7Q05

Crystal structure of TPADO in complex with TPA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005506	molecular_function	iron ion binding
A	0018628	molecular_function	terephthalate 1,2-dioxygenase activity
A	0018963	biological_process	phthalate metabolic process
A	0051213	molecular_function	dioxygenase activity
B	0005506	molecular_function	iron ion binding
B	0018628	molecular_function	terephthalate 1,2-dioxygenase activity
B	0018963	biological_process	phthalate metabolic process
B	0051213	molecular_function	dioxygenase activity
C	0005506	molecular_function	iron ion binding
C	0018628	molecular_function	terephthalate 1,2-dioxygenase activity
C	0018963	biological_process	phthalate metabolic process
C	0051213	molecular_function	dioxygenase activity
D	0005506	molecular_function	iron ion binding
D	0018628	molecular_function	terephthalate 1,2-dioxygenase activity
D	0018963	biological_process	phthalate metabolic process
D	0044237	biological_process	cellular metabolic process
D	0046872	molecular_function	metal ion binding
D	0051213	molecular_function	dioxygenase activity
D	0051537	molecular_function	2 iron, 2 sulfur cluster binding
E	0005506	molecular_function	iron ion binding
E	0018628	molecular_function	terephthalate 1,2-dioxygenase activity
E	0018963	biological_process	phthalate metabolic process
E	0044237	biological_process	cellular metabolic process
E	0046872	molecular_function	metal ion binding
E	0051213	molecular_function	dioxygenase activity
E	0051537	molecular_function	2 iron, 2 sulfur cluster binding
F	0005506	molecular_function	iron ion binding
F	0018628	molecular_function	terephthalate 1,2-dioxygenase activity
F	0018963	biological_process	phthalate metabolic process
F	0044237	biological_process	cellular metabolic process
F	0046872	molecular_function	metal ion binding
F	0051213	molecular_function	dioxygenase activity
F	0051537	molecular_function	2 iron, 2 sulfur cluster binding
H	0003796	molecular_function	lysozyme activity
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005615	cellular_component	extracellular space
H	0005737	cellular_component	cytoplasm
H	0005783	cellular_component	endoplasmic reticulum
H	0016231	molecular_function	beta-N-acetylglucosaminidase activity
H	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
H	0016998	biological_process	cell wall macromolecule catabolic process
H	0031640	biological_process	killing of cells of another organism
H	0042742	biological_process	defense response to bacterium
H	0042802	molecular_function	identical protein binding
H	0050829	biological_process	defense response to Gram-negative bacterium
H	0050830	biological_process	defense response to Gram-positive bacterium
H	0051672	biological_process	obsolete catabolism by organism of cell wall peptidoglycan in other organism

Functional Information from PROSITE/UniProt

site_id	PS00128
Number of Residues	19
Details	GLYCOSYL_HYDROL_F22_1 Glycosyl hydrolases family 22 (GH22) domain signature. CnipCsaLlssDItasvnC

Chain	Residue	Details
H	CYS76-CYS94

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site_id	PS00570
Number of Residues	24
Details	RING_HYDROXYL_ALPHA Bacterial ring hydroxylating dioxygenases alpha-subunit signature. CaHRGalialeksGRtdsfqCvYH

Chain	Residue	Details
D	CYS82-HIS105

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE:

Chain	Residue	Details
H	GLU35
F	HIS84
F	CYS102
F	HIS105
H	ASP52
D	CYS102
D	HIS105
E	CYS82
E	HIS84
E	CYS102
E	HIS105
F	CYS82

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site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING:

Chain	Residue	Details
H	ASP101

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	6
Details	M-CSA 203

Chain	Residue	Details
H	GLU35	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
H	ASN46
H	ASP48
H	SER50
H	ASP52	covalently attached, electrostatic stabiliser, nucleofuge, nucleophile, polar/non-polar interaction
H	ASN59

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