Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7TMR

V-ATPase from Saccharomyces cerevisiae, State 1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005524	molecular_function	ATP binding
A	0016887	molecular_function	ATP hydrolysis activity
A	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
A	0046034	biological_process	ATP metabolic process
A	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
A	1902600	biological_process	proton transmembrane transport
B	0000139	cellular_component	Golgi membrane
B	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
B	0000329	cellular_component	fungal-type vacuole membrane
B	0000425	biological_process	pexophagy
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005773	cellular_component	vacuole
B	0005774	cellular_component	vacuolar membrane
B	0006874	biological_process	intracellular calcium ion homeostasis
B	0007035	biological_process	vacuolar acidification
B	0010494	cellular_component	cytoplasmic stress granule
B	0016020	cellular_component	membrane
B	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
B	0033176	cellular_component	proton-transporting V-type ATPase complex
B	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
B	0045121	cellular_component	membrane raft
B	0046034	biological_process	ATP metabolic process
B	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
B	0048388	biological_process	endosomal lumen acidification
B	0055085	biological_process	transmembrane transport
B	0061795	biological_process	Golgi lumen acidification
B	1902600	biological_process	proton transmembrane transport
B	1902906	biological_process	proteasome storage granule assembly
B	1990816	cellular_component	vacuole-mitochondrion membrane contact site
C	0005524	molecular_function	ATP binding
C	0016887	molecular_function	ATP hydrolysis activity
C	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
C	0046034	biological_process	ATP metabolic process
C	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
C	1902600	biological_process	proton transmembrane transport
D	0000139	cellular_component	Golgi membrane
D	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
D	0000329	cellular_component	fungal-type vacuole membrane
D	0000425	biological_process	pexophagy
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005773	cellular_component	vacuole
D	0005774	cellular_component	vacuolar membrane
D	0006874	biological_process	intracellular calcium ion homeostasis
D	0007035	biological_process	vacuolar acidification
D	0010494	cellular_component	cytoplasmic stress granule
D	0016020	cellular_component	membrane
D	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
D	0033176	cellular_component	proton-transporting V-type ATPase complex
D	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
D	0045121	cellular_component	membrane raft
D	0046034	biological_process	ATP metabolic process
D	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
D	0048388	biological_process	endosomal lumen acidification
D	0055085	biological_process	transmembrane transport
D	0061795	biological_process	Golgi lumen acidification
D	1902600	biological_process	proton transmembrane transport
D	1902906	biological_process	proteasome storage granule assembly
D	1990816	cellular_component	vacuole-mitochondrion membrane contact site
E	0005524	molecular_function	ATP binding
E	0016887	molecular_function	ATP hydrolysis activity
E	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
E	0046034	biological_process	ATP metabolic process
E	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
E	1902600	biological_process	proton transmembrane transport
F	0000139	cellular_component	Golgi membrane
F	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
F	0000329	cellular_component	fungal-type vacuole membrane
F	0000425	biological_process	pexophagy
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0005773	cellular_component	vacuole
F	0005774	cellular_component	vacuolar membrane
F	0006874	biological_process	intracellular calcium ion homeostasis
F	0007035	biological_process	vacuolar acidification
F	0010494	cellular_component	cytoplasmic stress granule
F	0016020	cellular_component	membrane
F	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
F	0033176	cellular_component	proton-transporting V-type ATPase complex
F	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
F	0045121	cellular_component	membrane raft
F	0046034	biological_process	ATP metabolic process
F	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
F	0048388	biological_process	endosomal lumen acidification
F	0055085	biological_process	transmembrane transport
F	0061795	biological_process	Golgi lumen acidification
F	1902600	biological_process	proton transmembrane transport
