Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7KON

Structure of upper Tn Ca2+ free (rotated) and lower Tn Ca2+ bound cardiac native thin filament at pCa=5.8

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001725	cellular_component	stress fiber
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005856	cellular_component	cytoskeleton
A	0005865	cellular_component	striated muscle thin filament
A	0005884	cellular_component	actin filament
A	0010628	biological_process	positive regulation of gene expression
A	0016787	molecular_function	hydrolase activity
A	0030027	cellular_component	lamellipodium
A	0030175	cellular_component	filopodium
A	0030240	biological_process	skeletal muscle thin filament assembly
A	0044297	cellular_component	cell body
A	0048741	biological_process	skeletal muscle fiber development
A	0090131	biological_process	mesenchyme migration
B	0001725	cellular_component	stress fiber
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005856	cellular_component	cytoskeleton
B	0005865	cellular_component	striated muscle thin filament
B	0005884	cellular_component	actin filament
B	0010628	biological_process	positive regulation of gene expression
B	0016787	molecular_function	hydrolase activity
B	0030027	cellular_component	lamellipodium
B	0030175	cellular_component	filopodium
B	0030240	biological_process	skeletal muscle thin filament assembly
B	0044297	cellular_component	cell body
B	0048741	biological_process	skeletal muscle fiber development
B	0090131	biological_process	mesenchyme migration
C	0001725	cellular_component	stress fiber
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005856	cellular_component	cytoskeleton
C	0005865	cellular_component	striated muscle thin filament
C	0005884	cellular_component	actin filament
C	0010628	biological_process	positive regulation of gene expression
C	0016787	molecular_function	hydrolase activity
C	0030027	cellular_component	lamellipodium
C	0030175	cellular_component	filopodium
C	0030240	biological_process	skeletal muscle thin filament assembly
C	0044297	cellular_component	cell body
C	0048741	biological_process	skeletal muscle fiber development
C	0090131	biological_process	mesenchyme migration
D	0001725	cellular_component	stress fiber
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005856	cellular_component	cytoskeleton
D	0005865	cellular_component	striated muscle thin filament
D	0005884	cellular_component	actin filament
D	0010628	biological_process	positive regulation of gene expression
D	0016787	molecular_function	hydrolase activity
D	0030027	cellular_component	lamellipodium
D	0030175	cellular_component	filopodium
D	0030240	biological_process	skeletal muscle thin filament assembly
D	0044297	cellular_component	cell body
D	0048741	biological_process	skeletal muscle fiber development
D	0090131	biological_process	mesenchyme migration
E	0001725	cellular_component	stress fiber
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005856	cellular_component	cytoskeleton
E	0005865	cellular_component	striated muscle thin filament
E	0005884	cellular_component	actin filament
E	0010628	biological_process	positive regulation of gene expression
E	0016787	molecular_function	hydrolase activity
E	0030027	cellular_component	lamellipodium
E	0030175	cellular_component	filopodium
E	0030240	biological_process	skeletal muscle thin filament assembly
E	0044297	cellular_component	cell body
E	0048741	biological_process	skeletal muscle fiber development
E	0090131	biological_process	mesenchyme migration
F	0001725	cellular_component	stress fiber
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0005856	cellular_component	cytoskeleton
F	0005865	cellular_component	striated muscle thin filament
F	0005884	cellular_component	actin filament
F	0010628	biological_process	positive regulation of gene expression
F	0016787	molecular_function	hydrolase activity
F	0030027	cellular_component	lamellipodium
F	0030175	cellular_component	filopodium
F	0030240	biological_process	skeletal muscle thin filament assembly
F	0044297	cellular_component	cell body
F	0048741	biological_process	skeletal muscle fiber development
F	0090131	biological_process	mesenchyme migration
G	0001725	cellular_component	stress fiber
G	0005524	molecular_function	ATP binding
G	0005737	cellular_component	cytoplasm
G	0005856	cellular_component	cytoskeleton
G	0005865	cellular_component	striated muscle thin filament
G	0005884	cellular_component	actin filament
G	0010628	biological_process	positive regulation of gene expression
G	0016787	molecular_function	hydrolase activity
G	0030027	cellular_component	lamellipodium
G	0030175	cellular_component	filopodium
G	0030240	biological_process	skeletal muscle thin filament assembly
G	0044297	cellular_component	cell body
G	0048741	biological_process	skeletal muscle fiber development
G	0090131	biological_process	mesenchyme migration
H	0001725	cellular_component	stress fiber
H	0005524	molecular_function	ATP binding
H	0005737	cellular_component	cytoplasm
H	0005856	cellular_component	cytoskeleton
H	0005865	cellular_component	striated muscle thin filament
H	0005884	cellular_component	actin filament
H	0010628	biological_process	positive regulation of gene expression
H	0016787	molecular_function	hydrolase activity
H	0030027	cellular_component	lamellipodium
H	0030175	cellular_component	filopodium
