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7UA4

Structure of PKA phosphorylated human RyR2-R2474S in the open state in the presence of Calmodulin

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
A0001666biological_processresponse to hypoxia
A0002027biological_processregulation of heart rate
A0003143biological_processembryonic heart tube morphogenesis
A0003220biological_processleft ventricular cardiac muscle tissue morphogenesis
A0003300biological_processcardiac muscle hypertrophy
A0005216molecular_functionmonoatomic ion channel activity
A0005219molecular_functionryanodine-sensitive calcium-release channel activity
A0005262molecular_functioncalcium channel activity
A0005509molecular_functioncalcium ion binding
A0005513biological_processdetection of calcium ion
A0005515molecular_functionprotein binding
A0005516molecular_functioncalmodulin binding
A0005790cellular_componentsmooth endoplasmic reticulum
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006816biological_processcalcium ion transport
A0006874biological_processintracellular calcium ion homeostasis
A0006941biological_processstriated muscle contraction
A0008324molecular_functionmonoatomic cation transmembrane transporter activity
A0010460biological_processpositive regulation of heart rate
A0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
A0010882biological_processregulation of cardiac muscle contraction by calcium ion signaling
A0014701cellular_componentjunctional sarcoplasmic reticulum membrane
A0014808biological_processrelease of sequestered calcium ion into cytosol by sarcoplasmic reticulum
A0014850biological_processresponse to muscle activity
A0015278molecular_functionintracellularly gated calcium channel activity
A0016020cellular_componentmembrane
A0016529cellular_componentsarcoplasmic reticulum
A0019722biological_processcalcium-mediated signaling
A0019899molecular_functionenzyme binding
A0019901molecular_functionprotein kinase binding
A0030017cellular_componentsarcomere
A0030018cellular_componentZ disc
A0031000biological_processresponse to caffeine
A0032991cellular_componentprotein-containing complex
A0033017cellular_componentsarcoplasmic reticulum membrane
A0034236molecular_functionprotein kinase A catalytic subunit binding
A0034237molecular_functionprotein kinase A regulatory subunit binding
A0034704cellular_componentcalcium channel complex
A0035994biological_processresponse to muscle stretch
A0042383cellular_componentsarcolemma
A0042802molecular_functionidentical protein binding
A0043621molecular_functionobsolete protein self-association
A0043924molecular_functionsuramin binding
A0044325molecular_functiontransmembrane transporter binding
A0048763molecular_functioncalcium-induced calcium release activity
A0051209biological_processrelease of sequestered calcium ion into cytosol
A0051284biological_processpositive regulation of sequestering of calcium ion
A0051480biological_processregulation of cytosolic calcium ion concentration
A0051649biological_processestablishment of localization in cell
A0051775biological_processresponse to redox state
A0055085biological_processtransmembrane transport
A0055117biological_processregulation of cardiac muscle contraction
A0060048biological_processcardiac muscle contraction
A0060402biological_processcalcium ion transport into cytosol
A0070296biological_processsarcoplasmic reticulum calcium ion transport
A0070588biological_processcalcium ion transmembrane transport
A0071313biological_processcellular response to caffeine
A0071872biological_processcellular response to epinephrine stimulus
A0072599biological_processestablishment of protein localization to endoplasmic reticulum
A0086005biological_processventricular cardiac muscle cell action potential
A0086029biological_processPurkinje myocyte to ventricular cardiac muscle cell signaling
A0086064biological_processcell communication by electrical coupling involved in cardiac conduction
A0097050biological_processtype B pancreatic cell apoptotic process
A0097159molecular_functionorganic cyclic compound binding
A0097553biological_processcalcium ion transmembrane import into cytosol
A0098735biological_processpositive regulation of the force of heart contraction
A0098904biological_processregulation of AV node cell action potential
A0098907biological_processregulation of SA node cell action potential
A0098910biological_processregulation of atrial cardiac muscle cell action potential
A0098911biological_processregulation of ventricular cardiac muscle cell action potential
B0001666biological_processresponse to hypoxia
B0002027biological_processregulation of heart rate
B0003143biological_processembryonic heart tube morphogenesis
B0003220biological_processleft ventricular cardiac muscle tissue morphogenesis
B0003300biological_processcardiac muscle hypertrophy
B0005216molecular_functionmonoatomic ion channel activity
B0005219molecular_functionryanodine-sensitive calcium-release channel activity
B0005262molecular_functioncalcium channel activity
B0005509molecular_functioncalcium ion binding
B0005513biological_processdetection of calcium ion
B0005515molecular_functionprotein binding
B0005516molecular_functioncalmodulin binding
B0005790cellular_componentsmooth endoplasmic reticulum
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006816biological_processcalcium ion transport
B0006874biological_processintracellular calcium ion homeostasis
B0006941biological_processstriated muscle contraction
B0008324molecular_functionmonoatomic cation transmembrane transporter activity
B0010460biological_processpositive regulation of heart rate
B0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
B0010882biological_processregulation of cardiac muscle contraction by calcium ion signaling
B0014701cellular_componentjunctional sarcoplasmic reticulum membrane
B0014808biological_processrelease of sequestered calcium ion into cytosol by sarcoplasmic reticulum
B0014850biological_processresponse to muscle activity
B0015278molecular_functionintracellularly gated calcium channel activity
B0016020cellular_componentmembrane
B0016529cellular_componentsarcoplasmic reticulum
B0019722biological_processcalcium-mediated signaling
B0019899molecular_functionenzyme binding
B0019901molecular_functionprotein kinase binding
B0030017cellular_componentsarcomere
B0030018cellular_componentZ disc
B0031000biological_processresponse to caffeine
B0032991cellular_componentprotein-containing complex
B0033017cellular_componentsarcoplasmic reticulum membrane
B0034236molecular_functionprotein kinase A catalytic subunit binding
B0034237molecular_functionprotein kinase A regulatory subunit binding
B0034704cellular_componentcalcium channel complex
B0035994biological_processresponse to muscle stretch
B0042383cellular_componentsarcolemma
B0042802molecular_functionidentical protein binding
B0043621molecular_functionobsolete protein self-association
B0043924molecular_functionsuramin binding
