7S58

Crystal Structure of the tick evasin EVA-P974 complexed to human chemokine CCL7

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0019957	molecular_function	C-C chemokine binding
A	1900137	biological_process	negative regulation of chemokine activity
B	0019957	molecular_function	C-C chemokine binding
B	1900137	biological_process	negative regulation of chemokine activity
C	0019957	molecular_function	C-C chemokine binding
C	1900137	biological_process	negative regulation of chemokine activity
D	0019957	molecular_function	C-C chemokine binding
D	1900137	biological_process	negative regulation of chemokine activity
E	0002548	biological_process	monocyte chemotaxis
E	0005125	molecular_function	cytokine activity
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0006874	biological_process	intracellular calcium ion homeostasis
E	0006935	biological_process	chemotaxis
E	0006954	biological_process	inflammatory response
E	0006955	biological_process	immune response
E	0007010	biological_process	cytoskeleton organization
E	0007165	biological_process	signal transduction
E	0007267	biological_process	cell-cell signaling
E	0008009	molecular_function	chemokine activity
E	0008201	molecular_function	heparin binding
E	0008360	biological_process	regulation of cell shape
E	0010332	biological_process	response to gamma radiation
E	0030335	biological_process	positive regulation of cell migration
E	0031726	molecular_function	CCR1 chemokine receptor binding
E	0031727	molecular_function	CCR2 chemokine receptor binding
E	0048020	molecular_function	CCR chemokine receptor binding
E	0048245	biological_process	eosinophil chemotaxis
E	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
E	0070098	biological_process	chemokine-mediated signaling pathway
E	0071361	biological_process	cellular response to ethanol
E	2000503	biological_process	positive regulation of natural killer cell chemotaxis
F	0002548	biological_process	monocyte chemotaxis
F	0005125	molecular_function	cytokine activity
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0006874	biological_process	intracellular calcium ion homeostasis
F	0006935	biological_process	chemotaxis
F	0006954	biological_process	inflammatory response
F	0006955	biological_process	immune response
F	0007010	biological_process	cytoskeleton organization
F	0007165	biological_process	signal transduction
F	0007267	biological_process	cell-cell signaling
F	0008009	molecular_function	chemokine activity
F	0008201	molecular_function	heparin binding
F	0008360	biological_process	regulation of cell shape
F	0010332	biological_process	response to gamma radiation
F	0030335	biological_process	positive regulation of cell migration
F	0031726	molecular_function	CCR1 chemokine receptor binding
F	0031727	molecular_function	CCR2 chemokine receptor binding
F	0048020	molecular_function	CCR chemokine receptor binding
F	0048245	biological_process	eosinophil chemotaxis
F	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
F	0070098	biological_process	chemokine-mediated signaling pathway
F	0071361	biological_process	cellular response to ethanol
F	2000503	biological_process	positive regulation of natural killer cell chemotaxis
H	0002548	biological_process	monocyte chemotaxis
H	0005125	molecular_function	cytokine activity
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005615	cellular_component	extracellular space
H	0006874	biological_process	intracellular calcium ion homeostasis
H	0006935	biological_process	chemotaxis
H	0006954	biological_process	inflammatory response
H	0006955	biological_process	immune response
H	0007010	biological_process	cytoskeleton organization
H	0007165	biological_process	signal transduction
H	0007267	biological_process	cell-cell signaling
H	0008009	molecular_function	chemokine activity
H	0008201	molecular_function	heparin binding
H	0008360	biological_process	regulation of cell shape
H	0010332	biological_process	response to gamma radiation
H	0030335	biological_process	positive regulation of cell migration
H	0031726	molecular_function	CCR1 chemokine receptor binding
H	0031727	molecular_function	CCR2 chemokine receptor binding
H	0048020	molecular_function	CCR chemokine receptor binding
H	0048245	biological_process	eosinophil chemotaxis
H	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
H	0070098	biological_process	chemokine-mediated signaling pathway
H	0071361	biological_process	cellular response to ethanol
H	2000503	biological_process	positive regulation of natural killer cell chemotaxis
J	0002548	biological_process	monocyte chemotaxis
J	0005125	molecular_function	cytokine activity
J	0005515	molecular_function	protein binding
J	0005576	cellular_component	extracellular region
J	0005615	cellular_component	extracellular space
J	0006874	biological_process	intracellular calcium ion homeostasis
J	0006935	biological_process	chemotaxis
J	0006954	biological_process	inflammatory response
J	0006955	biological_process	immune response
J	0007010	biological_process	cytoskeleton organization
J	0007165	biological_process	signal transduction
J	0007267	biological_process	cell-cell signaling
J	0008009	molecular_function	chemokine activity
J	0008201	molecular_function	heparin binding
J	0008360	biological_process	regulation of cell shape
J	0010332	biological_process	response to gamma radiation
J	0030335	biological_process	positive regulation of cell migration
J	0031726	molecular_function	CCR1 chemokine receptor binding
J	0031727	molecular_function	CCR2 chemokine receptor binding
J	0048020	molecular_function	CCR chemokine receptor binding
J	0048245	biological_process	eosinophil chemotaxis
J	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
J	0070098	biological_process	chemokine-mediated signaling pathway
J	0071361	biological_process	cellular response to ethanol
J	2000503	biological_process	positive regulation of natural killer cell chemotaxis

Functional Information from PROSITE/UniProt

site_id	PS00472
Number of Residues	43
Details	SMALL_CYTOKINES_CC Small cytokines (intercrine/chemokine) C-C subfamily signature. CCYrfinkk..IpkqrLesYrrttssh.Cpre.AVIFktkldkei.CA

Chain	Residue	Details
E	CYS11-ALA53

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	MOD_RES: Pyrrolidone carboxylic acid => ECO:0000269|PubMed:15340161

Chain	Residue	Details
E	GLN1
F	GLN1
J	GLN1
H	GLN1

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site_id	SWS_FT_FI2
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
E	ASN6
F	ASN6
J	ASN6
H	ASN6

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