Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7PBJ

Cryo-EM structure of the GroEL-GroES complex with ADP bound to both rings ("wide" conformation).

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
Ad	0000287	molecular_function	magnesium ion binding
Ad	0005515	molecular_function	protein binding
Ad	0005524	molecular_function	ATP binding
Ad	0005737	cellular_component	cytoplasm
Ad	0005829	cellular_component	cytosol
Ad	0006457	biological_process	protein folding
Ad	0009314	biological_process	response to radiation
Ad	0009408	biological_process	response to heat
Ad	0016020	cellular_component	membrane
Ad	0016853	molecular_function	isomerase activity
Ad	0016887	molecular_function	ATP hydrolysis activity
Ad	0019068	biological_process	virion assembly
Ad	0042026	biological_process	protein refolding
Ad	0042802	molecular_function	identical protein binding
Ad	0051082	molecular_function	unfolded protein binding
Ad	0051085	biological_process	chaperone cofactor-dependent protein refolding
Ad	0140662	molecular_function	ATP-dependent protein folding chaperone
Ad	1990220	cellular_component	GroEL-GroES complex
Ae	0000287	molecular_function	magnesium ion binding
Ae	0005515	molecular_function	protein binding
Ae	0005524	molecular_function	ATP binding
Ae	0005737	cellular_component	cytoplasm
Ae	0005829	cellular_component	cytosol
Ae	0006457	biological_process	protein folding
Ae	0009314	biological_process	response to radiation
Ae	0009408	biological_process	response to heat
Ae	0016020	cellular_component	membrane
Ae	0016853	molecular_function	isomerase activity
Ae	0016887	molecular_function	ATP hydrolysis activity
Ae	0019068	biological_process	virion assembly
Ae	0042026	biological_process	protein refolding
Ae	0042802	molecular_function	identical protein binding
Ae	0051082	molecular_function	unfolded protein binding
Ae	0051085	biological_process	chaperone cofactor-dependent protein refolding
Ae	0140662	molecular_function	ATP-dependent protein folding chaperone
Ae	1990220	cellular_component	GroEL-GroES complex
Af	0005515	molecular_function	protein binding
Af	0005524	molecular_function	ATP binding
Af	0005737	cellular_component	cytoplasm
Af	0005829	cellular_component	cytosol
Af	0006457	biological_process	protein folding
Af	0009408	biological_process	response to heat
Af	0019068	biological_process	virion assembly
Af	0042802	molecular_function	identical protein binding
Af	0044183	molecular_function	protein folding chaperone
Af	0046872	molecular_function	metal ion binding
Af	0051082	molecular_function	unfolded protein binding
Af	0051085	biological_process	chaperone cofactor-dependent protein refolding
Af	0051087	molecular_function	protein-folding chaperone binding
Af	1990220	cellular_component	GroEL-GroES complex
Ak	0000287	molecular_function	magnesium ion binding
Ak	0005515	molecular_function	protein binding
Ak	0005524	molecular_function	ATP binding
Ak	0005737	cellular_component	cytoplasm
Ak	0005829	cellular_component	cytosol
Ak	0006457	biological_process	protein folding
Ak	0009314	biological_process	response to radiation
Ak	0009408	biological_process	response to heat
Ak	0016020	cellular_component	membrane
Ak	0016853	molecular_function	isomerase activity
Ak	0016887	molecular_function	ATP hydrolysis activity
Ak	0019068	biological_process	virion assembly
Ak	0042026	biological_process	protein refolding
Ak	0042802	molecular_function	identical protein binding
Ak	0051082	molecular_function	unfolded protein binding
Ak	0051085	biological_process	chaperone cofactor-dependent protein refolding
Ak	0140662	molecular_function	ATP-dependent protein folding chaperone
