7RLU
Structure of ALDH1L1 (10-formyltetrahydrofolate dehydrogenase) in complex with NADP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004029 | molecular_function | aldehyde dehydrogenase (NAD+) activity |
| A | 0004030 | molecular_function | aldehyde dehydrogenase [NAD(P)+] activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006730 | biological_process | one-carbon metabolic process |
| A | 0006740 | biological_process | NADPH regeneration |
| A | 0009058 | biological_process | biosynthetic process |
| A | 0009258 | biological_process | 10-formyltetrahydrofolate catabolic process |
| A | 0016155 | molecular_function | formyltetrahydrofolate dehydrogenase activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| A | 0032991 | cellular_component | protein-containing complex |
| A | 0033721 | molecular_function | aldehyde dehydrogenase (NADP+) activity |
| A | 0038183 | biological_process | bile acid signaling pathway |
| A | 0044877 | molecular_function | protein-containing complex binding |
| A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| A | 0046655 | biological_process | folic acid metabolic process |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004029 | molecular_function | aldehyde dehydrogenase (NAD+) activity |
| B | 0004030 | molecular_function | aldehyde dehydrogenase [NAD(P)+] activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006730 | biological_process | one-carbon metabolic process |
| B | 0006740 | biological_process | NADPH regeneration |
| B | 0009058 | biological_process | biosynthetic process |
| B | 0009258 | biological_process | 10-formyltetrahydrofolate catabolic process |
| B | 0016155 | molecular_function | formyltetrahydrofolate dehydrogenase activity |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| B | 0032991 | cellular_component | protein-containing complex |
| B | 0033721 | molecular_function | aldehyde dehydrogenase (NADP+) activity |
| B | 0038183 | biological_process | bile acid signaling pathway |
| B | 0044877 | molecular_function | protein-containing complex binding |
| B | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| B | 0046655 | biological_process | folic acid metabolic process |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004029 | molecular_function | aldehyde dehydrogenase (NAD+) activity |
| C | 0004030 | molecular_function | aldehyde dehydrogenase [NAD(P)+] activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006730 | biological_process | one-carbon metabolic process |
| C | 0006740 | biological_process | NADPH regeneration |
| C | 0009058 | biological_process | biosynthetic process |
| C | 0009258 | biological_process | 10-formyltetrahydrofolate catabolic process |
| C | 0016155 | molecular_function | formyltetrahydrofolate dehydrogenase activity |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| C | 0032991 | cellular_component | protein-containing complex |
| C | 0033721 | molecular_function | aldehyde dehydrogenase (NADP+) activity |
| C | 0038183 | biological_process | bile acid signaling pathway |
| C | 0044877 | molecular_function | protein-containing complex binding |
| C | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| C | 0046655 | biological_process | folic acid metabolic process |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004029 | molecular_function | aldehyde dehydrogenase (NAD+) activity |
| D | 0004030 | molecular_function | aldehyde dehydrogenase [NAD(P)+] activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006730 | biological_process | one-carbon metabolic process |
| D | 0006740 | biological_process | NADPH regeneration |
| D | 0009058 | biological_process | biosynthetic process |
| D | 0009258 | biological_process | 10-formyltetrahydrofolate catabolic process |
| D | 0016155 | molecular_function | formyltetrahydrofolate dehydrogenase activity |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| D | 0032991 | cellular_component | protein-containing complex |
| D | 0033721 | molecular_function | aldehyde dehydrogenase (NADP+) activity |
| D | 0038183 | biological_process | bile acid signaling pathway |
| D | 0044877 | molecular_function | protein-containing complex binding |
| D | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| D | 0046655 | biological_process | folic acid metabolic process |
Functional Information from PROSITE/UniProt
| site_id | PS00070 |
| Number of Residues | 12 |
| Details | ALDEHYDE_DEHYDR_CYS Aldehyde dehydrogenases cysteine active site. FfNKGENCIAAG |
| Chain | Residue | Details |
| A | PHE700-GLY711 |
| site_id | PS00373 |
| Number of Residues | 24 |
| Details | GART Phosphoribosylglycinamide formyltransferase active site. GfTIfWAdDgLDtGdlLlqkeceV |
| Chain | Residue | Details |