B0044325molecular_functiontransmembrane transporter binding
B0048763molecular_functioncalcium-induced calcium release activity
B0051209biological_processrelease of sequestered calcium ion into cytosol
B0051284biological_processpositive regulation of sequestering of calcium ion
B0051480biological_processregulation of cytosolic calcium ion concentration
B0051649biological_processestablishment of localization in cell
B0051775biological_processresponse to redox state
B0055085biological_processtransmembrane transport
B0055117biological_processregulation of cardiac muscle contraction
B0060048biological_processcardiac muscle contraction
B0060402biological_processcalcium ion transport into cytosol
B0070296biological_processsarcoplasmic reticulum calcium ion transport
B0070588biological_processcalcium ion transmembrane transport
B0071313biological_processcellular response to caffeine
B0071872biological_processcellular response to epinephrine stimulus
B0072599biological_processestablishment of protein localization to endoplasmic reticulum
B0086005biological_processventricular cardiac muscle cell action potential
B0086029biological_processPurkinje myocyte to ventricular cardiac muscle cell signaling
B0086064biological_processcell communication by electrical coupling involved in cardiac conduction
B0097050biological_processtype B pancreatic cell apoptotic process
B0097159molecular_functionorganic cyclic compound binding
B0097553biological_processcalcium ion transmembrane import into cytosol
B0098735biological_processpositive regulation of the force of heart contraction
B0098904biological_processregulation of AV node cell action potential
B0098907biological_processregulation of SA node cell action potential
B0098910biological_processregulation of atrial cardiac muscle cell action potential
B0098911biological_processregulation of ventricular cardiac muscle cell action potential
C0001666biological_processresponse to hypoxia
C0002027biological_processregulation of heart rate
C0003143biological_processembryonic heart tube morphogenesis
C0003220biological_processleft ventricular cardiac muscle tissue morphogenesis
C0003300biological_processcardiac muscle hypertrophy
C0005216molecular_functionmonoatomic ion channel activity
C0005219molecular_functionryanodine-sensitive calcium-release channel activity
C0005262molecular_functioncalcium channel activity
C0005509molecular_functioncalcium ion binding
C0005513biological_processdetection of calcium ion
C0005515molecular_functionprotein binding
C0005516molecular_functioncalmodulin binding
C0005790cellular_componentsmooth endoplasmic reticulum
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0006816biological_processcalcium ion transport
C0006874biological_processintracellular calcium ion homeostasis
C0006941biological_processstriated muscle contraction
C0008324molecular_functionmonoatomic cation transmembrane transporter activity
C0010460biological_processpositive regulation of heart rate
C0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
C0010882biological_processregulation of cardiac muscle contraction by calcium ion signaling
C0014701cellular_componentjunctional sarcoplasmic reticulum membrane
C0014808biological_processrelease of sequestered calcium ion into cytosol by sarcoplasmic reticulum
C0014850biological_processresponse to muscle activity
C0015278molecular_functionintracellularly gated calcium channel activity
C0016020cellular_componentmembrane
C0016529cellular_componentsarcoplasmic reticulum
C0019722biological_processcalcium-mediated signaling
C0019899molecular_functionenzyme binding
C0019901molecular_functionprotein kinase binding
C0030017cellular_componentsarcomere
C0030018cellular_componentZ disc
C0031000biological_processresponse to caffeine
C0032991cellular_componentprotein-containing complex
C0033017cellular_componentsarcoplasmic reticulum membrane
C0034236molecular_functionprotein kinase A catalytic subunit binding
C0034237molecular_functionprotein kinase A regulatory subunit binding
C0034704cellular_componentcalcium channel complex
C0035994biological_processresponse to muscle stretch
C0042383cellular_componentsarcolemma
C0042802molecular_functionidentical protein binding
C0043621molecular_functionobsolete protein self-association
C0043924molecular_functionsuramin binding
C0044325molecular_functiontransmembrane transporter binding
C0048763molecular_functioncalcium-induced calcium release activity
C0051209biological_processrelease of sequestered calcium ion into cytosol
C0051284biological_processpositive regulation of sequestering of calcium ion
C0051480biological_processregulation of cytosolic calcium ion concentration
C0051649biological_processestablishment of localization in cell
C0051775biological_processresponse to redox state
C0055085biological_processtransmembrane transport
C0055117biological_processregulation of cardiac muscle contraction
C0060048biological_processcardiac muscle contraction
C0060402biological_processcalcium ion transport into cytosol
C0070296biological_processsarcoplasmic reticulum calcium ion transport
C0070588biological_processcalcium ion transmembrane transport
C0071313biological_processcellular response to caffeine
C0071872biological_processcellular response to epinephrine stimulus
C0072599biological_processestablishment of protein localization to endoplasmic reticulum
C0086005biological_processventricular cardiac muscle cell action potential
C0086029biological_processPurkinje myocyte to ventricular cardiac muscle cell signaling
C0086064biological_processcell communication by electrical coupling involved in cardiac conduction
C0097050biological_processtype B pancreatic cell apoptotic process
C0097159molecular_functionorganic cyclic compound binding
C0097553biological_processcalcium ion transmembrane import into cytosol
C0098735biological_processpositive regulation of the force of heart contraction
C0098904biological_processregulation of AV node cell action potential
C0098907biological_processregulation of SA node cell action potential
C0098910biological_processregulation of atrial cardiac muscle cell action potential
C0098911biological_processregulation of ventricular cardiac muscle cell action potential
D0001666biological_processresponse to hypoxia
D0002027biological_processregulation of heart rate
D0003143biological_processembryonic heart tube morphogenesis
D0003220biological_processleft ventricular cardiac muscle tissue morphogenesis
D0003300biological_processcardiac muscle hypertrophy
D0005216molecular_functionmonoatomic ion channel activity
D0005219molecular_functionryanodine-sensitive calcium-release channel activity
D0005262molecular_functioncalcium channel activity
D0005509molecular_functioncalcium ion binding
D0005513biological_processdetection of calcium ion
D0005515molecular_functionprotein binding
D0005516molecular_functioncalmodulin binding
D0005790cellular_componentsmooth endoplasmic reticulum
