7R3E

Fusion construct of PqsE and RhlR in complex with the synthetic antagonist mBTL

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000976	molecular_function	transcription cis-regulatory region binding
A	0001216	molecular_function	DNA-binding transcription activator activity
A	0001217	molecular_function	DNA-binding transcription repressor activity
A	0003677	molecular_function	DNA binding
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0005737	cellular_component	cytoplasm
A	0006355	biological_process	regulation of DNA-templated transcription
A	0009372	biological_process	quorum sensing
A	0010467	biological_process	gene expression
A	0016787	molecular_function	hydrolase activity
A	0032993	cellular_component	protein-DNA complex
A	0038023	molecular_function	signaling receptor activity
A	0044550	biological_process	secondary metabolite biosynthetic process
A	0045862	biological_process	positive regulation of proteolysis
A	0045892	biological_process	negative regulation of DNA-templated transcription
A	0045893	biological_process	positive regulation of DNA-templated transcription
A	0046872	molecular_function	metal ion binding
A	0046889	biological_process	positive regulation of lipid biosynthetic process
A	0062162	biological_process	positive regulation of pyocyanine biosynthetic process
A	1900378	biological_process	positive regulation of secondary metabolite biosynthetic process
B	0000976	molecular_function	transcription cis-regulatory region binding
B	0001216	molecular_function	DNA-binding transcription activator activity
B	0001217	molecular_function	DNA-binding transcription repressor activity
B	0003677	molecular_function	DNA binding
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0005737	cellular_component	cytoplasm
B	0006355	biological_process	regulation of DNA-templated transcription
B	0009372	biological_process	quorum sensing
B	0010467	biological_process	gene expression
B	0016787	molecular_function	hydrolase activity
B	0032993	cellular_component	protein-DNA complex
B	0038023	molecular_function	signaling receptor activity
B	0044550	biological_process	secondary metabolite biosynthetic process
B	0045862	biological_process	positive regulation of proteolysis
B	0045892	biological_process	negative regulation of DNA-templated transcription
B	0045893	biological_process	positive regulation of DNA-templated transcription
B	0046872	molecular_function	metal ion binding
B	0046889	biological_process	positive regulation of lipid biosynthetic process
B	0062162	biological_process	positive regulation of pyocyanine biosynthetic process
B	1900378	biological_process	positive regulation of secondary metabolite biosynthetic process

Functional Information from PROSITE/UniProt

site_id	PS00622
Number of Residues	28
Details	HTH_LUXR_1 LuxR-type HTH domain signature. GksSgeIAiiLsIsesTVnfHhkNIqkK

Chain	Residue	Details
A	GLY526-LYS553

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	14
Details	BINDING: BINDING => ECO:0000269|PubMed:19788310, ECO:0000269|PubMed:20419351, ECO:0000269|PubMed:27082157

Chain	Residue	Details
A	HIS69
A	HIS71
A	ASP73
A	HIS74
A	HIS159
A	ASP178
A	HIS221
B	HIS69
B	HIS71
B	ASP73
B	HIS74
B	HIS159
B	ASP178
B	HIS221

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site_id	SWS_FT_FI2
Number of Residues	38
Details	DNA_BIND: H-T-H motif => ECO:0000255|PROSITE-ProRule:PRU00411

Chain	Residue	Details
A	SER529-LYS548
B	SER529-LYS548

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