Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7UPN

Maedi visna virus Vif in complex with CypA and E3 ubiquitin ligase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000413	biological_process	protein peptidyl-prolyl isomerization
A	0001933	biological_process	negative regulation of protein phosphorylation
A	0001934	biological_process	positive regulation of protein phosphorylation
A	0003723	molecular_function	RNA binding
A	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
A	0005178	molecular_function	integrin binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005925	cellular_component	focal adhesion
A	0006457	biological_process	protein folding
A	0006469	biological_process	negative regulation of protein kinase activity
A	0006915	biological_process	apoptotic process
A	0016018	molecular_function	cyclosporin A binding
A	0016020	cellular_component	membrane
A	0019076	biological_process	viral release from host cell
A	0030168	biological_process	platelet activation
A	0030182	biological_process	neuron differentiation
A	0030593	biological_process	neutrophil chemotaxis
A	0030595	biological_process	leukocyte chemotaxis
A	0031982	cellular_component	vesicle
A	0032148	biological_process	activation of protein kinase B activity
A	0032873	biological_process	negative regulation of stress-activated MAPK cascade
A	0032991	cellular_component	protein-containing complex
A	0034389	biological_process	lipid droplet organization
A	0034599	biological_process	cellular response to oxidative stress
A	0034774	cellular_component	secretory granule lumen
A	0035307	biological_process	positive regulation of protein dephosphorylation
A	0042118	biological_process	endothelial cell activation
A	0043410	biological_process	positive regulation of MAPK cascade
A	0045069	biological_process	regulation of viral genome replication
A	0045070	biological_process	positive regulation of viral genome replication
A	0046790	molecular_function	virion binding
A	0050714	biological_process	positive regulation of protein secretion
A	0051082	molecular_function	unfolded protein binding
A	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
A	0060352	biological_process	cell adhesion molecule production
A	0061944	biological_process	negative regulation of protein K48-linked ubiquitination
A	0070062	cellular_component	extracellular exosome
A	0070527	biological_process	platelet aggregation
A	1902176	biological_process	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
A	1903901	biological_process	negative regulation of viral life cycle
A	1904399	molecular_function	heparan sulfate binding
A	1904813	cellular_component	ficolin-1-rich granule lumen
A	2001233	biological_process	regulation of apoptotic signaling pathway
B	0000413	biological_process	protein peptidyl-prolyl isomerization
B	0001933	biological_process	negative regulation of protein phosphorylation
B	0001934	biological_process	positive regulation of protein phosphorylation
B	0003723	molecular_function	RNA binding
B	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
B	0005178	molecular_function	integrin binding
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005925	cellular_component	focal adhesion
B	0006457	biological_process	protein folding
B	0006469	biological_process	negative regulation of protein kinase activity
B	0006915	biological_process	apoptotic process
B	0016018	molecular_function	cyclosporin A binding
B	0016020	cellular_component	membrane
B	0019076	biological_process	viral release from host cell
B	0030168	biological_process	platelet activation
B	0030182	biological_process	neuron differentiation
B	0030593	biological_process	neutrophil chemotaxis
B	0030595	biological_process	leukocyte chemotaxis
B	0031982	cellular_component	vesicle
B	0032148	biological_process	activation of protein kinase B activity
B	0032873	biological_process	negative regulation of stress-activated MAPK cascade
B	0032991	cellular_component	protein-containing complex
B	0034389	biological_process	lipid droplet organization
B	0034599	biological_process	cellular response to oxidative stress
B	0034774	cellular_component	secretory granule lumen
B	0035307	biological_process	positive regulation of protein dephosphorylation
B	0042118	biological_process	endothelial cell activation
B	0043410	biological_process	positive regulation of MAPK cascade
B	0045069	biological_process	regulation of viral genome replication
B	0045070	biological_process	positive regulation of viral genome replication
B	0046790	molecular_function	virion binding
B	0050714	biological_process	positive regulation of protein secretion
B	0051082	molecular_function	unfolded protein binding
B	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
B	0060352	biological_process	cell adhesion molecule production
B	0061944	biological_process	negative regulation of protein K48-linked ubiquitination
B	0070062	cellular_component	extracellular exosome
B	0070527	biological_process	platelet aggregation
B	1902176	biological_process	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
B	1903901	biological_process	negative regulation of viral life cycle
B	1904399	molecular_function	heparan sulfate binding
B	1904813	cellular_component	ficolin-1-rich granule lumen
B	2001233	biological_process	regulation of apoptotic signaling pathway
C	0030430	cellular_component	host cell cytoplasm
C	0044423	cellular_component	virion component
E	0006511	biological_process	ubiquitin-dependent protein catabolic process
F	0030430	cellular_component	host cell cytoplasm
F	0044423	cellular_component	virion component
G	0006511	biological_process	ubiquitin-dependent protein catabolic process
H	0001222	molecular_function	transcription corepressor binding
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005829	cellular_component	cytosol
H	0006367	biological_process	transcription initiation at RNA polymerase II promoter
H	0006368	biological_process	transcription elongation by RNA polymerase II
H	0016567	biological_process	protein ubiquitination
H	0030891	cellular_component	VCB complex
H	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
H	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
H	0031625	molecular_function	ubiquitin protein ligase binding
H	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
H	0065003	biological_process	protein-containing complex assembly
H	0070449	cellular_component	elongin complex
H	0140958	biological_process	target-directed miRNA degradation
I	0001222	molecular_function	transcription corepressor binding
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005829	cellular_component	cytosol
I	0006367	biological_process	transcription initiation at RNA polymerase II promoter
I	0006368	biological_process	transcription elongation by RNA polymerase II
I	0016567	biological_process	protein ubiquitination
I	0030891	cellular_component	VCB complex
I	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
I	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
I	0031625	molecular_function	ubiquitin protein ligase binding
I	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
I	0065003	biological_process	protein-containing complex assembly
I	0070449	cellular_component	elongin complex
I	0140958	biological_process	target-directed miRNA degradation