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0006816biological_processcalcium ion transport
D0006874biological_processintracellular calcium ion homeostasis
D0006941biological_processstriated muscle contraction
D0008324molecular_functionmonoatomic cation transmembrane transporter activity
D0010460biological_processpositive regulation of heart rate
D0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
D0010882biological_processregulation of cardiac muscle contraction by calcium ion signaling
D0014701cellular_componentjunctional sarcoplasmic reticulum membrane
D0014808biological_processrelease of sequestered calcium ion into cytosol by sarcoplasmic reticulum
D0014850biological_processresponse to muscle activity
D0015278molecular_functionintracellularly gated calcium channel activity
D0016020cellular_componentmembrane
D0016529cellular_componentsarcoplasmic reticulum
D0019722biological_processcalcium-mediated signaling
D0019899molecular_functionenzyme binding
D0019901molecular_functionprotein kinase binding
D0030017cellular_componentsarcomere
D0030018cellular_componentZ disc
D0031000biological_processresponse to caffeine
D0032991cellular_componentprotein-containing complex
D0033017cellular_componentsarcoplasmic reticulum membrane
D0034236molecular_functionprotein kinase A catalytic subunit binding
D0034237molecular_functionprotein kinase A regulatory subunit binding
D0034704cellular_componentcalcium channel complex
D0035994biological_processresponse to muscle stretch
D0042383cellular_componentsarcolemma
D0042802molecular_functionidentical protein binding
D0043621molecular_functionobsolete protein self-association
D0043924molecular_functionsuramin binding
D0044325molecular_functiontransmembrane transporter binding
D0048763molecular_functioncalcium-induced calcium release activity
D0051209biological_processrelease of sequestered calcium ion into cytosol
D0051284biological_processpositive regulation of sequestering of calcium ion
D0051480biological_processregulation of cytosolic calcium ion concentration
D0051649biological_processestablishment of localization in cell
D0051775biological_processresponse to redox state
D0055085biological_processtransmembrane transport
D0055117biological_processregulation of cardiac muscle contraction
D0060048biological_processcardiac muscle contraction
D0060402biological_processcalcium ion transport into cytosol
D0070296biological_processsarcoplasmic reticulum calcium ion transport
D0070588biological_processcalcium ion transmembrane transport
D0071313biological_processcellular response to caffeine
D0071872biological_processcellular response to epinephrine stimulus
D0072599biological_processestablishment of protein localization to endoplasmic reticulum
D0086005biological_processventricular cardiac muscle cell action potential
D0086029biological_processPurkinje myocyte to ventricular cardiac muscle cell signaling
D0086064biological_processcell communication by electrical coupling involved in cardiac conduction
D0097050biological_processtype B pancreatic cell apoptotic process
D0097159molecular_functionorganic cyclic compound binding
D0097553biological_processcalcium ion transmembrane import into cytosol
D0098735biological_processpositive regulation of the force of heart contraction
D0098904biological_processregulation of AV node cell action potential
D0098907biological_processregulation of SA node cell action potential
D0098910biological_processregulation of atrial cardiac muscle cell action potential
D0098911biological_processregulation of ventricular cardiac muscle cell action potential
E0002027biological_processregulation of heart rate
E0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
E0005102molecular_functionsignaling receptor binding
E0005219molecular_functionryanodine-sensitive calcium-release channel activity
E0005515molecular_functionprotein binding
E0005528molecular_functionFK506 binding
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0006458biological_process'de novo' protein folding
E0006939biological_processsmooth muscle contraction
E0007204biological_processpositive regulation of cytosolic calcium ion concentration
E0009749biological_processresponse to glucose
E0010033biological_processresponse to organic substance
E0010459biological_processnegative regulation of heart rate
E0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
E0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
E0016020cellular_componentmembrane
E0016247molecular_functionchannel regulator activity
E0016529cellular_componentsarcoplasmic reticulum
E0019227biological_processneuronal action potential propagation
E0019722biological_processcalcium-mediated signaling
E0019855molecular_functioncalcium channel inhibitor activity
E0022417biological_processprotein maturation by protein folding
E0030018cellular_componentZ disc
E0030073biological_processinsulin secretion
E0030551molecular_functioncyclic nucleotide binding
E0033017cellular_componentsarcoplasmic reticulum membrane
E0033197biological_processresponse to vitamin E
E0034704cellular_componentcalcium channel complex
E0035773biological_processinsulin secretion involved in cellular response to glucose stimulus
E0042026biological_processprotein refolding
E0042098biological_processT cell proliferation
E0042542biological_processresponse to hydrogen peroxide
E0044325molecular_functiontransmembrane transporter binding
E0048680biological_processpositive regulation of axon regeneration
E0050849biological_processnegative regulation of calcium-mediated signaling
E0051209biological_processrelease of sequestered calcium ion into cytosol
E0051280biological_processnegative regulation of release of sequestered calcium ion into cytosol
E0051284biological_processpositive regulation of sequestering of calcium ion
E0051480biological_processregulation of cytosolic calcium ion concentration
E0051775biological_processresponse to redox state
E0061179biological_processnegative regulation of insulin secretion involved in cellular response to glucose stimulus
F0002027biological_processregulation of heart rate
F0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
F0005102molecular_functionsignaling receptor binding
F0005219molecular_functionryanodine-sensitive calcium-release channel activity
F0005515molecular_functionprotein binding
F0005528molecular_functionFK506 binding
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0006458biological_process'de novo' protein folding
F0006939biological_processsmooth muscle contraction
F0007204biological_processpositive regulation of cytosolic calcium ion concentration
F0009749biological_processresponse to glucose
F0010033biological_processresponse to organic substance
F0010459biological_processnegative regulation of heart rate
F0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
F0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
F0016020cellular_componentmembrane
F0016247molecular_functionchannel regulator activity
