7PKS

Structural basis of Integrator-mediated transcription regulation

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000428	cellular_component	DNA-directed RNA polymerase complex
A	0001055	molecular_function	RNA polymerase II activity
A	0003677	molecular_function	DNA binding
A	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
A	0005634	cellular_component	nucleus
A	0005665	cellular_component	RNA polymerase II, core complex
A	0006351	biological_process	DNA-templated transcription
A	0006366	biological_process	transcription by RNA polymerase II
A	0016779	molecular_function	nucleotidyltransferase activity
A	0031981	cellular_component	nuclear lumen
A	0032991	cellular_component	protein-containing complex
A	0046872	molecular_function	metal ion binding
B	0000428	cellular_component	DNA-directed RNA polymerase complex
B	0001055	molecular_function	RNA polymerase II activity
B	0003677	molecular_function	DNA binding
B	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
B	0005665	cellular_component	RNA polymerase II, core complex
B	0006351	biological_process	DNA-templated transcription
B	0006366	biological_process	transcription by RNA polymerase II
B	0016779	molecular_function	nucleotidyltransferase activity
B	0032549	molecular_function	ribonucleoside binding
B	0034062	molecular_function	5'-3' RNA polymerase activity
B	0046872	molecular_function	metal ion binding
C	0003677	molecular_function	DNA binding
C	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
C	0006351	biological_process	DNA-templated transcription
C	0046983	molecular_function	protein dimerization activity
D	0000166	molecular_function	nucleotide binding
D	0006352	biological_process	DNA-templated transcription initiation
D	0030880	cellular_component	RNA polymerase complex
D	0044237	biological_process	cellular metabolic process
E	0001054	molecular_function	RNA polymerase I activity
E	0001055	molecular_function	RNA polymerase II activity
E	0001056	molecular_function	RNA polymerase III activity
E	0003677	molecular_function	DNA binding
E	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
E	0005634	cellular_component	nucleus
E	0005665	cellular_component	RNA polymerase II, core complex
E	0005666	cellular_component	RNA polymerase III complex
E	0005736	cellular_component	RNA polymerase I complex
E	0006351	biological_process	DNA-templated transcription
E	0006362	biological_process	transcription elongation by RNA polymerase I
E	0006366	biological_process	transcription by RNA polymerase II
E	0016591	cellular_component	RNA polymerase II, holoenzyme
E	0042797	biological_process	tRNA transcription by RNA polymerase III
F	0000428	cellular_component	DNA-directed RNA polymerase complex
F	0001650	cellular_component	fibrillar center
F	0003677	molecular_function	DNA binding
F	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005665	cellular_component	RNA polymerase II, core complex
F	0005666	cellular_component	RNA polymerase III complex
F	0005736	cellular_component	RNA polymerase I complex
F	0006351	biological_process	DNA-templated transcription
F	0006366	biological_process	transcription by RNA polymerase II
G	0003676	molecular_function	nucleic acid binding
G	0006351	biological_process	DNA-templated transcription
G	0006352	biological_process	DNA-templated transcription initiation
H	0000428	cellular_component	DNA-directed RNA polymerase complex
H	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
H	0005634	cellular_component	nucleus
H	0005665	cellular_component	RNA polymerase II, core complex
H	0006351	biological_process	DNA-templated transcription
I	0000428	cellular_component	DNA-directed RNA polymerase complex
I	0001193	biological_process	maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II
I	0003676	molecular_function	nucleic acid binding
I	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005665	cellular_component	RNA polymerase II, core complex
I	0005730	cellular_component	nucleolus
I	0006283	biological_process	transcription-coupled nucleotide-excision repair
I	0006351	biological_process	DNA-templated transcription
I	0006366	biological_process	transcription by RNA polymerase II
I	0006367	biological_process	transcription initiation at RNA polymerase II promoter
I	0008270	molecular_function	zinc ion binding
I	0016591	cellular_component	RNA polymerase II, holoenzyme
I	0046872	molecular_function	metal ion binding
J	0000428	cellular_component	DNA-directed RNA polymerase complex
J	0001054	molecular_function	RNA polymerase I activity
J	0001055	molecular_function	RNA polymerase II activity
J	0001056	molecular_function	RNA polymerase III activity
