7M2U

Nucleotide Excision Repair complex TFIIH Rad4-33

Functional Information from GO Data

Chain	GOid	namespace	contents
0	0000019	biological_process	regulation of mitotic recombination
0	0000112	cellular_component	nucleotide-excision repair factor 3 complex
0	0000439	cellular_component	transcription factor TFIIH core complex
0	0003676	molecular_function	nucleic acid binding
0	0003677	molecular_function	DNA binding
0	0003678	molecular_function	DNA helicase activity
0	0003684	molecular_function	damaged DNA binding
0	0004386	molecular_function	helicase activity
0	0005515	molecular_function	protein binding
0	0005524	molecular_function	ATP binding
0	0005634	cellular_component	nucleus
0	0005675	cellular_component	transcription factor TFIIH holo complex
0	0005829	cellular_component	cytosol
0	0006139	biological_process	nucleobase-containing compound metabolic process
0	0006281	biological_process	DNA repair
0	0006289	biological_process	nucleotide-excision repair
0	0006366	biological_process	transcription by RNA polymerase II
0	0006367	biological_process	transcription initiation at RNA polymerase II promoter
0	0006974	biological_process	DNA damage response
0	0008094	molecular_function	ATP-dependent activity, acting on DNA
0	0016787	molecular_function	hydrolase activity
0	0016818	molecular_function	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
0	0016887	molecular_function	ATP hydrolysis activity
0	0032508	biological_process	DNA duplex unwinding
0	0032991	cellular_component	protein-containing complex
0	0043139	molecular_function	5'-3' DNA helicase activity
0	0043229	cellular_component	intracellular organelle
0	0045951	biological_process	positive regulation of mitotic recombination
0	0046872	molecular_function	metal ion binding
0	0051539	molecular_function	4 iron, 4 sulfur cluster binding
0	0071840	biological_process	cellular component organization or biogenesis
1	0000112	cellular_component	nucleotide-excision repair factor 3 complex
1	0000439	cellular_component	transcription factor TFIIH core complex
1	0005515	molecular_function	protein binding
1	0005634	cellular_component	nucleus
1	0005675	cellular_component	transcription factor TFIIH holo complex
1	0005829	cellular_component	cytosol
1	0006281	biological_process	DNA repair
1	0006289	biological_process	nucleotide-excision repair
1	0006351	biological_process	DNA-templated transcription
1	0006360	biological_process	transcription by RNA polymerase I
1	0006366	biological_process	transcription by RNA polymerase II
1	0006367	biological_process	transcription initiation at RNA polymerase II promoter
1	0010314	molecular_function	phosphatidylinositol-5-phosphate binding
1	0032266	molecular_function	phosphatidylinositol-3-phosphate binding
2	0000112	cellular_component	nucleotide-excision repair factor 3 complex
2	0000439	cellular_component	transcription factor TFIIH core complex
2	0001671	molecular_function	ATPase activator activity
2	0003690	molecular_function	double-stranded DNA binding
2	0005515	molecular_function	protein binding
2	0005634	cellular_component	nucleus
2	0005675	cellular_component	transcription factor TFIIH holo complex
2	0006281	biological_process	DNA repair
2	0006289	biological_process	nucleotide-excision repair
2	0006366	biological_process	transcription by RNA polymerase II
2	0006367	biological_process	transcription initiation at RNA polymerase II promoter
4	0000112	cellular_component	nucleotide-excision repair factor 3 complex
4	0000439	cellular_component	transcription factor TFIIH core complex
4	0005634	cellular_component	nucleus
4	0005675	cellular_component	transcription factor TFIIH holo complex
4	0006281	biological_process	DNA repair
4	0006289	biological_process	nucleotide-excision repair
4	0006355	biological_process	regulation of DNA-templated transcription
4	0006366	biological_process	transcription by RNA polymerase II
4	0006367	biological_process	transcription initiation at RNA polymerase II promoter
4	0008270	molecular_function	zinc ion binding
4	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
4	0046872	molecular_function	metal ion binding
5	0000439	cellular_component	transcription factor TFIIH core complex
5	0000993	molecular_function	RNA polymerase II complex binding
5	0005515	molecular_function	protein binding
5	0005634	cellular_component	nucleus
5	0005675	cellular_component	transcription factor TFIIH holo complex
