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7LDD

native AMPA receptor

Functional Information from GO Data
ChainGOidnamespacecontents
A0005216molecular_functionmonoatomic ion channel activity
A0006811biological_processmonoatomic ion transport
A0015276molecular_functionligand-gated monoatomic ion channel activity
A0016020cellular_componentmembrane
A0038023molecular_functionsignaling receptor activity
B0005216molecular_functionmonoatomic ion channel activity
B0006811biological_processmonoatomic ion transport
B0015276molecular_functionligand-gated monoatomic ion channel activity
B0016020cellular_componentmembrane
B0038023molecular_functionsignaling receptor activity
C0005216molecular_functionmonoatomic ion channel activity
C0006811biological_processmonoatomic ion transport
C0015276molecular_functionligand-gated monoatomic ion channel activity
C0016020cellular_componentmembrane
C0038023molecular_functionsignaling receptor activity
D0005216molecular_functionmonoatomic ion channel activity
D0006811biological_processmonoatomic ion transport
D0015276molecular_functionligand-gated monoatomic ion channel activity
D0016020cellular_componentmembrane
D0038023molecular_functionsignaling receptor activity
E0005515molecular_functionprotein binding
E0005783cellular_componentendoplasmic reticulum
E0005789cellular_componentendoplasmic reticulum membrane
E0005886cellular_componentplasma membrane
E0014069cellular_componentpostsynaptic density
E0016192biological_processvesicle-mediated transport
E0016247molecular_functionchannel regulator activity
E0030425cellular_componentdendrite
E0032281cellular_componentAMPA glutamate receptor complex
E0035249biological_processsynaptic transmission, glutamatergic
E0042391biological_processregulation of membrane potential
E0042995cellular_componentcell projection
E0043197cellular_componentdendritic spine
E0043198cellular_componentdendritic shaft
E0045202cellular_componentsynapse
E0045211cellular_componentpostsynaptic membrane
E0051668biological_processlocalization within membrane
E0098839cellular_componentpostsynaptic density membrane
E0098978cellular_componentglutamatergic synapse
E1902684biological_processnegative regulation of receptor localization to synapse
E1903743biological_processnegative regulation of anterograde synaptic vesicle transport
E2000311biological_processregulation of AMPA receptor activity
F0005515molecular_functionprotein binding
F0005783cellular_componentendoplasmic reticulum
F0005789cellular_componentendoplasmic reticulum membrane
F0005886cellular_componentplasma membrane
F0014069cellular_componentpostsynaptic density
F0016192biological_processvesicle-mediated transport
F0016247molecular_functionchannel regulator activity
F0030425cellular_componentdendrite
F0032281cellular_componentAMPA glutamate receptor complex
F0035249biological_processsynaptic transmission, glutamatergic
F0042391biological_processregulation of membrane potential
F0042995cellular_componentcell projection
F0043197cellular_componentdendritic spine
F0043198cellular_componentdendritic shaft
F0045202cellular_componentsynapse
F0045211cellular_componentpostsynaptic membrane
F0051668biological_processlocalization within membrane
F0098839cellular_componentpostsynaptic density membrane
F0098978cellular_componentglutamatergic synapse
F1902684biological_processnegative regulation of receptor localization to synapse
F1903743biological_processnegative regulation of anterograde synaptic vesicle transport
F2000311biological_processregulation of AMPA receptor activity
G0005245molecular_functionvoltage-gated calcium channel activity
G0005246molecular_functioncalcium channel regulator activity
G0005262molecular_functioncalcium channel activity
G0005515molecular_functionprotein binding
G0005886cellular_componentplasma membrane
G0006816biological_processcalcium ion transport
G0014069cellular_componentpostsynaptic density
G0016020cellular_componentmembrane
G0016247molecular_functionchannel regulator activity
G0019226biological_processtransmission of nerve impulse
G0030346molecular_functionprotein phosphatase 2B binding
G0032281cellular_componentAMPA glutamate receptor complex
G0032590cellular_componentdendrite membrane
G0034702cellular_componentmonoatomic ion channel complex
G0035255molecular_functionionotropic glutamate receptor binding
G0045202cellular_componentsynapse
G0045211cellular_componentpostsynaptic membrane
G0051968biological_processpositive regulation of synaptic transmission, glutamatergic
G0070588biological_processcalcium ion transmembrane transport
G0098685cellular_componentSchaffer collateral - CA1 synapse
G0098839cellular_componentpostsynaptic density membrane
G0098943biological_processneurotransmitter receptor transport, postsynaptic endosome to lysosome
G0098970biological_processpostsynaptic neurotransmitter receptor diffusion trapping
G0098978cellular_componentglutamatergic synapse
G0099072biological_processregulation of postsynaptic membrane neurotransmitter receptor levels
G0099590biological_processneurotransmitter receptor internalization
G1990454cellular_componentL-type voltage-gated calcium channel complex
G2000311biological_processregulation of AMPA receptor activity
H0005245molecular_functionvoltage-gated calcium channel activity
H0005246molecular_functioncalcium channel regulator activity
H0005262molecular_functioncalcium channel activity
H0005515molecular_functionprotein binding
H0005886cellular_componentplasma membrane
H0006816biological_processcalcium ion transport
H0014069cellular_componentpostsynaptic density
H0016020cellular_componentmembrane
H0016247molecular_functionchannel regulator activity
H0019226biological_processtransmission of nerve impulse
H0030346molecular_functionprotein phosphatase 2B binding
H0032281cellular_componentAMPA glutamate receptor complex
H0032590cellular_componentdendrite membrane
H0034702cellular_componentmonoatomic ion channel complex
H0035255molecular_functionionotropic glutamate receptor binding
H0045202cellular_componentsynapse
H0045211cellular_componentpostsynaptic membrane
H0051968biological_processpositive regulation of synaptic transmission, glutamatergic
H0070588biological_processcalcium ion transmembrane transport
H0098685cellular_componentSchaffer collateral - CA1 synapse
H0098839cellular_componentpostsynaptic density membrane
H0098943biological_processneurotransmitter receptor transport, postsynaptic endosome to lysosome
H0098970biological_processpostsynaptic neurotransmitter receptor diffusion trapping
H0098978cellular_componentglutamatergic synapse
H0099072biological_processregulation of postsynaptic membrane neurotransmitter receptor levels
H0099590biological_processneurotransmitter receptor internalization
H1990454cellular_componentL-type voltage-gated calcium channel complex
H2000311biological_processregulation of AMPA receptor activity
Functional Information from PROSITE/UniProt
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH
ChainResidueDetails
JTYR193-HIS199