F	1902906	biological_process	proteasome storage granule assembly
F	1990816	cellular_component	vacuole-mitochondrion membrane contact site
G	0000139	cellular_component	Golgi membrane
G	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
G	0000329	cellular_component	fungal-type vacuole membrane
G	0005515	molecular_function	protein binding
G	0005773	cellular_component	vacuole
G	0005774	cellular_component	vacuolar membrane
G	0007035	biological_process	vacuolar acidification
G	0016020	cellular_component	membrane
G	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
G	0033176	cellular_component	proton-transporting V-type ATPase complex
G	0033178	cellular_component	proton-transporting two-sector ATPase complex, catalytic domain
G	0045121	cellular_component	membrane raft
G	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
G	0048388	biological_process	endosomal lumen acidification
G	0061795	biological_process	Golgi lumen acidification
G	1902600	biological_process	proton transmembrane transport
H	0000139	cellular_component	Golgi membrane
H	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
H	0000329	cellular_component	fungal-type vacuole membrane
H	0005515	molecular_function	protein binding
H	0005773	cellular_component	vacuole
H	0005774	cellular_component	vacuolar membrane
H	0007035	biological_process	vacuolar acidification
H	0016020	cellular_component	membrane
H	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
H	0016887	molecular_function	ATP hydrolysis activity
H	0033176	cellular_component	proton-transporting V-type ATPase complex
H	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
H	0048388	biological_process	endosomal lumen acidification
H	0061795	biological_process	Golgi lumen acidification
H	1902600	biological_process	proton transmembrane transport
I	0000139	cellular_component	Golgi membrane
I	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
I	0000329	cellular_component	fungal-type vacuole membrane
I	0005515	molecular_function	protein binding
I	0005773	cellular_component	vacuole
I	0005774	cellular_component	vacuolar membrane
I	0007035	biological_process	vacuolar acidification
I	0016020	cellular_component	membrane
I	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
I	0033176	cellular_component	proton-transporting V-type ATPase complex
I	0033178	cellular_component	proton-transporting two-sector ATPase complex, catalytic domain
I	0045121	cellular_component	membrane raft
I	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
I	0048388	biological_process	endosomal lumen acidification
I	0061795	biological_process	Golgi lumen acidification
I	1902600	biological_process	proton transmembrane transport
J	0000139	cellular_component	Golgi membrane
J	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
J	0000329	cellular_component	fungal-type vacuole membrane
J	0005515	molecular_function	protein binding
J	0005773	cellular_component	vacuole
J	0005774	cellular_component	vacuolar membrane
J	0007035	biological_process	vacuolar acidification
J	0016020	cellular_component	membrane
J	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
J	0016887	molecular_function	ATP hydrolysis activity
J	0033176	cellular_component	proton-transporting V-type ATPase complex
J	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
J	0048388	biological_process	endosomal lumen acidification
J	0061795	biological_process	Golgi lumen acidification
J	1902600	biological_process	proton transmembrane transport
K	0000139	cellular_component	Golgi membrane
K	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
K	0000329	cellular_component	fungal-type vacuole membrane
K	0005515	molecular_function	protein binding
K	0005773	cellular_component	vacuole
K	0005774	cellular_component	vacuolar membrane
K	0007035	biological_process	vacuolar acidification
K	0016020	cellular_component	membrane
K	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
K	0033176	cellular_component	proton-transporting V-type ATPase complex
K	0033178	cellular_component	proton-transporting two-sector ATPase complex, catalytic domain
K	0045121	cellular_component	membrane raft
K	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
K	0048388	biological_process	endosomal lumen acidification
K	0061795	biological_process	Golgi lumen acidification
K	1902600	biological_process	proton transmembrane transport
L	0000139	cellular_component	Golgi membrane
L	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
L	0000329	cellular_component	fungal-type vacuole membrane
L	0005515	molecular_function	protein binding
L	0005773	cellular_component	vacuole
L	0005774	cellular_component	vacuolar membrane
L	0007035	biological_process	vacuolar acidification
L	0016020	cellular_component	membrane