F0016529cellular_componentsarcoplasmic reticulum
F0019227biological_processneuronal action potential propagation
F0019722biological_processcalcium-mediated signaling
F0019855molecular_functioncalcium channel inhibitor activity
F0022417biological_processprotein maturation by protein folding
F0030018cellular_componentZ disc
F0030073biological_processinsulin secretion
F0030551molecular_functioncyclic nucleotide binding
F0033017cellular_componentsarcoplasmic reticulum membrane
F0033197biological_processresponse to vitamin E
F0034704cellular_componentcalcium channel complex
F0035773biological_processinsulin secretion involved in cellular response to glucose stimulus
F0042026biological_processprotein refolding
F0042098biological_processT cell proliferation
F0042542biological_processresponse to hydrogen peroxide
F0044325molecular_functiontransmembrane transporter binding
F0048680biological_processpositive regulation of axon regeneration
F0050849biological_processnegative regulation of calcium-mediated signaling
F0051209biological_processrelease of sequestered calcium ion into cytosol
F0051280biological_processnegative regulation of release of sequestered calcium ion into cytosol
F0051284biological_processpositive regulation of sequestering of calcium ion
F0051480biological_processregulation of cytosolic calcium ion concentration
F0051775biological_processresponse to redox state
F0061179biological_processnegative regulation of insulin secretion involved in cellular response to glucose stimulus
G0002027biological_processregulation of heart rate
G0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
G0005102molecular_functionsignaling receptor binding
G0005219molecular_functionryanodine-sensitive calcium-release channel activity
G0005515molecular_functionprotein binding
G0005528molecular_functionFK506 binding
G0005737cellular_componentcytoplasm
G0005829cellular_componentcytosol
G0006458biological_process'de novo' protein folding
G0006939biological_processsmooth muscle contraction
G0007204biological_processpositive regulation of cytosolic calcium ion concentration
G0009749biological_processresponse to glucose
G0010033biological_processresponse to organic substance
G0010459biological_processnegative regulation of heart rate
G0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
G0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
G0016020cellular_componentmembrane
G0016247molecular_functionchannel regulator activity
G0016529cellular_componentsarcoplasmic reticulum
G0019227biological_processneuronal action potential propagation
G0019722biological_processcalcium-mediated signaling
G0019855molecular_functioncalcium channel inhibitor activity
G0022417biological_processprotein maturation by protein folding
G0030018cellular_componentZ disc
G0030073biological_processinsulin secretion
G0030551molecular_functioncyclic nucleotide binding
G0033017cellular_componentsarcoplasmic reticulum membrane
G0033197biological_processresponse to vitamin E
G0034704cellular_componentcalcium channel complex
G0035773biological_processinsulin secretion involved in cellular response to glucose stimulus
G0042026biological_processprotein refolding
G0042098biological_processT cell proliferation
G0042542biological_processresponse to hydrogen peroxide
G0044325molecular_functiontransmembrane transporter binding
G0048680biological_processpositive regulation of axon regeneration
G0050849biological_processnegative regulation of calcium-mediated signaling
G0051209biological_processrelease of sequestered calcium ion into cytosol
G0051280biological_processnegative regulation of release of sequestered calcium ion into cytosol
G0051284biological_processpositive regulation of sequestering of calcium ion
G0051480biological_processregulation of cytosolic calcium ion concentration
G0051775biological_processresponse to redox state
G0061179biological_processnegative regulation of insulin secretion involved in cellular response to glucose stimulus
H0002027biological_processregulation of heart rate
H0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
H0005102molecular_functionsignaling receptor binding
H0005219molecular_functionryanodine-sensitive calcium-release channel activity
H0005515molecular_functionprotein binding
H0005528molecular_functionFK506 binding
H0005737cellular_componentcytoplasm
H0005829cellular_componentcytosol
H0006458biological_process'de novo' protein folding
H0006939biological_processsmooth muscle contraction
H0007204biological_processpositive regulation of cytosolic calcium ion concentration
H0009749biological_processresponse to glucose
H0010033biological_processresponse to organic substance
H0010459biological_processnegative regulation of heart rate
H0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
H0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
H0016020cellular_componentmembrane
H0016247molecular_functionchannel regulator activity
H0016529cellular_componentsarcoplasmic reticulum
H0019227biological_processneuronal action potential propagation
H0019722biological_processcalcium-mediated signaling
H0019855molecular_functioncalcium channel inhibitor activity
H0022417biological_processprotein maturation by protein folding
H0030018cellular_componentZ disc
H0030073biological_processinsulin secretion
H0030551molecular_functioncyclic nucleotide binding
H0033017cellular_componentsarcoplasmic reticulum membrane
H0033197biological_processresponse to vitamin E
H0034704cellular_componentcalcium channel complex
H0035773biological_processinsulin secretion involved in cellular response to glucose stimulus
H0042026biological_processprotein refolding
H0042098biological_processT cell proliferation
H0042542biological_processresponse to hydrogen peroxide
H0044325molecular_functiontransmembrane transporter binding
H0048680biological_processpositive regulation of axon regeneration
H0050849biological_processnegative regulation of calcium-mediated signaling
H0051209biological_processrelease of sequestered calcium ion into cytosol
H0051280biological_processnegative regulation of release of sequestered calcium ion into cytosol
H0051284biological_processpositive regulation of sequestering of calcium ion
H0051480biological_processregulation of cytosolic calcium ion concentration
H0051775biological_processresponse to redox state
H0061179biological_processnegative regulation of insulin secretion involved in cellular response to glucose stimulus
I0000086biological_processG2/M transition of mitotic cell cycle
I0000922cellular_componentspindle pole
I0002027biological_processregulation of heart rate
I0005509molecular_functioncalcium ion binding
I0005513biological_processdetection of calcium ion
I0005515molecular_functionprotein binding
I0005576cellular_componentextracellular region
I0005634cellular_componentnucleus
I0005654cellular_componentnucleoplasm
I0005737cellular_componentcytoplasm
I0005813cellular_componentcentrosome
I0005819cellular_componentspindle
