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7N6Q

Structure of PPPA bound human ACAT2

Functional Information from GO Data
ChainGOidnamespacecontents
A0000062molecular_functionfatty-acyl-CoA binding
A0004772molecular_functionsterol O-acyltransferase activity
A0005515molecular_functionprotein binding
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005903cellular_componentbrush border
A0008203biological_processcholesterol metabolic process
A0008374molecular_functionO-acyltransferase activity
A0010742biological_processmacrophage derived foam cell differentiation
A0010878biological_processcholesterol storage
A0015485molecular_functioncholesterol binding
A0016020cellular_componentmembrane
A0016746molecular_functionacyltransferase activity
A0030299biological_processintestinal cholesterol absorption
A0033344biological_processcholesterol efflux
A0034379biological_processvery-low-density lipoprotein particle assembly
A0034383biological_processlow-density lipoprotein particle clearance
A0034736molecular_functioncholesterol O-acyltransferase activity
A0042632biological_processcholesterol homeostasis
B0000062molecular_functionfatty-acyl-CoA binding
B0004772molecular_functionsterol O-acyltransferase activity
B0005515molecular_functionprotein binding
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0005903cellular_componentbrush border
B0008203biological_processcholesterol metabolic process
B0008374molecular_functionO-acyltransferase activity
B0010742biological_processmacrophage derived foam cell differentiation
B0010878biological_processcholesterol storage
B0015485molecular_functioncholesterol binding
B0016020cellular_componentmembrane
B0016746molecular_functionacyltransferase activity
B0030299biological_processintestinal cholesterol absorption
B0033344biological_processcholesterol efflux
B0034379biological_processvery-low-density lipoprotein particle assembly
B0034383biological_processlow-density lipoprotein particle clearance
B0034736molecular_functioncholesterol O-acyltransferase activity
B0042632biological_processcholesterol homeostasis
C0000062molecular_functionfatty-acyl-CoA binding
C0004772molecular_functionsterol O-acyltransferase activity
C0005515molecular_functionprotein binding
C0005783cellular_componentendoplasmic reticulum
C0005789cellular_componentendoplasmic reticulum membrane
C0005903cellular_componentbrush border
C0008203biological_processcholesterol metabolic process
C0008374molecular_functionO-acyltransferase activity
C0010742biological_processmacrophage derived foam cell differentiation
C0010878biological_processcholesterol storage
C0015485molecular_functioncholesterol binding
C0016020cellular_componentmembrane
C0016746molecular_functionacyltransferase activity
C0030299biological_processintestinal cholesterol absorption
C0033344biological_processcholesterol efflux
C0034379biological_processvery-low-density lipoprotein particle assembly
C0034383biological_processlow-density lipoprotein particle clearance
C0034736molecular_functioncholesterol O-acyltransferase activity
C0042632biological_processcholesterol homeostasis
D0000062molecular_functionfatty-acyl-CoA binding
D0004772molecular_functionsterol O-acyltransferase activity
D0005515molecular_functionprotein binding
D0005783cellular_componentendoplasmic reticulum
D0005789cellular_componentendoplasmic reticulum membrane
D0005903cellular_componentbrush border
D0008203biological_processcholesterol metabolic process
D0008374molecular_functionO-acyltransferase activity
D0010742biological_processmacrophage derived foam cell differentiation
D0010878biological_processcholesterol storage
D0015485molecular_functioncholesterol binding
D0016020cellular_componentmembrane
D0016746molecular_functionacyltransferase activity
D0030299biological_processintestinal cholesterol absorption
D0033344biological_processcholesterol efflux
D0034379biological_processvery-low-density lipoprotein particle assembly
D0034383biological_processlow-density lipoprotein particle clearance
D0034736molecular_functioncholesterol O-acyltransferase activity
D0042632biological_processcholesterol homeostasis
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues84
DetailsTRANSMEM: Helical; Name=1 => ECO:0000250|UniProtKB:P35610
ChainResidueDetails
AARG121-ASP142
BARG121-ASP142
CARG121-ASP142
DARG121-ASP142

site_idSWS_FT_FI2
Number of Residues264
DetailsTOPO_DOM: Lumenal => ECO:0000305
ChainResidueDetails
APHE143-GLN162
AGLU221-SER228
ASER327-ALA343
AGLY443-VAL448
APRO503-THR522
BPHE143-GLN162
BGLU221-SER228
BSER327-ALA343
BGLY443-VAL448
BPRO503-THR522
CPHE143-GLN162
CGLU221-SER228
CSER327-ALA343
CGLY443-VAL448
CPRO503-THR522
DPHE143-GLN162
DGLU221-SER228
DSER327-ALA343
DGLY443-VAL448
DPRO503-THR522