J	0003677	molecular_function	DNA binding
J	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
J	0005665	cellular_component	RNA polymerase II, core complex
J	0005666	cellular_component	RNA polymerase III complex
J	0005736	cellular_component	RNA polymerase I complex
J	0006351	biological_process	DNA-templated transcription
J	0006360	biological_process	transcription by RNA polymerase I
J	0006366	biological_process	transcription by RNA polymerase II
J	0008270	molecular_function	zinc ion binding
J	0042797	biological_process	tRNA transcription by RNA polymerase III
J	0046872	molecular_function	metal ion binding
K	0000428	cellular_component	DNA-directed RNA polymerase complex
K	0001055	molecular_function	RNA polymerase II activity
K	0003677	molecular_function	DNA binding
K	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
K	0005634	cellular_component	nucleus
K	0005665	cellular_component	RNA polymerase II, core complex
K	0006351	biological_process	DNA-templated transcription
K	0006366	biological_process	transcription by RNA polymerase II
K	0016591	cellular_component	RNA polymerase II, holoenzyme
K	0046983	molecular_function	protein dimerization activity
L	0003677	molecular_function	DNA binding
L	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
L	0005634	cellular_component	nucleus
L	0005665	cellular_component	RNA polymerase II, core complex
L	0005666	cellular_component	RNA polymerase III complex
L	0005736	cellular_component	RNA polymerase I complex
L	0006351	biological_process	DNA-templated transcription
L	0006366	biological_process	transcription by RNA polymerase II
L	0008270	molecular_function	zinc ion binding
L	0046872	molecular_function	metal ion binding
M	0003677	molecular_function	DNA binding
M	0006366	biological_process	transcription by RNA polymerase II
U	0003682	molecular_function	chromatin binding
U	0005515	molecular_function	protein binding
U	0005634	cellular_component	nucleus
U	0005654	cellular_component	nucleoplasm
U	0005829	cellular_component	cytosol
U	0016604	cellular_component	nuclear body
U	0031401	biological_process	positive regulation of protein modification process
U	0032021	cellular_component	NELF complex
U	0034244	biological_process	negative regulation of transcription elongation by RNA polymerase II
U	0045944	biological_process	positive regulation of transcription by RNA polymerase II
U	0060090	molecular_function	molecular adaptor activity
V	0003723	molecular_function	RNA binding
V	0005515	molecular_function	protein binding
V	0005634	cellular_component	nucleus
V	0005654	cellular_component	nucleoplasm
V	0005737	cellular_component	cytoplasm
V	0008283	biological_process	cell population proliferation
V	0032021	cellular_component	NELF complex
V	0034244	biological_process	negative regulation of transcription elongation by RNA polymerase II
V	0045892	biological_process	negative regulation of DNA-templated transcription
V	0048863	biological_process	stem cell differentiation
V	2000737	biological_process	negative regulation of stem cell differentiation
W	0003723	molecular_function	RNA binding
W	0005515	molecular_function	protein binding
W	0005634	cellular_component	nucleus
W	0005654	cellular_component	nucleoplasm
W	0016020	cellular_component	membrane
W	0032021	cellular_component	NELF complex
W	0034244	biological_process	negative regulation of transcription elongation by RNA polymerase II
W	0045892	biological_process	negative regulation of DNA-templated transcription
Z	0000122	biological_process	negative regulation of transcription by RNA polymerase II
Z	0003682	molecular_function	chromatin binding
Z	0003723	molecular_function	RNA binding
Z	0003729	molecular_function	mRNA binding
Z	0005515	molecular_function	protein binding
Z	0005634	cellular_component	nucleus
Z	0005654	cellular_component	nucleoplasm
Z	0006354	biological_process	DNA-templated transcription elongation
Z	0006357	biological_process	regulation of transcription by RNA polymerase II
Z	0006368	biological_process	transcription elongation by RNA polymerase II
Z	0016239	biological_process	positive regulation of macroautophagy
Z	0019899	molecular_function	enzyme binding
Z	0032044	cellular_component	DSIF complex
Z	0032784	biological_process	regulation of DNA-templated transcription elongation
Z	0032785	biological_process	negative regulation of DNA-templated transcription, elongation
Z	0032786	biological_process	positive regulation of DNA-templated transcription, elongation
Z	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
Z	0045944	biological_process	positive regulation of transcription by RNA polymerase II
Z	0046982	molecular_function	protein heterodimerization activity