I0005829cellular_componentcytosol
I0005856cellular_componentcytoskeleton
I0005876cellular_componentspindle microtubule
I0005886cellular_componentplasma membrane
I0007186biological_processG protein-coupled receptor signaling pathway
I0008076cellular_componentvoltage-gated potassium channel complex
I0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
I0010801biological_processnegative regulation of peptidyl-threonine phosphorylation
I0010856molecular_functionadenylate cyclase activator activity
I0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
I0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
I0016020cellular_componentmembrane
I0016240biological_processautophagosome membrane docking
I0019855molecular_functioncalcium channel inhibitor activity
I0019901molecular_functionprotein kinase binding
I0021762biological_processsubstantia nigra development
I0030017cellular_componentsarcomere
I0031432molecular_functiontitin binding
I0031514cellular_componentmotile cilium
I0031954biological_processpositive regulation of protein autophosphorylation
I0031982cellular_componentvesicle
I0032465biological_processregulation of cytokinesis
I0032516biological_processpositive regulation of phosphoprotein phosphatase activity
I0032991cellular_componentprotein-containing complex
I0034704cellular_componentcalcium channel complex
I0035307biological_processpositive regulation of protein dephosphorylation
I0035458biological_processcellular response to interferon-beta
I0043209cellular_componentmyelin sheath
I0043539molecular_functionprotein serine/threonine kinase activator activity
I0044325molecular_functiontransmembrane transporter binding
I0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
I0046872molecular_functionmetal ion binding
I0048306molecular_functioncalcium-dependent protein binding
I0050848biological_processregulation of calcium-mediated signaling
I0051343biological_processpositive regulation of cyclic-nucleotide phosphodiesterase activity
I0051592biological_processresponse to calcium ion
I0055117biological_processregulation of cardiac muscle contraction
I0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
I0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
I0060316biological_processpositive regulation of ryanodine-sensitive calcium-release channel activity
I0071346biological_processcellular response to type II interferon
I0071902biological_processpositive regulation of protein serine/threonine kinase activity
I0072542molecular_functionprotein phosphatase activator activity
I0097225cellular_componentsperm midpiece
I0098901biological_processregulation of cardiac muscle cell action potential
I0140056biological_processorganelle localization by membrane tethering
I1901842biological_processnegative regulation of high voltage-gated calcium channel activity
I1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
I1902494cellular_componentcatalytic complex
I1905913biological_processnegative regulation of calcium ion export across plasma membrane
I1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
J0000086biological_processG2/M transition of mitotic cell cycle
J0000922cellular_componentspindle pole
J0002027biological_processregulation of heart rate
J0005509molecular_functioncalcium ion binding
J0005513biological_processdetection of calcium ion
J0005515molecular_functionprotein binding
J0005576cellular_componentextracellular region
J0005634cellular_componentnucleus
J0005654cellular_componentnucleoplasm
J0005737cellular_componentcytoplasm
J0005813cellular_componentcentrosome
J0005819cellular_componentspindle
J0005829cellular_componentcytosol
J0005856cellular_componentcytoskeleton
J0005876cellular_componentspindle microtubule
J0005886cellular_componentplasma membrane
J0007186biological_processG protein-coupled receptor signaling pathway
J0008076cellular_componentvoltage-gated potassium channel complex
J0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
J0010801biological_processnegative regulation of peptidyl-threonine phosphorylation
J0010856molecular_functionadenylate cyclase activator activity
J0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
J0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
J0016020cellular_componentmembrane
J0016240biological_processautophagosome membrane docking
J0019855molecular_functioncalcium channel inhibitor activity
J0019901molecular_functionprotein kinase binding
J0021762biological_processsubstantia nigra development
J0030017cellular_componentsarcomere
J0031432molecular_functiontitin binding
J0031514cellular_componentmotile cilium
J0031954biological_processpositive regulation of protein autophosphorylation
J0031982cellular_componentvesicle
J0032465biological_processregulation of cytokinesis
J0032516biological_processpositive regulation of phosphoprotein phosphatase activity
J0032991cellular_componentprotein-containing complex
J0034704cellular_componentcalcium channel complex
J0035307biological_processpositive regulation of protein dephosphorylation
J0035458biological_processcellular response to interferon-beta
J0043209cellular_componentmyelin sheath
J0043539molecular_functionprotein serine/threonine kinase activator activity
J0044325molecular_functiontransmembrane transporter binding
J0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
J0046872molecular_functionmetal ion binding
J0048306molecular_functioncalcium-dependent protein binding
J0050848biological_processregulation of calcium-mediated signaling
J0051343biological_processpositive regulation of cyclic-nucleotide phosphodiesterase activity
J0051592biological_processresponse to calcium ion
J0055117biological_processregulation of cardiac muscle contraction
J0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
J0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
J0060316biological_processpositive regulation of ryanodine-sensitive calcium-release channel activity
J0071346biological_processcellular response to type II interferon
J0071902biological_processpositive regulation of protein serine/threonine kinase activity
J0072542molecular_functionprotein phosphatase activator activity
J0097225cellular_componentsperm midpiece
J0098901biological_processregulation of cardiac muscle cell action potential
J0140056biological_processorganelle localization by membrane tethering
J1901842biological_processnegative regulation of high voltage-gated calcium channel activity
J1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
J1902494cellular_componentcatalytic complex
J1905913biological_processnegative regulation of calcium ion export across plasma membrane
J1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
K0000086biological_processG2/M transition of mitotic cell cycle
K0000922cellular_componentspindle pole
K0002027biological_processregulation of heart rate
K0005509molecular_functioncalcium ion binding
K0005513biological_processdetection of calcium ion
K0005515molecular_functionprotein binding