H	0030240	biological_process	skeletal muscle thin filament assembly
H	0044297	cellular_component	cell body
H	0048741	biological_process	skeletal muscle fiber development
H	0090131	biological_process	mesenchyme migration
I	0001725	cellular_component	stress fiber
I	0005524	molecular_function	ATP binding
I	0005737	cellular_component	cytoplasm
I	0005856	cellular_component	cytoskeleton
I	0005865	cellular_component	striated muscle thin filament
I	0005884	cellular_component	actin filament
I	0010628	biological_process	positive regulation of gene expression
I	0016787	molecular_function	hydrolase activity
I	0030027	cellular_component	lamellipodium
I	0030175	cellular_component	filopodium
I	0030240	biological_process	skeletal muscle thin filament assembly
I	0044297	cellular_component	cell body
I	0048741	biological_process	skeletal muscle fiber development
I	0090131	biological_process	mesenchyme migration
J	0001725	cellular_component	stress fiber
J	0005524	molecular_function	ATP binding
J	0005737	cellular_component	cytoplasm
J	0005856	cellular_component	cytoskeleton
J	0005865	cellular_component	striated muscle thin filament
J	0005884	cellular_component	actin filament
J	0010628	biological_process	positive regulation of gene expression
J	0016787	molecular_function	hydrolase activity
J	0030027	cellular_component	lamellipodium
J	0030175	cellular_component	filopodium
J	0030240	biological_process	skeletal muscle thin filament assembly
J	0044297	cellular_component	cell body
J	0048741	biological_process	skeletal muscle fiber development
J	0090131	biological_process	mesenchyme migration
K	0001725	cellular_component	stress fiber
K	0005524	molecular_function	ATP binding
K	0005737	cellular_component	cytoplasm
K	0005856	cellular_component	cytoskeleton
K	0005865	cellular_component	striated muscle thin filament
K	0005884	cellular_component	actin filament
K	0010628	biological_process	positive regulation of gene expression
K	0016787	molecular_function	hydrolase activity
K	0030027	cellular_component	lamellipodium
K	0030175	cellular_component	filopodium
K	0030240	biological_process	skeletal muscle thin filament assembly
K	0044297	cellular_component	cell body
K	0048741	biological_process	skeletal muscle fiber development
K	0090131	biological_process	mesenchyme migration
L	0001725	cellular_component	stress fiber
L	0005524	molecular_function	ATP binding
L	0005737	cellular_component	cytoplasm
L	0005856	cellular_component	cytoskeleton
L	0005865	cellular_component	striated muscle thin filament
L	0005884	cellular_component	actin filament
L	0010628	biological_process	positive regulation of gene expression
L	0016787	molecular_function	hydrolase activity
L	0030027	cellular_component	lamellipodium
L	0030175	cellular_component	filopodium
L	0030240	biological_process	skeletal muscle thin filament assembly
L	0044297	cellular_component	cell body
L	0048741	biological_process	skeletal muscle fiber development
L	0090131	biological_process	mesenchyme migration
M	0001725	cellular_component	stress fiber
M	0005524	molecular_function	ATP binding
M	0005737	cellular_component	cytoplasm
M	0005856	cellular_component	cytoskeleton
M	0005865	cellular_component	striated muscle thin filament
M	0005884	cellular_component	actin filament
M	0010628	biological_process	positive regulation of gene expression
M	0016787	molecular_function	hydrolase activity
M	0030027	cellular_component	lamellipodium
M	0030175	cellular_component	filopodium
M	0030240	biological_process	skeletal muscle thin filament assembly
M	0044297	cellular_component	cell body
M	0048741	biological_process	skeletal muscle fiber development
M	0090131	biological_process	mesenchyme migration
N	0001725	cellular_component	stress fiber
N	0005524	molecular_function	ATP binding
N	0005737	cellular_component	cytoplasm
N	0005856	cellular_component	cytoskeleton
N	0005865	cellular_component	striated muscle thin filament
N	0005884	cellular_component	actin filament
N	0010628	biological_process	positive regulation of gene expression
N	0016787	molecular_function	hydrolase activity
N	0030027	cellular_component	lamellipodium
N	0030175	cellular_component	filopodium
N	0030240	biological_process	skeletal muscle thin filament assembly
N	0044297	cellular_component	cell body
N	0048741	biological_process	skeletal muscle fiber development
N	0090131	biological_process	mesenchyme migration
O	0001725	cellular_component	stress fiber
O	0005524	molecular_function	ATP binding
O	0005737	cellular_component	cytoplasm
O	0005856	cellular_component	cytoskeleton
O	0005865	cellular_component	striated muscle thin filament
O	0005884	cellular_component	actin filament
O	0010628	biological_process	positive regulation of gene expression
O	0016787	molecular_function	hydrolase activity
O	0030027	cellular_component	lamellipodium
O	0030175	cellular_component	filopodium
O	0030240	biological_process	skeletal muscle thin filament assembly
O	0044297	cellular_component	cell body
O	0048741	biological_process	skeletal muscle fiber development
O	0090131	biological_process	mesenchyme migration
P	0003779	molecular_function	actin binding
P	0005737	cellular_component	cytoplasm
P	0005856	cellular_component	cytoskeleton
P	0005884	cellular_component	actin filament
P	0007015	biological_process	actin filament organization
P	0015629	cellular_component	actin cytoskeleton
