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7FII

luteinizing hormone/choriogonadotropin receptor-chorionic gonadotropin-Gs complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0003924molecular_functionGTPase activity
A0007186biological_processG protein-coupled receptor signaling pathway
A0019001molecular_functionguanyl nucleotide binding
A0031683molecular_functionG-protein beta/gamma-subunit complex binding
B0001750cellular_componentphotoreceptor outer segment
B0001917cellular_componentphotoreceptor inner segment
B0003924molecular_functionGTPase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005834cellular_componentheterotrimeric G-protein complex
B0005886cellular_componentplasma membrane
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
B0007204biological_processpositive regulation of cytosolic calcium ion concentration
B0008283biological_processcell population proliferation
B0010659biological_processcardiac muscle cell apoptotic process
B0030159molecular_functionsignaling receptor complex adaptor activity
B0030425cellular_componentdendrite
B0030507molecular_functionspectrin binding
B0042622cellular_componentphotoreceptor outer segment membrane
B0044297cellular_componentcell body
B0044877molecular_functionprotein-containing complex binding
B0047391molecular_functionalkylglycerophosphoethanolamine phosphodiesterase activity
B0050909biological_processsensory perception of taste
B0051020molecular_functionGTPase binding
B0060041biological_processretina development in camera-type eye
B0071456biological_processcellular response to hypoxia
G0003924molecular_functionGTPase activity
G0005515molecular_functionprotein binding
G0005834cellular_componentheterotrimeric G-protein complex
G0005886cellular_componentplasma membrane
G0007165biological_processsignal transduction
G0007186biological_processG protein-coupled receptor signaling pathway
G0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
G0016020cellular_componentmembrane
G0031681molecular_functionG-protein beta-subunit binding
G0071380biological_processcellular response to prostaglandin E stimulus
G0071870biological_processcellular response to catecholamine stimulus
R0001541biological_processovarian follicle development
R0004930molecular_functionG protein-coupled receptor activity
R0004964molecular_functionluteinizing hormone receptor activity
R0005615cellular_componentextracellular space
R0005768cellular_componentendosome
R0005886cellular_componentplasma membrane
R0006622biological_processprotein targeting to lysosome
R0007186biological_processG protein-coupled receptor signaling pathway
R0007187biological_processG protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
R0007188biological_processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
R0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
R0007190biological_processactivation of adenylate cyclase activity
R0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
R0007283biological_processspermatogenesis
R0008528molecular_functionG protein-coupled peptide receptor activity
R0008584biological_processmale gonad development
R0008585biological_processfemale gonad development
R0009410biological_processresponse to xenobiotic stimulus
R0009755biological_processhormone-mediated signaling pathway
R0010524biological_processpositive regulation of calcium ion transport into cytosol
R0016020cellular_componentmembrane
R0016500molecular_functionprotein-hormone receptor activity
R0017046molecular_functionpeptide hormone binding
R0022602biological_processovulation cycle process
R0030539biological_processmale genitalia development
R0032962biological_processpositive regulation of inositol trisphosphate biosynthetic process
R0034451cellular_componentcentriolar satellite
R0034699biological_processresponse to luteinizing hormone
R0035472molecular_functionchoriogonadotropin hormone receptor activity
R0038106molecular_functionchoriogonadotropin hormone binding
R0042700biological_processluteinizing hormone signaling pathway
R0042802molecular_functionidentical protein binding
R0043235cellular_componentreceptor complex
R0046544biological_processdevelopment of secondary male sexual characteristics
R0046886biological_processpositive regulation of hormone biosynthetic process
R0050482biological_processarachidonic acid secretion
R0050810biological_processregulation of steroid biosynthetic process
R0050850biological_processpositive regulation of calcium-mediated signaling
R0050890biological_processcognition
R0051117molecular_functionATPase binding
R0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
R0060065biological_processuterus development
R0071371biological_processcellular response to gonadotropin stimulus
R0071373biological_processcellular response to luteinizing hormone stimulus
R0072520biological_processseminiferous tubule development
R0090030biological_processregulation of steroid hormone biosynthetic process
X0005179molecular_functionhormone activity
X0005576cellular_componentextracellular region
Y0005179molecular_functionhormone activity
Y0005576cellular_componentextracellular region
Functional Information from PROSITE/UniProt
site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. LSVyTLTVITLERWHtI
ChainResidueDetails
RLEU452-ILE468

site_idPS00261
Number of Residues7
DetailsGLYCO_HORMONE_BETA_1 Glycoprotein hormones beta chain signature 1. CAGYCpT
ChainResidueDetails
YCYS34-THR40

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
BLEU70-SER84
BILE157-ILE171
BLEU285-ALA299

site_idPS00689
Number of Residues28
DetailsGLYCO_HORMONE_BETA_2 Glycoprotein hormones beta chain signature 2. AVAlsCqCalCrrstTDCggpkdh..PltC
ChainResidueDetails
YALA83-CYS110

site_idPS00779
Number of Residues13
DetailsGLYCO_HORMONE_ALPHA_1 Glycoprotein hormones alpha chain signature 1. CmGCCFSRAYPTP
ChainResidueDetails
XCYS28-PRO40

site_idPS00780
Number of Residues14
DetailsGLYCO_HORMONE_ALPHA_2 Glycoprotein hormones alpha chain signature 2. NHTaChCsTCyyHK
ChainResidueDetails
XASN78-LYS91

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0007744|PDB:1HRP
ChainResidueDetails
YASN13
YASN30

site_idSWS_FT_FI2
Number of Residues4
DetailsCARBOHYD: O-linked (GalNAc...) serine => ECO:0000269|PubMed:1150658
ChainResidueDetails
YSER121
YSER127
YSER132
YSER138

site_idSWS_FT_FI3
Number of Residues20
DetailsTRANSMEM: Helical; Name=2 => ECO:0000255
ChainResidueDetails
RPHE396-ALA416

site_idSWS_FT_FI4
Number of Residues51
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
RSER417-CYS439
RSER506-GLN525
RLYS595-LYS605

site_idSWS_FT_FI5
Number of Residues22
DetailsTRANSMEM: Helical; Name=3 => ECO:0000255
ChainResidueDetails
RSER440-LEU462

site_idSWS_FT_FI6
Number of Residues22
DetailsTRANSMEM: Helical; Name=4 => ECO:0000255
ChainResidueDetails
RALA483-VAL505

site_idSWS_FT_FI7
Number of Residues23
DetailsTRANSMEM: Helical; Name=5 => ECO:0000255
ChainResidueDetails
RVAL526-ILE549

site_idSWS_FT_FI8
Number of Residues23
DetailsTRANSMEM: Helical; Name=6 => ECO:0000255
ChainResidueDetails
RMET571-PHE594

site_idSWS_FT_FI9
Number of Residues21
DetailsTRANSMEM: Helical; Name=7 => ECO:0000255
ChainResidueDetails
RVAL606-THR627

site_idSWS_FT_FI10
Number of Residues1
DetailsMOD_RES: Sulfotyrosine => ECO:0000305|PubMed:11847099
ChainResidueDetails
RTYR331

site_idSWS_FT_FI11
Number of Residues2
DetailsLIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:15539429
ChainResidueDetails
RCYS643
RCYS644

site_idSWS_FT_FI12
Number of Residues6
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
RASN99
RASN174
RASN195
RASN291
RASN299
RASN313

219869

PDB entries from 2024-05-15

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