Functional Information from PROSITE/UniProt

site_id	PS00170
Number of Residues	18
Details	CSA_PPIASE_1 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. YkgScFHRIIpgFMcQGG

Chain	Residue	Details
A	TYR48-GLY65

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: N-acetylmethionine => ECO:0000269\|Ref.6, ECO:0007744\|PubMed:19413330, ECO:0007744\|PubMed:22814378

Chain	Residue	Details
H	MET1
I	MET1

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0000250\|UniProtKB:P62869

Chain	Residue	Details
H	THR84
I	THR84

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P62869

Chain	Residue	Details
H	SER108
H	SER111
I	SER108
I	SER111

site_id	SWS_FT_FI4
Number of Residues	6
Details	MOD_RES: N6-acetyllysine => ECO:0007744\|PubMed:19608861

Chain	Residue	Details
A	LYS44
A	LYS76
A	LYS131
B	LYS44
B	LYS76
B	LYS131

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
A	SER77
B	SER77

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:20068231

Chain	Residue	Details
A	THR93
B	THR93

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0000269\|PubMed:20364129, ECO:0000269\|PubMed:25678563, ECO:0007744\|PubMed:19608861

Chain	Residue	Details
A	LYS125
B	LYS125

site_id	SWS_FT_FI8
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0000250\|UniProtKB:P17742

Chain	Residue	Details
A	LYS133
B	LYS133

site_id	SWS_FT_FI9
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN108
B	ASN108

site_id	SWS_FT_FI10
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate

Chain	Residue	Details
A	LYS28
B	LYS28

site_id	SWS_FT_FI11
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744\|PubMed:28112733

Chain	Residue	Details
A	LYS82
B	LYS82

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	7
Details	M-CSA 189

Chain	Residue	Details
A	ARG55	electrostatic stabiliser, hydrogen bond donor, steric role
A	PHE60	polar/non-polar interaction, steric role
A	GLN63	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
A	ASN102	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
A	PHE113	polar/non-polar interaction, steric role
A	LEU122	polar/non-polar interaction, steric role
A	HIS126	polar/non-polar interaction, steric role

site_id	MCSA2
Number of Residues	7
Details	M-CSA 189

Chain	Residue	Details
B	ARG55	electrostatic stabiliser, hydrogen bond donor, steric role
B	PHE60	polar/non-polar interaction, steric role
B	GLN63	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
B	ASN102	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
B	PHE113	polar/non-polar interaction, steric role
B	LEU122	polar/non-polar interaction, steric role
B	HIS126	polar/non-polar interaction, steric role

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)