Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7OZN

RNA Polymerase II dimer (Class 1)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
A	0006351	biological_process	DNA-templated transcription
A	0006366	biological_process	transcription by RNA polymerase II
B	0000428	cellular_component	DNA-directed RNA polymerase complex
B	0001055	molecular_function	RNA polymerase II activity
B	0003677	molecular_function	DNA binding
B	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
B	0005665	cellular_component	RNA polymerase II, core complex
B	0006351	biological_process	DNA-templated transcription
B	0006366	biological_process	transcription by RNA polymerase II
B	0016779	molecular_function	nucleotidyltransferase activity
B	0032549	molecular_function	ribonucleoside binding
B	0034062	molecular_function	5'-3' RNA polymerase activity
B	0046872	molecular_function	metal ion binding
C	0003677	molecular_function	DNA binding
C	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
C	0006351	biological_process	DNA-templated transcription
C	0046983	molecular_function	protein dimerization activity
D	0000166	molecular_function	nucleotide binding
D	0006352	biological_process	DNA-templated transcription initiation
D	0030880	cellular_component	RNA polymerase complex
D	0044237	biological_process	cellular metabolic process
E	0001054	molecular_function	RNA polymerase I activity
E	0001055	molecular_function	RNA polymerase II activity
E	0001056	molecular_function	RNA polymerase III activity
E	0003677	molecular_function	DNA binding
E	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
E	0005634	cellular_component	nucleus
E	0005665	cellular_component	RNA polymerase II, core complex
E	0005666	cellular_component	RNA polymerase III complex
E	0005736	cellular_component	RNA polymerase I complex
E	0006351	biological_process	DNA-templated transcription
E	0006362	biological_process	transcription elongation by RNA polymerase I
E	0006366	biological_process	transcription by RNA polymerase II
E	0016591	cellular_component	RNA polymerase II, holoenzyme
E	0042797	biological_process	tRNA transcription by RNA polymerase III
F	0000428	cellular_component	DNA-directed RNA polymerase complex
F	0001650	cellular_component	fibrillar center
F	0003677	molecular_function	DNA binding
F	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005665	cellular_component	RNA polymerase II, core complex
F	0005666	cellular_component	RNA polymerase III complex
F	0005736	cellular_component	RNA polymerase I complex
F	0006351	biological_process	DNA-templated transcription
F	0006366	biological_process	transcription by RNA polymerase II
G	0003676	molecular_function	nucleic acid binding
G	0006351	biological_process	DNA-templated transcription
G	0006352	biological_process	DNA-templated transcription initiation
H	0000428	cellular_component	DNA-directed RNA polymerase complex
H	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
H	0005634	cellular_component	nucleus
H	0005665	cellular_component	RNA polymerase II, core complex
H	0006351	biological_process	DNA-templated transcription
I	0000428	cellular_component	DNA-directed RNA polymerase complex
I	0001193	biological_process	maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II
I	0003676	molecular_function	nucleic acid binding
I	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005665	cellular_component	RNA polymerase II, core complex
I	0005730	cellular_component	nucleolus
I	0006283	biological_process	transcription-coupled nucleotide-excision repair
I	0006351	biological_process	DNA-templated transcription
I	0006366	biological_process	transcription by RNA polymerase II
I	0006367	biological_process	transcription initiation at RNA polymerase II promoter
I	0008270	molecular_function	zinc ion binding
I	0016591	cellular_component	RNA polymerase II, holoenzyme
I	0046872	molecular_function	metal ion binding
J	0003677	molecular_function	DNA binding
J	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
J	0006351	biological_process	DNA-templated transcription
J	0008270	molecular_function	zinc ion binding
K	0000428	cellular_component	DNA-directed RNA polymerase complex
K	0001055	molecular_function	RNA polymerase II activity
K	0003677	molecular_function	DNA binding
K	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
K	0005634	cellular_component	nucleus
K	0005665	cellular_component	RNA polymerase II, core complex
K	0006351	biological_process	DNA-templated transcription
K	0006366	biological_process	transcription by RNA polymerase II
K	0016591	cellular_component	RNA polymerase II, holoenzyme
K	0046983	molecular_function	protein dimerization activity
L	0003677	molecular_function	DNA binding
L	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
L	0005634	cellular_component	nucleus
L	0005665	cellular_component	RNA polymerase II, core complex
L	0005666	cellular_component	RNA polymerase III complex
L	0005736	cellular_component	RNA polymerase I complex
L	0006351	biological_process	DNA-templated transcription
L	0006366	biological_process	transcription by RNA polymerase II
L	0008270	molecular_function	zinc ion binding
L	0046872	molecular_function	metal ion binding
M	0003677	molecular_function	DNA binding