Z	0140673	biological_process	transcription elongation-coupled chromatin remodeling
a	0001832	biological_process	blastocyst growth
a	0001833	biological_process	inner cell mass cell proliferation
a	0005634	cellular_component	nucleus
a	0005654	cellular_component	nucleoplasm
a	0007566	biological_process	embryo implantation
a	0016020	cellular_component	membrane
a	0016180	biological_process	snRNA processing
a	0031965	cellular_component	nuclear membrane
a	0032039	cellular_component	integrator complex
a	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
a	0034474	biological_process	U2 snRNA 3'-end processing
a	0043066	biological_process	negative regulation of apoptotic process
b	0005515	molecular_function	protein binding
b	0005634	cellular_component	nucleus
b	0005654	cellular_component	nucleoplasm
b	0005737	cellular_component	cytoplasm
b	0016020	cellular_component	membrane
b	0016180	biological_process	snRNA processing
b	0031965	cellular_component	nuclear membrane
b	0032039	cellular_component	integrator complex
b	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
b	0034472	biological_process	snRNA 3'-end processing
d	0005515	molecular_function	protein binding
d	0005634	cellular_component	nucleus
d	0005654	cellular_component	nucleoplasm
d	0005730	cellular_component	nucleolus
d	0016180	biological_process	snRNA processing
d	0032039	cellular_component	integrator complex
d	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
e	0005515	molecular_function	protein binding
e	0005634	cellular_component	nucleus
e	0005654	cellular_component	nucleoplasm
e	0005737	cellular_component	cytoplasm
e	0005829	cellular_component	cytosol
e	0016020	cellular_component	membrane
e	0016180	biological_process	snRNA processing
e	0031965	cellular_component	nuclear membrane
e	0032039	cellular_component	integrator complex
e	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
e	0034472	biological_process	snRNA 3'-end processing
f	0004888	molecular_function	transmembrane signaling receptor activity
f	0005515	molecular_function	protein binding
f	0005634	cellular_component	nucleus
f	0005654	cellular_component	nucleoplasm
f	0015629	cellular_component	actin cytoskeleton
f	0016180	biological_process	snRNA processing
f	0032039	cellular_component	integrator complex
f	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
f	0034472	biological_process	snRNA 3'-end processing
g	0000077	biological_process	DNA damage checkpoint signaling
g	0005515	molecular_function	protein binding
g	0005634	cellular_component	nucleus
g	0005654	cellular_component	nucleoplasm
g	0005694	cellular_component	chromosome
g	0005737	cellular_component	cytoplasm
g	0006974	biological_process	DNA damage response
g	0016180	biological_process	snRNA processing
g	0016604	cellular_component	nuclear body
g	0032039	cellular_component	integrator complex
g	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
g	0034472	biological_process	snRNA 3'-end processing
g	0071479	biological_process	cellular response to ionizing radiation
h	0005515	molecular_function	protein binding
h	0005634	cellular_component	nucleus
h	0005654	cellular_component	nucleoplasm
h	0016180	biological_process	snRNA processing
h	0032039	cellular_component	integrator complex
h	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
h	0034472	biological_process	snRNA 3'-end processing
i	0005515	molecular_function	protein binding
i	0005634	cellular_component	nucleus
i	0005654	cellular_component	nucleoplasm
i	0005829	cellular_component	cytosol
i	0016180	biological_process	snRNA processing
i	0030512	biological_process	negative regulation of transforming growth factor beta receptor signaling pathway
i	0032039	cellular_component	integrator complex
i	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
i	0034472	biological_process	snRNA 3'-end processing
k	0004521	molecular_function	RNA endonuclease activity
k	0005515	molecular_function	protein binding
k	0005634	cellular_component	nucleus
k	0005654	cellular_component	nucleoplasm
k	0005737	cellular_component	cytoplasm
k	0005829	cellular_component	cytosol
k	0016180	biological_process	snRNA processing
k	0016787	molecular_function	hydrolase activity
k	0032039	cellular_component	integrator complex
k	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
k	0072562	cellular_component	blood microparticle
p	0000159	cellular_component	protein phosphatase type 2A complex
p	0000775	cellular_component	chromosome, centromeric region
p	0004722	molecular_function	protein serine/threonine phosphatase activity
p	0005515	molecular_function	protein binding
p	0005634	cellular_component	nucleus
