Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7PBX

Cryo-EM structure of the GroEL-GroES complex with ADP bound to both rings ("tight" conformation).

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
Ac	0000287	molecular_function	magnesium ion binding
Ac	0005515	molecular_function	protein binding
Ac	0005524	molecular_function	ATP binding
Ac	0005737	cellular_component	cytoplasm
Ac	0005829	cellular_component	cytosol
Ac	0006457	biological_process	protein folding
Ac	0009314	biological_process	response to radiation
Ac	0009408	biological_process	response to heat
Ac	0016020	cellular_component	membrane
Ac	0016853	molecular_function	isomerase activity
Ac	0016887	molecular_function	ATP hydrolysis activity
Ac	0019068	biological_process	virion assembly
Ac	0042026	biological_process	protein refolding
Ac	0042802	molecular_function	identical protein binding
Ac	0051082	molecular_function	unfolded protein binding
Ac	0051085	biological_process	chaperone cofactor-dependent protein refolding
Ac	0140662	molecular_function	ATP-dependent protein folding chaperone
Ac	1990220	cellular_component	GroEL-GroES complex
Ad	0000287	molecular_function	magnesium ion binding
Ad	0005515	molecular_function	protein binding
Ad	0005524	molecular_function	ATP binding
Ad	0005737	cellular_component	cytoplasm
Ad	0005829	cellular_component	cytosol
Ad	0006457	biological_process	protein folding
Ad	0009314	biological_process	response to radiation
Ad	0009408	biological_process	response to heat
Ad	0016020	cellular_component	membrane
Ad	0016853	molecular_function	isomerase activity
Ad	0016887	molecular_function	ATP hydrolysis activity
Ad	0019068	biological_process	virion assembly
Ad	0042026	biological_process	protein refolding
Ad	0042802	molecular_function	identical protein binding
Ad	0051082	molecular_function	unfolded protein binding
Ad	0051085	biological_process	chaperone cofactor-dependent protein refolding
Ad	0140662	molecular_function	ATP-dependent protein folding chaperone
Ad	1990220	cellular_component	GroEL-GroES complex
Af	0005515	molecular_function	protein binding
Af	0005524	molecular_function	ATP binding
Af	0005737	cellular_component	cytoplasm
Af	0005829	cellular_component	cytosol
Af	0006457	biological_process	protein folding
Af	0009408	biological_process	response to heat
Af	0019068	biological_process	virion assembly
Af	0042802	molecular_function	identical protein binding
Af	0044183	molecular_function	protein folding chaperone
Af	0046872	molecular_function	metal ion binding
Af	0051082	molecular_function	unfolded protein binding
Af	0051085	biological_process	chaperone cofactor-dependent protein refolding
Af	0051087	molecular_function	protein-folding chaperone binding
Af	1990220	cellular_component	GroEL-GroES complex
Ai	0000287	molecular_function	magnesium ion binding
Ai	0005515	molecular_function	protein binding
Ai	0005524	molecular_function	ATP binding
Ai	0005737	cellular_component	cytoplasm
Ai	0005829	cellular_component	cytosol
Ai	0006457	biological_process	protein folding
Ai	0009314	biological_process	response to radiation
Ai	0009408	biological_process	response to heat
Ai	0016020	cellular_component	membrane
Ai	0016853	molecular_function	isomerase activity
Ai	0016887	molecular_function	ATP hydrolysis activity
Ai	0019068	biological_process	virion assembly
Ai	0042026	biological_process	protein refolding
Ai	0042802	molecular_function	identical protein binding
Ai	0051082	molecular_function	unfolded protein binding
Ai	0051085	biological_process	chaperone cofactor-dependent protein refolding
Ai	0140662	molecular_function	ATP-dependent protein folding chaperone
