7QU4

Recombinant Human Fetal Hemoglobin mutant - alpha subunit mutations K11E,K56E,N78D,K90E

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004601	molecular_function	peroxidase activity
A	0005344	molecular_function	oxygen carrier activity
A	0005506	molecular_function	iron ion binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005829	cellular_component	cytosol
A	0005833	cellular_component	hemoglobin complex
A	0015670	biological_process	carbon dioxide transport
A	0015671	biological_process	oxygen transport
A	0016020	cellular_component	membrane
A	0019825	molecular_function	oxygen binding
A	0020037	molecular_function	heme binding
A	0030185	biological_process	nitric oxide transport
A	0031720	molecular_function	haptoglobin binding
A	0031838	cellular_component	haptoglobin-hemoglobin complex
A	0042542	biological_process	response to hydrogen peroxide
A	0042744	biological_process	hydrogen peroxide catabolic process
A	0043177	molecular_function	organic acid binding
A	0046872	molecular_function	metal ion binding
A	0070062	cellular_component	extracellular exosome
A	0071682	cellular_component	endocytic vesicle lumen
A	0072562	cellular_component	blood microparticle
A	0098869	biological_process	cellular oxidant detoxification
B	0004601	molecular_function	peroxidase activity
B	0005344	molecular_function	oxygen carrier activity
B	0005506	molecular_function	iron ion binding
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005829	cellular_component	cytosol
B	0005833	cellular_component	hemoglobin complex
B	0015670	biological_process	carbon dioxide transport
B	0015671	biological_process	oxygen transport
B	0016020	cellular_component	membrane
B	0019825	molecular_function	oxygen binding
B	0020037	molecular_function	heme binding
B	0030185	biological_process	nitric oxide transport
B	0031720	molecular_function	haptoglobin binding
B	0031838	cellular_component	haptoglobin-hemoglobin complex
B	0042542	biological_process	response to hydrogen peroxide
B	0042744	biological_process	hydrogen peroxide catabolic process
B	0043177	molecular_function	organic acid binding
B	0046872	molecular_function	metal ion binding
B	0070062	cellular_component	extracellular exosome
B	0071682	cellular_component	endocytic vesicle lumen
B	0072562	cellular_component	blood microparticle
B	0098869	biological_process	cellular oxidant detoxification
G	0004601	molecular_function	peroxidase activity
G	0005344	molecular_function	oxygen carrier activity
G	0005515	molecular_function	protein binding
G	0005829	cellular_component	cytosol
G	0005833	cellular_component	hemoglobin complex
G	0015670	biological_process	carbon dioxide transport
G	0015671	biological_process	oxygen transport
G	0019825	molecular_function	oxygen binding
G	0020037	molecular_function	heme binding
G	0031720	molecular_function	haptoglobin binding
G	0031721	molecular_function	hemoglobin alpha binding
G	0031838	cellular_component	haptoglobin-hemoglobin complex
G	0042744	biological_process	hydrogen peroxide catabolic process
G	0043177	molecular_function	organic acid binding
G	0046872	molecular_function	metal ion binding
G	0072562	cellular_component	blood microparticle
G	0098869	biological_process	cellular oxidant detoxification
H	0004601	molecular_function	peroxidase activity
H	0005344	molecular_function	oxygen carrier activity
H	0005515	molecular_function	protein binding
H	0005829	cellular_component	cytosol
H	0005833	cellular_component	hemoglobin complex
H	0015670	biological_process	carbon dioxide transport
H	0015671	biological_process	oxygen transport
H	0019825	molecular_function	oxygen binding
H	0020037	molecular_function	heme binding
H	0031720	molecular_function	haptoglobin binding
H	0031721	molecular_function	hemoglobin alpha binding
H	0031838	cellular_component	haptoglobin-hemoglobin complex
H	0042744	biological_process	hydrogen peroxide catabolic process
H	0043177	molecular_function	organic acid binding
H	0046872	molecular_function	metal ion binding
H	0072562	cellular_component	blood microparticle
H	0098869	biological_process	cellular oxidant detoxification

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00238

Chain	Residue	Details
A	HIS59
B	HIS59

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: proximal binding residue => ECO:0000255|PROSITE-ProRule:PRU00238

Chain	Residue	Details
A	HIS88
B	HIS88

---

site_id	SWS_FT_FI3
Number of Residues	28
Details	SITE: (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433

Chain	Residue	Details
A	THR9
A	ALA14
A	TYR25
A	LEU30
A	HIS46
A	ASP48
A	SER53
A	VAL56
A	GLY60
A	LEU92
A	LEU107
A	THR109
A	VAL122
A	SER134
B	THR9
B	ALA14
B	TYR25
B	LEU30
B	HIS46
B	ASP48
B	SER53
B	VAL56
B	GLY60
B	LEU92
B	LEU107
B	THR109
B	VAL122
B	SER134

---

site_id	SWS_FT_FI4
Number of Residues	10
Details	SITE: Not glycated => ECO:0000269|PubMed:7358733

Chain	Residue	Details
A	GLU12
A	GLU57
A	LYS61
A	GLU91
A	LYS100
B	GLU12
B	GLU57
B	LYS61
B	GLU91
B	LYS100

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
A	SER4
A	SER36
A	SER50
B	SER4
B	SER36
B	SER50
H	SER44
H	SER50
H	SER52
H	SER139
H	SER142
H	SER143

---

site_id	SWS_FT_FI6
Number of Residues	6
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P01942

Chain	Residue	Details
A	LYS8
A	LYS17
A	LYS41
B	LYS8
B	LYS17
B	LYS41

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
A	THR9
B	THR9

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P01942

Chain	Residue	Details
A	GLU12
B	GLU12

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
A	TYR25
B	TYR25

---

site_id	SWS_FT_FI10
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P01942

Chain	Residue	Details
A	SER103
A	SER125
A	SER132
A	SER139
B	SER103
B	SER125
B	SER132
B	SER139

---

site_id	SWS_FT_FI11
Number of Residues	6
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P01942

Chain	Residue	Details
A	THR109
A	THR135
A	THR138
B	THR109
B	THR135
B	THR138

---

site_id	SWS_FT_FI12
Number of Residues	6
Details	CARBOHYD: N-linked (Glc) (glycation) lysine; alternate => ECO:0000269|PubMed:7358733

Chain	Residue	Details
A	LYS8
A	LYS17
A	LYS41
B	LYS8
B	LYS17
B	LYS41

---

site_id	SWS_FT_FI13
Number of Residues	2
Details	CARBOHYD: N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:7358733

Chain	Residue	Details
A	LYS62
B	LYS62

---