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7NDT

UL40:01 TCR in complex with HLA-E with a non-natural amino acid

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
BBB0000139cellular_componentGolgi membrane
BBB0001913biological_processT cell mediated cytotoxicity
BBB0001916biological_processpositive regulation of T cell mediated cytotoxicity
BBB0002237biological_processresponse to molecule of bacterial origin
BBB0002474biological_processantigen processing and presentation of peptide antigen via MHC class I
BBB0002481biological_processantigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
BBB0002502biological_processpeptide antigen assembly with MHC class I protein complex
BBB0002503biological_processpeptide antigen assembly with MHC class II protein complex
BBB0002726biological_processpositive regulation of T cell cytokine production
BBB0005198molecular_functionstructural molecule activity
BBB0005515molecular_functionprotein binding
BBB0005576cellular_componentextracellular region
BBB0005615cellular_componentextracellular space
BBB0005765cellular_componentlysosomal membrane
BBB0005783cellular_componentendoplasmic reticulum
BBB0005788cellular_componentendoplasmic reticulum lumen
BBB0005794cellular_componentGolgi apparatus
BBB0005829cellular_componentcytosol
BBB0005886cellular_componentplasma membrane
BBB0005925cellular_componentfocal adhesion
BBB0006826biological_processiron ion transport
BBB0006879biological_processintracellular iron ion homeostasis
BBB0006955biological_processimmune response
BBB0007608biological_processsensory perception of smell
BBB0007611biological_processlearning or memory
BBB0009897cellular_componentexternal side of plasma membrane
BBB0009986cellular_componentcell surface
BBB0010977biological_processnegative regulation of neuron projection development
BBB0012507cellular_componentER to Golgi transport vesicle membrane
BBB0016020cellular_componentmembrane
BBB0019885biological_processantigen processing and presentation of endogenous peptide antigen via MHC class I
BBB0019886biological_processantigen processing and presentation of exogenous peptide antigen via MHC class II
BBB0023026molecular_functionMHC class II protein complex binding
BBB0030670cellular_componentphagocytic vesicle membrane
BBB0031901cellular_componentearly endosome membrane
BBB0031902cellular_componentlate endosome membrane
BBB0031905cellular_componentearly endosome lumen
BBB0032092biological_processpositive regulation of protein binding
BBB0033077biological_processT cell differentiation in thymus
BBB0034756biological_processregulation of iron ion transport
BBB0035580cellular_componentspecific granule lumen
BBB0042026biological_processprotein refolding
BBB0042605molecular_functionpeptide antigen binding
BBB0042612cellular_componentMHC class I protein complex
BBB0042613cellular_componentMHC class II protein complex
BBB0042802molecular_functionidentical protein binding
BBB0042803molecular_functionprotein homodimerization activity
BBB0042824cellular_componentMHC class I peptide loading complex
BBB0045646biological_processregulation of erythrocyte differentiation
BBB0048260biological_processpositive regulation of receptor-mediated endocytosis
BBB0050680biological_processnegative regulation of epithelial cell proliferation
BBB0050768biological_processnegative regulation of neurogenesis
BBB0050778biological_processpositive regulation of immune response
BBB0050870biological_processpositive regulation of T cell activation
BBB0051289biological_processprotein homotetramerization
BBB0055038cellular_componentrecycling endosome membrane
BBB0060586biological_processmulticellular organismal-level iron ion homeostasis
BBB0070062cellular_componentextracellular exosome
BBB0071281biological_processcellular response to iron ion
BBB0071283biological_processcellular response to iron(III) ion
BBB0071316biological_processcellular response to nicotine
BBB1900121biological_processnegative regulation of receptor binding
BBB1900122biological_processpositive regulation of receptor binding
BBB1904434biological_processpositive regulation of ferrous iron binding
BBB1904437biological_processpositive regulation of transferrin receptor binding
BBB1904724cellular_componenttertiary granule lumen
BBB1990000biological_processamyloid fibril formation
BBB1990712cellular_componentHFE-transferrin receptor complex
BBB2000774biological_processpositive regulation of cellular senescence
BBB2000978biological_processnegative regulation of forebrain neuron differentiation
GGG0000139cellular_componentGolgi membrane
GGG0001913biological_processT cell mediated cytotoxicity
GGG0001916biological_processpositive regulation of T cell mediated cytotoxicity
GGG0002237biological_processresponse to molecule of bacterial origin
GGG0002474biological_processantigen processing and presentation of peptide antigen via MHC class I
GGG0002481biological_processantigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