Ai	1990220	cellular_component	GroEL-GroES complex
Aj	0000287	molecular_function	magnesium ion binding
Aj	0005515	molecular_function	protein binding
Aj	0005524	molecular_function	ATP binding
Aj	0005737	cellular_component	cytoplasm
Aj	0005829	cellular_component	cytosol
Aj	0006457	biological_process	protein folding
Aj	0009314	biological_process	response to radiation
Aj	0009408	biological_process	response to heat
Aj	0016020	cellular_component	membrane
Aj	0016853	molecular_function	isomerase activity
Aj	0016887	molecular_function	ATP hydrolysis activity
Aj	0019068	biological_process	virion assembly
Aj	0042026	biological_process	protein refolding
Aj	0042802	molecular_function	identical protein binding
Aj	0051082	molecular_function	unfolded protein binding
Aj	0051085	biological_process	chaperone cofactor-dependent protein refolding
Aj	0140662	molecular_function	ATP-dependent protein folding chaperone
Aj	1990220	cellular_component	GroEL-GroES complex
Al	0005515	molecular_function	protein binding
Al	0005524	molecular_function	ATP binding
Al	0005737	cellular_component	cytoplasm
Al	0005829	cellular_component	cytosol
Al	0006457	biological_process	protein folding
Al	0009408	biological_process	response to heat
Al	0019068	biological_process	virion assembly
Al	0042802	molecular_function	identical protein binding
Al	0044183	molecular_function	protein folding chaperone
Al	0046872	molecular_function	metal ion binding
Al	0051082	molecular_function	unfolded protein binding
Al	0051085	biological_process	chaperone cofactor-dependent protein refolding
Al	0051087	molecular_function	protein-folding chaperone binding
Al	1990220	cellular_component	GroEL-GroES complex
Ao	0000287	molecular_function	magnesium ion binding
Ao	0005515	molecular_function	protein binding
Ao	0005524	molecular_function	ATP binding
Ao	0005737	cellular_component	cytoplasm
Ao	0005829	cellular_component	cytosol
Ao	0006457	biological_process	protein folding
Ao	0009314	biological_process	response to radiation
Ao	0009408	biological_process	response to heat
Ao	0016020	cellular_component	membrane
Ao	0016853	molecular_function	isomerase activity
Ao	0016887	molecular_function	ATP hydrolysis activity
Ao	0019068	biological_process	virion assembly
Ao	0042026	biological_process	protein refolding
Ao	0042802	molecular_function	identical protein binding
Ao	0051082	molecular_function	unfolded protein binding
Ao	0051085	biological_process	chaperone cofactor-dependent protein refolding
Ao	0140662	molecular_function	ATP-dependent protein folding chaperone
Ao	1990220	cellular_component	GroEL-GroES complex
Ap	0000287	molecular_function	magnesium ion binding
Ap	0005515	molecular_function	protein binding
Ap	0005524	molecular_function	ATP binding
Ap	0005737	cellular_component	cytoplasm
Ap	0005829	cellular_component	cytosol
Ap	0006457	biological_process	protein folding
Ap	0009314	biological_process	response to radiation
Ap	0009408	biological_process	response to heat
Ap	0016020	cellular_component	membrane
Ap	0016853	molecular_function	isomerase activity
Ap	0016887	molecular_function	ATP hydrolysis activity
Ap	0019068	biological_process	virion assembly
Ap	0042026	biological_process	protein refolding
Ap	0042802	molecular_function	identical protein binding
Ap	0051082	molecular_function	unfolded protein binding
Ap	0051085	biological_process	chaperone cofactor-dependent protein refolding
Ap	0140662	molecular_function	ATP-dependent protein folding chaperone
Ap	1990220	cellular_component	GroEL-GroES complex
Ar	0005515	molecular_function	protein binding
Ar	0005524	molecular_function	ATP binding