P	0042802	molecular_function	identical protein binding
P	0042803	molecular_function	protein homodimerization activity
P	0046982	molecular_function	protein heterodimerization activity
P	0051015	molecular_function	actin filament binding
P	0060048	biological_process	cardiac muscle contraction
Q	0003779	molecular_function	actin binding
Q	0005737	cellular_component	cytoplasm
Q	0005856	cellular_component	cytoskeleton
Q	0005884	cellular_component	actin filament
Q	0007015	biological_process	actin filament organization
Q	0015629	cellular_component	actin cytoskeleton
Q	0042802	molecular_function	identical protein binding
Q	0042803	molecular_function	protein homodimerization activity
Q	0046982	molecular_function	protein heterodimerization activity
Q	0051015	molecular_function	actin filament binding
Q	0060048	biological_process	cardiac muscle contraction
R	0003779	molecular_function	actin binding
R	0005737	cellular_component	cytoplasm
R	0005856	cellular_component	cytoskeleton
R	0005884	cellular_component	actin filament
R	0007015	biological_process	actin filament organization
R	0015629	cellular_component	actin cytoskeleton
R	0042802	molecular_function	identical protein binding
R	0042803	molecular_function	protein homodimerization activity
R	0046982	molecular_function	protein heterodimerization activity
R	0051015	molecular_function	actin filament binding
R	0060048	biological_process	cardiac muscle contraction
S	0003779	molecular_function	actin binding
S	0005737	cellular_component	cytoplasm
S	0005856	cellular_component	cytoskeleton
S	0005884	cellular_component	actin filament
S	0007015	biological_process	actin filament organization
S	0015629	cellular_component	actin cytoskeleton
S	0042802	molecular_function	identical protein binding
S	0042803	molecular_function	protein homodimerization activity
S	0046982	molecular_function	protein heterodimerization activity
S	0051015	molecular_function	actin filament binding
S	0060048	biological_process	cardiac muscle contraction
T	0005861	cellular_component	troponin complex
T	0006937	biological_process	regulation of muscle contraction
U	0005861	cellular_component	troponin complex
V	0003009	biological_process	skeletal muscle contraction
V	0005509	molecular_function	calcium ion binding
V	0031013	molecular_function	troponin I binding
V	0046872	molecular_function	metal ion binding
V	0048306	molecular_function	calcium-dependent protein binding
V	0060048	biological_process	cardiac muscle contraction
V	1990584	cellular_component	cardiac Troponin complex
W	0003779	molecular_function	actin binding
W	0005737	cellular_component	cytoplasm
W	0005856	cellular_component	cytoskeleton
W	0005884	cellular_component	actin filament
W	0007015	biological_process	actin filament organization
W	0015629	cellular_component	actin cytoskeleton
W	0042802	molecular_function	identical protein binding
W	0042803	molecular_function	protein homodimerization activity
W	0046982	molecular_function	protein heterodimerization activity
W	0051015	molecular_function	actin filament binding
W	0060048	biological_process	cardiac muscle contraction
X	0003779	molecular_function	actin binding
X	0005737	cellular_component	cytoplasm
X	0005856	cellular_component	cytoskeleton
X	0005884	cellular_component	actin filament
X	0007015	biological_process	actin filament organization
X	0015629	cellular_component	actin cytoskeleton
X	0042802	molecular_function	identical protein binding
X	0042803	molecular_function	protein homodimerization activity
X	0046982	molecular_function	protein heterodimerization activity
X	0051015	molecular_function	actin filament binding
X	0060048	biological_process	cardiac muscle contraction
Y	0003779	molecular_function	actin binding
Y	0005737	cellular_component	cytoplasm
Y	0005856	cellular_component	cytoskeleton
Y	0005884	cellular_component	actin filament
Y	0007015	biological_process	actin filament organization
Y	0015629	cellular_component	actin cytoskeleton
Y	0042802	molecular_function	identical protein binding
Y	0042803	molecular_function	protein homodimerization activity
Y	0046982	molecular_function	protein heterodimerization activity
Y	0051015	molecular_function	actin filament binding
Y	0060048	biological_process	cardiac muscle contraction
Z	0003779	molecular_function	actin binding
Z	0005737	cellular_component	cytoplasm
Z	0005856	cellular_component	cytoskeleton
Z	0005884	cellular_component	actin filament
Z	0007015	biological_process	actin filament organization
Z	0015629	cellular_component	actin cytoskeleton
Z	0042802	molecular_function	identical protein binding
Z	0042803	molecular_function	protein homodimerization activity
Z	0046982	molecular_function	protein heterodimerization activity
Z	0051015	molecular_function	actin filament binding
Z	0060048	biological_process	cardiac muscle contraction
a	0005861	cellular_component	troponin complex
a	0006937	biological_process	regulation of muscle contraction
b	0005861	cellular_component	troponin complex
c	0003009	biological_process	skeletal muscle contraction
c	0005509	molecular_function	calcium ion binding
c	0031013	molecular_function	troponin I binding
c	0046872	molecular_function	metal ion binding
c	0048306	molecular_function	calcium-dependent protein binding
c	0060048	biological_process	cardiac muscle contraction
c	1990584	cellular_component	cardiac Troponin complex

