Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7UIK

Mediator-PIC Early (Tail A + Upstream DNA & Activator)

Functional Information from GO Data

Chain	GOid	namespace	contents
T	0000981	molecular_function	DNA-binding transcription factor activity, RNA polymerase II-specific
T	0003700	molecular_function	DNA-binding transcription factor activity
T	0006355	biological_process	regulation of DNA-templated transcription
T	0008270	molecular_function	zinc ion binding
U	0000981	molecular_function	DNA-binding transcription factor activity, RNA polymerase II-specific
U	0003700	molecular_function	DNA-binding transcription factor activity
U	0006355	biological_process	regulation of DNA-templated transcription
U	0008270	molecular_function	zinc ion binding
b	0000122	biological_process	negative regulation of transcription by RNA polymerase II
b	0003713	molecular_function	transcription coactivator activity
b	0005634	cellular_component	nucleus
b	0005829	cellular_component	cytosol
b	0016592	cellular_component	mediator complex
b	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
b	0034976	biological_process	response to endoplasmic reticulum stress
b	0045944	biological_process	positive regulation of transcription by RNA polymerase II
b	0051123	biological_process	RNA polymerase II preinitiation complex assembly
b	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
b	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
b	0070847	cellular_component	core mediator complex
b	0090399	biological_process	replicative senescence
c	0000122	biological_process	negative regulation of transcription by RNA polymerase II
c	0000979	molecular_function	RNA polymerase II core promoter sequence-specific DNA binding
c	0003712	molecular_function	transcription coregulator activity
c	0003713	molecular_function	transcription coactivator activity
c	0005515	molecular_function	protein binding
c	0005634	cellular_component	nucleus
c	0006357	biological_process	regulation of transcription by RNA polymerase II
c	0016592	cellular_component	mediator complex
c	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
c	0034605	biological_process	cellular response to heat
c	0045944	biological_process	positive regulation of transcription by RNA polymerase II
c	0051123	biological_process	RNA polymerase II preinitiation complex assembly
c	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
c	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
c	0070847	cellular_component	core mediator complex
e	0003674	molecular_function	molecular_function
e	0003712	molecular_function	transcription coregulator activity
e	0005515	molecular_function	protein binding
e	0005634	cellular_component	nucleus
e	0005739	cellular_component	mitochondrion
e	0006357	biological_process	regulation of transcription by RNA polymerase II
e	0006366	biological_process	transcription by RNA polymerase II
e	0016592	cellular_component	mediator complex
e	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
e	0051123	biological_process	RNA polymerase II preinitiation complex assembly
e	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
e	0070847	cellular_component	core mediator complex
o	0000122	biological_process	negative regulation of transcription by RNA polymerase II
o	0001095	molecular_function	TFIIE-class transcription factor complex binding
o	0001097	molecular_function	TFIIH-class transcription factor complex binding
o	0003712	molecular_function	transcription coregulator activity
o	0003713	molecular_function	transcription coactivator activity
o	0005515	molecular_function	protein binding
o	0005634	cellular_component	nucleus
o	0006355	biological_process	regulation of DNA-templated transcription
o	0006357	biological_process	regulation of transcription by RNA polymerase II
o	0016592	cellular_component	mediator complex
o	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
o	0034605	biological_process	cellular response to heat
o	0045944	biological_process	positive regulation of transcription by RNA polymerase II
o	0051123	biological_process	RNA polymerase II preinitiation complex assembly
o	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
o	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
o	0070202	biological_process	regulation of establishment of protein localization to chromosome
o	0070847	cellular_component	core mediator complex
o	2000219	biological_process	positive regulation of invasive growth in response to glucose limitation
p	0000122	biological_process	negative regulation of transcription by RNA polymerase II
p	0005515	molecular_function	protein binding
p	0005634	cellular_component	nucleus
p	0016592	cellular_component	mediator complex
p	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
p	0034605	biological_process	cellular response to heat
p	0045944	biological_process	positive regulation of transcription by RNA polymerase II
p	0051123	biological_process	RNA polymerase II preinitiation complex assembly
p	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
p	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
p	0070202	biological_process	regulation of establishment of protein localization to chromosome
p	0070847	cellular_component	core mediator complex

Functional Information from PROSITE/UniProt

site_id	PS00463
Number of Residues	29
Details	ZN2_CY6_FUNGAL_1 Zn(2)-C6 fungal-type DNA-binding domain signature. ACdiCRlkKlkCskekpk......CakClknnwe..C

Chain	Residue	Details
T	ALA10-CYS38

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:17330950

Chain	Residue	Details
n	THR1036
U	CYS11-CYS38

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine; by CDK8 => ECO:0000269\|PubMed:14988503, ECO:0000269\|PubMed:16109375

Chain	Residue	Details
b	SER208
o	SER736
o	SER752
T	CYS28
T	CYS31
T	CYS38
U	CYS11
U	CYS14
U	CYS21
U	CYS28
U	CYS31
U	CYS38

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:15665377, ECO:0007744\|PubMed:19779198

Chain	Residue	Details
o	SER783

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:19779198

Chain	Residue	Details
o	SER785
o	SER789
o	SER831
o	SER1008

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:18407956, ECO:0007744\|PubMed:19779198

Chain	Residue	Details
o	THR793

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:18407956, ECO:0007744\|PubMed:19779198

Chain	Residue	Details
o	SER1003
o	SER1018

site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:17287358, ECO:0007744\|PubMed:17330950, ECO:0007744\|PubMed:18407956, ECO:0007744\|PubMed:19779198

Chain	Residue	Details
o	SER1034

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)