Ar	0005737	cellular_component	cytoplasm
Ar	0005829	cellular_component	cytosol
Ar	0006457	biological_process	protein folding
Ar	0009408	biological_process	response to heat
Ar	0019068	biological_process	virion assembly
Ar	0042802	molecular_function	identical protein binding
Ar	0044183	molecular_function	protein folding chaperone
Ar	0046872	molecular_function	metal ion binding
Ar	0051082	molecular_function	unfolded protein binding
Ar	0051085	biological_process	chaperone cofactor-dependent protein refolding
Ar	0051087	molecular_function	protein-folding chaperone binding
Ar	1990220	cellular_component	GroEL-GroES complex
Au	0000287	molecular_function	magnesium ion binding
Au	0005515	molecular_function	protein binding
Au	0005524	molecular_function	ATP binding
Au	0005737	cellular_component	cytoplasm
Au	0005829	cellular_component	cytosol
Au	0006457	biological_process	protein folding
Au	0009314	biological_process	response to radiation
Au	0009408	biological_process	response to heat
Au	0016020	cellular_component	membrane
Au	0016853	molecular_function	isomerase activity
Au	0016887	molecular_function	ATP hydrolysis activity
Au	0019068	biological_process	virion assembly
Au	0042026	biological_process	protein refolding
Au	0042802	molecular_function	identical protein binding
Au	0051082	molecular_function	unfolded protein binding
Au	0051085	biological_process	chaperone cofactor-dependent protein refolding
Au	0140662	molecular_function	ATP-dependent protein folding chaperone
Au	1990220	cellular_component	GroEL-GroES complex
Av	0000287	molecular_function	magnesium ion binding
Av	0005515	molecular_function	protein binding
Av	0005524	molecular_function	ATP binding
Av	0005737	cellular_component	cytoplasm
Av	0005829	cellular_component	cytosol
Av	0006457	biological_process	protein folding
Av	0009314	biological_process	response to radiation
Av	0009408	biological_process	response to heat
Av	0016020	cellular_component	membrane
Av	0016853	molecular_function	isomerase activity
Av	0016887	molecular_function	ATP hydrolysis activity
Av	0019068	biological_process	virion assembly
Av	0042026	biological_process	protein refolding
Av	0042802	molecular_function	identical protein binding
Av	0051082	molecular_function	unfolded protein binding
Av	0051085	biological_process	chaperone cofactor-dependent protein refolding
Av	0140662	molecular_function	ATP-dependent protein folding chaperone
Av	1990220	cellular_component	GroEL-GroES complex
Ax	0005515	molecular_function	protein binding
Ax	0005524	molecular_function	ATP binding
Ax	0005737	cellular_component	cytoplasm
Ax	0005829	cellular_component	cytosol
Ax	0006457	biological_process	protein folding
Ax	0009408	biological_process	response to heat
Ax	0019068	biological_process	virion assembly
Ax	0042802	molecular_function	identical protein binding
Ax	0044183	molecular_function	protein folding chaperone
Ax	0046872	molecular_function	metal ion binding
Ax	0051082	molecular_function	unfolded protein binding
Ax	0051085	biological_process	chaperone cofactor-dependent protein refolding
Ax	0051087	molecular_function	protein-folding chaperone binding
Ax	1990220	cellular_component	GroEL-GroES complex
Ba	0000287	molecular_function	magnesium ion binding
Ba	0005515	molecular_function	protein binding
Ba	0005524	molecular_function	ATP binding
Ba	0005737	cellular_component	cytoplasm
Ba	0005829	cellular_component	cytosol
Ba	0006457	biological_process	protein folding
Ba	0009314	biological_process	response to radiation
Ba	0009408	biological_process	response to heat
Ba	0016020	cellular_component	membrane
