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7STC

AQP5 T41H with Ni2+

Functional Information from GO Data
ChainGOidnamespacecontents
A0005515molecular_functionprotein binding
A0005783cellular_componentendoplasmic reticulum
A0005886cellular_componentplasma membrane
A0005902cellular_componentmicrovillus
A0006833biological_processwater transport
A0009925cellular_componentbasal plasma membrane
A0015250molecular_functionwater channel activity
A0015267molecular_functionchannel activity
A0015670biological_processcarbon dioxide transport
A0016020cellular_componentmembrane
A0016324cellular_componentapical plasma membrane
A0030157biological_processpancreatic juice secretion
A0030659cellular_componentcytoplasmic vesicle membrane
A0031410cellular_componentcytoplasmic vesicle
A0042476biological_processodontogenesis
A0042802molecular_functionidentical protein binding
A0046541biological_processsaliva secretion
A0048593biological_processcamera-type eye morphogenesis
A0051289biological_processprotein homotetramerization
A0055085biological_processtransmembrane transport
A0070062cellular_componentextracellular exosome
A0071476biological_processcellular hypotonic response
B0005515molecular_functionprotein binding
B0005783cellular_componentendoplasmic reticulum
B0005886cellular_componentplasma membrane
B0005902cellular_componentmicrovillus
B0006833biological_processwater transport
B0009925cellular_componentbasal plasma membrane
B0015250molecular_functionwater channel activity
B0015267molecular_functionchannel activity
B0015670biological_processcarbon dioxide transport
B0016020cellular_componentmembrane
B0016324cellular_componentapical plasma membrane
B0030157biological_processpancreatic juice secretion
B0030659cellular_componentcytoplasmic vesicle membrane
B0031410cellular_componentcytoplasmic vesicle
B0042476biological_processodontogenesis
B0042802molecular_functionidentical protein binding
B0046541biological_processsaliva secretion
B0048593biological_processcamera-type eye morphogenesis
B0051289biological_processprotein homotetramerization
B0055085biological_processtransmembrane transport
B0070062cellular_componentextracellular exosome
B0071476biological_processcellular hypotonic response
C0005515molecular_functionprotein binding
C0005783cellular_componentendoplasmic reticulum
C0005886cellular_componentplasma membrane
C0005902cellular_componentmicrovillus
C0006833biological_processwater transport
C0009925cellular_componentbasal plasma membrane
C0015250molecular_functionwater channel activity
C0015267molecular_functionchannel activity
C0015670biological_processcarbon dioxide transport
C0016020cellular_componentmembrane
C0016324cellular_componentapical plasma membrane
C0030157biological_processpancreatic juice secretion
C0030659cellular_componentcytoplasmic vesicle membrane
C0031410cellular_componentcytoplasmic vesicle
C0042476biological_processodontogenesis
C0042802molecular_functionidentical protein binding
C0046541biological_processsaliva secretion
C0048593biological_processcamera-type eye morphogenesis
C0051289biological_processprotein homotetramerization
C0055085biological_processtransmembrane transport
C0070062cellular_componentextracellular exosome
C0071476biological_processcellular hypotonic response
D0005515molecular_functionprotein binding
D0005783cellular_componentendoplasmic reticulum
D0005886cellular_componentplasma membrane
D0005902cellular_componentmicrovillus
D0006833biological_processwater transport
D0009925cellular_componentbasal plasma membrane
D0015250molecular_functionwater channel activity
D0015267molecular_functionchannel activity
D0015670biological_processcarbon dioxide transport
D0016020cellular_componentmembrane
D0016324cellular_componentapical plasma membrane
D0030157biological_processpancreatic juice secretion
D0030659cellular_componentcytoplasmic vesicle membrane
D0031410cellular_componentcytoplasmic vesicle
D0042476biological_processodontogenesis
D0042802molecular_functionidentical protein binding
D0046541biological_processsaliva secretion
D0048593biological_processcamera-type eye morphogenesis
D0051289biological_processprotein homotetramerization
D0055085biological_processtransmembrane transport
D0070062cellular_componentextracellular exosome
D0071476biological_processcellular hypotonic response
Functional Information from PROSITE/UniProt
site_idPS00221
Number of Residues9
DetailsMIP MIP family signature. HINPAITLA
ChainResidueDetails
AHIS67-ALA75

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues480
DetailsTRANSMEM: Helical => ECO:0000269|PubMed:18768791, ECO:0000269|PubMed:26569106
ChainResidueDetails
AALA13-LEU33
APRO40-LEU60
APHE88-VAL108
ATHR127-PHE147
AGLY159-PHE179
ATRP204-LEU224
BALA13-LEU33
BPRO40-LEU60
BPHE88-VAL108
BTHR127-PHE147
BGLY159-PHE179
BTRP204-LEU224
CALA13-LEU33
CPRO40-LEU60
CPHE88-VAL108
CTHR127-PHE147
CGLY159-PHE179
CTRP204-LEU224
DALA13-LEU33
DPRO40-LEU60
DPHE88-VAL108
DTHR127-PHE147
DGLY159-PHE179
DTRP204-LEU224

site_idSWS_FT_FI2
Number of Residues136
DetailsTOPO_DOM: Extracellular => ECO:0000269|PubMed:18768791, ECO:0000269|PubMed:26569106
ChainResidueDetails
ALYS34-LEU39
AALA109-THR126
ATHR180
APRO192-HIS203
BLYS34-LEU39
BALA109-THR126
BTHR180
BPRO192-HIS203
CLYS34-LEU39
CALA109-THR126
CTHR180
CPRO192-HIS203
DLYS34-LEU39
DALA109-THR126
DTHR180
DPRO192-HIS203

site_idSWS_FT_FI3
Number of Residues264
DetailsTOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:18768791, ECO:0000269|PubMed:26569106
ChainResidueDetails
AGLY61-GLY65
AALA75-ALA87
AALA148-VAL158
ALEU225-ARG265
BGLY61-GLY65
BALA75-ALA87
BALA148-VAL158
BLEU225-ARG265
CGLY61-GLY65
CALA75-ALA87
CALA148-VAL158
CLEU225-ARG265
DGLY61-GLY65
DALA75-ALA87
DALA148-VAL158
DLEU225-ARG265

site_idSWS_FT_FI4
Number of Residues72
DetailsINTRAMEM: Discontinuously helical => ECO:0000269|PubMed:18768791, ECO:0000269|PubMed:26569106
ChainResidueDetails
AGLY66-LEU74
AGLY181-GLY191
BGLY66-LEU74
BGLY181-GLY191
CGLY66-LEU74
CGLY181-GLY191
DGLY66-LEU74
DGLY181-GLY191

site_idSWS_FT_FI5
Number of Residues8
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN124
AASN125
BASN124
BASN125
CASN124
CASN125
DASN124
DASN125

219869

PDB entries from 2024-05-15

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