7LG1

Cryo-EM structure of human cGMP-bound CNGA1_E365Q channel in Na+/Ca2+

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0055085	biological_process	transmembrane transport
B	0005216	molecular_function	monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0055085	biological_process	transmembrane transport
C	0005216	molecular_function	monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0055085	biological_process	transmembrane transport
D	0005216	molecular_function	monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0055085	biological_process	transmembrane transport

Functional Information from PROSITE/UniProt

site_id	PS00888
Number of Residues	17
Details	CNMP_BINDING_1 Cyclic nucleotide-binding domain signature 1. ICkKGDiGReMYIIkeG

Chain	Residue	Details
A	ILE506-GLY522

---

site_id	PS00889
Number of Residues	24
Details	CNMP_BINDING_2 Cyclic nucleotide-binding domain signature 2. FGEiSIlnikgskagnrRTAnIkS

Chain	Residue	Details
A	PHE544-SER567

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	84
Details	TRANSMEM: Helical; Name=S1 => ECO:0000269|PubMed:34699778, ECO:0007744|PDB:7RH9

Chain	Residue	Details
A	TYR166-ALA187
B	TYR166-ALA187
C	TYR166-ALA187
D	TYR166-ALA187

---

site_id	SWS_FT_FI2
Number of Residues	280
Details	TOPO_DOM: Extracellular => ECO:0000305

Chain	Residue	Details
D	PHE318-TYR375
A	CYS188-LEU197
D	CYS188-LEU197
D	LEU263-TYR267
A	LEU263-TYR267
A	PHE318-TYR375
B	CYS188-LEU197
B	LEU263-TYR267
B	PHE318-TYR375
C	CYS188-LEU197
C	LEU263-TYR267
C	PHE318-TYR375

---

site_id	SWS_FT_FI3
Number of Residues	80
Details	TRANSMEM: Helical; Name=S2 => ECO:0000269|PubMed:34699778, ECO:0007744|PDB:7RH9

Chain	Residue	Details
A	GLU198-ARG218
B	GLU198-ARG218
C	GLU198-ARG218
D	GLU198-ARG218

---

site_id	SWS_FT_FI4
Number of Residues	1260
Details	TOPO_DOM: Cytoplasmic => ECO:0000305

Chain	Residue	Details
D	SER401-PRO686
A	THR219-ASN243
D	THR219-ASN243
D	ARG287-ASN293
A	ARG287-ASN293
A	SER401-PRO686
B	THR219-ASN243
B	ARG287-ASN293
B	SER401-PRO686
C	THR219-ASN243
C	ARG287-ASN293
C	SER401-PRO686

---

site_id	SWS_FT_FI5
Number of Residues	72
Details	TRANSMEM: Helical; Name=S3 => ECO:0000269|PubMed:34699778, ECO:0007744|PDB:7RH9

Chain	Residue	Details
A	LEU244-LYS262
B	LEU244-LYS262
C	LEU244-LYS262
D	LEU244-LYS262

---

site_id	SWS_FT_FI6
Number of Residues	72
Details	TRANSMEM: Helical; Name=S4 => ECO:0000269|PubMed:34699778, ECO:0007744|PDB:7RH9

Chain	Residue	Details
A	PRO268-GLN286
B	PRO268-GLN286
C	PRO268-GLN286
D	PRO268-GLN286

---

site_id	SWS_FT_FI7
Number of Residues	92
Details	TRANSMEM: Helical; Name=S5 => ECO:0000269|PubMed:34699778, ECO:0007744|PDB:7RH9

Chain	Residue	Details
A	TYR294-VAL317
B	TYR294-VAL317
C	TYR294-VAL317
D	TYR294-VAL317

---

site_id	SWS_FT_FI8
Number of Residues	96
Details	TRANSMEM: Helical; Name=S6 => ECO:0000269|PubMed:34699778, ECO:0007744|PDB:7RH9

Chain	Residue	Details
A	VAL376-ILE400
B	VAL376-ILE400
C	VAL376-ILE400
D	VAL376-ILE400

---

site_id	SWS_FT_FI9
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269|PubMed:34699778, ECO:0007744|PDB:7RHH

Chain	Residue	Details
A	ALA557
D	GLY541
D	PHE544
D	ALA557
D	GLY558
A	GLY541
C	PHE544
C	ALA557
C	GLY558
A	PHE544
A	GLY558
B	GLY541
B	PHE544
B	ALA557
B	GLY558
C	GLY541

---

site_id	SWS_FT_FI10
Number of Residues	8
Details	SITE: Central gate => ECO:0000305|PubMed:34699778

Chain	Residue	Details
C	GLY385
C	PHE389
D	GLY385
D	PHE389
B	GLY385
B	PHE389
A	GLY385
A	PHE389

---

site_id	SWS_FT_FI11
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000250|UniProtKB:Q00194

Chain	Residue	Details
A	ILE325
B	ILE325
C	ILE325
D	ILE325

---