| A | GLY131-VAL154 |
| site_id | PS00687 |
| Number of Residues | 8 |
| Details | ALDEHYDE_DEHYDR_GLU Aldehyde dehydrogenases glutamic acid active site. LELGGKSP |
| Chain | Residue | Details |
| A | LEU672-PRO679 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton donor => ECO:0000305|PubMed:10585460, ECO:0000305|PubMed:14729668 |
| Chain | Residue | Details |
| A | HIS106 | |
| B | HIS106 | |
| D | HIS106 | |
| C | HIS106 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton acceptor => ECO:0000305|PubMed:17302434 |
| Chain | Residue | Details |
| B | GLU673 | |
| D | GLU673 | |
| C | GLU673 | |
| A | GLU673 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton donor => ECO:0000305|PubMed:17302434, ECO:0000305|PubMed:21540484, ECO:0007744|PDB:2O2Q, ECO:0007744|PDB:3RHO |
| Chain | Residue | Details |
| B | CYS707 | |
| D | CYS707 | |
| C | CYS707 | |
| A | CYS707 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:O75891 |
| Chain | Residue | Details |
| B | GLN88 | |
| D | GLN88 | |
| D | ASP142 | |
| C | GLN88 | |
| C | ASP142 | |
| A | ASP142 | |
| B | ASP142 | |
| A | GLN88 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 16 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17302434, ECO:0000269|PubMed:21540484, ECO:0007744|PDB:2O2Q, ECO:0007744|PDB:2O2R, ECO:0007744|PDB:3RHJ, ECO:0007744|PDB:3RHL, ECO:0007744|PDB:3RHO, ECO:0007744|PDB:3RHQ, ECO:0007744|PDB:3RHR |
| Chain | Residue | Details |
| A | GLY630 | |
| B | ILE571 | |
| B | LYS597 | |
| B | GLY630 | |
| B | GLY650 | |
| D | ILE571 | |
| D | LYS597 | |
| D | GLY630 | |
| D | GLY650 | |
| C | ILE571 | |
| C | LYS597 | |
| C | GLY630 | |
| C | GLY650 | |
| A | LYS597 | |
| A | GLY650 | |
| A | ILE571 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17302434, ECO:0000269|PubMed:21540484, ECO:0007744|PDB:2O2Q, ECO:0007744|PDB:3RHJ, ECO:0007744|PDB:3RHL, ECO:0007744|PDB:3RHO, ECO:0007744|PDB:3RHQ, ECO:0007744|PDB:3RHR |
| Chain | Residue | Details |
| B | GLU673 | |
| D | GLU673 | |
| D | GLU804 | |
| C | GLU673 | |
| C | GLU804 | |
| A | GLU804 | |
| B | GLU804 | |
| A | GLU673 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21540484, ECO:0007744|PDB:3RHO |
| Chain | Residue | Details |
| A | LYS757 | |
| B | LYS757 | |
| D | LYS757 | |
| C | LYS757 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | SITE: Essential for catalytic activity => ECO:0000269|PubMed:10585460 |
| Chain | Residue | Details |
| A | ASP142 | |
| B | ASP142 | |
| D | ASP142 | |
| C | ASP142 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 16 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:O75891 |
| Chain | Residue | Details |
| D | SER9 | |
| D | SER629 | |
| D | SER631 | |
| D | SER825 | |
| C | SER9 | |
| C | SER629 | |
| C | SER631 | |
| C | SER825 | |
| A | SER9 | |
| B | SER629 | |
| B | SER631 | |
| B | SER825 | |
| A | SER629 | |
| A | SER631 | |
| A | SER825 | |
| B | SER9 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 8 |
| Details | MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q8R0Y6 |
| Chain | Residue | Details |
| D | LYS38 | |
| D | LYS767 | |
| C | LYS38 | |
| C | LYS767 | |
| A | LYS38 | |
| A | LYS767 | |
| B | LYS38 | |
| B | LYS767 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 4 |
| Details | MOD_RES: O-(pantetheine 4'-phosphoryl)serine => ECO:0000255|PROSITE-ProRule:PRU00258, ECO:0000269|PubMed:17884809 |
| Chain | Residue | Details |
| A | SER354 | |
| B | SER354 | |
| D | SER354 | |
| C | SER354 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 4 |
| Details | MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q8K009 |
| Chain | Residue | Details |
| A | LYS660 | |
| B | LYS660 | |
| D | LYS660 | |
| C | LYS660 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 4 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q3SY69 |
| Chain | Residue | Details |
| A | LYS882 | |
| B | LYS882 | |
| D | LYS882 | |
| C | LYS882 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 3 |
| Details | M-CSA 766 |
| Chain | Residue | Details |
| A | HIS106 | electrostatic stabiliser |
| A | ASP142 | electrostatic stabiliser |
| A | CYS707 |
| site_id | MCSA2 |
| Number of Residues | 3 |
| Details | M-CSA 766 |
| Chain | Residue | Details |
| B | HIS106 | electrostatic stabiliser |
| B | ASP142 | electrostatic stabiliser |
| B | CYS707 |
| site_id | MCSA3 |
| Number of Residues | 3 |
| Details | M-CSA 766 |
| Chain | Residue | Details |
| D | HIS106 | electrostatic stabiliser |
| D | ASP142 | electrostatic stabiliser |
| D | CYS707 |
| site_id | MCSA4 |
| Number of Residues | 3 |
| Details | M-CSA 766 |
| Chain | Residue | Details |
| C | HIS106 | electrostatic stabiliser |
| C | ASP142 | electrostatic stabiliser |
| C | CYS707 |