Ba	0016853	molecular_function	isomerase activity
Ba	0016887	molecular_function	ATP hydrolysis activity
Ba	0019068	biological_process	virion assembly
Ba	0042026	biological_process	protein refolding
Ba	0042802	molecular_function	identical protein binding
Ba	0051082	molecular_function	unfolded protein binding
Ba	0051085	biological_process	chaperone cofactor-dependent protein refolding
Ba	0140662	molecular_function	ATP-dependent protein folding chaperone
Ba	1990220	cellular_component	GroEL-GroES complex
Bb	0000287	molecular_function	magnesium ion binding
Bb	0005515	molecular_function	protein binding
Bb	0005524	molecular_function	ATP binding
Bb	0005737	cellular_component	cytoplasm
Bb	0005829	cellular_component	cytosol
Bb	0006457	biological_process	protein folding
Bb	0009314	biological_process	response to radiation
Bb	0009408	biological_process	response to heat
Bb	0016020	cellular_component	membrane
Bb	0016853	molecular_function	isomerase activity
Bb	0016887	molecular_function	ATP hydrolysis activity
Bb	0019068	biological_process	virion assembly
Bb	0042026	biological_process	protein refolding
Bb	0042802	molecular_function	identical protein binding
Bb	0051082	molecular_function	unfolded protein binding
Bb	0051085	biological_process	chaperone cofactor-dependent protein refolding
Bb	0140662	molecular_function	ATP-dependent protein folding chaperone
Bb	1990220	cellular_component	GroEL-GroES complex
Bd	0005515	molecular_function	protein binding
Bd	0005524	molecular_function	ATP binding
Bd	0005737	cellular_component	cytoplasm
Bd	0005829	cellular_component	cytosol
Bd	0006457	biological_process	protein folding
Bd	0009408	biological_process	response to heat
Bd	0019068	biological_process	virion assembly
Bd	0042802	molecular_function	identical protein binding
Bd	0044183	molecular_function	protein folding chaperone
Bd	0046872	molecular_function	metal ion binding
Bd	0051082	molecular_function	unfolded protein binding
Bd	0051085	biological_process	chaperone cofactor-dependent protein refolding
Bd	0051087	molecular_function	protein-folding chaperone binding
Bd	1990220	cellular_component	GroEL-GroES complex
Bg	0000287	molecular_function	magnesium ion binding
Bg	0005515	molecular_function	protein binding
Bg	0005524	molecular_function	ATP binding
Bg	0005737	cellular_component	cytoplasm
Bg	0005829	cellular_component	cytosol
Bg	0006457	biological_process	protein folding
Bg	0009314	biological_process	response to radiation
Bg	0009408	biological_process	response to heat
Bg	0016020	cellular_component	membrane
Bg	0016853	molecular_function	isomerase activity
Bg	0016887	molecular_function	ATP hydrolysis activity
Bg	0019068	biological_process	virion assembly
Bg	0042026	biological_process	protein refolding
Bg	0042802	molecular_function	identical protein binding
Bg	0051082	molecular_function	unfolded protein binding
Bg	0051085	biological_process	chaperone cofactor-dependent protein refolding
Bg	0140662	molecular_function	ATP-dependent protein folding chaperone
Bg	1990220	cellular_component	GroEL-GroES complex
Bh	0000287	molecular_function	magnesium ion binding
Bh	0005515	molecular_function	protein binding
Bh	0005524	molecular_function	ATP binding
Bh	0005737	cellular_component	cytoplasm
Bh	0005829	cellular_component	cytosol
Bh	0006457	biological_process	protein folding
Bh	0009314	biological_process	response to radiation
Bh	0009408	biological_process	response to heat
Bh	0016020	cellular_component	membrane
Bh	0016853	molecular_function	isomerase activity
Bh	0016887	molecular_function	ATP hydrolysis activity
Bh	0019068	biological_process	virion assembly