K0005576cellular_componentextracellular region
K0005634cellular_componentnucleus
K0005654cellular_componentnucleoplasm
K0005737cellular_componentcytoplasm
K0005813cellular_componentcentrosome
K0005819cellular_componentspindle
K0005829cellular_componentcytosol
K0005856cellular_componentcytoskeleton
K0005876cellular_componentspindle microtubule
K0005886cellular_componentplasma membrane
K0007186biological_processG protein-coupled receptor signaling pathway
K0008076cellular_componentvoltage-gated potassium channel complex
K0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
K0010801biological_processnegative regulation of peptidyl-threonine phosphorylation
K0010856molecular_functionadenylate cyclase activator activity
K0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
K0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
K0016020cellular_componentmembrane
K0016240biological_processautophagosome membrane docking
K0019855molecular_functioncalcium channel inhibitor activity
K0019901molecular_functionprotein kinase binding
K0021762biological_processsubstantia nigra development
K0030017cellular_componentsarcomere
K0031432molecular_functiontitin binding
K0031514cellular_componentmotile cilium
K0031954biological_processpositive regulation of protein autophosphorylation
K0031982cellular_componentvesicle
K0032465biological_processregulation of cytokinesis
K0032516biological_processpositive regulation of phosphoprotein phosphatase activity
K0032991cellular_componentprotein-containing complex
K0034704cellular_componentcalcium channel complex
K0035307biological_processpositive regulation of protein dephosphorylation
K0035458biological_processcellular response to interferon-beta
K0043209cellular_componentmyelin sheath
K0043539molecular_functionprotein serine/threonine kinase activator activity
K0044325molecular_functiontransmembrane transporter binding
K0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
K0046872molecular_functionmetal ion binding
K0048306molecular_functioncalcium-dependent protein binding
K0050848biological_processregulation of calcium-mediated signaling
K0051343biological_processpositive regulation of cyclic-nucleotide phosphodiesterase activity
K0051592biological_processresponse to calcium ion
K0055117biological_processregulation of cardiac muscle contraction
K0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
K0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
K0060316biological_processpositive regulation of ryanodine-sensitive calcium-release channel activity
K0071346biological_processcellular response to type II interferon
K0071902biological_processpositive regulation of protein serine/threonine kinase activity
K0072542molecular_functionprotein phosphatase activator activity
K0097225cellular_componentsperm midpiece
K0098901biological_processregulation of cardiac muscle cell action potential
K0140056biological_processorganelle localization by membrane tethering
K1901842biological_processnegative regulation of high voltage-gated calcium channel activity
K1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
K1902494cellular_componentcatalytic complex
K1905913biological_processnegative regulation of calcium ion export across plasma membrane
K1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
L0000086biological_processG2/M transition of mitotic cell cycle
L0000922cellular_componentspindle pole
L0002027biological_processregulation of heart rate
L0005509molecular_functioncalcium ion binding
L0005513biological_processdetection of calcium ion
L0005515molecular_functionprotein binding
L0005576cellular_componentextracellular region
L0005634cellular_componentnucleus
L0005654cellular_componentnucleoplasm
L0005737cellular_componentcytoplasm
L0005813cellular_componentcentrosome
L0005819cellular_componentspindle
L0005829cellular_componentcytosol
L0005856cellular_componentcytoskeleton
L0005876cellular_componentspindle microtubule
L0005886cellular_componentplasma membrane
L0007186biological_processG protein-coupled receptor signaling pathway
L0008076cellular_componentvoltage-gated potassium channel complex
L0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
L0010801biological_processnegative regulation of peptidyl-threonine phosphorylation
L0010856molecular_functionadenylate cyclase activator activity
L0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
L0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
L0016020cellular_componentmembrane
L0016240biological_processautophagosome membrane docking
L0019855molecular_functioncalcium channel inhibitor activity
L0019901molecular_functionprotein kinase binding
L0021762biological_processsubstantia nigra development
L0030017cellular_componentsarcomere
L0031432molecular_functiontitin binding
L0031514cellular_componentmotile cilium
L0031954biological_processpositive regulation of protein autophosphorylation
L0031982cellular_componentvesicle
L0032465biological_processregulation of cytokinesis
L0032516biological_processpositive regulation of phosphoprotein phosphatase activity
L0032991cellular_componentprotein-containing complex
L0034704cellular_componentcalcium channel complex
L0035307biological_processpositive regulation of protein dephosphorylation
L0035458biological_processcellular response to interferon-beta
L0043209cellular_componentmyelin sheath
L0043539molecular_functionprotein serine/threonine kinase activator activity
L0044325molecular_functiontransmembrane transporter binding
L0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
L0046872molecular_functionmetal ion binding
L0048306molecular_functioncalcium-dependent protein binding
L0050848biological_processregulation of calcium-mediated signaling
L0051343biological_processpositive regulation of cyclic-nucleotide phosphodiesterase activity
L0051592biological_processresponse to calcium ion
L0055117biological_processregulation of cardiac muscle contraction
L0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
L0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
L0060316biological_processpositive regulation of ryanodine-sensitive calcium-release channel activity
L0071346biological_processcellular response to type II interferon
L0071902biological_processpositive regulation of protein serine/threonine kinase activity
L0072542molecular_functionprotein phosphatase activator activity
L0097225cellular_componentsperm midpiece
L0098901biological_processregulation of cardiac muscle cell action potential
L0140056biological_processorganelle localization by membrane tethering
L1901842biological_processnegative regulation of high voltage-gated calcium channel activity
L1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
L1902494cellular_componentcatalytic complex
L1905913biological_processnegative regulation of calcium ion export across plasma membrane
L1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DKDGDGTITtkEL
ChainResidueDetails
IASP21-LEU33
IASP57-PHE69
IASP94-LEU106
IASP130-PHE142

