7TRB

CRYSTAL STRUCTURE OF FARNESOID X-ACTIVATED RECEPTOR COMPLEXED WITH COMPOUND-32 AKA (1S,3S)-N-({4-[5-(2-FLUOROPR OPAN-2-YL)-1,2,4-OXADIAZOL-3-YL]BICYCLO[2.2.2]OCTAN-1-YL}M ETHYL)-3-HYDROXY-N-[4'-(2-HYDROXYPROPAN-2-YL)-[1,1'-BIPHEN YL]-3-YL]-3-(TRIFLUOROMETHYL)CYCLOBUTANE-1-CARBOXAMIDE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004879	molecular_function	nuclear receptor activity
A	0006355	biological_process	regulation of DNA-templated transcription
A	0032052	molecular_function	bile acid binding
A	0038183	biological_process	bile acid signaling pathway
B	0003677	molecular_function	DNA binding
B	0004879	molecular_function	nuclear receptor activity
B	0006355	biological_process	regulation of DNA-templated transcription
B	0032052	molecular_function	bile acid binding
B	0038183	biological_process	bile acid signaling pathway

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	BINDING: BINDING => ECO:0007744|PDB:6HL1

Chain	Residue	Details
A	ARG335
A	TYR365
A	TYR373
A	HIS451
B	ARG335
B	TYR365
B	TYR373
B	HIS451

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site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphothreonine; by PKC/PRKCZ => ECO:0000305|PubMed:18668687

Chain	Residue	Details
A	THR446
B	THR446

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site_id	SWS_FT_FI3
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1) => ECO:0000305|PubMed:23546875

Chain	Residue	Details
A	LYS279
B	LYS279

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