7WE4
Human Nav1.8 with A-803467, class I
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001518 | cellular_component | voltage-gated sodium channel complex |
| A | 0002027 | biological_process | regulation of heart rate |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005248 | molecular_function | voltage-gated sodium channel activity |
| A | 0005261 | molecular_function | monoatomic cation channel activity |
| A | 0005272 | molecular_function | sodium channel activity |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006814 | biological_process | sodium ion transport |
| A | 0007600 | biological_process | sensory perception |
| A | 0016020 | cellular_component | membrane |
| A | 0030424 | cellular_component | axon |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| A | 0034702 | cellular_component | monoatomic ion channel complex |
| A | 0034765 | biological_process | regulation of monoatomic ion transmembrane transport |
| A | 0035725 | biological_process | sodium ion transmembrane transport |
| A | 0042475 | biological_process | odontogenesis of dentin-containing tooth |
| A | 0042734 | cellular_component | presynaptic membrane |
| A | 0044325 | molecular_function | transmembrane transporter binding |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0055117 | biological_process | regulation of cardiac muscle contraction |
| A | 0060371 | biological_process | regulation of atrial cardiac muscle cell membrane depolarization |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0071439 | cellular_component | clathrin complex |
| A | 0086002 | biological_process | cardiac muscle cell action potential involved in contraction |
| A | 0086010 | biological_process | membrane depolarization during action potential |
| A | 0086016 | biological_process | AV node cell action potential |
| A | 0086043 | biological_process | bundle of His cell action potential |
| A | 0098978 | cellular_component | glutamatergic synapse |
| A | 0099505 | biological_process | regulation of presynaptic membrane potential |
| A | 0099508 | molecular_function | voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1015 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305 |
| Chain | Residue | Details |
| A | MET1-LYS125 | |
| A | ASP1419-ASP1471 | |
| A | ARG1531-THR1536 | |
| A | THR1595-ASN1609 | |
| A | GLU1723-PRO1956 | |
| A | ARG175-ASP187 | |
| A | LYS233-ASP248 | |
| A | TYR400-PHE659 | |
| A | ASP720-LYS727 | |
| A | ASN774-ASN789 | |
| A | ASN891-ARG1147 | |
| A | LYS1211-ASN1216 | |
| A | GLU1265-ASN1283 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=S1 of repeat I => ECO:0000255 |
| Chain | Residue | Details |
| A | VAL126-ARG149 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 261 |
| Details | TOPO_DOM: Extracellular => ECO:0000305 |
| Chain | Residue | Details |
| A | THR150-GLU154 | |
| A | GLU1239-GLU1242 | |
| A | ASN1312-VAL1353 | |
| A | ALA1376-ASN1391 | |
| A | GLU1496-LYS1506 | |
| A | LYS1561-PHE1572 | |
| A | ARG1633-THR1646 | |
| A | ILE1670-VAL1697 | |
| A | ASP207-SER212 | |
| A | LYS273-SER341 | |
| A | ARG367-TYR373 | |
| A | GLU685-ALA695 | |
| A | LYS748-SER753 | |
| A | GLU811-ASP834 | |
| A | ALA856-SER864 | |
| A | GLU1172-ALA1184 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=S2 of repeat I => ECO:0000255 |
| Chain | Residue | Details |
| A | LYS155-ALA174 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S3 of repeat I => ECO:0000255 |
| Chain | Residue | Details |
| A | PRO188-ILE206 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Voltage-sensor; Name=S4 of repeat I => ECO:0000255 |
| Chain | Residue | Details |
| A | GLY213-LEU232 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=S5 of repeat I => ECO:0000255 |
| Chain | Residue | Details |
| A | VAL249-LEU272 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 87 |
| Details | INTRAMEM: Pore-forming => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | PHE342-LEU366 | |
| A | PHE835-TRP855 | |
| A | ALA1354-ALA1375 | |
| A | PHE1647-PRO1669 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 25 |
| Details | TRANSMEM: Helical; Name=S6 of repeat I => ECO:0000255 |
| Chain | Residue | Details |
| A | MET374-ALA399 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=S1 of repeat II => ECO:0000255 |
| Chain | Residue | Details |
| A | GLY660-MET684 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=S2 of repeat II => ECO:0000255 |
| Chain | Residue | Details |
| A | MET696-PHE719 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=S3 of repeat II => ECO:0000255 |
| Chain | Residue | Details |
| A | LYS728-ALA747 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Voltage-sensor; Name=S4 of repeat II => ECO:0000255 |
| Chain | Residue | Details |
| A | VAL754-LEU773 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=S5 of repeat II => ECO:0000255 |
| Chain | Residue | Details |
| A | LEU790-GLY810 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 25 |
| Details | TRANSMEM: Helical; Name=S6 of repeat II => ECO:0000255 |
| Chain | Residue | Details |
| A | ILE865-LEU890 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=S1 of repeat III => ECO:0000255 |
| Chain | Residue | Details |
| A | ILE1148-PHE1171 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 25 |
| Details | TRANSMEM: Helical; Name=S2 of repeat III => ECO:0000255 |
| Chain | Residue | Details |
| A | LEU1185-PHE1210 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=S3 of repeat III => ECO:0000255 |
| Chain | Residue | Details |
| A | ALA1217-LEU1238 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Voltage-sensor; Name=S4 of repeat III => ECO:0000255 |
| Chain | Residue | Details |
| A | VAL1243-PHE1264 |
| site_id | SWS_FT_FI20 |
| Number of Residues | 27 |
| Details | TRANSMEM: Helical; Name=S5 of repeat III => ECO:0000255 |
| Chain | Residue | Details |
| A | VAL1284-ILE1311 |
| site_id | SWS_FT_FI21 |
| Number of Residues | 26 |
| Details | TRANSMEM: Helical; Name=S6 of repeat III => ECO:0000255 |
| Chain | Residue | Details |
| A | VAL1392-ILE1418 |
| site_id | SWS_FT_FI22 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=S1 of repeat IV => ECO:0000255 |
| Chain | Residue | Details |
| A | ILE1472-VAL1495 |
| site_id | SWS_FT_FI23 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=S2 of repeat IV => ECO:0000255 |
| Chain | Residue | Details |
| A | ILE1507-LEU1530 |
| site_id | SWS_FT_FI24 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=S3 of repeat IV => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN1537-LEU1560 |
| site_id | SWS_FT_FI25 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Voltage-sensor; Name=S4 of repeat IV => ECO:0000255 |
| Chain | Residue | Details |
| A | ARG1573-ARG1594 |
| site_id | SWS_FT_FI26 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=S5 of repeat IV => ECO:0000255 |
| Chain | Residue | Details |
| A | ILE1610-VAL1632 |
| site_id | SWS_FT_FI27 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=S6 of repeat IV => ECO:0000255 |
| Chain | Residue | Details |
| A | GLY1698-LEU1722 |
| site_id | SWS_FT_FI28 |
| Number of Residues | 6 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q14524 |
| Chain | Residue | Details |
| A | SER441 | |
| A | SER444 | |
| A | SER467 | |
| A | SER479 | |
| A | SER612 | |
| A | SER615 |
| site_id | SWS_FT_FI29 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by PKC => ECO:0000250|UniProtKB:Q14524 |
| Chain | Residue | Details |
| A | SER1451 |
| site_id | SWS_FT_FI30 |
| Number of Residues | 9 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN284 | |
| A | ASN288 | |
| A | ASN312 | |
| A | ASN335 | |
| A | ASN819 | |
| A | ASN1312 | |
| A | ASN1328 | |
| A | ASN1336 | |
| A | ASN1686 |