Ak	1990220	cellular_component	GroEL-GroES complex
Al	0000287	molecular_function	magnesium ion binding
Al	0005515	molecular_function	protein binding
Al	0005524	molecular_function	ATP binding
Al	0005737	cellular_component	cytoplasm
Al	0005829	cellular_component	cytosol
Al	0006457	biological_process	protein folding
Al	0009314	biological_process	response to radiation
Al	0009408	biological_process	response to heat
Al	0016020	cellular_component	membrane
Al	0016853	molecular_function	isomerase activity
Al	0016887	molecular_function	ATP hydrolysis activity
Al	0019068	biological_process	virion assembly
Al	0042026	biological_process	protein refolding
Al	0042802	molecular_function	identical protein binding
Al	0051082	molecular_function	unfolded protein binding
Al	0051085	biological_process	chaperone cofactor-dependent protein refolding
Al	0140662	molecular_function	ATP-dependent protein folding chaperone
Al	1990220	cellular_component	GroEL-GroES complex
Am	0005515	molecular_function	protein binding
Am	0005524	molecular_function	ATP binding
Am	0005737	cellular_component	cytoplasm
Am	0005829	cellular_component	cytosol
Am	0006457	biological_process	protein folding
Am	0009408	biological_process	response to heat
Am	0019068	biological_process	virion assembly
Am	0042802	molecular_function	identical protein binding
Am	0044183	molecular_function	protein folding chaperone
Am	0046872	molecular_function	metal ion binding
Am	0051082	molecular_function	unfolded protein binding
Am	0051085	biological_process	chaperone cofactor-dependent protein refolding
Am	0051087	molecular_function	protein-folding chaperone binding
Am	1990220	cellular_component	GroEL-GroES complex
Ar	0000287	molecular_function	magnesium ion binding
Ar	0005515	molecular_function	protein binding
Ar	0005524	molecular_function	ATP binding
Ar	0005737	cellular_component	cytoplasm
Ar	0005829	cellular_component	cytosol
Ar	0006457	biological_process	protein folding
Ar	0009314	biological_process	response to radiation
Ar	0009408	biological_process	response to heat
Ar	0016020	cellular_component	membrane
Ar	0016853	molecular_function	isomerase activity
Ar	0016887	molecular_function	ATP hydrolysis activity
Ar	0019068	biological_process	virion assembly
Ar	0042026	biological_process	protein refolding
Ar	0042802	molecular_function	identical protein binding
Ar	0051082	molecular_function	unfolded protein binding
Ar	0051085	biological_process	chaperone cofactor-dependent protein refolding
Ar	0140662	molecular_function	ATP-dependent protein folding chaperone
Ar	1990220	cellular_component	GroEL-GroES complex
As	0000287	molecular_function	magnesium ion binding
As	0005515	molecular_function	protein binding
As	0005524	molecular_function	ATP binding
As	0005737	cellular_component	cytoplasm
As	0005829	cellular_component	cytosol
As	0006457	biological_process	protein folding
As	0009314	biological_process	response to radiation
As	0009408	biological_process	response to heat
As	0016020	cellular_component	membrane
As	0016853	molecular_function	isomerase activity
As	0016887	molecular_function	ATP hydrolysis activity
As	0019068	biological_process	virion assembly
As	0042026	biological_process	protein refolding
As	0042802	molecular_function	identical protein binding
As	0051082	molecular_function	unfolded protein binding
As	0051085	biological_process	chaperone cofactor-dependent protein refolding
As	0140662	molecular_function	ATP-dependent protein folding chaperone
As	1990220	cellular_component	GroEL-GroES complex
At	0005515	molecular_function	protein binding
At	0005524	molecular_function	ATP binding