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues40
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:1474585, ECO:0000269|PubMed:25441029, ECO:0000269|PubMed:27564677, ECO:0007744|PDB:1CLL, ECO:0007744|PDB:4UMO, ECO:0007744|PDB:4V0C, ECO:0007744|PDB:5J03
ChainResidueDetails
IASP21
IGLU68
JASP21
JTHR27
JGLU32
JASN61
JTHR63
IASP23
JGLU68
IASP25
ITHR27
IGLU32
KASP21
KASP23
KASP25
KTHR27
KGLU32
KASP57
KASP59
KASN61
KTHR63
KGLU68
LASP21
LASP23
LASP25
LTHR27
LGLU32
LASP57
LASP59
LASN61
LTHR63
LGLU68
IASP57
IASP59
IASN61
ITHR63
JASP23
JASP25
JASP57
JASP59

site_idSWS_FT_FI2
Number of Residues40
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:1474585, ECO:0000269|PubMed:27564677, ECO:0007744|PDB:1CLL, ECO:0007744|PDB:5J03
ChainResidueDetails
IASP94
IGLU141
JASP94
JASP96
JASN98
JTYR100
JGLU105
JASP130
JASP132
JASP134
JGLN136
IASP96
JGLU141
KASP94
IASN98
ITYR100
IGLU105
IASP132
IASP134
IGLN136
KGLU105
KASP130
KASP132
KASP134
KGLN136
KGLU141
LASP94
LASP96
LASN98
LTYR100
LGLU105
LASP130
LASP132
LASP134
LGLN136
LGLU141
IASP130
KASP96
KASN98
KTYR100