Bh	0042026	biological_process	protein refolding
Bh	0042802	molecular_function	identical protein binding
Bh	0051082	molecular_function	unfolded protein binding
Bh	0051085	biological_process	chaperone cofactor-dependent protein refolding
Bh	0140662	molecular_function	ATP-dependent protein folding chaperone
Bh	1990220	cellular_component	GroEL-GroES complex
Bj	0005515	molecular_function	protein binding
Bj	0005524	molecular_function	ATP binding
Bj	0005737	cellular_component	cytoplasm
Bj	0005829	cellular_component	cytosol
Bj	0006457	biological_process	protein folding
Bj	0009408	biological_process	response to heat
Bj	0019068	biological_process	virion assembly
Bj	0042802	molecular_function	identical protein binding
Bj	0044183	molecular_function	protein folding chaperone
Bj	0046872	molecular_function	metal ion binding
Bj	0051082	molecular_function	unfolded protein binding
Bj	0051085	biological_process	chaperone cofactor-dependent protein refolding
Bj	0051087	molecular_function	protein-folding chaperone binding
Bj	1990220	cellular_component	GroEL-GroES complex
Bm	0000287	molecular_function	magnesium ion binding
Bm	0005515	molecular_function	protein binding
Bm	0005524	molecular_function	ATP binding
Bm	0005737	cellular_component	cytoplasm
Bm	0005829	cellular_component	cytosol
Bm	0006457	biological_process	protein folding
Bm	0009314	biological_process	response to radiation
Bm	0009408	biological_process	response to heat
Bm	0016020	cellular_component	membrane
Bm	0016853	molecular_function	isomerase activity
Bm	0016887	molecular_function	ATP hydrolysis activity
Bm	0019068	biological_process	virion assembly
Bm	0042026	biological_process	protein refolding
Bm	0042802	molecular_function	identical protein binding
Bm	0051082	molecular_function	unfolded protein binding
Bm	0051085	biological_process	chaperone cofactor-dependent protein refolding
Bm	0140662	molecular_function	ATP-dependent protein folding chaperone
Bm	1990220	cellular_component	GroEL-GroES complex
Bn	0000287	molecular_function	magnesium ion binding
Bn	0005515	molecular_function	protein binding
Bn	0005524	molecular_function	ATP binding
Bn	0005737	cellular_component	cytoplasm
Bn	0005829	cellular_component	cytosol
Bn	0006457	biological_process	protein folding
Bn	0009314	biological_process	response to radiation
Bn	0009408	biological_process	response to heat
Bn	0016020	cellular_component	membrane
Bn	0016853	molecular_function	isomerase activity
Bn	0016887	molecular_function	ATP hydrolysis activity
Bn	0019068	biological_process	virion assembly
Bn	0042026	biological_process	protein refolding
Bn	0042802	molecular_function	identical protein binding
Bn	0051082	molecular_function	unfolded protein binding
Bn	0051085	biological_process	chaperone cofactor-dependent protein refolding
Bn	0140662	molecular_function	ATP-dependent protein folding chaperone
Bn	1990220	cellular_component	GroEL-GroES complex
Bp	0005515	molecular_function	protein binding
Bp	0005524	molecular_function	ATP binding
Bp	0005737	cellular_component	cytoplasm
Bp	0005829	cellular_component	cytosol
Bp	0006457	biological_process	protein folding
Bp	0009408	biological_process	response to heat
Bp	0019068	biological_process	virion assembly
Bp	0042802	molecular_function	identical protein binding
Bp	0044183	molecular_function	protein folding chaperone
Bp	0046872	molecular_function	metal ion binding
Bp	0051082	molecular_function	unfolded protein binding
Bp	0051085	biological_process	chaperone cofactor-dependent protein refolding
Bp	0051087	molecular_function	protein-folding chaperone binding
Bp	1990220	cellular_component	GroEL-GroES complex