At	0005737	cellular_component	cytoplasm
At	0005829	cellular_component	cytosol
At	0006457	biological_process	protein folding
At	0009408	biological_process	response to heat
At	0019068	biological_process	virion assembly
At	0042802	molecular_function	identical protein binding
At	0044183	molecular_function	protein folding chaperone
At	0046872	molecular_function	metal ion binding
At	0051082	molecular_function	unfolded protein binding
At	0051085	biological_process	chaperone cofactor-dependent protein refolding
At	0051087	molecular_function	protein-folding chaperone binding
At	1990220	cellular_component	GroEL-GroES complex
Ay	0000287	molecular_function	magnesium ion binding
Ay	0005515	molecular_function	protein binding
Ay	0005524	molecular_function	ATP binding
Ay	0005737	cellular_component	cytoplasm
Ay	0005829	cellular_component	cytosol
Ay	0006457	biological_process	protein folding
Ay	0009314	biological_process	response to radiation
Ay	0009408	biological_process	response to heat
Ay	0016020	cellular_component	membrane
Ay	0016853	molecular_function	isomerase activity
Ay	0016887	molecular_function	ATP hydrolysis activity
Ay	0019068	biological_process	virion assembly
Ay	0042026	biological_process	protein refolding
Ay	0042802	molecular_function	identical protein binding
Ay	0051082	molecular_function	unfolded protein binding
Ay	0051085	biological_process	chaperone cofactor-dependent protein refolding
Ay	0140662	molecular_function	ATP-dependent protein folding chaperone
Ay	1990220	cellular_component	GroEL-GroES complex
Az	0000287	molecular_function	magnesium ion binding
Az	0005515	molecular_function	protein binding
Az	0005524	molecular_function	ATP binding
Az	0005737	cellular_component	cytoplasm
Az	0005829	cellular_component	cytosol
Az	0006457	biological_process	protein folding
Az	0009314	biological_process	response to radiation
Az	0009408	biological_process	response to heat
Az	0016020	cellular_component	membrane
Az	0016853	molecular_function	isomerase activity
Az	0016887	molecular_function	ATP hydrolysis activity
Az	0019068	biological_process	virion assembly
Az	0042026	biological_process	protein refolding
Az	0042802	molecular_function	identical protein binding
Az	0051082	molecular_function	unfolded protein binding
Az	0051085	biological_process	chaperone cofactor-dependent protein refolding
Az	0140662	molecular_function	ATP-dependent protein folding chaperone
Az	1990220	cellular_component	GroEL-GroES complex
Ba	0005515	molecular_function	protein binding
Ba	0005524	molecular_function	ATP binding
Ba	0005737	cellular_component	cytoplasm
Ba	0005829	cellular_component	cytosol
Ba	0006457	biological_process	protein folding
Ba	0009408	biological_process	response to heat
Ba	0019068	biological_process	virion assembly
Ba	0042802	molecular_function	identical protein binding
Ba	0044183	molecular_function	protein folding chaperone
Ba	0046872	molecular_function	metal ion binding
Ba	0051082	molecular_function	unfolded protein binding
Ba	0051085	biological_process	chaperone cofactor-dependent protein refolding
Ba	0051087	molecular_function	protein-folding chaperone binding
Ba	1990220	cellular_component	GroEL-GroES complex
Bf	0000287	molecular_function	magnesium ion binding
Bf	0005515	molecular_function	protein binding
Bf	0005524	molecular_function	ATP binding
Bf	0005737	cellular_component	cytoplasm
Bf	0005829	cellular_component	cytosol
Bf	0006457	biological_process	protein folding
Bf	0009314	biological_process	response to radiation
Bf	0009408	biological_process	response to heat
Bf	0016020	cellular_component	membrane