p	0005694	cellular_component	chromosome
p	0005737	cellular_component	cytoplasm
p	0005739	cellular_component	mitochondrion
p	0005829	cellular_component	cytosol
p	0005886	cellular_component	plasma membrane
p	0007059	biological_process	chromosome segregation
p	0007143	biological_process	female meiotic nuclear division
p	0015630	cellular_component	microtubule cytoskeleton
p	0016020	cellular_component	membrane
p	0016328	cellular_component	lateral plasma membrane
p	0019888	molecular_function	protein phosphatase regulator activity
p	0030425	cellular_component	dendrite
p	0035331	biological_process	negative regulation of hippo signaling
p	0035556	biological_process	intracellular signal transduction
p	0040008	biological_process	regulation of growth
p	0042995	cellular_component	cell projection
p	0043005	cellular_component	neuron projection
p	0043025	cellular_component	neuronal cell body
p	0043029	biological_process	T cell homeostasis
p	0045202	cellular_component	synapse
p	0045595	biological_process	regulation of cell differentiation
p	0046982	molecular_function	protein heterodimerization activity
p	0051232	biological_process	meiotic spindle elongation
p	0051306	biological_process	mitotic sister chromatid separation
p	0051754	biological_process	meiotic sister chromatid cohesion, centromeric
p	0051898	biological_process	negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
p	0065003	biological_process	protein-containing complex assembly
p	0070062	cellular_component	extracellular exosome
p	0090443	cellular_component	FAR/SIN/STRIPAK complex
p	0098978	cellular_component	glutamatergic synapse
p	1903538	biological_process	regulation of meiotic cell cycle process involved in oocyte maturation
p	1990405	molecular_function	protein antigen binding
p	2001241	biological_process	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
q	0000159	cellular_component	protein phosphatase type 2A complex
q	0000278	biological_process	mitotic cell cycle
q	0000775	cellular_component	chromosome, centromeric region
q	0000922	cellular_component	spindle pole
q	0001932	biological_process	regulation of protein phosphorylation
q	0004721	molecular_function	phosphoprotein phosphatase activity
q	0004722	molecular_function	protein serine/threonine phosphatase activity
q	0004725	molecular_function	protein tyrosine phosphatase activity
q	0005515	molecular_function	protein binding
q	0005634	cellular_component	nucleus
q	0005694	cellular_component	chromosome
q	0005737	cellular_component	cytoplasm
q	0005739	cellular_component	mitochondrion
q	0005829	cellular_component	cytosol
q	0005856	cellular_component	cytoskeleton
q	0005886	cellular_component	plasma membrane
q	0006470	biological_process	protein dephosphorylation
q	0007498	biological_process	mesoderm development
q	0008287	cellular_component	protein serine/threonine phosphatase complex
q	0010288	biological_process	response to lead ion
q	0010719	biological_process	negative regulation of epithelial to mesenchymal transition
q	0015630	cellular_component	microtubule cytoskeleton
q	0016020	cellular_component	membrane
q	0016787	molecular_function	hydrolase activity
q	0017018	molecular_function	myosin phosphatase activity
q	0035331	biological_process	negative regulation of hippo signaling
q	0035556	biological_process	intracellular signal transduction
q	0035970	biological_process	peptidyl-threonine dephosphorylation
q	0040008	biological_process	regulation of growth
q	0043029	biological_process	T cell homeostasis
q	0045121	cellular_component	membrane raft
q	0045202	cellular_component	synapse
q	0045595	biological_process	regulation of cell differentiation
q	0046872	molecular_function	metal ion binding
q	0046982	molecular_function	protein heterodimerization activity
q	0048156	molecular_function	tau protein binding
q	0050811	molecular_function	GABA receptor binding
q	0051321	biological_process	meiotic cell cycle
q	0051898	biological_process	negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
q	0070062	cellular_component	extracellular exosome
q	0070262	biological_process	peptidyl-serine dephosphorylation
q	0071902	biological_process	positive regulation of protein serine/threonine kinase activity
q	0090443	cellular_component	FAR/SIN/STRIPAK complex
q	1900227	biological_process	positive regulation of NLRP3 inflammasome complex assembly
q	1904526	biological_process	regulation of microtubule binding
q	1904528	biological_process	positive regulation of microtubule binding
q	1904539	biological_process	negative regulation of glycolytic process through fructose-6-phosphate
q	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DNDPSDYVEqdDI

