7UAE

Human meprin alpha (active state)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004222	molecular_function	metalloendopeptidase activity
A	0006508	biological_process	proteolysis
A	0008237	molecular_function	metallopeptidase activity
A	0008270	molecular_function	zinc ion binding
A	0016020	cellular_component	membrane

Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. IIEHEILHAL

Chain	Residue	Details
A	ILE152-LEU161

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site_id	PS00740
Number of Residues	41
Details	MAM_1 MAM domain signature. GyFMqfsTssgsaeeaal.LesriLypkrkqqCLqFfYkmtG

Chain	Residue	Details
A	GLY312-GLY352

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU01211

Chain	Residue	Details
A	GLU156

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site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01211

Chain	Residue	Details
A	HIS155
A	HIS159
A	HIS165

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site_id	SWS_FT_FI3
Number of Residues	7
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN140
A	ASN222
A	ASN258
A	ASN414
A	ASN440
A	ASN447
A	ASN539

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