M	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
M	0006351	biological_process	DNA-templated transcription
M	0006366	biological_process	transcription by RNA polymerase II
N	0000428	cellular_component	DNA-directed RNA polymerase complex
N	0001055	molecular_function	RNA polymerase II activity
N	0003677	molecular_function	DNA binding
N	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
N	0005665	cellular_component	RNA polymerase II, core complex
N	0006351	biological_process	DNA-templated transcription
N	0006366	biological_process	transcription by RNA polymerase II
N	0016779	molecular_function	nucleotidyltransferase activity
N	0032549	molecular_function	ribonucleoside binding
N	0034062	molecular_function	5'-3' RNA polymerase activity
N	0046872	molecular_function	metal ion binding
O	0003677	molecular_function	DNA binding
O	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
O	0006351	biological_process	DNA-templated transcription
O	0046983	molecular_function	protein dimerization activity
P	0000166	molecular_function	nucleotide binding
P	0006352	biological_process	DNA-templated transcription initiation
P	0030880	cellular_component	RNA polymerase complex
P	0044237	biological_process	cellular metabolic process
Q	0001054	molecular_function	RNA polymerase I activity
Q	0001055	molecular_function	RNA polymerase II activity
Q	0001056	molecular_function	RNA polymerase III activity
Q	0003677	molecular_function	DNA binding
Q	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
Q	0005634	cellular_component	nucleus
Q	0005665	cellular_component	RNA polymerase II, core complex
Q	0005666	cellular_component	RNA polymerase III complex
Q	0005736	cellular_component	RNA polymerase I complex
Q	0006351	biological_process	DNA-templated transcription
Q	0006362	biological_process	transcription elongation by RNA polymerase I
Q	0006366	biological_process	transcription by RNA polymerase II
Q	0016591	cellular_component	RNA polymerase II, holoenzyme
Q	0042797	biological_process	tRNA transcription by RNA polymerase III
R	0000428	cellular_component	DNA-directed RNA polymerase complex
R	0001650	cellular_component	fibrillar center
R	0003677	molecular_function	DNA binding
R	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005665	cellular_component	RNA polymerase II, core complex
R	0005666	cellular_component	RNA polymerase III complex
R	0005736	cellular_component	RNA polymerase I complex
R	0006351	biological_process	DNA-templated transcription
R	0006366	biological_process	transcription by RNA polymerase II
S	0003676	molecular_function	nucleic acid binding
S	0006351	biological_process	DNA-templated transcription
S	0006352	biological_process	DNA-templated transcription initiation
T	0000428	cellular_component	DNA-directed RNA polymerase complex
T	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
T	0005634	cellular_component	nucleus
T	0005665	cellular_component	RNA polymerase II, core complex
T	0006351	biological_process	DNA-templated transcription
U	0000428	cellular_component	DNA-directed RNA polymerase complex
U	0001193	biological_process	maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II
U	0003676	molecular_function	nucleic acid binding
U	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
U	0005634	cellular_component	nucleus
U	0005654	cellular_component	nucleoplasm
U	0005665	cellular_component	RNA polymerase II, core complex
U	0005730	cellular_component	nucleolus
U	0006283	biological_process	transcription-coupled nucleotide-excision repair
U	0006351	biological_process	DNA-templated transcription
U	0006366	biological_process	transcription by RNA polymerase II
U	0006367	biological_process	transcription initiation at RNA polymerase II promoter
U	0008270	molecular_function	zinc ion binding
U	0016591	cellular_component	RNA polymerase II, holoenzyme
U	0046872	molecular_function	metal ion binding
V	0003677	molecular_function	DNA binding
V	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
V	0006351	biological_process	DNA-templated transcription
V	0008270	molecular_function	zinc ion binding
W	0000428	cellular_component	DNA-directed RNA polymerase complex
W	0001055	molecular_function	RNA polymerase II activity
W	0003677	molecular_function	DNA binding
W	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
W	0005634	cellular_component	nucleus
W	0005665	cellular_component	RNA polymerase II, core complex
W	0006351	biological_process	DNA-templated transcription
W	0006366	biological_process	transcription by RNA polymerase II
W	0016591	cellular_component	RNA polymerase II, holoenzyme
W	0046983	molecular_function	protein dimerization activity
X	0003677	molecular_function	DNA binding
X	0003899	molecular_function	DNA-directed 5'-3' RNA polymerase activity
X	0005634	cellular_component	nucleus
X	0005665	cellular_component	RNA polymerase II, core complex
X	0005666	cellular_component	RNA polymerase III complex
X	0005736	cellular_component	RNA polymerase I complex
X	0006351	biological_process	DNA-templated transcription
X	0006366	biological_process	transcription by RNA polymerase II
X	0008270	molecular_function	zinc ion binding
X	0046872	molecular_function	metal ion binding