Bf	0016853	molecular_function	isomerase activity
Bf	0016887	molecular_function	ATP hydrolysis activity
Bf	0019068	biological_process	virion assembly
Bf	0042026	biological_process	protein refolding
Bf	0042802	molecular_function	identical protein binding
Bf	0051082	molecular_function	unfolded protein binding
Bf	0051085	biological_process	chaperone cofactor-dependent protein refolding
Bf	0140662	molecular_function	ATP-dependent protein folding chaperone
Bf	1990220	cellular_component	GroEL-GroES complex
Bg	0000287	molecular_function	magnesium ion binding
Bg	0005515	molecular_function	protein binding
Bg	0005524	molecular_function	ATP binding
Bg	0005737	cellular_component	cytoplasm
Bg	0005829	cellular_component	cytosol
Bg	0006457	biological_process	protein folding
Bg	0009314	biological_process	response to radiation
Bg	0009408	biological_process	response to heat
Bg	0016020	cellular_component	membrane
Bg	0016853	molecular_function	isomerase activity
Bg	0016887	molecular_function	ATP hydrolysis activity
Bg	0019068	biological_process	virion assembly
Bg	0042026	biological_process	protein refolding
Bg	0042802	molecular_function	identical protein binding
Bg	0051082	molecular_function	unfolded protein binding
Bg	0051085	biological_process	chaperone cofactor-dependent protein refolding
Bg	0140662	molecular_function	ATP-dependent protein folding chaperone
Bg	1990220	cellular_component	GroEL-GroES complex
Bh	0005515	molecular_function	protein binding
Bh	0005524	molecular_function	ATP binding
Bh	0005737	cellular_component	cytoplasm
Bh	0005829	cellular_component	cytosol
Bh	0006457	biological_process	protein folding
Bh	0009408	biological_process	response to heat
Bh	0019068	biological_process	virion assembly
Bh	0042802	molecular_function	identical protein binding
Bh	0044183	molecular_function	protein folding chaperone
Bh	0046872	molecular_function	metal ion binding
Bh	0051082	molecular_function	unfolded protein binding
Bh	0051085	biological_process	chaperone cofactor-dependent protein refolding
Bh	0051087	molecular_function	protein-folding chaperone binding
Bh	1990220	cellular_component	GroEL-GroES complex
Bm	0000287	molecular_function	magnesium ion binding
Bm	0005515	molecular_function	protein binding
Bm	0005524	molecular_function	ATP binding
Bm	0005737	cellular_component	cytoplasm
Bm	0005829	cellular_component	cytosol
Bm	0006457	biological_process	protein folding
Bm	0009314	biological_process	response to radiation
Bm	0009408	biological_process	response to heat
Bm	0016020	cellular_component	membrane
Bm	0016853	molecular_function	isomerase activity
Bm	0016887	molecular_function	ATP hydrolysis activity
Bm	0019068	biological_process	virion assembly
Bm	0042026	biological_process	protein refolding
Bm	0042802	molecular_function	identical protein binding
Bm	0051082	molecular_function	unfolded protein binding
Bm	0051085	biological_process	chaperone cofactor-dependent protein refolding
Bm	0140662	molecular_function	ATP-dependent protein folding chaperone
Bm	1990220	cellular_component	GroEL-GroES complex
Bn	0000287	molecular_function	magnesium ion binding
Bn	0005515	molecular_function	protein binding
Bn	0005524	molecular_function	ATP binding
Bn	0005737	cellular_component	cytoplasm
Bn	0005829	cellular_component	cytosol
Bn	0006457	biological_process	protein folding
Bn	0009314	biological_process	response to radiation
Bn	0009408	biological_process	response to heat
Bn	0016020	cellular_component	membrane
Bn	0016853	molecular_function	isomerase activity
Bn	0016887	molecular_function	ATP hydrolysis activity
Bn	0019068	biological_process	virion assembly
