7U8O

Structure of porcine V-ATPase with mEAK7 and SidK, Rotary state 2

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005764	cellular_component	lysosome
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006879	biological_process	intracellular iron ion homeostasis
A	0015986	biological_process	proton motive force-driven ATP synthesis
A	0016020	cellular_component	membrane
A	0016887	molecular_function	ATP hydrolysis activity
A	0030133	cellular_component	transport vesicle
A	0030665	cellular_component	clathrin-coated vesicle membrane
A	0031410	cellular_component	cytoplasmic vesicle
A	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
A	0036295	biological_process	cellular response to increased oxygen levels
A	0046034	biological_process	ATP metabolic process
A	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
A	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
A	1902600	biological_process	proton transmembrane transport
B	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005764	cellular_component	lysosome
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006879	biological_process	intracellular iron ion homeostasis
B	0015986	biological_process	proton motive force-driven ATP synthesis
B	0016020	cellular_component	membrane
B	0016887	molecular_function	ATP hydrolysis activity
B	0030133	cellular_component	transport vesicle
B	0030665	cellular_component	clathrin-coated vesicle membrane
B	0031410	cellular_component	cytoplasmic vesicle
B	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
B	0036295	biological_process	cellular response to increased oxygen levels
B	0046034	biological_process	ATP metabolic process
B	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
B	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
B	1902600	biological_process	proton transmembrane transport
C	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005764	cellular_component	lysosome
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006879	biological_process	intracellular iron ion homeostasis
C	0015986	biological_process	proton motive force-driven ATP synthesis
C	0016020	cellular_component	membrane
C	0016887	molecular_function	ATP hydrolysis activity
C	0030133	cellular_component	transport vesicle
C	0030665	cellular_component	clathrin-coated vesicle membrane
C	0031410	cellular_component	cytoplasmic vesicle
C	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
C	0036295	biological_process	cellular response to increased oxygen levels
C	0046034	biological_process	ATP metabolic process
C	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
C	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
C	1902600	biological_process	proton transmembrane transport
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0007035	biological_process	vacuolar acidification
D	0016324	cellular_component	apical plasma membrane
D	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
D	0046034	biological_process	ATP metabolic process
D	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
D	1902600	biological_process	proton transmembrane transport
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0007035	biological_process	vacuolar acidification
E	0016324	cellular_component	apical plasma membrane
E	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
E	0046034	biological_process	ATP metabolic process
E	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
E	1902600	biological_process	proton transmembrane transport
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0007035	biological_process	vacuolar acidification
F	0016324	cellular_component	apical plasma membrane
F	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
F	0046034	biological_process	ATP metabolic process
F	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
F	1902600	biological_process	proton transmembrane transport
G	0005886	cellular_component	plasma membrane
G	0015078	molecular_function	proton transmembrane transporter activity
G	0030665	cellular_component	clathrin-coated vesicle membrane
G	0030672	cellular_component	synaptic vesicle membrane
G	0033176	cellular_component	proton-transporting V-type ATPase complex
G	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
G	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
G	0097401	biological_process	synaptic vesicle lumen acidification
G	1902495	cellular_component	transmembrane transporter complex
G	1902600	biological_process	proton transmembrane transport
G	1904949	cellular_component	ATPase complex
H	0006811	biological_process	monoatomic ion transport
H	0030030	biological_process	cell projection organization
H	0030665	cellular_component	clathrin-coated vesicle membrane
H	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
H	1902600	biological_process	proton transmembrane transport
I	0005737	cellular_component	cytoplasm
I	0005768	cellular_component	endosome
I	0005829	cellular_component	cytosol
I	0005886	cellular_component	plasma membrane
I	0005902	cellular_component	microvillus