L	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
L	0016887	molecular_function	ATP hydrolysis activity
L	0033176	cellular_component	proton-transporting V-type ATPase complex
L	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
L	0048388	biological_process	endosomal lumen acidification
L	0061795	biological_process	Golgi lumen acidification
L	1902600	biological_process	proton transmembrane transport
M	0000139	cellular_component	Golgi membrane
M	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
M	0000329	cellular_component	fungal-type vacuole membrane
M	0005515	molecular_function	protein binding
M	0005773	cellular_component	vacuole
M	0005774	cellular_component	vacuolar membrane
M	0007035	biological_process	vacuolar acidification
M	0016020	cellular_component	membrane
M	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
M	0033176	cellular_component	proton-transporting V-type ATPase complex
M	0045121	cellular_component	membrane raft
M	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
M	0048388	biological_process	endosomal lumen acidification
M	0061795	biological_process	Golgi lumen acidification
M	1902600	biological_process	proton transmembrane transport
N	0000139	cellular_component	Golgi membrane
N	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
N	0000329	cellular_component	fungal-type vacuole membrane
N	0005515	molecular_function	protein binding
N	0005773	cellular_component	vacuole
N	0005774	cellular_component	vacuolar membrane
N	0007035	biological_process	vacuolar acidification
N	0016020	cellular_component	membrane
N	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
N	0033176	cellular_component	proton-transporting V-type ATPase complex
N	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
N	0034220	biological_process	monoatomic ion transmembrane transport
N	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
N	0048388	biological_process	endosomal lumen acidification
N	0061795	biological_process	Golgi lumen acidification
N	1902600	biological_process	proton transmembrane transport
O	0000139	cellular_component	Golgi membrane
O	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
O	0000329	cellular_component	fungal-type vacuole membrane
O	0005515	molecular_function	protein binding
O	0005524	molecular_function	ATP binding
O	0005773	cellular_component	vacuole
O	0005774	cellular_component	vacuolar membrane
O	0007035	biological_process	vacuolar acidification
O	0015078	molecular_function	proton transmembrane transporter activity
O	0016020	cellular_component	membrane
O	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
O	0033176	cellular_component	proton-transporting V-type ATPase complex
O	0033180	cellular_component	proton-transporting V-type ATPase, V1 domain
O	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
O	0048388	biological_process	endosomal lumen acidification
O	0061795	biological_process	Golgi lumen acidification
O	1902600	biological_process	proton transmembrane transport
P	0000139	cellular_component	Golgi membrane
P	0000221	cellular_component	vacuolar proton-transporting V-type ATPase, V1 domain
P	0000329	cellular_component	fungal-type vacuole membrane
P	0005515	molecular_function	protein binding
P	0005773	cellular_component	vacuole
P	0005774	cellular_component	vacuolar membrane
P	0007035	biological_process	vacuolar acidification
P	0016020	cellular_component	membrane
P	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
P	0033176	cellular_component	proton-transporting V-type ATPase complex
P	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
P	0048388	biological_process	endosomal lumen acidification
P	0061795	biological_process	Golgi lumen acidification
P	1902600	biological_process	proton transmembrane transport
a	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
a	0000324	cellular_component	fungal-type vacuole
a	0000329	cellular_component	fungal-type vacuole membrane
a	0005515	molecular_function	protein binding
a	0005773	cellular_component	vacuole
a	0005774	cellular_component	vacuolar membrane
a	0006797	biological_process	polyphosphate metabolic process
a	0007035	biological_process	vacuolar acidification
a	0016020	cellular_component	membrane
a	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
a	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
a	0045121	cellular_component	membrane raft
a	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
a	0051117	molecular_function	ATPase binding
a	0065003	biological_process	protein-containing complex assembly
a	0071469	biological_process	cellular response to alkaline pH
a	0071474	biological_process	cellular hyperosmotic response
a	0080025	molecular_function	phosphatidylinositol-3,5-bisphosphate binding
a	1902600	biological_process	proton transmembrane transport