Chain	Residue	Details
C	ASP136-ILE148

---

site_id	PS00019
Number of Residues	10
Details	ACTININ_1 Actinin-type actin-binding domain signature 1. QPeTYYKWDN

Chain	Residue	Details
a	GLN620-ASN629

---

site_id	PS00039
Number of Residues	9
Details	DEAD_ATP_HELICASE DEAD-box subfamily ATP-dependent helicases signature. MIDEADEfV

Chain	Residue	Details
f	MET627-VAL635

---

site_id	PS00125
Number of Residues	6
Details	SER_THR_PHOSPHATASE Serine/threonine specific protein phosphatases signature. LRGNHE

Chain	Residue	Details
q	LEU114-GLU119

---

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YVCTAPH

Chain	Residue	Details
I	TYR112-HIS118

---

site_id	PS00446
Number of Residues	41
Details	RNA_POL_D_30KD RNA polymerases D / 30 to 40 Kd subunits signature. NSIRRvfiaevpiiAidwVqidaNsSvlhDEfIAhRLGLIP

Chain	Residue	Details
C	ASN32-PRO72

---

site_id	PS00466
Number of Residues	38
Details	ZF_TFIIS_1 Zinc finger TFIIS-type signature. CqkCghkeavffqSHSARaEDAmrlyyvCtaph.CghrW

Chain	Residue	Details
I	CYS86-TRP123

---

site_id	PS01030
Number of Residues	27
Details	RNA_POL_M_15KD RNA polymerases M / 15 Kd subunits signature. FCqECNNMLypkedkenrillyaCrnC

Chain	Residue	Details
I	PHE16-CYS42

---

site_id	PS01110
Number of Residues	14
Details	RNA_POL_H_23KD RNA polymerases H / 23 Kd subunits signature. HELVPEHvvMtkEE

Chain	Residue	Details
E	HIS142-GLU155

---

site_id	PS01111
Number of Residues	15
Details	RNA_POL_K_14KD RNA polymerases K / 14 to 18 Kd subunits signature. TkYErARvLGtRAlQ

Chain	Residue	Details
F	THR58-GLN72

---

site_id	PS01112
Number of Residues	10
Details	RNA_POL_N_8KD RNA polymerases N / 8 Kd subunits signature. IIPVrCFTCG

Chain	Residue	Details
J	ILE2-GLY11

---

site_id	PS01154
Number of Residues	32
Details	RNA_POL_L_13KD RNA polymerases L / 13 to 16 Kd subunits signature. InkEdHTLgNiIksqLlkdpqVlfagYkvpHP

Chain	Residue	Details
K	ILE35-PRO66

---

site_id	PS01166
Number of Residues	13
Details	RNA_POL_BETA RNA polymerases beta chain signature. GdKFASrHGQKGT

Chain	Residue	Details
B	GLY932-THR944

---

site_id	PS00115
Number of Residues	7
Details	RNA_POL_II_REPEAT Eukaryotic RNA polymerase II heptapeptide repeat. YSPTSPA

Chain	Residue	Details
A	TYR1755-SER1761
A	TYR1818-SER1824
A	TYR1825-SER1831
A	TYR1832-LYS1838
A	TYR1839-SER1845
A	TYR1853-LYS1859
A	TYR1930-LYS1936
A	TYR1671-SER1677
A	TYR1720-SER1726
A	TYR1593-ALA1599
A	TYR1678-SER1684
A	TYR1685-SER1691
A	TYR1692-SER1698
A	TYR1699-SER1705
A	TYR1706-SER1712
A	TYR1713-SER1719
A	TYR1615-SER1621
A	TYR1762-SER1768
A	TYR1769-ASN1775
A	TYR1776-ASN1782
A	TYR1783-SER1789
A	TYR1790-SER1796
A	TYR1797-SER1803
A	TYR1622-SER1628
A	TYR1888-THR1894
A	TYR1902-LYS1908
A	TYR1629-ASN1635
A	TYR1916-LYS1922
A	TYR1636-SER1642
A	TYR1643-SER1649
A	TYR1650-SER1656
A	TYR1657-SER1663
A	TYR1664-SER1670
A	TYR1727-SER1733
A	TYR1734-SER1740
A	TYR1741-ASN1747
A	TYR1748-ASN1754
A	TYR1860-LYS1866
A	TYR1867-LYS1873
A	TYR1874-THR1880
A	TYR1909-THR1915
A	TYR1923-THR1929
A	TYR1947-THR1953
M	TYR1622-SER1628

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	25
Details	ZN_FING: C4-type => ECO:0000255

Chain	Residue	Details
e	VAL930-LEU950
I	CYS17-CYS42
g	SER809

---

site_id	SWS_FT_FI2
Number of Residues	42
Details	ZN_FING: TFIIS-type => ECO:0000255|PROSITE-ProRule:PRU00472

Chain	Residue	Details
q	ASP85
q	ASN117
q	HIS167
q	HIS241
I	GLU82-THR124
q	HIS59

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P27999

Chain	Residue	Details
I	CYS17
I	CYS20
I	CYS39
I	CYS42

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00472

Chain	Residue	Details
I	CYS86
I	CYS89
I	CYS114
I	CYS119

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: N-acetylmethionine => ECO:0000250|UniProtKB:P36954

Chain	Residue	Details
Z	SER804
I	MET1
a	SER924

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
a	SER307

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231

Chain	Residue	Details
a	SER1318

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q6P4S8

Chain	Residue	Details
a	SER1335
a	SER1336

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
Z	THR806
Z	THR791

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
Z	THR1034

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site_id	SWS_FT_FI11
Number of Residues	1
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25218447, ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:28112733

Chain	Residue	Details
Z	LYS143

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site_id	SWS_FT_FI12
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
Z	LYS1037

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