I	0006811	biological_process	monoatomic ion transport
I	0016324	cellular_component	apical plasma membrane
I	0030665	cellular_component	clathrin-coated vesicle membrane
I	0030672	cellular_component	synaptic vesicle membrane
I	0031410	cellular_component	cytoplasmic vesicle
I	0033178	cellular_component	proton-transporting two-sector ATPase complex, catalytic domain
I	0045202	cellular_component	synapse
I	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
I	0097401	biological_process	synaptic vesicle lumen acidification
I	1902600	biological_process	proton transmembrane transport
J	0005737	cellular_component	cytoplasm
J	0005768	cellular_component	endosome
J	0005829	cellular_component	cytosol
J	0005886	cellular_component	plasma membrane
J	0005902	cellular_component	microvillus
J	0006811	biological_process	monoatomic ion transport
J	0016324	cellular_component	apical plasma membrane
J	0030665	cellular_component	clathrin-coated vesicle membrane
J	0030672	cellular_component	synaptic vesicle membrane
J	0031410	cellular_component	cytoplasmic vesicle
J	0033178	cellular_component	proton-transporting two-sector ATPase complex, catalytic domain
J	0045202	cellular_component	synapse
J	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
J	0097401	biological_process	synaptic vesicle lumen acidification
J	1902600	biological_process	proton transmembrane transport
K	0005737	cellular_component	cytoplasm
K	0005768	cellular_component	endosome
K	0005829	cellular_component	cytosol
K	0005886	cellular_component	plasma membrane
K	0005902	cellular_component	microvillus
K	0006811	biological_process	monoatomic ion transport
K	0016324	cellular_component	apical plasma membrane
K	0030665	cellular_component	clathrin-coated vesicle membrane
K	0030672	cellular_component	synaptic vesicle membrane
K	0031410	cellular_component	cytoplasmic vesicle
K	0033178	cellular_component	proton-transporting two-sector ATPase complex, catalytic domain
K	0045202	cellular_component	synapse
K	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
K	0097401	biological_process	synaptic vesicle lumen acidification
K	1902600	biological_process	proton transmembrane transport
L	0016020	cellular_component	membrane
L	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
L	0033176	cellular_component	proton-transporting V-type ATPase complex
L	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
L	0034220	biological_process	monoatomic ion transmembrane transport
L	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
L	0097401	biological_process	synaptic vesicle lumen acidification
L	0098793	cellular_component	presynapse
L	1902495	cellular_component	transmembrane transporter complex
L	1902600	biological_process	proton transmembrane transport
M	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
M	0005765	cellular_component	lysosomal membrane
M	0005829	cellular_component	cytosol
M	0005886	cellular_component	plasma membrane
M	0006879	biological_process	intracellular iron ion homeostasis
M	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
M	0016887	molecular_function	ATP hydrolysis activity
M	0033176	cellular_component	proton-transporting V-type ATPase complex
M	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
M	0036295	biological_process	cellular response to increased oxygen levels
M	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
M	0051117	molecular_function	ATPase binding
M	0097401	biological_process	synaptic vesicle lumen acidification
M	0098793	cellular_component	presynapse
M	1902495	cellular_component	transmembrane transporter complex
M	1902600	biological_process	proton transmembrane transport
M	1904949	cellular_component	ATPase complex
N	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
N	0005765	cellular_component	lysosomal membrane
N	0005829	cellular_component	cytosol
N	0005886	cellular_component	plasma membrane
N	0006879	biological_process	intracellular iron ion homeostasis
N	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
N	0016887	molecular_function	ATP hydrolysis activity
N	0033176	cellular_component	proton-transporting V-type ATPase complex
N	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
N	0036295	biological_process	cellular response to increased oxygen levels
N	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
N	0051117	molecular_function	ATPase binding
N	0097401	biological_process	synaptic vesicle lumen acidification
N	0098793	cellular_component	presynapse
N	1902495	cellular_component	transmembrane transporter complex
N	1902600	biological_process	proton transmembrane transport
N	1904949	cellular_component	ATPase complex
O	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
O	0005765	cellular_component	lysosomal membrane
O	0005829	cellular_component	cytosol
O	0005886	cellular_component	plasma membrane
O	0006879	biological_process	intracellular iron ion homeostasis
O	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
O	0016887	molecular_function	ATP hydrolysis activity