a	1903778	biological_process	protein localization to vacuolar membrane
c	0000139	cellular_component	Golgi membrane
c	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
c	0000329	cellular_component	fungal-type vacuole membrane
c	0005773	cellular_component	vacuole
c	0005774	cellular_component	vacuolar membrane
c	0007035	biological_process	vacuolar acidification
c	0008553	molecular_function	P-type proton-exporting transporter activity
c	0015078	molecular_function	proton transmembrane transporter activity
c	0016020	cellular_component	membrane
c	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
c	0033176	cellular_component	proton-transporting V-type ATPase complex
c	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
c	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
c	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
c	0048388	biological_process	endosomal lumen acidification
c	0061795	biological_process	Golgi lumen acidification
c	1902600	biological_process	proton transmembrane transport
d	0000139	cellular_component	Golgi membrane
d	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
d	0000329	cellular_component	fungal-type vacuole membrane
d	0005515	molecular_function	protein binding
d	0005773	cellular_component	vacuole
d	0005774	cellular_component	vacuolar membrane
d	0007034	biological_process	vacuolar transport
d	0007035	biological_process	vacuolar acidification
d	0016020	cellular_component	membrane
d	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
d	0033176	cellular_component	proton-transporting V-type ATPase complex
d	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
d	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
d	0048388	biological_process	endosomal lumen acidification
d	0061795	biological_process	Golgi lumen acidification
d	1902600	biological_process	proton transmembrane transport
e	0000032	biological_process	cell wall mannoprotein biosynthetic process
e	0000139	cellular_component	Golgi membrane
e	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
e	0000329	cellular_component	fungal-type vacuole membrane
e	0005773	cellular_component	vacuole
e	0005774	cellular_component	vacuolar membrane
e	0007035	biological_process	vacuolar acidification
e	0016020	cellular_component	membrane
e	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
e	0033176	cellular_component	proton-transporting V-type ATPase complex
e	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
e	0042625	molecular_function	ATPase-coupled ion transmembrane transporter activity
e	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
e	0048388	biological_process	endosomal lumen acidification
e	0055085	biological_process	transmembrane transport
e	0061795	biological_process	Golgi lumen acidification
e	0065003	biological_process	protein-containing complex assembly
e	1902600	biological_process	proton transmembrane transport
f	0000139	cellular_component	Golgi membrane
f	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
f	0000329	cellular_component	fungal-type vacuole membrane
f	0003674	molecular_function	molecular_function
f	0004521	molecular_function	RNA endonuclease activity
f	0005575	cellular_component	cellular_component
f	0005773	cellular_component	vacuole
f	0005774	cellular_component	vacuolar membrane
f	0005783	cellular_component	endoplasmic reticulum
f	0005789	cellular_component	endoplasmic reticulum membrane
f	0007035	biological_process	vacuolar acidification
f	0008150	biological_process	biological_process
f	0016020	cellular_component	membrane
f	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
f	0033176	cellular_component	proton-transporting V-type ATPase complex
f	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
f	0048388	biological_process	endosomal lumen acidification
f	0061795	biological_process	Golgi lumen acidification
f	0090304	biological_process	nucleic acid metabolic process
f	1902600	biological_process	proton transmembrane transport
g	0000139	cellular_component	Golgi membrane
g	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
g	0000329	cellular_component	fungal-type vacuole membrane
g	0005773	cellular_component	vacuole
g	0005774	cellular_component	vacuolar membrane
g	0006623	biological_process	protein targeting to vacuole
g	0006878	biological_process	intracellular copper ion homeostasis
g	0006879	biological_process	intracellular iron ion homeostasis
g	0006897	biological_process	endocytosis
g	0007033	biological_process	vacuole organization
g	0007035	biological_process	vacuolar acidification
g	0015078	molecular_function	proton transmembrane transporter activity
g	0016020	cellular_component	membrane
g	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