site_idPS01340
Number of Residues15
DetailsCORNICHON Cornichon family signature. IafdELrtDFkNPID
ChainResidueDetails
EILE29-ASP43

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1384
DetailsTOPO_DOM: Extracellular => ECO:0000250
ChainResidueDetails
BASN4-ALA522
BTHR617-ASN791
DASN4-ALA522
DTHR617-ASN791
GVAL318-GLY338
HVAL19-ILE39
HSER127-ALA147
HILE157-ILE177
HPHE207-ILE227
HVAL318-GLY338

site_idSWS_FT_FI2
Number of Residues80
DetailsTRANSMEM: Helical => ECO:0000250
ChainResidueDetails
BTYR523-VAL543
BLEU596-TYR616
DTYR523-VAL543
DLEU596-TYR616
FSER73-LEU93
FLEU139-SER159

site_idSWS_FT_FI3
Number of Residues160
DetailsTOPO_DOM: Cytoplasmic => ECO:0000250
ChainResidueDetails
BSER544-GLU570
BASP590-SER595
BGLU813-ILE862
DSER544-GLU570
DASP590-SER595
DGLU813-ILE862

site_idSWS_FT_FI4
Number of Residues30
DetailsINTRAMEM: Helical; Pore-forming => ECO:0000250
ChainResidueDetails
BPHE571-ARG586
DPHE571-ARG586

site_idSWS_FT_FI5
Number of Residues4
DetailsINTRAMEM: INTRAMEM => ECO:0000250
ChainResidueDetails
BGLN587-CYS589
DGLN587-CYS589

site_idSWS_FT_FI6
Number of Residues40
DetailsTRANSMEM: Helical; Name=M4 => ECO:0000250
ChainResidueDetails
BVAL792-ILE812
DVAL792-ILE812

site_idSWS_FT_FI7
Number of Residues6
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
CPRO474
CARG481
CSER650
CGLU701
BTYR450
BARG485
BGLU705
DTYR450
DARG485
DGLU705

site_idSWS_FT_FI8
Number of Residues2
DetailsMOD_RES: Phosphoserine; by PKC => ECO:0000250|UniProtKB:P19491
ChainResidueDetails
BSER662
DSER662
ASER831
CSER627
CSER692
CSER831

site_idSWS_FT_FI9
Number of Residues2
DetailsMOD_RES: Phosphoserine; by PKG => ECO:0000250|UniProtKB:P19491
ChainResidueDetails
BSER696
DSER696

site_idSWS_FT_FI10
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:21183079
ChainResidueDetails
BSER839
BSER842
DSER839
DSER842

site_idSWS_FT_FI11
Number of Residues2
DetailsMOD_RES: Phosphotyrosine => ECO:0000269|PubMed:15240807
ChainResidueDetails
BTYR855
DTYR855
AASN239
AASN345
AASN383
AASN388
CASN45
CASN231
CASN239
CASN345
CASN383
CASN388

site_idSWS_FT_FI12
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:10501226
ChainResidueDetails
BSER859
DSER859

site_idSWS_FT_FI13
Number of Residues4
DetailsLIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:16129400
ChainResidueDetails
BCYS589
BCYS815
DCYS589
DCYS815

site_idSWS_FT_FI14
Number of Residues8
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
BASN235
BASN349
BASN385
BASN392
DASN235
DASN349
DASN385
DASN392

220472

PDB entries from 2024-05-29

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