7U6B
Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with Indolethyl Piperidine-4-acrylhydroxamic Acid Inhibitor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0016236 | biological_process | macroautophagy |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0019213 | molecular_function | deacetylase activity |
| B | 0033558 | molecular_function | protein lysine deacetylase activity |
| B | 0035825 | biological_process | homologous recombination |
| B | 0036269 | biological_process | swimming behavior |
| B | 0040029 | biological_process | epigenetic regulation of gene expression |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0047609 | molecular_function | acetylputrescine deacetylase activity |
| B | 0047611 | molecular_function | acetylspermidine deacetylase activity |
| B | 0090043 | biological_process | regulation of tubulin deacetylation |
| B | 0106047 | biological_process | polyamine deacetylation |
| B | 0106048 | biological_process | spermidine deacetylation |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton donor/acceptor => ECO:0000269|PubMed:28516954, ECO:0007744|PDB:5TD7 |
| Chain | Residue | Details |
| B | HIS137 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:28516954, ECO:0007744|PDB:5TD7 |
| Chain | Residue | Details |
| B | ASP22 | |
| B | ALA94 | |
| B | ASP174 | |
| B | HIS176 | |
| B | ASP267 | |
| B | TYR307 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | SITE: Substrate specificity => ECO:0000269|PubMed:28516954 |
| Chain | Residue | Details |
| B | GLU274 |
