7WZR

Cryo-EM structure of Mec1-HU

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0000077	biological_process	DNA damage checkpoint signaling
C	0000722	biological_process	telomere maintenance via recombination
C	0000723	biological_process	telomere maintenance
C	0004672	molecular_function	protein kinase activity
C	0004674	molecular_function	protein serine/threonine kinase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0005694	cellular_component	chromosome
C	0005739	cellular_component	mitochondrion
C	0006139	biological_process	nucleobase-containing compound metabolic process
C	0006260	biological_process	DNA replication
C	0006281	biological_process	DNA repair
C	0006310	biological_process	DNA recombination
C	0006325	biological_process	chromatin organization
C	0007131	biological_process	reciprocal meiotic recombination
C	0016301	molecular_function	kinase activity
C	0019219	biological_process	regulation of nucleobase-containing compound metabolic process
C	0035556	biological_process	intracellular signal transduction
C	0042770	biological_process	signal transduction in response to DNA damage
C	0051321	biological_process	meiotic cell cycle
C	0070310	cellular_component	ATR-ATRIP complex
C	0106310	molecular_function	protein serine kinase activity
C	2000105	biological_process	positive regulation of DNA-templated DNA replication
C	2000779	biological_process	regulation of double-strand break repair
D	0000077	biological_process	DNA damage checkpoint signaling
D	0000228	cellular_component	nuclear chromosome
D	0003684	molecular_function	damaged DNA binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0006139	biological_process	nucleobase-containing compound metabolic process
D	0006281	biological_process	DNA repair
D	0006325	biological_process	chromatin organization
D	0007004	biological_process	telomere maintenance via telomerase
D	0045184	biological_process	establishment of protein localization
D	0070310	cellular_component	ATR-ATRIP complex
D	2000779	biological_process	regulation of double-strand break repair
E	0000077	biological_process	DNA damage checkpoint signaling
E	0000228	cellular_component	nuclear chromosome
E	0003684	molecular_function	damaged DNA binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0006139	biological_process	nucleobase-containing compound metabolic process
E	0006281	biological_process	DNA repair
E	0006325	biological_process	chromatin organization
E	0007004	biological_process	telomere maintenance via telomerase
E	0045184	biological_process	establishment of protein localization
E	0070310	cellular_component	ATR-ATRIP complex
E	2000779	biological_process	regulation of double-strand break repair
F	0000077	biological_process	DNA damage checkpoint signaling
F	0000722	biological_process	telomere maintenance via recombination
F	0000723	biological_process	telomere maintenance
F	0004672	molecular_function	protein kinase activity
F	0004674	molecular_function	protein serine/threonine kinase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005634	cellular_component	nucleus
F	0005694	cellular_component	chromosome
F	0005739	cellular_component	mitochondrion
F	0006139	biological_process	nucleobase-containing compound metabolic process
F	0006260	biological_process	DNA replication
F	0006281	biological_process	DNA repair
F	0006310	biological_process	DNA recombination
F	0006325	biological_process	chromatin organization
F	0007131	biological_process	reciprocal meiotic recombination
F	0016301	molecular_function	kinase activity
F	0019219	biological_process	regulation of nucleobase-containing compound metabolic process
F	0035556	biological_process	intracellular signal transduction
F	0042770	biological_process	signal transduction in response to DNA damage
F	0051321	biological_process	meiotic cell cycle
F	0070310	cellular_component	ATR-ATRIP complex
F	0106310	molecular_function	protein serine kinase activity
F	2000105	biological_process	positive regulation of DNA-templated DNA replication
F	2000779	biological_process	regulation of double-strand break repair

Functional Information from PROSITE/UniProt

site_id	PS00915
Number of Residues	14
Details	PI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. CKk..EDVRQDnqymQ

Chain	Residue	Details
C	CYS2079-GLN2092

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site_id	PS00916
Number of Residues	21
Details	PI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. SyAvmaMvgHILgLgDRHceN

Chain	Residue	Details
C	SER2209-ASN2229

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18407956

Chain	Residue	Details
E	SER10
E	SER11
E	SER76
D	SER10
D	SER11
D	SER76

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