site_idSWS_FT_FI3
Number of Residues4
DetailsMOD_RES: N-acetylalanine => ECO:0000269|PubMed:7093203, ECO:0000269|Ref.7, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378, ECO:0007744|PubMed:25944712
ChainResidueDetails
IALA2
JALA2
KALA2
LALA2

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861
ChainResidueDetails
ILYS22
BSER2947
CSER2797
CSER2811
CSER2947
DSER1341
DSER2369
DSER2797
DSER2811
JLYS22
DSER2947
KLYS22
LLYS22
BSER1341
ASER2947
BSER2369
BSER2797
BSER2811
CSER1341
CSER2369

site_idSWS_FT_FI5
Number of Residues4
DetailsMOD_RES: Phosphothreonine; by CaMK4 => ECO:0000250|UniProtKB:P0DP29
ChainResidueDetails
ITHR45
JTHR45
LTHR45
CSER1869
CSER2697
DSER1869
DSER2697
KTHR45

site_idSWS_FT_FI6
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ISER82
JSER82
LSER82
KSER82

site_idSWS_FT_FI7
Number of Residues4
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
ILYS95
JLYS95
KLYS95
LLYS95

site_idSWS_FT_FI8
Number of Residues4
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332
ChainResidueDetails
ITYR100
JTYR100
LTYR100
KTYR100

site_idSWS_FT_FI9
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
ISER102
JSER102
KSER102
LSER102

site_idSWS_FT_FI10
Number of Residues4
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569
ChainResidueDetails
ITHR111
JTHR111
KTHR111
LTHR111

site_idSWS_FT_FI11
Number of Residues4
DetailsMOD_RES: N6-methyllysine; alternate => ECO:0007744|PubMed:24129315
ChainResidueDetails
ILYS116
JLYS116
KLYS116
LLYS116

site_idSWS_FT_FI12
Number of Residues4
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:19690332
ChainResidueDetails
ITYR139
JTYR139
KTYR139
LTYR139

site_idSWS_FT_FI13
Number of Residues8
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P62157
ChainResidueDetails
ILYS22
JLYS22
KLYS22
LLYS22

221051

PDB entries from 2024-06-12

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