Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

7QUV

Crystal structure of human Calprotectin (S100A8/S100A9) in complex with Peptide 3

Functional Information from GO Data
ChainGOidnamespacecontents
A0002523biological_processleukocyte migration involved in inflammatory response
A0002544biological_processchronic inflammatory response
A0002790biological_processpeptide secretion
A0002793biological_processpositive regulation of peptide secretion
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005886cellular_componentplasma membrane
A0006914biological_processautophagy
A0006915biological_processapoptotic process
A0006919biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process
A0006935biological_processchemotaxis
A0006954biological_processinflammatory response
A0008017molecular_functionmicrotubule binding
A0008270molecular_functionzinc ion binding
A0010043biological_processresponse to zinc ion
A0014002biological_processastrocyte development
A0018119biological_processpeptidyl-cysteine S-nitrosylation
A0030307biological_processpositive regulation of cell growth
A0030593biological_processneutrophil chemotaxis
A0032119biological_processsequestering of zinc ion
A0032496biological_processresponse to lipopolysaccharide
A0034121biological_processregulation of toll-like receptor signaling pathway
A0034774cellular_componentsecretory granule lumen
A0035425biological_processautocrine signaling
A0035662molecular_functionToll-like receptor 4 binding
A0042742biological_processdefense response to bacterium
A0045087biological_processinnate immune response
A0045111cellular_componentintermediate filament cytoskeleton
A0045471biological_processresponse to ethanol
A0046872molecular_functionmetal ion binding
A0048306molecular_functioncalcium-dependent protein binding
A0050544molecular_functionarachidonic acid binding
A0050729biological_processpositive regulation of inflammatory response
A0050786molecular_functionRAGE receptor binding
A0050832biological_processdefense response to fungus
A0051092biological_processpositive regulation of NF-kappaB transcription factor activity
A0051493biological_processregulation of cytoskeleton organization
A0062023cellular_componentcollagen-containing extracellular matrix
A0070062cellular_componentextracellular exosome
A0070488biological_processneutrophil aggregation
A1990660cellular_componentcalprotectin complex
A2001244biological_processpositive regulation of intrinsic apoptotic signaling pathway
B0002523biological_processleukocyte migration involved in inflammatory response
B0002544biological_processchronic inflammatory response
B0005509molecular_functioncalcium ion binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0005886cellular_componentplasma membrane
B0006914biological_processautophagy
B0006915biological_processapoptotic process
B0006919biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process
B0006935biological_processchemotaxis
B0006954biological_processinflammatory response
B0007267biological_processcell-cell signaling
B0008017molecular_functionmicrotubule binding
B0008270molecular_functionzinc ion binding
B0010976biological_processpositive regulation of neuron projection development
B0014002biological_processastrocyte development
B0016209molecular_functionantioxidant activity
B0030307biological_processpositive regulation of cell growth
B0030593biological_processneutrophil chemotaxis
B0032119biological_processsequestering of zinc ion
B0032496biological_processresponse to lipopolysaccharide
B0034121biological_processregulation of toll-like receptor signaling pathway
B0034774cellular_componentsecretory granule lumen
B0035425biological_processautocrine signaling
B0035606biological_processpeptidyl-cysteine S-trans-nitrosylation
B0035662molecular_functionToll-like receptor 4 binding
B0035821biological_processmodulation of process of another organism
B0042742biological_processdefense response to bacterium
B0043542biological_processendothelial cell migration
B0045087biological_processinnate immune response
B0045113biological_processregulation of integrin biosynthetic process
B0046872molecular_functionmetal ion binding
B0048306molecular_functioncalcium-dependent protein binding
B0050544molecular_functionarachidonic acid binding
B0050729biological_processpositive regulation of inflammatory response
B0050786molecular_functionRAGE receptor binding
B0050832biological_processdefense response to fungus
B0051092biological_processpositive regulation of NF-kappaB transcription factor activity
B0051493biological_processregulation of cytoskeleton organization
B0060264biological_processregulation of respiratory burst involved in inflammatory response
B0061844biological_processantimicrobial humoral immune response mediated by antimicrobial peptide
B0062023cellular_componentcollagen-containing extracellular matrix
B0070062cellular_componentextracellular exosome
B0070488biological_processneutrophil aggregation
B0098869biological_processcellular oxidant detoxification
B1990660cellular_componentcalprotectin complex
B1990662cellular_componentS100A9 complex
B2001244biological_processpositive regulation of intrinsic apoptotic signaling pathway
Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DTNADKQLSfeEF
ChainResidueDetails
AASP61-PHE73
BASP69-PHE81

site_idPS00303
Number of Residues22
DetailsS100_CABP S-100/ICaBP type calcium binding protein signature. IMedLDtnaDkqlSFeEFimLM
ChainResidueDetails
BILE64-MET85
ATRP56-VAL77

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsBINDING: BINDING => ECO:0000305|PubMed:17553524
ChainResidueDetails
AHIS89
BHIS22
BASP32
BHIS93
BHIS97

site_idSWS_FT_FI2
Number of Residues5
DetailsBINDING: BINDING => ECO:0000269|PubMed:11851337, ECO:0000269|PubMed:17553524, ECO:0007744|PDB:1IRJ, ECO:0007744|PDB:1XK4
ChainResidueDetails
BGLU38
BLEU28
BHIS30
BTHR33
BSER25

site_idSWS_FT_FI3
Number of Residues5
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:11851337, ECO:0000269|PubMed:17553524, ECO:0007744|PDB:1IRJ, ECO:0007744|PDB:1XK4
ChainResidueDetails
BASN71
BASP73
BGLN75
BGLU80
BASP69

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Blocked amino end (Thr)
ChainResidueDetails
BTHR4

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: S-nitrosocysteine; transient => ECO:0000305|PubMed:25417112
ChainResidueDetails
BSER5

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: Pros-methylhistidine => ECO:0000250|UniProtKB:P50116
ChainResidueDetails
BHIS107

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: Phosphothreonine; by MAPK14 => ECO:0000269|PubMed:15331440, ECO:0000269|PubMed:15905572, ECO:0000269|PubMed:2478889, ECO:0007744|PubMed:18318008, ECO:0007744|PubMed:19367720, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:24275569
ChainResidueDetails
BTHR115

219869

PDB entries from 2024-05-15

PDB statisticsPDBj update infoContact PDBjnumon