5	0005829	cellular_component	cytosol
5	0006281	biological_process	DNA repair
5	0006289	biological_process	nucleotide-excision repair
5	0006294	biological_process	nucleotide-excision repair, preincision complex assembly
5	0006366	biological_process	transcription by RNA polymerase II
5	0006367	biological_process	transcription initiation at RNA polymerase II promoter
6	0000112	cellular_component	nucleotide-excision repair factor 3 complex
6	0000439	cellular_component	transcription factor TFIIH core complex
6	0005634	cellular_component	nucleus
6	0005675	cellular_component	transcription factor TFIIH holo complex
6	0006281	biological_process	DNA repair
6	0006289	biological_process	nucleotide-excision repair
6	0006351	biological_process	DNA-templated transcription
6	0006357	biological_process	regulation of transcription by RNA polymerase II
6	0006366	biological_process	transcription by RNA polymerase II
6	0006367	biological_process	transcription initiation at RNA polymerase II promoter
6	0008270	molecular_function	zinc ion binding
6	0046872	molecular_function	metal ion binding
6	0061630	molecular_function	ubiquitin protein ligase activity
7	0000019	biological_process	regulation of mitotic recombination
7	0000112	cellular_component	nucleotide-excision repair factor 3 complex
7	0000439	cellular_component	transcription factor TFIIH core complex
7	0001111	biological_process	RNA polymerase II promoter clearance
7	0001113	biological_process	transcription open complex formation at RNA polymerase II promoter
7	0001174	biological_process	transcriptional start site selection at RNA polymerase II promoter
7	0003677	molecular_function	DNA binding
7	0003678	molecular_function	DNA helicase activity
7	0004386	molecular_function	helicase activity
7	0005524	molecular_function	ATP binding
7	0005634	cellular_component	nucleus
7	0005675	cellular_component	transcription factor TFIIH holo complex
7	0005829	cellular_component	cytosol
7	0006281	biological_process	DNA repair
7	0006289	biological_process	nucleotide-excision repair
7	0006366	biological_process	transcription by RNA polymerase II
7	0006367	biological_process	transcription initiation at RNA polymerase II promoter
7	0015616	molecular_function	DNA translocase activity
7	0016787	molecular_function	hydrolase activity
7	0016853	molecular_function	isomerase activity
7	0016887	molecular_function	ATP hydrolysis activity
7	0016973	biological_process	poly(A)+ mRNA export from nucleus
7	0032508	biological_process	DNA duplex unwinding
7	0043138	molecular_function	3'-5' DNA helicase activity
7	0097550	cellular_component	transcription preinitiation complex
A	0000111	cellular_component	nucleotide-excision repair factor 2 complex
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0000715	biological_process	nucleotide-excision repair, DNA damage recognition
A	0003677	molecular_function	DNA binding
A	0003684	molecular_function	damaged DNA binding
A	0003697	molecular_function	single-stranded DNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006265	biological_process	DNA topological change
A	0006281	biological_process	DNA repair
A	0006289	biological_process	nucleotide-excision repair
A	0006298	biological_process	mismatch repair
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0071942	cellular_component	XPC complex
A	1990165	molecular_function	single-strand break-containing DNA binding
E	0003674	molecular_function	molecular_function
E	0005634	cellular_component	nucleus
E	0006281	biological_process	DNA repair
E	0006289	biological_process	nucleotide-excision repair

Functional Information from PROSITE/UniProt

site_id	PS00028
Number of Residues	21
Details	ZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. Ced..CkqeFcvdcdvfiHeil..H

Chain	Residue	Details
6	CYS429-HIS449

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site_id	PS00690
Number of Residues	10
Details	DEAH_ATP_HELICASE DEAH-box subfamily ATP-dependent helicases signature. SiVIFDEAHN

Chain	Residue	Details
0	SER230-ASN239

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: N-acetylserine => ECO:0007744|PubMed:22814378

Chain	Residue	Details
E	SER2

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site_id	SWS_FT_FI2
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0007744|PubMed:22106047

Chain	Residue	Details
E	LYS19
0	CYS133
0	CYS156
0	CYS191

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