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7SHM

Cryo-EM structure of ATP-bound human peroxisomal fatty acid transporter ABCD1

Functional Information from GO Data
ChainGOidnamespacecontents
A0000038biological_processvery long-chain fatty acid metabolic process
A0002082biological_processregulation of oxidative phosphorylation
A0005324molecular_functionlong-chain fatty acid transmembrane transporter activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005764cellular_componentlysosome
A0005765cellular_componentlysosomal membrane
A0005777cellular_componentperoxisome
A0005778cellular_componentperoxisomal membrane
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005829cellular_componentcytosol
A0006635biological_processfatty acid beta-oxidation
A0007031biological_processperoxisome organization
A0015607molecular_functionABC-type fatty-acyl-CoA transporter activity
A0015910biological_processlong-chain fatty acid import into peroxisome
A0015916biological_processfatty-acyl-CoA transport
A0015919biological_processperoxisomal membrane transport
A0016020cellular_componentmembrane
A0016787molecular_functionhydrolase activity
A0016887molecular_functionATP hydrolysis activity
A0019899molecular_functionenzyme binding
A0030497biological_processfatty acid elongation
A0031966cellular_componentmitochondrial membrane
A0031998biological_processregulation of fatty acid beta-oxidation
A0032000biological_processpositive regulation of fatty acid beta-oxidation
A0036109biological_processalpha-linolenic acid metabolic process
A0036113biological_processvery long-chain fatty-acyl-CoA catabolic process
A0042626molecular_functionATPase-coupled transmembrane transporter activity
A0042758biological_processlong-chain fatty acid catabolic process
A0042760biological_processvery long-chain fatty acid catabolic process
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0043217biological_processmyelin maintenance
A0043531molecular_functionADP binding
A0043651biological_processlinoleic acid metabolic process
A0046982molecular_functionprotein heterodimerization activity
A0047617molecular_functionfatty acyl-CoA hydrolase activity
A0048471cellular_componentperinuclear region of cytoplasm
A0051900biological_processregulation of mitochondrial depolarization
A0052817molecular_functionvery long-chain fatty acyl-CoA hydrolase activity
A0055085biological_processtransmembrane transport
A0055089biological_processfatty acid homeostasis
A0055092biological_processsterol homeostasis
A0140359molecular_functionABC-type transporter activity
A1900016biological_processnegative regulation of cytokine production involved in inflammatory response
A1900407biological_processregulation of cellular response to oxidative stress
A1903427biological_processnegative regulation of reactive oxygen species biosynthetic process
A1990535biological_processneuron projection maintenance
A2001280biological_processpositive regulation of unsaturated fatty acid biosynthetic process
B0000038biological_processvery long-chain fatty acid metabolic process
B0002082biological_processregulation of oxidative phosphorylation
B0005324molecular_functionlong-chain fatty acid transmembrane transporter activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005764cellular_componentlysosome
B0005765cellular_componentlysosomal membrane
B0005777cellular_componentperoxisome
B0005778cellular_componentperoxisomal membrane
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0005829cellular_componentcytosol
B0006635biological_processfatty acid beta-oxidation
B0007031biological_processperoxisome organization
B0015607molecular_functionABC-type fatty-acyl-CoA transporter activity
B0015910biological_processlong-chain fatty acid import into peroxisome
B0015916biological_processfatty-acyl-CoA transport
B0015919biological_processperoxisomal membrane transport
B0016020cellular_componentmembrane
B0016787molecular_functionhydrolase activity
B0016887molecular_functionATP hydrolysis activity
B0019899molecular_functionenzyme binding
B0030497biological_processfatty acid elongation
B0031966cellular_componentmitochondrial membrane
B0031998biological_processregulation of fatty acid beta-oxidation
B0032000biological_processpositive regulation of fatty acid beta-oxidation
B0036109biological_processalpha-linolenic acid metabolic process
B0036113biological_processvery long-chain fatty-acyl-CoA catabolic process
B0042626molecular_functionATPase-coupled transmembrane transporter activity
B0042758biological_processlong-chain fatty acid catabolic process
B0042760biological_processvery long-chain fatty acid catabolic process
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0043217biological_processmyelin maintenance
B0043531molecular_functionADP binding
B0043651biological_processlinoleic acid metabolic process
B0046982molecular_functionprotein heterodimerization activity
B0047617molecular_functionfatty acyl-CoA hydrolase activity
B0048471cellular_componentperinuclear region of cytoplasm
B0051900biological_processregulation of mitochondrial depolarization
B0052817molecular_functionvery long-chain fatty acyl-CoA hydrolase activity
B0055085biological_processtransmembrane transport
B0055089biological_processfatty acid homeostasis
B0055092biological_processsterol homeostasis
B0140359molecular_functionABC-type transporter activity
B1900016biological_processnegative regulation of cytokine production involved in inflammatory response
B1900407biological_processregulation of cellular response to oxidative stress
B1903427biological_processnegative regulation of reactive oxygen species biosynthetic process
B1990535biological_processneuron projection maintenance
B2001280biological_processpositive regulation of unsaturated fatty acid biosynthetic process
Functional Information from PROSITE/UniProt
site_idPS00211
Number of Residues15
DetailsABC_TRANSPORTER_1 ABC transporters family signature. LSGGEKQRIGMARMF
ChainResidueDetails
ALEU605-PHE619

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues200
DetailsTRANSMEM: Helical => ECO:0000255|PROSITE-ProRule:PRU00441
ChainResidueDetails
AGLY92-ALA112
AGLY131-ILE151
AALA238-LEU258
APHE333-THR353
AGLY473-LEU493
BGLY92-ALA112
BGLY131-ILE151
BALA238-LEU258
BPHE333-THR353
BGLY473-LEU493

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00434
ChainResidueDetails
AGLY507
BGLY507

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976
ChainResidueDetails
BSER733
ASER733

site_idSWS_FT_FI4
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
BASN214
AASN214

219869

PDB entries from 2024-05-15

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