GGG0002502biological_processpeptide antigen assembly with MHC class I protein complex
GGG0002503biological_processpeptide antigen assembly with MHC class II protein complex
GGG0002726biological_processpositive regulation of T cell cytokine production
GGG0005198molecular_functionstructural molecule activity
GGG0005515molecular_functionprotein binding
GGG0005576cellular_componentextracellular region
GGG0005615cellular_componentextracellular space
GGG0005765cellular_componentlysosomal membrane
GGG0005783cellular_componentendoplasmic reticulum
GGG0005788cellular_componentendoplasmic reticulum lumen
GGG0005794cellular_componentGolgi apparatus
GGG0005829cellular_componentcytosol
GGG0005886cellular_componentplasma membrane
GGG0005925cellular_componentfocal adhesion
GGG0006826biological_processiron ion transport
GGG0006879biological_processintracellular iron ion homeostasis
GGG0006955biological_processimmune response
GGG0007608biological_processsensory perception of smell
GGG0007611biological_processlearning or memory
GGG0009897cellular_componentexternal side of plasma membrane
GGG0009986cellular_componentcell surface
GGG0010977biological_processnegative regulation of neuron projection development
GGG0012507cellular_componentER to Golgi transport vesicle membrane
GGG0016020cellular_componentmembrane
GGG0019885biological_processantigen processing and presentation of endogenous peptide antigen via MHC class I
GGG0019886biological_processantigen processing and presentation of exogenous peptide antigen via MHC class II
GGG0023026molecular_functionMHC class II protein complex binding
GGG0030670cellular_componentphagocytic vesicle membrane
GGG0031901cellular_componentearly endosome membrane
GGG0031902cellular_componentlate endosome membrane
GGG0031905cellular_componentearly endosome lumen
GGG0032092biological_processpositive regulation of protein binding
GGG0033077biological_processT cell differentiation in thymus
GGG0034756biological_processregulation of iron ion transport
GGG0035580cellular_componentspecific granule lumen
GGG0042026biological_processprotein refolding
GGG0042605molecular_functionpeptide antigen binding
GGG0042612cellular_componentMHC class I protein complex
GGG0042613cellular_componentMHC class II protein complex
GGG0042802molecular_functionidentical protein binding
GGG0042803molecular_functionprotein homodimerization activity
GGG0042824cellular_componentMHC class I peptide loading complex
GGG0045646biological_processregulation of erythrocyte differentiation
GGG0048260biological_processpositive regulation of receptor-mediated endocytosis
GGG0050680biological_processnegative regulation of epithelial cell proliferation
GGG0050768biological_processnegative regulation of neurogenesis
GGG0050778biological_processpositive regulation of immune response
GGG0050870biological_processpositive regulation of T cell activation
GGG0051289biological_processprotein homotetramerization
GGG0055038cellular_componentrecycling endosome membrane
GGG0060586biological_processmulticellular organismal-level iron ion homeostasis
GGG0070062cellular_componentextracellular exosome
GGG0071281biological_processcellular response to iron ion
GGG0071283biological_processcellular response to iron(III) ion
GGG0071316biological_processcellular response to nicotine
GGG1900121biological_processnegative regulation of receptor binding
GGG1900122biological_processpositive regulation of receptor binding
GGG1904434biological_processpositive regulation of ferrous iron binding
GGG1904437biological_processpositive regulation of transferrin receptor binding
GGG1904724cellular_componenttertiary granule lumen
GGG1990000biological_processamyloid fibril formation
GGG1990712cellular_componentHFE-transferrin receptor complex
GGG2000774biological_processpositive regulation of cellular senescence
GGG2000978biological_processnegative regulation of forebrain neuron differentiation
Functional Information from PROSITE/UniProt
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCHVQH
ChainResidueDetails
AAATYR261-HIS267
BBBTYR78-HIS84

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498
ChainResidueDetails
EEEASN198
JJJASN198
IIIASN24
IIIASN65

site_idSWS_FT_FI2
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498, ECO:0000269|PubMed:19349973
ChainResidueDetails
DDDASN161
DDDASN195
IIIASN161
IIIASN195

site_idSWS_FT_FI3
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498
ChainResidueDetails
DDDASN206
IIIASN206
BBBLYS48
BBBLYS58
BBBLYS91
BBBLYS94
GGGLYS19
GGGLYS41
GGGLYS48
GGGLYS58
GGGLYS91
GGGLYS94

site_idSWS_FT_FI4
Number of Residues14
DetailsBINDING: BINDING => ECO:0000269|PubMed:18339401
ChainResidueDetails
AAAASN77
AAATYR84
AAASER143
AAALYS146
AAAGLN156
AAATYR159
AAATYR171
FFFASN77
FFFTYR84
FFFSER143
FFFLYS146
FFFGLN156
FFFTYR159
FFFTYR171

site_idSWS_FT_FI5
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19349973
ChainResidueDetails
AAAASN86
FFFASN86

221051

PDB entries from 2024-06-12

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