Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7OCK

MAT in complex with SAMH

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016740	molecular_function	transferase activity
A	0016829	molecular_function	lyase activity
A	0047625	molecular_function	S-adenosyl-L-methionine lyase activity
B	0000287	molecular_function	magnesium ion binding
B	0004478	molecular_function	methionine adenosyltransferase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006556	biological_process	S-adenosylmethionine biosynthetic process
B	0006730	biological_process	one-carbon metabolic process
B	0016740	molecular_function	transferase activity
B	0030955	molecular_function	potassium ion binding
B	0033353	biological_process	S-adenosylmethionine cycle
B	0042802	molecular_function	identical protein binding
B	0046872	molecular_function	metal ion binding
C	0000287	molecular_function	magnesium ion binding
C	0004478	molecular_function	methionine adenosyltransferase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006556	biological_process	S-adenosylmethionine biosynthetic process
C	0006730	biological_process	one-carbon metabolic process
C	0016740	molecular_function	transferase activity
C	0030955	molecular_function	potassium ion binding
C	0033353	biological_process	S-adenosylmethionine cycle
C	0042802	molecular_function	identical protein binding
C	0046872	molecular_function	metal ion binding
D	0000287	molecular_function	magnesium ion binding
D	0004478	molecular_function	methionine adenosyltransferase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006556	biological_process	S-adenosylmethionine biosynthetic process
D	0006730	biological_process	one-carbon metabolic process
D	0016740	molecular_function	transferase activity
D	0030955	molecular_function	potassium ion binding
D	0033353	biological_process	S-adenosylmethionine cycle
D	0042802	molecular_function	identical protein binding
D	0046872	molecular_function	metal ion binding
E	0000287	molecular_function	magnesium ion binding
E	0004478	molecular_function	methionine adenosyltransferase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006556	biological_process	S-adenosylmethionine biosynthetic process
E	0006730	biological_process	one-carbon metabolic process
E	0016740	molecular_function	transferase activity
E	0030955	molecular_function	potassium ion binding
E	0033353	biological_process	S-adenosylmethionine cycle
E	0042802	molecular_function	identical protein binding
E	0046872	molecular_function	metal ion binding
F	0000287	molecular_function	magnesium ion binding
F	0004478	molecular_function	methionine adenosyltransferase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006556	biological_process	S-adenosylmethionine biosynthetic process
F	0006730	biological_process	one-carbon metabolic process
F	0016740	molecular_function	transferase activity
F	0030955	molecular_function	potassium ion binding
F	0033353	biological_process	S-adenosylmethionine cycle
F	0042802	molecular_function	identical protein binding
F	0046872	molecular_function	metal ion binding
G	0000287	molecular_function	magnesium ion binding
G	0004478	molecular_function	methionine adenosyltransferase activity
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006556	biological_process	S-adenosylmethionine biosynthetic process
G	0006730	biological_process	one-carbon metabolic process
G	0016740	molecular_function	transferase activity
G	0030955	molecular_function	potassium ion binding
G	0033353	biological_process	S-adenosylmethionine cycle
G	0042802	molecular_function	identical protein binding
G	0046872	molecular_function	metal ion binding
H	0000287	molecular_function	magnesium ion binding
H	0004478	molecular_function	methionine adenosyltransferase activity
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006556	biological_process	S-adenosylmethionine biosynthetic process
H	0006730	biological_process	one-carbon metabolic process
H	0016740	molecular_function	transferase activity
H	0030955	molecular_function	potassium ion binding
H	0033353	biological_process	S-adenosylmethionine cycle
H	0042802	molecular_function	identical protein binding
H	0046872	molecular_function	metal ion binding
I	0000287	molecular_function	magnesium ion binding
I	0004478	molecular_function	methionine adenosyltransferase activity
I	0005515	molecular_function	protein binding
I	0005524	molecular_function	ATP binding
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0006556	biological_process	S-adenosylmethionine biosynthetic process
I	0006730	biological_process	one-carbon metabolic process
I	0016740	molecular_function	transferase activity
I	0030955	molecular_function	potassium ion binding
I	0033353	biological_process	S-adenosylmethionine cycle
I	0042802	molecular_function	identical protein binding
I	0046872	molecular_function	metal ion binding
J	0016740	molecular_function	transferase activity
J	0016829	molecular_function	lyase activity
J	0047625	molecular_function	S-adenosyl-L-methionine lyase activity
K	0016740	molecular_function	transferase activity
K	0016829	molecular_function	lyase activity
K	0047625	molecular_function	S-adenosyl-L-methionine lyase activity
L	0016740	molecular_function	transferase activity
L	0016829	molecular_function	lyase activity
L	0047625	molecular_function	S-adenosyl-L-methionine lyase activity