Functional Information from PROSITE/UniProt

site_id	PS00296
Number of Residues	12
Details	CHAPERONINS_CPN60 Chaperonins cpn60 signature. AAVEEGVVaGGG

Chain	Residue	Details
Ac	ALA405-GLY416

site_id	PS00681
Number of Residues	25
Details	CHAPERONINS_CPN10 Chaperonins cpn10 signature. IrPLhDRVIVKrkevetksaGgIVL

Chain	Residue	Details
Af	ILE3-LEU27

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	7
Details	MOD_RES: N6-succinyllysine => ECO:0000269\|PubMed:21151122

Chain	Residue	Details
Af	LYS34
Ad	ASP495
Ai	THR30
Ai	ASP87
Ai	GLY415
Ai	ASN479
Ai	ASP495
Aj	THR30
Aj	ASP87
Aj	GLY415
Aj	ASN479
Al	LYS34
Aj	ASP495
Ao	THR30
Ao	ASP87
Ao	GLY415
Ao	ASN479
Ao	ASP495
Ap	THR30
Ap	ASP87
Ap	GLY415
Ap	ASN479
Ar	LYS34
Ap	ASP495
Au	THR30
Au	ASP87
Au	GLY415
Au	ASN479
Au	ASP495
Av	THR30
Av	ASP87
Av	GLY415
Av	ASN479
Ax	LYS34
Av	ASP495
Ba	THR30
Ba	ASP87
Ba	GLY415
Ba	ASN479
Ba	ASP495
Bb	THR30
Bb	ASP87
Bb	GLY415
Bb	ASN479
Bd	LYS34
Bb	ASP495
Bg	THR30
Bg	ASP87
Bg	GLY415
Bg	ASN479
Bg	ASP495
Bh	THR30
Bh	ASP87
Bh	GLY415
Bh	ASN479
Bj	LYS34
Bh	ASP495
Bm	THR30
Bm	ASP87
Bm	GLY415
Bm	ASN479
Bm	ASP495
Bn	THR30
Bn	ASP87
Bn	GLY415
Bn	ASN479
Bp	LYS34
Bn	ASP495
Ad	GLY415
Ad	ASN479

site_id	SWS_FT_FI2
Number of Residues	14
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_00600, ECO:0000269\|PubMed:25174333, ECO:0000305\|PubMed:14517228, ECO:0000305\|PubMed:9285585, ECO:0007744\|PDB:1AON, ECO:0007744\|PDB:1PF9, ECO:0007744\|PDB:3WVL

Chain	Residue	Details
Ac	LYS51
Bb	LYS51
Bg	LYS51
Bh	LYS51
Bm	LYS51
Bn	LYS51
Ad	LYS51
Ai	LYS51
Aj	LYS51
Ao	LYS51
Ap	LYS51
Au	LYS51
Av	LYS51
Ba	LYS51

site_id	SWS_FT_FI3
Number of Residues	70
Details	MOD_RES: N6-succinyllysine => ECO:0000269\|PubMed:21151122

Chain	Residue	Details
Ac	LYS34
Ad	LYS390
Ai	LYS34
Ai	LYS51
Ai	LYS277
Ai	LYS321
Ai	LYS390
Aj	LYS34
Aj	LYS51
Aj	LYS277
Aj	LYS321
Ac	LYS51
Aj	LYS390
Ao	LYS34
Ao	LYS51
Ao	LYS277
Ao	LYS321
Ao	LYS390
Ap	LYS34
Ap	LYS51
Ap	LYS277
Ap	LYS321
Ac	LYS277
Ap	LYS390
Au	LYS34
Au	LYS51
Au	LYS277
Au	LYS321
Au	LYS390
Av	LYS34
Av	LYS51
Av	LYS277
Av	LYS321
Ac	LYS321
Av	LYS390
Ba	LYS34
Ba	LYS51
Ba	LYS277
Ba	LYS321
Ba	LYS390
Bb	LYS34
Bb	LYS51
Bb	LYS277
Bb	LYS321
Ac	LYS390
Bb	LYS390
Bg	LYS34
Bg	LYS51
Bg	LYS277
Bg	LYS321
Bg	LYS390
Bh	LYS34
Bh	LYS51
Bh	LYS277
Bh	LYS321
Ad	LYS34
Bh	LYS390
Bm	LYS34
Bm	LYS51
Bm	LYS277
Bm	LYS321
Bm	LYS390
Bn	LYS34
Bn	LYS51
Bn	LYS277
Bn	LYS321
Ad	LYS51
Bn	LYS390
Ad	LYS277
Ad	LYS321

site_id	SWS_FT_FI4
Number of Residues	14
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000269\|PubMed:21151122

Chain	Residue	Details
Ac	LYS117
Bb	LYS117
Bg	LYS117
Bh	LYS117
Bm	LYS117
Bn	LYS117
Ad	LYS117
Ai	LYS117
Aj	LYS117
Ao	LYS117
Ap	LYS117
Au	LYS117
Av	LYS117
Ba	LYS117

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		Validation report (PDF)