Functional Information from PROSITE/UniProt

site_id	PS00115
Number of Residues	7
Details	RNA_POL_II_REPEAT Eukaryotic RNA polymerase II heptapeptide repeat. YSPTSPA

Chain	Residue	Details
A	TYR1593-ALA1599
A	TYR1615-SER1621
A	TYR1622-SER1628
A	TYR1629-ASN1635
A	TYR1636-SER1642
A	TYR1643-SER1649
A	TYR1650-SER1656
A	TYR1657-SER1663
A	TYR1664-SER1670
A	TYR1671-SER1677
A	TYR1678-SER1684
A	TYR1685-SER1691
A	TYR1692-SER1698
A	TYR1699-SER1705
A	TYR1706-SER1712
A	TYR1713-SER1719
A	TYR1720-SER1726
A	TYR1727-SER1733
A	TYR1734-SER1740
A	TYR1741-ASN1747
A	TYR1748-ASN1754
A	TYR1755-SER1761
A	TYR1762-SER1768
A	TYR1769-ASN1775
A	TYR1776-ASN1782
A	TYR1783-SER1789
A	TYR1790-SER1796
A	TYR1797-SER1803
A	TYR1818-SER1824
A	TYR1825-SER1831
A	TYR1832-LYS1838
A	TYR1839-SER1845
A	TYR1853-LYS1859
A	TYR1860-LYS1866
A	TYR1867-LYS1873
A	TYR1874-THR1880
A	TYR1888-THR1894
A	TYR1902-LYS1908
A	TYR1909-THR1915
A	TYR1916-LYS1922
A	TYR1923-THR1929
A	TYR1930-LYS1936
A	TYR1947-THR1953

site_id	PS01112
Number of Residues	10
Details	RNA_POL_N_8KD RNA polymerases N / 8 Kd subunits signature. IIPVrCFTCG

Chain	Residue	Details
J	ILE2-GLY11

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YVCTAPH

Chain	Residue	Details
I	TYR112-HIS118

site_id	PS00466
Number of Residues	38
Details	ZF_TFIIS_1 Zinc finger TFIIS-type signature. CqkCghkeavffqSHSARaEDAmrlyyvCtaph.CghrW

Chain	Residue	Details
I	CYS86-TRP123

site_id	PS01030
Number of Residues	27
Details	RNA_POL_M_15KD RNA polymerases M / 15 Kd subunits signature. FCQECNNMLypkedkenrillyaCrnC

Chain	Residue	Details
I	PHE16-CYS42

site_id	PS01111
Number of Residues	15
Details	RNA_POL_K_14KD RNA polymerases K / 14 to 18 Kd subunits signature. TkYErARvLGtRAlQ

Chain	Residue	Details
F	THR58-GLN72

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DNDPSDYVEqdDI

Chain	Residue	Details
C	ASP136-ILE148

site_id	PS00446
Number of Residues	41
Details	RNA_POL_D_30KD RNA polymerases D / 30 to 40 Kd subunits signature. NSIRRvfiaevpiiAidwVqidaNsSvlhDEfIAhRLGLIP

Chain	Residue	Details
C	ASN32-PRO72

site_id	PS01154
Number of Residues	32
Details	RNA_POL_L_13KD RNA polymerases L / 13 to 16 Kd subunits signature. InkEdHTLgNiIksqLlkdpqVlfagYkvpHP

Chain	Residue	Details
K	ILE35-PRO66

site_id	PS01110
Number of Residues	14
Details	RNA_POL_H_23KD RNA polymerases H / 23 Kd subunits signature. HELVPEHvvMtkEE

Chain	Residue	Details
E	HIS142-GLU155

site_id	PS01166
Number of Residues	13
Details	RNA_POL_BETA RNA polymerases beta chain signature. GdKFASrHGQKGT

Chain	Residue	Details
B	GLY932-THR944

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	50
Details	ZN_FING: C4-type => ECO:0000255

Chain	Residue	Details
I	CYS17-CYS42
U	CYS17-CYS42

site_id	SWS_FT_FI2
Number of Residues	84
Details	ZN_FING: TFIIS-type => ECO:0000255\|PROSITE-ProRule:PRU00472

Chain	Residue	Details
U	GLU82-THR124
I	GLU82-THR124

site_id	SWS_FT_FI3
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255\|PROSITE-ProRule:PRU10145

Chain	Residue	Details
U	CYS17
U	CYS20
U	CYS39
U	CYS42
I	CYS17
I	CYS20
I	CYS39
I	CYS42

site_id	SWS_FT_FI4
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255\|PROSITE-ProRule:PRU00472

Chain	Residue	Details
U	CYS86
U	CYS89
U	CYS114
U	CYS119
I	CYS86
I	CYS89
I	CYS114
I	CYS119

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: N-acetylmethionine => ECO:0000250\|UniProtKB:P36954

Chain	Residue	Details
U	MET1
I	MET1

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)