O	0033176	cellular_component	proton-transporting V-type ATPase complex
O	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
O	0036295	biological_process	cellular response to increased oxygen levels
O	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
O	0051117	molecular_function	ATPase binding
O	0097401	biological_process	synaptic vesicle lumen acidification
O	0098793	cellular_component	presynapse
O	1902495	cellular_component	transmembrane transporter complex
O	1902600	biological_process	proton transmembrane transport
O	1904949	cellular_component	ATPase complex
T	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
T	0016020	cellular_component	membrane
T	0030665	cellular_component	clathrin-coated vesicle membrane
T	0031410	cellular_component	cytoplasmic vesicle
T	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
T	1902600	biological_process	proton transmembrane transport
a	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
a	0005886	cellular_component	plasma membrane
a	0007035	biological_process	vacuolar acidification
a	0016020	cellular_component	membrane
a	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
a	0030665	cellular_component	clathrin-coated vesicle membrane
a	0030672	cellular_component	synaptic vesicle membrane
a	0031410	cellular_component	cytoplasmic vesicle
a	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
a	0042470	cellular_component	melanosome
a	0045202	cellular_component	synapse
a	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
a	0051117	molecular_function	ATPase binding
a	1902600	biological_process	proton transmembrane transport
b	0006811	biological_process	monoatomic ion transport
b	0015078	molecular_function	proton transmembrane transporter activity
b	0016020	cellular_component	membrane
b	0016469	cellular_component	proton-transporting two-sector ATPase complex
b	0030665	cellular_component	clathrin-coated vesicle membrane
b	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
b	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
b	0043231	cellular_component	intracellular membrane-bounded organelle
b	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
b	1902600	biological_process	proton transmembrane transport
d	0005765	cellular_component	lysosomal membrane
d	0005769	cellular_component	early endosome
d	0007034	biological_process	vacuolar transport
d	0007035	biological_process	vacuolar acidification
d	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
d	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
d	0033181	cellular_component	plasma membrane proton-transporting V-type ATPase complex
d	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
d	1902600	biological_process	proton transmembrane transport
e	0016020	cellular_component	membrane
e	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
e	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
e	1902600	biological_process	proton transmembrane transport
f	0004521	molecular_function	RNA endonuclease activity
f	0090304	biological_process	nucleic acid metabolic process
g	0005773	cellular_component	vacuole
g	0005774	cellular_component	vacuolar membrane
g	0015078	molecular_function	proton transmembrane transporter activity
g	0016020	cellular_component	membrane
g	0016469	cellular_component	proton-transporting two-sector ATPase complex
g	0030665	cellular_component	clathrin-coated vesicle membrane
g	0030672	cellular_component	synaptic vesicle membrane
g	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
g	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
g	0043231	cellular_component	intracellular membrane-bounded organelle
g	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
g	1902600	biological_process	proton transmembrane transport
h	0005773	cellular_component	vacuole
h	0005774	cellular_component	vacuolar membrane
h	0015078	molecular_function	proton transmembrane transporter activity
h	0016020	cellular_component	membrane
h	0016469	cellular_component	proton-transporting two-sector ATPase complex
h	0030665	cellular_component	clathrin-coated vesicle membrane
h	0030672	cellular_component	synaptic vesicle membrane
h	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
h	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
h	0043231	cellular_component	intracellular membrane-bounded organelle
h	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
h	1902600	biological_process	proton transmembrane transport
i	0005773	cellular_component	vacuole
i	0005774	cellular_component	vacuolar membrane
i	0015078	molecular_function	proton transmembrane transporter activity
i	0016020	cellular_component	membrane
i	0016469	cellular_component	proton-transporting two-sector ATPase complex
i	0030665	cellular_component	clathrin-coated vesicle membrane
i	0030672	cellular_component	synaptic vesicle membrane
i	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
i	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
i	0043231	cellular_component	intracellular membrane-bounded organelle
