Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

7F5N

Crystal structure of TCPTP catalytic domain

Functional Information from GO Data
ChainGOidnamespacecontents
A0004725molecular_functionprotein tyrosine phosphatase activity
A0006470biological_processprotein dephosphorylation
A0016311biological_processdephosphorylation
B0004725molecular_functionprotein tyrosine phosphatase activity
B0006470biological_processprotein dephosphorylation
B0016311biological_processdephosphorylation
C0004725molecular_functionprotein tyrosine phosphatase activity
C0006470biological_processprotein dephosphorylation
C0016311biological_processdephosphorylation
Functional Information from PROSITE/UniProt
site_idPS00383
Number of Residues11
DetailsTYR_PHOSPHATASE_1 Tyrosine specific protein phosphatases active site. IHCsaGigRSG
ChainResidueDetails
AILE214-GLY224

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsACT_SITE: Phosphocysteine intermediate => ECO:0000255|PROSITE-ProRule:PRU00160, ECO:0000255|PROSITE-ProRule:PRU10044
ChainResidueDetails
BCYS216
CCYS216
ACYS216

site_idSWS_FT_FI2
Number of Residues9
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
CASP182
CCYS216
CGLN260
AGLN260
BASP182
BCYS216
BGLN260
AASP182
ACYS216

site_idSWS_FT_FI3
Number of Residues6
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P18031
ChainResidueDetails
BTYR22
BTYR68
CTYR22
CTYR68
ATYR22
ATYR68

site_idSWS_FT_FI4
Number of Residues3
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P18031
ChainResidueDetails
BSER52
CSER52
ASER52

site_idSWS_FT_FI5
Number of Residues3
DetailsMOD_RES: S-nitrosocysteine => ECO:0000250|UniProtKB:P18031
ChainResidueDetails
BCYS216
CCYS216
ACYS216

site_idSWS_FT_FI6
Number of Residues3
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER293
BSER293
CSER293

site_idSWS_FT_FI7
Number of Residues3
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
ASER298
BSER298
CSER298

site_idSWS_FT_FI8
Number of Residues3
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
ASER304
BSER304
CSER304

221051

PDB entries from 2024-06-12

PDB statisticsPDBj update infoContact PDBjnumon