Functional Information from PROSITE/UniProt

site_id	PS00376
Number of Residues	11
Details	ADOMET_SYNTHASE_1 S-adenosylmethionine synthase signature 1. GAGDQGlmfGY

Chain	Residue	Details
B	GLY115-TYR125

site_id	PS00377
Number of Residues	9
Details	ADOMET_SYNTHASE_2 S-adenosylmethionine synthase signature 2. GGGAFSgKD

Chain	Residue	Details
B	GLY258-ASP266

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	56
Details	BINDING: in other chain => ECO:0000255\|HAMAP-Rule:MF_00086, ECO:0000269\|PubMed:14967023, ECO:0007744\|PDB:1P7L, ECO:0007744\|PDB:1RG9

Chain	Residue	Details
E	ASP163
E	ARG229
E	ARG244
E	LYS269
F	HIS14
F	GLU55
F	GLN98
F	ASP163
F	ARG229
F	ARG244
F	LYS269
G	HIS14
G	GLU55
G	GLN98
G	ASP163
G	ARG229
G	ARG244
G	LYS269
H	HIS14
H	GLU55
H	GLN98
H	ASP163
H	ARG229
H	ARG244
H	LYS269
I	HIS14
I	GLU55
I	GLN98
I	ASP163
I	ARG229
I	ARG244
I	LYS269
B	HIS14
B	GLU55
B	GLN98
B	ASP163
B	ARG229
B	ARG244
B	LYS269
C	HIS14
C	GLU55
C	GLN98
C	ASP163
C	ARG229
C	ARG244
C	LYS269
D	HIS14
D	GLU55
D	GLN98
D	ASP163
D	ARG229
D	ARG244
D	LYS269
E	HIS14
E	GLU55
E	GLN98

site_id	SWS_FT_FI2
Number of Residues	24
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_00086, ECO:0000269\|PubMed:14967023, ECO:0007744\|PDB:1P7L, ECO:0007744\|PDB:1RG9

Chain	Residue	Details
B	ASP16
D	LYS265
E	ASP16
E	ALA261
E	LYS265
F	ASP16
F	ALA261
F	LYS265
G	ASP16
G	ALA261
G	LYS265
H	ASP16
H	ALA261
H	LYS265
I	ASP16
I	ALA261
I	LYS265
B	ALA261
B	LYS265
C	ASP16
C	ALA261
C	LYS265
D	ASP16
D	ALA261

site_id	SWS_FT_FI3
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_00086, ECO:0000269\|PubMed:14967023, ECO:0000305\|PubMed:7629147, ECO:0007744\|PDB:1MXC, ECO:0007744\|PDB:1P7L, ECO:0007744\|PDB:1RG9

Chain	Residue	Details
B	GLU42
C	GLU42
D	GLU42
E	GLU42
F	GLU42
G	GLU42
H	GLU42
I	GLU42

site_id	SWS_FT_FI4
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_00086, ECO:0000269\|PubMed:14967023, ECO:0007744\|PDB:1P7L

Chain	Residue	Details
B	ASP238
C	ASP238
D	ASP238
E	ASP238
F	ASP238
G	ASP238
H	ASP238
I	ASP238

site_id	SWS_FT_FI5
Number of Residues	8
Details	MOD_RES: N6-acetyllysine => ECO:0000269\|PubMed:18723842

Chain	Residue	Details
B	LYS2
C	LYS2
D	LYS2
E	LYS2
F	LYS2
G	LYS2
H	LYS2
I	LYS2

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)