i	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
i	1902600	biological_process	proton transmembrane transport
j	0005773	cellular_component	vacuole
j	0005774	cellular_component	vacuolar membrane
j	0015078	molecular_function	proton transmembrane transporter activity
j	0016020	cellular_component	membrane
j	0016469	cellular_component	proton-transporting two-sector ATPase complex
j	0030665	cellular_component	clathrin-coated vesicle membrane
j	0030672	cellular_component	synaptic vesicle membrane
j	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
j	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
j	0043231	cellular_component	intracellular membrane-bounded organelle
j	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
j	1902600	biological_process	proton transmembrane transport
k	0005773	cellular_component	vacuole
k	0005774	cellular_component	vacuolar membrane
k	0015078	molecular_function	proton transmembrane transporter activity
k	0016020	cellular_component	membrane
k	0016469	cellular_component	proton-transporting two-sector ATPase complex
k	0030665	cellular_component	clathrin-coated vesicle membrane
k	0030672	cellular_component	synaptic vesicle membrane
k	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
k	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
k	0043231	cellular_component	intracellular membrane-bounded organelle
k	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
k	1902600	biological_process	proton transmembrane transport
l	0005773	cellular_component	vacuole
l	0005774	cellular_component	vacuolar membrane
l	0015078	molecular_function	proton transmembrane transporter activity
l	0016020	cellular_component	membrane
l	0016469	cellular_component	proton-transporting two-sector ATPase complex
l	0030665	cellular_component	clathrin-coated vesicle membrane
l	0030672	cellular_component	synaptic vesicle membrane
l	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
l	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
l	0043231	cellular_component	intracellular membrane-bounded organelle
l	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
l	1902600	biological_process	proton transmembrane transport
m	0005773	cellular_component	vacuole
m	0005774	cellular_component	vacuolar membrane
m	0015078	molecular_function	proton transmembrane transporter activity
m	0016020	cellular_component	membrane
m	0016469	cellular_component	proton-transporting two-sector ATPase complex
m	0030665	cellular_component	clathrin-coated vesicle membrane
m	0030672	cellular_component	synaptic vesicle membrane
m	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
m	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
m	0043231	cellular_component	intracellular membrane-bounded organelle
m	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
m	1902600	biological_process	proton transmembrane transport
n	0005773	cellular_component	vacuole
n	0005774	cellular_component	vacuolar membrane
n	0015078	molecular_function	proton transmembrane transporter activity
n	0016020	cellular_component	membrane
n	0016469	cellular_component	proton-transporting two-sector ATPase complex
n	0030665	cellular_component	clathrin-coated vesicle membrane
n	0030672	cellular_component	synaptic vesicle membrane
n	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
n	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
n	0043231	cellular_component	intracellular membrane-bounded organelle
n	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
n	1902600	biological_process	proton transmembrane transport
o	0005773	cellular_component	vacuole
o	0005774	cellular_component	vacuolar membrane
o	0015078	molecular_function	proton transmembrane transporter activity
o	0016020	cellular_component	membrane
o	0016469	cellular_component	proton-transporting two-sector ATPase complex
o	0030665	cellular_component	clathrin-coated vesicle membrane
o	0030672	cellular_component	synaptic vesicle membrane
o	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
o	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
o	0043231	cellular_component	intracellular membrane-bounded organelle
o	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
o	1902600	biological_process	proton transmembrane transport
p	0016020	cellular_component	membrane
p	0038023	molecular_function	signaling receptor activity

Functional Information from PROSITE/UniProt

site_id	PS00152
Number of Residues	10
Details	ATPASE_ALPHA_BETA ATP synthase alpha and beta subunits signature. PSVNWLISYS

Chain	Residue	Details
A	PRO446-SER455
D	PRO384-SER393

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9UI12

Chain	Residue	Details
T	SER483
B	GLY250
C	GLY250

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P38606

Chain	Residue	Details
A	THR136
B	THR136
C	THR136

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	MOD_RES: Phosphoserine; by AMPK => ECO:0000250|UniProtKB:P50516

Chain	Residue	Details
A	SER384
B	SER384
C	SER384

---