7RJI

BthTX-II variant b, from Bothrops jararacussu venom, complexed with stearic acid

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004623	molecular_function	phospholipase A2 activity
A	0005509	molecular_function	calcium ion binding
A	0005543	molecular_function	phospholipid binding
A	0005576	cellular_component	extracellular region
A	0006644	biological_process	phospholipid metabolic process
A	0016042	biological_process	lipid catabolic process
A	0035821	biological_process	modulation of process of another organism
A	0042130	biological_process	negative regulation of T cell proliferation
A	0047498	molecular_function	calcium-dependent phospholipase A2 activity
A	0050482	biological_process	arachidonic acid secretion
A	0090729	molecular_function	toxin activity

Functional Information from PROSITE/UniProt

site_id	PS00118
Number of Residues	8
Details	PA2_HIS Phospholipase A2 histidine active site. CCFvHDcC

Chain	Residue	Details
A	CYS43-CYS50

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site_id	PS00119
Number of Residues	11
Details	PA2_ASP Phospholipase A2 aspartic acid active site. ICECDKAAaVC

Chain	Residue	Details
A	ILE85-CYS95

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	SITE: Putative hydrophobic membrane-disrupting site (MDiS) => ECO:0000250|UniProtKB:P20474

Chain	Residue	Details
A	TRP3
A	LEU10
A	LEU16

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site_id	SWS_FT_FI2
Number of Residues	1
Details	SITE: Putative membrane-disrupting site (MDiS) => ECO:0000250|UniProtKB:P20474

Chain	Residue	Details
A	LYS15

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site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Putative cationic membrane-docking site (MDoS) => ECO:0000250|UniProtKB:P20474

Chain	Residue	Details
A	ARG63

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site_id	SWS_FT_FI4
Number of Residues	1
Details	SITE: Important residue of the cationic membrane-docking site (MDoS) => ECO:0000250|UniProtKB:I6L8L6

Chain	Residue	Details
A	LYS105

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site_id	SWS_FT_FI5
Number of Residues	1
Details	SITE: Hydrophobic membrane-disruption site (MDiS) => ECO:0000250|UniProtKB:I6L8L6

Chain	Residue	Details
A	LEU114

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site_id	SWS_FT_FI6
Number of Residues	1
Details	SITE: Cationic membrane-docking site (MDoS) => ECO:0000250|UniProtKB:I6L8L6

Chain	Residue	Details
A	LYS117

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