site_idSWS_FT_FI3
Number of Residues100
DetailsTRANSMEM: Helical; Name=2 => ECO:0000250|UniProtKB:P35610
ChainResidueDetails
ALEU163-TRP188
BLEU163-TRP188
CLEU163-TRP188
DLEU163-TRP188

site_idSWS_FT_FI4
Number of Residues396
DetailsTOPO_DOM: Cytoplasmic => ECO:0000305
ChainResidueDetails
AALA189-ALA196
AGLY253-ARG293
ALEU370-ARG417
AHIS465-GLY470
BALA189-ALA196
BGLY253-ARG293
BLEU370-ARG417
BHIS465-GLY470
CALA189-ALA196
CGLY253-ARG293
CLEU370-ARG417
CHIS465-GLY470
DALA189-ALA196
DGLY253-ARG293
DLEU370-ARG417
DHIS465-GLY470

site_idSWS_FT_FI5
Number of Residues92
DetailsTRANSMEM: Helical; Name=3 => ECO:0000250|UniProtKB:P35610
ChainResidueDetails
ATHR197-VAL220
BTHR197-VAL220
CTHR197-VAL220
DTHR197-VAL220

site_idSWS_FT_FI6
Number of Residues92
DetailsTRANSMEM: Helical; Name=4 => ECO:0000250|UniProtKB:P35610
ChainResidueDetails
AARG229-PRO252
BARG229-PRO252
CARG229-PRO252
DARG229-PRO252

site_idSWS_FT_FI7
Number of Residues128
DetailsTRANSMEM: Helical; Name=5 => ECO:0000250|UniProtKB:P35610
ChainResidueDetails
ATRP294-MET326
BTRP294-MET326
CTRP294-MET326
DTRP294-MET326

site_idSWS_FT_FI8
Number of Residues100
DetailsTRANSMEM: Helical; Name=6 => ECO:0000250|UniProtKB:P35610
ChainResidueDetails
ATHR344-MET369
BTHR344-MET369
CTHR344-MET369
DTHR344-MET369

site_idSWS_FT_FI9
Number of Residues96
DetailsTRANSMEM: Helical; Name=7 => ECO:0000250|UniProtKB:P35610
ChainResidueDetails
AALA418-LEU442
BALA418-LEU442
CALA418-LEU442
DALA418-LEU442

site_idSWS_FT_FI10
Number of Residues60
DetailsTRANSMEM: Helical; Name=8 => ECO:0000250|UniProtKB:P35610
ChainResidueDetails
AMET449-MET464
BMET449-MET464
CMET449-MET464
DMET449-MET464

site_idSWS_FT_FI11
Number of Residues124
DetailsTRANSMEM: Helical; Name=9 => ECO:0000250|UniProtKB:P35610
ChainResidueDetails
APRO471-CYS502
BPRO471-CYS502
CPRO471-CYS502
DPRO471-CYS502

site_idSWS_FT_FI12
Number of Residues4
DetailsACT_SITE: ACT_SITE => ECO:0000305|PubMed:16647063
ChainResidueDetails
BHIS434
CHIS434
DHIS434
AHIS434

site_idSWS_FT_FI13
Number of Residues28
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P35610
ChainResidueDetails
AHIS399
ATYR407
ASER430
BHIS119
BASN389
BARG392
BASN395
BHIS399
BTYR407
BSER430
CHIS119
CASN389
CARG392
CASN395
CHIS399
CTYR407
CSER430
DHIS119
DASN389
DARG392
DASN395
DHIS399
DTYR407
DSER430
AASN389
AARG392
AASN395
AHIS119

site_idSWS_FT_FI14
Number of Residues4
DetailsMOD_RES: Cysteine sulfenic acid (-SOH); alternate => ECO:0000269|PubMed:28604676
ChainResidueDetails
ACYS277
BCYS277
CCYS277
DCYS277

site_idSWS_FT_FI15
Number of Residues8
DetailsCROSSLNK: Glycyl cysteine thioester (Cys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000269|PubMed:28604676
ChainResidueDetails
CCYS277
DCYS277
BCYS277
ACYS277

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PDB entries from 2024-06-12

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