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DEDGSGTVDfdEF

Chain	Residue	Details
c	ASP65-PHE77
c	ASP105-LEU117
c	ASP141-PHE153

site_id	PS00326
Number of Residues	9
Details	TROPOMYOSIN Tropomyosins signature. LKEAEtRAE

Chain	Residue	Details
P	LEU232-GLU240

site_id	PS00406
Number of Residues	11
Details	ACTINS_1 Actins signature 1. YVGDEAQs.KRG

Chain	Residue	Details
A	TYR53-GLY63

site_id	PS00432
Number of Residues	9
Details	ACTINS_2 Actins signature 2. WITKqEYDE

Chain	Residue	Details
A	TRP356-GLU364

site_id	PS01132
Number of Residues	13
Details	ACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEApLNPkaNR

Chain	Residue	Details
A	LEU104-ARG116

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	30
Details	BINDING: BINDING => ECO:0000255\|PROSITE-ProRule:PRU00448

Chain	Residue	Details
V	ASP65
V	ASP67
V	SER69
V	THR71
V	GLU76
V	ASP105
V	ASN107
V	ASP109
V	TYR111
V	GLU116
V	ASP141
V	ASN143
V	ASP145
V	ARG147
V	GLU152
c	ASP65
c	ASP67
c	SER69
c	THR71
c	GLU76
c	ASP105
c	ASN107
c	ASP109
c	TYR111
c	GLU116
c	ASP141
c	ASN143
c	ASP145
c	ARG147
c	GLU152

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P19123

Chain	Residue	Details
K	LYS61
L	LYS61
M	LYS61
N	LYS61
O	LYS61
V	SER98
c	SER98
R	SER45
S	SER45
W	SER45
X	SER45
Y	SER45
Z	SER45
I	LYS61
J	LYS61

site_id	SWS_FT_FI3
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P09493

Chain	Residue	Details
K	HIS73
L	HIS73
M	HIS73
N	HIS73
O	HIS73
P	SER174
Q	SER174
R	SER174
S	SER174
W	SER174
X	SER174
Y	SER174
Z	SER174
I	HIS73
J	HIS73

site_id	SWS_FT_FI4
Number of Residues	32
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P58771

Chain	Residue	Details
P	SER252
P	SER271
Q	SER186
Q	SER206
Q	SER252
Q	SER271
R	SER186
R	SER206
R	SER252
R	SER271
S	SER186
S	SER206
S	SER252
S	SER271
W	SER186
W	SER206
W	SER252
W	SER271
X	SER186
X	SER206
X	SER252
X	SER271
Y	SER186
Y	SER206
Y	SER252
Y	SER271
Z	SER186
Z	SER206
Z	SER252
Z	SER271
P	SER186
P	SER206

site_id	SWS_FT_FI5
Number of Residues	8
Details	MOD_RES: Phosphotyrosine => ECO:0000250\|UniProtKB:P04692

Chain	Residue	Details
P	TYR261
Q	TYR261
R	TYR261
S	TYR261
W	TYR261
X	TYR261
Y	TYR261
Z	TYR261

site_id	SWS_FT_FI6
Number of Residues	8
Details	MOD_RES: Phosphoserine; by DAPK1 => ECO:0000250\|UniProtKB:P09493

Chain	Residue	Details
P	SER283
Q	SER283
R	SER283
S	SER283
W	SER283
X	SER283
Y	SER283
Z	SER283

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)