Bn	0042026	biological_process	protein refolding
Bn	0042802	molecular_function	identical protein binding
Bn	0051082	molecular_function	unfolded protein binding
Bn	0051085	biological_process	chaperone cofactor-dependent protein refolding
Bn	0140662	molecular_function	ATP-dependent protein folding chaperone
Bn	1990220	cellular_component	GroEL-GroES complex
Bo	0005515	molecular_function	protein binding
Bo	0005524	molecular_function	ATP binding
Bo	0005737	cellular_component	cytoplasm
Bo	0005829	cellular_component	cytosol
Bo	0006457	biological_process	protein folding
Bo	0009408	biological_process	response to heat
Bo	0019068	biological_process	virion assembly
Bo	0042802	molecular_function	identical protein binding
Bo	0044183	molecular_function	protein folding chaperone
Bo	0046872	molecular_function	metal ion binding
Bo	0051082	molecular_function	unfolded protein binding
Bo	0051085	biological_process	chaperone cofactor-dependent protein refolding
Bo	0051087	molecular_function	protein-folding chaperone binding
Bo	1990220	cellular_component	GroEL-GroES complex
Bt	0000287	molecular_function	magnesium ion binding
Bt	0005515	molecular_function	protein binding
Bt	0005524	molecular_function	ATP binding
Bt	0005737	cellular_component	cytoplasm
Bt	0005829	cellular_component	cytosol
Bt	0006457	biological_process	protein folding
Bt	0009314	biological_process	response to radiation
Bt	0009408	biological_process	response to heat
Bt	0016020	cellular_component	membrane
Bt	0016853	molecular_function	isomerase activity
Bt	0016887	molecular_function	ATP hydrolysis activity
Bt	0019068	biological_process	virion assembly
Bt	0042026	biological_process	protein refolding
Bt	0042802	molecular_function	identical protein binding
Bt	0051082	molecular_function	unfolded protein binding
Bt	0051085	biological_process	chaperone cofactor-dependent protein refolding
Bt	0140662	molecular_function	ATP-dependent protein folding chaperone
Bt	1990220	cellular_component	GroEL-GroES complex
Bu	0000287	molecular_function	magnesium ion binding
Bu	0005515	molecular_function	protein binding
Bu	0005524	molecular_function	ATP binding
Bu	0005737	cellular_component	cytoplasm
Bu	0005829	cellular_component	cytosol
Bu	0006457	biological_process	protein folding
Bu	0009314	biological_process	response to radiation
Bu	0009408	biological_process	response to heat
Bu	0016020	cellular_component	membrane
Bu	0016853	molecular_function	isomerase activity
Bu	0016887	molecular_function	ATP hydrolysis activity
Bu	0019068	biological_process	virion assembly
Bu	0042026	biological_process	protein refolding
Bu	0042802	molecular_function	identical protein binding
Bu	0051082	molecular_function	unfolded protein binding
Bu	0051085	biological_process	chaperone cofactor-dependent protein refolding
Bu	0140662	molecular_function	ATP-dependent protein folding chaperone
Bu	1990220	cellular_component	GroEL-GroES complex
Bv	0005515	molecular_function	protein binding
Bv	0005524	molecular_function	ATP binding
Bv	0005737	cellular_component	cytoplasm
Bv	0005829	cellular_component	cytosol
Bv	0006457	biological_process	protein folding
Bv	0009408	biological_process	response to heat
Bv	0019068	biological_process	virion assembly
Bv	0042802	molecular_function	identical protein binding
Bv	0044183	molecular_function	protein folding chaperone
Bv	0046872	molecular_function	metal ion binding
Bv	0051082	molecular_function	unfolded protein binding
Bv	0051085	biological_process	chaperone cofactor-dependent protein refolding
Bv	0051087	molecular_function	protein-folding chaperone binding
Bv	1990220	cellular_component	GroEL-GroES complex