g	0033176	cellular_component	proton-transporting V-type ATPase complex
g	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
g	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
g	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
g	0048388	biological_process	endosomal lumen acidification
g	0061795	biological_process	Golgi lumen acidification
g	1902600	biological_process	proton transmembrane transport
h	0000139	cellular_component	Golgi membrane
h	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
h	0000329	cellular_component	fungal-type vacuole membrane
h	0005773	cellular_component	vacuole
h	0005774	cellular_component	vacuolar membrane
h	0006623	biological_process	protein targeting to vacuole
h	0006878	biological_process	intracellular copper ion homeostasis
h	0006879	biological_process	intracellular iron ion homeostasis
h	0006897	biological_process	endocytosis
h	0007033	biological_process	vacuole organization
h	0007035	biological_process	vacuolar acidification
h	0015078	molecular_function	proton transmembrane transporter activity
h	0016020	cellular_component	membrane
h	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
h	0033176	cellular_component	proton-transporting V-type ATPase complex
h	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
h	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
h	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
h	0048388	biological_process	endosomal lumen acidification
h	0061795	biological_process	Golgi lumen acidification
h	1902600	biological_process	proton transmembrane transport
i	0000139	cellular_component	Golgi membrane
i	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
i	0000329	cellular_component	fungal-type vacuole membrane
i	0005773	cellular_component	vacuole
i	0005774	cellular_component	vacuolar membrane
i	0006623	biological_process	protein targeting to vacuole
i	0006878	biological_process	intracellular copper ion homeostasis
i	0006879	biological_process	intracellular iron ion homeostasis
i	0006897	biological_process	endocytosis
i	0007033	biological_process	vacuole organization
i	0007035	biological_process	vacuolar acidification
i	0015078	molecular_function	proton transmembrane transporter activity
i	0016020	cellular_component	membrane
i	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
i	0033176	cellular_component	proton-transporting V-type ATPase complex
i	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
i	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
i	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
i	0048388	biological_process	endosomal lumen acidification
i	0061795	biological_process	Golgi lumen acidification
i	1902600	biological_process	proton transmembrane transport
j	0000139	cellular_component	Golgi membrane
j	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
j	0000329	cellular_component	fungal-type vacuole membrane
j	0005773	cellular_component	vacuole
j	0005774	cellular_component	vacuolar membrane
j	0006623	biological_process	protein targeting to vacuole
j	0006878	biological_process	intracellular copper ion homeostasis
j	0006879	biological_process	intracellular iron ion homeostasis
j	0006897	biological_process	endocytosis
j	0007033	biological_process	vacuole organization
j	0007035	biological_process	vacuolar acidification
j	0015078	molecular_function	proton transmembrane transporter activity
j	0016020	cellular_component	membrane
j	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
j	0033176	cellular_component	proton-transporting V-type ATPase complex
j	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
j	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
j	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
j	0048388	biological_process	endosomal lumen acidification
j	0061795	biological_process	Golgi lumen acidification
j	1902600	biological_process	proton transmembrane transport
k	0000139	cellular_component	Golgi membrane
k	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
k	0000329	cellular_component	fungal-type vacuole membrane
k	0005773	cellular_component	vacuole
k	0005774	cellular_component	vacuolar membrane
k	0006623	biological_process	protein targeting to vacuole
k	0006878	biological_process	intracellular copper ion homeostasis
k	0006879	biological_process	intracellular iron ion homeostasis
k	0006897	biological_process	endocytosis
k	0007033	biological_process	vacuole organization
k	0007035	biological_process	vacuolar acidification
k	0015078	molecular_function	proton transmembrane transporter activity
k	0016020	cellular_component	membrane
k	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
k	0033176	cellular_component	proton-transporting V-type ATPase complex
k	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
