22814378

Chain	Residue	Details
S	MET1
C	SER333
C	SER528
C	SER684
c	SER73
c	SER333
c	SER528
c	SER684

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
N	SER235
c	SER96

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
N	SER282
U	SER232
c	THR130
c	THR734

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
H	LYS67
C	SER189
R	LYS22
c	SER189

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163

Chain	Residue	Details
U	SER111
c	THR183
T	SER386

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q8C4M7

Chain	Residue	Details
U	SER116
U	SER120
U	SER190

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648

Chain	Residue	Details
U	SER136
c	SER261

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163

Chain	Residue	Details
U	SER139
U	SER141

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
U	SER194
C	SER397
c	SER376
c	SER397

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
U	LYS185
c	SER439

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
C	SER538
c	SER538

---

site_id	SWS_FT_FI12
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692

Chain	Residue	Details
C	SER709
C	SER710
c	SER709
c	SER710

---

site_id	SWS_FT_FI13
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231

Chain	Residue	Details
C	SER763
c	SER763

---

site_id	SWS_FT_FI14
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231

Chain	Residue	Details
C	SER773
c	SER773

---

site_id	SWS_FT_FI15
Number of Residues	32
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
C	LYS45
C	LYS273
C	LYS297
C	LYS440
C	LYS534
C	LYS677
C	LYS727
C	LYS807
c	LYS45
c	LYS119
c	LYS134
c	LYS180
c	LYS212
c	LYS238
c	LYS260
c	LYS271
c	LYS273
c	LYS297
c	LYS440
c	LYS534
C	LYS119
c	LYS677
c	LYS727
c	LYS807
C	LYS134
C	LYS180
C	LYS212
C	LYS238
C	LYS260
C	LYS271

---

site_id	SWS_FT_FI16
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25755297

Chain	Residue	Details
C	LYS217
c	LYS217

---