Functional Information from PROSITE/UniProt

site_id	PS00296
Number of Residues	12
Details	CHAPERONINS_CPN60 Chaperonins cpn60 signature. AAVEEGVVaGGG

Chain	Residue	Details
Ad	ALA405-GLY416

site_id	PS00681
Number of Residues	25
Details	CHAPERONINS_CPN10 Chaperonins cpn10 signature. IrPLhDRVIVKrkevetksaGgIVL

Chain	Residue	Details
Af	ILE3-LEU27

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	7
Details	MOD_RES: N6-succinyllysine => ECO:0000269\|PubMed:21151122

Chain	Residue	Details
Bv	LYS34
Bf	GLY415
Bf	ASN479
Bf	ASP495
Bg	THR30
Bg	ASP87
Bg	GLY415
Bg	ASN479
Bg	ASP495
Bm	THR30
Bm	ASP87
Bm	GLY415
Bm	ASN479
Bm	ASP495
Bn	THR30
Bn	ASP87
Bn	GLY415
Bn	ASN479
Bn	ASP495
Bt	THR30
Bt	ASP87
Bt	GLY415
Bt	ASN479
Bt	ASP495
Bu	THR30
Bu	ASP87
Bu	GLY415
Bu	ASN479
Bu	ASP495
Ae	GLY415
Ae	ASN479
Ae	ASP495
Ak	THR30
Ak	ASP87
Ak	GLY415
Ak	ASN479
Ak	ASP495
Al	THR30
Al	ASP87
Al	GLY415
Al	ASN479
Al	ASP495
Ar	THR30
Ar	ASP87
Ar	GLY415
Ar	ASN479
Ar	ASP495
As	THR30
As	ASP87
As	GLY415
As	ASN479
As	ASP495
Ay	THR30
Ay	ASP87
Ay	GLY415
Ay	ASN479
Ay	ASP495
Az	THR30
Az	ASP87
Az	GLY415
Az	ASN479
Az	ASP495
Bf	THR30
Bf	ASP87
Af	LYS34
Am	LYS34
At	LYS34
Ba	LYS34
Bh	LYS34
Bo	LYS34

site_id	SWS_FT_FI2
Number of Residues	14
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_00600, ECO:0000269\|PubMed:25174333, ECO:0000305\|PubMed:14517228, ECO:0000305\|PubMed:9285585, ECO:0007744\|PDB:1AON, ECO:0007744\|PDB:1PF9, ECO:0007744\|PDB:3WVL

Chain	Residue	Details
Ar	LYS51
As	LYS51
Ay	LYS51
Bf	LYS51
Bg	LYS51
Bm	LYS51
Bn	LYS51
Bt	LYS51
Bu	LYS51
Az	LYS51
Ad	LYS51
Ae	LYS51
Ak	LYS51
Al	LYS51

site_id	SWS_FT_FI3
Number of Residues	70
Details	MOD_RES: N6-succinyllysine => ECO:0000269\|PubMed:21151122

Chain	Residue	Details
Ak	LYS390
Al	LYS34
Al	LYS51
Al	LYS277
Al	LYS321
Al	LYS390
Ar	LYS34
Ar	LYS51
Ar	LYS277
Ar	LYS321
Ar	LYS390
As	LYS34
As	LYS51
As	LYS277
As	LYS321
As	LYS390
Ay	LYS34
Ay	LYS51
Ay	LYS277
Ay	LYS321
Ay	LYS390
Az	LYS34
Az	LYS51
Az	LYS277
Az	LYS321
Az	LYS390
Bf	LYS34
Bf	LYS51
Bf	LYS277
Bf	LYS321
Bf	LYS390
Bg	LYS34
Bg	LYS51
Bg	LYS277
Bg	LYS321
Bg	LYS390
Bm	LYS34
Bm	LYS51
Bm	LYS277
Bm	LYS321
Bm	LYS390
Bn	LYS34
Bn	LYS51
Bn	LYS277
Bn	LYS321
Bn	LYS390
Bt	LYS34
Bt	LYS51
Bt	LYS277
Bt	LYS321
Bt	LYS390
Bu	LYS34
Bu	LYS51
Bu	LYS277
Bu	LYS321
Bu	LYS390
Ad	LYS277
Ad	LYS321
Ad	LYS390
Ae	LYS34
Ae	LYS51
Ae	LYS277
Ae	LYS321
Ae	LYS390
Ak	LYS34
Ak	LYS51
Ak	LYS277
Ak	LYS321
Ad	LYS34
Ad	LYS51

site_id	SWS_FT_FI4
Number of Residues	14
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000269\|PubMed:21151122

Chain	Residue	Details
Bm	LYS117
Bn	LYS117
Bt	LYS117
Bu	LYS117
Ad	LYS117
Ae	LYS117
Ak	LYS117
Al	LYS117
Ar	LYS117
As	LYS117
Ay	LYS117
Az	LYS117
Bf	LYS117
Bg	LYS117

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		Validation report (PDF)