k	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
k	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
k	0048388	biological_process	endosomal lumen acidification
k	0061795	biological_process	Golgi lumen acidification
k	1902600	biological_process	proton transmembrane transport
l	0000139	cellular_component	Golgi membrane
l	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
l	0000329	cellular_component	fungal-type vacuole membrane
l	0005773	cellular_component	vacuole
l	0005774	cellular_component	vacuolar membrane
l	0006623	biological_process	protein targeting to vacuole
l	0006878	biological_process	intracellular copper ion homeostasis
l	0006879	biological_process	intracellular iron ion homeostasis
l	0006897	biological_process	endocytosis
l	0007033	biological_process	vacuole organization
l	0007035	biological_process	vacuolar acidification
l	0015078	molecular_function	proton transmembrane transporter activity
l	0016020	cellular_component	membrane
l	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
l	0033176	cellular_component	proton-transporting V-type ATPase complex
l	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
l	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
l	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
l	0048388	biological_process	endosomal lumen acidification
l	0061795	biological_process	Golgi lumen acidification
l	1902600	biological_process	proton transmembrane transport
m	0000139	cellular_component	Golgi membrane
m	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
m	0000329	cellular_component	fungal-type vacuole membrane
m	0005773	cellular_component	vacuole
m	0005774	cellular_component	vacuolar membrane
m	0006623	biological_process	protein targeting to vacuole
m	0006878	biological_process	intracellular copper ion homeostasis
m	0006879	biological_process	intracellular iron ion homeostasis
m	0006897	biological_process	endocytosis
m	0007033	biological_process	vacuole organization
m	0007035	biological_process	vacuolar acidification
m	0015078	molecular_function	proton transmembrane transporter activity
m	0016020	cellular_component	membrane
m	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
m	0033176	cellular_component	proton-transporting V-type ATPase complex
m	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
m	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
m	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
m	0048388	biological_process	endosomal lumen acidification
m	0061795	biological_process	Golgi lumen acidification
m	1902600	biological_process	proton transmembrane transport
n	0000139	cellular_component	Golgi membrane
n	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
n	0000329	cellular_component	fungal-type vacuole membrane
n	0005773	cellular_component	vacuole
n	0005774	cellular_component	vacuolar membrane
n	0006623	biological_process	protein targeting to vacuole
n	0006878	biological_process	intracellular copper ion homeostasis
n	0006879	biological_process	intracellular iron ion homeostasis
n	0006897	biological_process	endocytosis
n	0007033	biological_process	vacuole organization
n	0007035	biological_process	vacuolar acidification
n	0015078	molecular_function	proton transmembrane transporter activity
n	0016020	cellular_component	membrane
n	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
n	0033176	cellular_component	proton-transporting V-type ATPase complex
n	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
n	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
n	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
n	0048388	biological_process	endosomal lumen acidification
n	0061795	biological_process	Golgi lumen acidification
n	1902600	biological_process	proton transmembrane transport
o	0000139	cellular_component	Golgi membrane
o	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
o	0000324	cellular_component	fungal-type vacuole
o	0000329	cellular_component	fungal-type vacuole membrane
o	0005773	cellular_component	vacuole
o	0005774	cellular_component	vacuolar membrane
o	0007035	biological_process	vacuolar acidification
o	0015078	molecular_function	proton transmembrane transporter activity
o	0016020	cellular_component	membrane
o	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
o	0033176	cellular_component	proton-transporting V-type ATPase complex
o	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
o	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
o	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
o	0048388	biological_process	endosomal lumen acidification
o	0061795	biological_process	Golgi lumen acidification
o	0071944	cellular_component	cell periphery
o	1902600	biological_process	proton transmembrane transport

