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7XER

Structure of mTRPV2_Q525T

Functional Information from GO Data
ChainGOidnamespacecontents
A0005216molecular_functionmonoatomic ion channel activity
A0005261molecular_functionmonoatomic cation channel activity
A0005262molecular_functioncalcium channel activity
A0005737cellular_componentcytoplasm
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006915biological_processapoptotic process
A0008285biological_processnegative regulation of cell population proliferation
A0009266biological_processresponse to temperature stimulus
A0009986cellular_componentcell surface
A0012505cellular_componentendomembrane system
A0016020cellular_componentmembrane
A0030027cellular_componentlamellipodium
A0030424cellular_componentaxon
A0032584cellular_componentgrowth cone membrane
A0042470cellular_componentmelanosome
A0042802molecular_functionidentical protein binding
A0044295cellular_componentaxonal growth cone
A0044297cellular_componentcell body
A0045773biological_processpositive regulation of axon extension
A0055085biological_processtransmembrane transport
A0070588biological_processcalcium ion transmembrane transport
A0090280biological_processpositive regulation of calcium ion import
A0120162biological_processpositive regulation of cold-induced thermogenesis
B0005216molecular_functionmonoatomic ion channel activity
B0005261molecular_functionmonoatomic cation channel activity
B0005262molecular_functioncalcium channel activity
B0005737cellular_componentcytoplasm
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006915biological_processapoptotic process
B0008285biological_processnegative regulation of cell population proliferation
B0009266biological_processresponse to temperature stimulus
B0009986cellular_componentcell surface
B0012505cellular_componentendomembrane system
B0016020cellular_componentmembrane
B0030027cellular_componentlamellipodium
B0030424cellular_componentaxon
B0032584cellular_componentgrowth cone membrane
B0042470cellular_componentmelanosome
B0042802molecular_functionidentical protein binding
B0044295cellular_componentaxonal growth cone
B0044297cellular_componentcell body
B0045773biological_processpositive regulation of axon extension
B0055085biological_processtransmembrane transport
B0070588biological_processcalcium ion transmembrane transport
B0090280biological_processpositive regulation of calcium ion import
B0120162biological_processpositive regulation of cold-induced thermogenesis
C0005216molecular_functionmonoatomic ion channel activity
C0005261molecular_functionmonoatomic cation channel activity
C0005262molecular_functioncalcium channel activity
C0005737cellular_componentcytoplasm
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0006915biological_processapoptotic process
C0008285biological_processnegative regulation of cell population proliferation
C0009266biological_processresponse to temperature stimulus
C0009986cellular_componentcell surface
C0012505cellular_componentendomembrane system
C0016020cellular_componentmembrane
C0030027cellular_componentlamellipodium
C0030424cellular_componentaxon
C0032584cellular_componentgrowth cone membrane
C0042470cellular_componentmelanosome
C0042802molecular_functionidentical protein binding
C0044295cellular_componentaxonal growth cone
C0044297cellular_componentcell body
C0045773biological_processpositive regulation of axon extension
C0055085biological_processtransmembrane transport
C0070588biological_processcalcium ion transmembrane transport
C0090280biological_processpositive regulation of calcium ion import
C0120162biological_processpositive regulation of cold-induced thermogenesis
D0005216molecular_functionmonoatomic ion channel activity
D0005261molecular_functionmonoatomic cation channel activity
D0005262molecular_functioncalcium channel activity
D0005737cellular_componentcytoplasm
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0006915biological_processapoptotic process
D0008285biological_processnegative regulation of cell population proliferation
D0009266biological_processresponse to temperature stimulus
D0009986cellular_componentcell surface
D0012505cellular_componentendomembrane system
D0016020cellular_componentmembrane
D0030027cellular_componentlamellipodium
D0030424cellular_componentaxon
D0032584cellular_componentgrowth cone membrane
D0042470cellular_componentmelanosome
D0042802molecular_functionidentical protein binding
D0044295cellular_componentaxonal growth cone
D0044297cellular_componentcell body
D0045773biological_processpositive regulation of axon extension
D0055085biological_processtransmembrane transport
D0070588biological_processcalcium ion transmembrane transport
D0090280biological_processpositive regulation of calcium ion import
D0120162biological_processpositive regulation of cold-induced thermogenesis
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2116
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
AMET1-ARG387
ATYR450-ARG455
AARG512-LEU532
AALA638-HIS756
BMET1-ARG387
BTYR450-ARG455
BARG512-LEU532
BALA638-HIS756
CMET1-ARG387
CTYR450-ARG455
CARG512-LEU532
CALA638-HIS756
DMET1-ARG387
DTYR450-ARG455
DARG512-LEU532
DALA638-HIS756

site_idSWS_FT_FI2
Number of Residues480
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
APHE388-HIS408
ALEU429-TRP449
ALEU456-LEU476
ATRP491-THR511
ALEU533-LEU553
AVAL617-ILE637
BPHE388-HIS408
BLEU429-TRP449
BLEU456-LEU476
BTRP491-THR511
BLEU533-LEU553
BVAL617-ILE637
CPHE388-HIS408
CLEU429-TRP449
CLEU456-LEU476
CTRP491-THR511
CLEU533-LEU553
CVAL617-ILE637
DPHE388-HIS408
DLEU429-TRP449
DLEU456-LEU476
DTRP491-THR511
DLEU533-LEU553
DVAL617-ILE637

site_idSWS_FT_FI3
Number of Residues128
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
AGLN409-MET428
ALEU477-GLU490
BGLN409-MET428
BLEU477-GLU490
CGLN409-MET428
CLEU477-GLU490
DGLN409-MET428
DLEU477-GLU490

site_idSWS_FT_FI4
Number of Residues144
DetailsINTRAMEM: Pore-forming => ECO:0000255
ChainResidueDetails
ATHR568-GLU604
BTHR568-GLU604
CTHR568-GLU604
DTHR568-GLU604

site_idSWS_FT_FI5
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:19144319, ECO:0007744|PubMed:21183079
ChainResidueDetails
ASER15
BSER15
CSER15
DSER15

site_idSWS_FT_FI6
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9WUD2
ChainResidueDetails
ASER77
BSER77
CSER77
DSER77

site_idSWS_FT_FI7
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:21183079
ChainResidueDetails
ASER743
BSER743
CSER743
DSER743

site_idSWS_FT_FI8
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:19144319
ChainResidueDetails
ASER755
BSER755
CSER755
DSER755

site_idSWS_FT_FI9
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN567
BASN567
CASN567
DASN567

219869

PDB entries from 2024-05-15

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