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7TDT

Cryo-EM structure of nanodisc-embedded human ABCA1

Functional Information from GO Data
ChainGOidnamespacecontents
A0002790biological_processpeptide secretion
A0005102molecular_functionsignaling receptor binding
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005548molecular_functionphospholipid transporter activity
A0005768cellular_componentendosome
A0005789cellular_componentendoplasmic reticulum membrane
A0005794cellular_componentGolgi apparatus
A0005886cellular_componentplasma membrane
A0006869biological_processlipid transport
A0006911biological_processphagocytosis, engulfment
A0007040biological_processlysosome organization
A0007186biological_processG protein-coupled receptor signaling pathway
A0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
A0007584biological_processresponse to nutrient
A0008035molecular_functionhigh-density lipoprotein particle binding
A0008203biological_processcholesterol metabolic process
A0008320molecular_functionprotein transmembrane transporter activity
A0009306biological_processprotein secretion
A0009410biological_processresponse to xenobiotic stimulus
A0009897cellular_componentexternal side of plasma membrane
A0009986cellular_componentcell surface
A0010745biological_processnegative regulation of macrophage derived foam cell differentiation
A0010875biological_processpositive regulation of cholesterol efflux
A0010887biological_processnegative regulation of cholesterol storage
A0015485molecular_functioncholesterol binding
A0015914biological_processphospholipid transport
A0016020cellular_componentmembrane
A0016197biological_processendosomal transport
A0016323cellular_componentbasolateral plasma membrane
A0016887molecular_functionATP hydrolysis activity
A0019905molecular_functionsyntaxin binding
A0023061biological_processsignal release
A0030139cellular_componentendocytic vesicle
A0030301biological_processcholesterol transport
A0031210molecular_functionphosphatidylcholine binding
A0031267molecular_functionsmall GTPase binding
A0031667biological_processresponse to nutrient levels
A0032367biological_processintracellular cholesterol transport
A0032489biological_processregulation of Cdc42 protein signal transduction
A0033344biological_processcholesterol efflux
A0033552biological_processresponse to vitamin B3
A0033700biological_processphospholipid efflux
A0034185molecular_functionapolipoprotein binding
A0034186molecular_functionapolipoprotein A-I binding
A0034188molecular_functionapolipoprotein A-I receptor activity
A0034380biological_processhigh-density lipoprotein particle assembly
A0034616biological_processresponse to laminar fluid shear stress
A0038027biological_processapolipoprotein A-I-mediated signaling pathway
A0042157biological_processlipoprotein metabolic process
A0042158biological_processlipoprotein biosynthetic process
A0042626molecular_functionATPase-coupled transmembrane transporter activity
A0042632biological_processcholesterol homeostasis
A0043231cellular_componentintracellular membrane-bounded organelle
A0043691biological_processreverse cholesterol transport
A0045121cellular_componentmembrane raft
A0045332biological_processphospholipid translocation
A0045335cellular_componentphagocytic vesicle
A0046623molecular_functionsphingolipid floppase activity
A0048471cellular_componentperinuclear region of cytoplasm
A0051117molecular_functionATPase binding
A0051649biological_processestablishment of localization in cell
A0055085biological_processtransmembrane transport
A0055091biological_processphospholipid homeostasis
A0060155biological_processplatelet dense granule organization
A0071222biological_processcellular response to lipopolysaccharide
A0071300biological_processcellular response to retinoic acid
A0071345biological_processcellular response to cytokine stimulus
A0071397biological_processcellular response to cholesterol
A0071404biological_processcellular response to low-density lipoprotein particle stimulus
A0071466biological_processcellular response to xenobiotic stimulus
A0071806biological_processprotein transmembrane transport
A0090107biological_processregulation of high-density lipoprotein particle assembly
A0090108biological_processpositive regulation of high-density lipoprotein particle assembly
A0090554molecular_functionphosphatidylcholine floppase activity
A0090556molecular_functionphosphatidylserine floppase activity
A0097708cellular_componentintracellular vesicle
A0099039biological_processsphingolipid translocation
A0120020molecular_functioncholesterol transfer activity
A0140115biological_processexport across plasma membrane
A0140326molecular_functionATPase-coupled intramembrane lipid transporter activity
A0140328molecular_functionfloppase activity
A0140359molecular_functionABC-type transporter activity
Functional Information from PROSITE/UniProt
site_idPS00211
Number of Residues15
DetailsABC_TRANSPORTER_1 ABC transporters family signature. LSGGMQRKLSVALAF
ChainResidueDetails
ALEU1033-PHE1047

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues296
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
ATHR22-VAL42
AVAL1657-ILE1677
APHE1703-CYS1723
ALEU1735-PRO1755
AVAL1768-LEU1788
AILE1802-MET1822
AASN1852-TYR1872
AMET640-VAL660
APHE683-ILE703
ASER716-ILE736
ALEU745-VAL765
AILE777-PHE797
AMET827-PRO847
ALEU1041-ASP1057
AILE1351-PHE1371

site_idSWS_FT_FI2
Number of Residues880
DetailsTOPO_DOM: Extracellular
ChainResidueDetails
AARG43-SER639
AGLY1372-LEU1656

site_idSWS_FT_FI3
Number of Residues2
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00434
ChainResidueDetails
AGLY933
AGLY1946

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphoserine; by PKA => ECO:0000269|PubMed:12196520
ChainResidueDetails
ASER1042
ASER2054

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P41233
ChainResidueDetails
ASER1296

site_idSWS_FT_FI6
Number of Residues4
DetailsLIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:19556522
ChainResidueDetails
ACYS3
ACYS23
ACYS1110
ACYS1111

site_idSWS_FT_FI7
Number of Residues19
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN14
AASN489
AASN521
AASN820
AASN1144
AASN1294
AASN1453
AASN1504
AASN1637
AASN2044
AASN2238
AASN151
AASN161
AASN196
AASN292
AASN337
AASN349
AASN400
AASN478

site_idSWS_FT_FI8
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218
ChainResidueDetails
AASN98
AASN244

220113

PDB entries from 2024-05-22

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