Functional Information from PROSITE/UniProt

site_id	PS00152
Number of Residues	10
Details	ATPASE_ALPHA_BETA ATP synthase alpha and beta subunits signature. PSINTSVSYS

Chain	Residue	Details
A	PRO452-SER461
B	PRO371-SER380

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: N-acetylalanine => ECO:0000269\|Ref.6

Chain	Residue	Details
K	SER2
I	SER2
j	MET1-TYR8
j	CYS75-GLN90
j	ASN151-CYS160
k	MET1-TYR8
k	CYS75-GLN90
k	ASN151-CYS160
l	MET1-TYR8
l	CYS75-GLN90
l	ASN151-CYS160
m	MET1-TYR8
m	CYS75-GLN90
m	ASN151-CYS160
n	MET1-TYR8
n	CYS75-GLN90
n	ASN151-CYS160
h	ASN151-CYS160
i	MET1-TYR8
i	CYS75-GLN90
i	ASN151-CYS160
O	ALA2
a	LYS657-THR719
a	SER805-SER840

site_id	SWS_FT_FI2
Number of Residues	3
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:15665377, ECO:0007744\|PubMed:18407956

Chain	Residue	Details
D	SER4
F	SER4
B	SER4
i	ILE54-VAL74
i	LEU91-GLY112
i	LEU125-LEU150
j	ALA9-GLY31
j	ILE54-VAL74
j	LEU91-GLY112
j	LEU125-LEU150
k	ALA9-GLY31
k	ILE54-VAL74
k	LEU91-GLY112
k	LEU125-LEU150
l	ALA9-GLY31
l	ILE54-VAL74
l	LEU91-GLY112
l	LEU125-LEU150
m	ALA9-GLY31
m	ILE54-VAL74
m	LEU91-GLY112
m	LEU125-LEU150
n	ALA9-GLY31
n	ILE54-VAL74
n	LEU91-GLY112
n	LEU125-LEU150
i	ALA9-GLY31
a	LEU637-PHE656
a	TYR535-PHE554
a	ILE573-LYS593
a	ILE720-ALA744
a	GLY766-GLU804

site_id	SWS_FT_FI3
Number of Residues	3
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:18407956, ECO:0007744\|PubMed:19779198

Chain	Residue	Details
F	SER137
D	SER137
B	SER137
k	ASP113-ARG124
l	THR32-ASN53
l	ASP113-ARG124
m	THR32-ASN53
m	ASP113-ARG124
n	THR32-ASN53
n	ASP113-ARG124
i	THR32-ASN53
i	ASP113-ARG124
j	THR32-ASN53
j	ASP113-ARG124
k	THR32-ASN53
a	GLN745-VAL765

site_id	SWS_FT_FI4
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:18407956

Chain	Residue	Details
B	SER504
D	SER503
D	SER504
F	SER503
F	SER504
m	GLU137
n	GLU137
B	SER503

site_id	SWS_FT_FI5
Number of Residues	3
Details	MOD_RES: Phosphoserine; by ATM or ATR => ECO:0007744\|PubMed:17330950, ECO:0007744\|PubMed:19779198

Chain	Residue	Details
B	SER511
D	SER511
F	SER511

site_id	SWS_FT_FI6
Number of Residues	3
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:17330950, ECO:0007744\|PubMed:19779198

Chain	Residue	Details
B	SER515
D	SER515
F	SER515

site_id	SWS_FT_FI7
Number of Residues	9
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0007744\|PubMed:22106047

Chain	Residue	Details
B	LYS14
B	LYS508
D	LYS14
D	LYS508
F	LYS14
F	LYS508

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	9
Details	M-CSA 508

Chain	Residue	Details
A	CYS283	covalent catalysis
A	SER358	electrostatic stabiliser
A	TRP360	electrostatic stabiliser
A	ALA361	proton shuttle (general acid/base)
A	SER583	proton shuttle (general acid/base)

site_id	MCSA2
Number of Residues	9
Details	M-CSA 508

Chain	Residue	Details
C	CYS283	covalent catalysis
C	SER358	electrostatic stabiliser
C	TRP360	electrostatic stabiliser
C	ALA361	proton shuttle (general acid/base)
C	SER583	proton shuttle (general acid/base)

site_id	MCSA3
Number of Residues	9
Details	M-CSA 508

Chain	Residue	Details
E	CYS283	covalent catalysis
E	SER358	electrostatic stabiliser
E	TRP360	electrostatic stabiliser
E	ALA361	proton shuttle (general acid/base)
E	SER583	proton shuttle (general acid/base)

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)