7WC4
Crystal structure of serotonin 2A receptor in complex with serotonin
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004930 | molecular_function | G protein-coupled receptor activity |
| A | 0004993 | molecular_function | G protein-coupled serotonin receptor activity |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| A | 0009055 | molecular_function | electron transfer activity |
| A | 0016020 | cellular_component | membrane |
| A | 0020037 | molecular_function | heme binding |
| A | 0022900 | biological_process | electron transport chain |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000250 |
| Chain | Residue | Details |
| A | TRP76-VAL99 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 29 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000250 |
| Chain | Residue | Details |
| A | SER100-ASN110 | |
| A | ASP172-LYS191 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000250 |
| Chain | Residue | Details |
| A | TYR111-MET132 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 47 |
| Details | TOPO_DOM: Extracellular => ECO:0000250 |
| Chain | Residue | Details |
| A | LEU133-CYS148 | |
| A | GLN216-ASN233 | |
| A | VAL347-LEU362 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000250 |
| Chain | Residue | Details |
| A | ALA149-LEU171 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000250 |
| Chain | Residue | Details |
| A | ALA192-LEU215 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000250 |
| Chain | Residue | Details |
| A | PHE234-TYR254 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000250 |
| Chain | Residue | Details |
| A | LEU325-ALA346 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000250 |
| Chain | Residue | Details |
| A | ASN363-ASN384 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P41595 |
| Chain | Residue | Details |
| A | THR160 | |
| A | LEU229 | |
| A | ASP155 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | SITE: Hydrophobic barrier that decreases the speed of ligand binding and dissociation => ECO:0000269|PubMed:28129538 |
| Chain | Residue | Details |
| A | LEU229 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:24637012 |
| Chain | Residue | Details |
| A | ALA1037 |
