7EVO

The cryo-EM structure of the human 17S U2 snRNP

Functional Information from GO Data

Chain	GOid	namespace	contents
1	0000245	biological_process	spliceosomal complex assembly
1	0000375	biological_process	RNA splicing, via transesterification reactions
1	0000398	biological_process	mRNA splicing, via spliceosome
1	0003723	molecular_function	RNA binding
1	0003729	molecular_function	mRNA binding
1	0005515	molecular_function	protein binding
1	0005634	cellular_component	nucleus
1	0005654	cellular_component	nucleoplasm
1	0005681	cellular_component	spliceosomal complex
1	0005684	cellular_component	U2-type spliceosomal complex
1	0005686	cellular_component	U2 snRNP
1	0005689	cellular_component	U12-type spliceosomal complex
1	0005730	cellular_component	nucleolus
1	0006338	biological_process	chromatin remodeling
1	0006397	biological_process	mRNA processing
1	0008380	biological_process	RNA splicing
1	0016607	cellular_component	nuclear speck
1	0034693	cellular_component	U11/U12 snRNP
1	0045943	biological_process	positive regulation of transcription by RNA polymerase I
1	0045944	biological_process	positive regulation of transcription by RNA polymerase II
1	0045945	biological_process	positive regulation of transcription by RNA polymerase III
1	0071004	cellular_component	U2-type prespliceosome
1	0071005	cellular_component	U2-type precatalytic spliceosome
1	0071013	cellular_component	catalytic step 2 spliceosome
1	0110016	cellular_component	B-WICH complex
1	1903241	biological_process	U2-type prespliceosome assembly
1	1990935	molecular_function	splicing factor binding
2	0000398	biological_process	mRNA splicing, via spliceosome
2	0003723	molecular_function	RNA binding
2	0005515	molecular_function	protein binding
2	0005634	cellular_component	nucleus
2	0005654	cellular_component	nucleoplasm
2	0005681	cellular_component	spliceosomal complex
2	0005684	cellular_component	U2-type spliceosomal complex
2	0005686	cellular_component	U2 snRNP
2	0005689	cellular_component	U12-type spliceosomal complex
2	0006397	biological_process	mRNA processing
2	0008380	biological_process	RNA splicing
2	0016607	cellular_component	nuclear speck
2	0071005	cellular_component	U2-type precatalytic spliceosome
2	0071011	cellular_component	precatalytic spliceosome
2	0071013	cellular_component	catalytic step 2 spliceosome
2	1903241	biological_process	U2-type prespliceosome assembly
3	0000124	cellular_component	SAGA complex
3	0000375	biological_process	RNA splicing, via transesterification reactions
3	0000398	biological_process	mRNA splicing, via spliceosome
3	0003676	molecular_function	nucleic acid binding
3	0005515	molecular_function	protein binding
3	0005634	cellular_component	nucleus
3	0005654	cellular_component	nucleoplasm
3	0005681	cellular_component	spliceosomal complex
3	0005684	cellular_component	U2-type spliceosomal complex
3	0005686	cellular_component	U2 snRNP
3	0005689	cellular_component	U12-type spliceosomal complex
3	0005730	cellular_component	nucleolus
3	0006282	biological_process	regulation of DNA repair
3	0006397	biological_process	mRNA processing
3	0008380	biological_process	RNA splicing
3	0030620	molecular_function	U2 snRNA binding
3	0042177	biological_process	negative regulation of protein catabolic process
3	0043484	biological_process	regulation of RNA splicing
3	0044877	molecular_function	protein-containing complex binding
3	0045893	biological_process	positive regulation of DNA-templated transcription
3	0071005	cellular_component	U2-type precatalytic spliceosome
3	0071013	cellular_component	catalytic step 2 spliceosome
3	1903241	biological_process	U2-type prespliceosome assembly
4	0000375	biological_process	RNA splicing, via transesterification reactions
4	0000398	biological_process	mRNA splicing, via spliceosome
4	0003676	molecular_function	nucleic acid binding
4	0003723	molecular_function	RNA binding
4	0005515	molecular_function	protein binding
4	0005634	cellular_component	nucleus
4	0005654	cellular_component	nucleoplasm
4	0005681	cellular_component	spliceosomal complex
4	0005684	cellular_component	U2-type spliceosomal complex
4	0005686	cellular_component	U2 snRNP
4	0005689	cellular_component	U12-type spliceosomal complex
4	0006397	biological_process	mRNA processing
4	0008380	biological_process	RNA splicing
4	0048026	biological_process	positive regulation of mRNA splicing, via spliceosome
4	0071005	cellular_component	U2-type precatalytic spliceosome
4	1903241	biological_process	U2-type prespliceosome assembly
4	1990935	molecular_function	splicing factor binding
5	0000124	cellular_component	SAGA complex
5	0000398	biological_process	mRNA splicing, via spliceosome
5	0003723	molecular_function	RNA binding
5	0005515	molecular_function	protein binding
5	0005634	cellular_component	nucleus
5	0005654	cellular_component	nucleoplasm
5	0005681	cellular_component	spliceosomal complex
5	0005684	cellular_component	U2-type spliceosomal complex
5	0005686	cellular_component	U2 snRNP
5	0005689	cellular_component	U12-type spliceosomal complex
5	0006282	biological_process	regulation of DNA repair
5	0006397	biological_process	mRNA processing
5	0008380	biological_process	RNA splicing
5	0043484	biological_process	regulation of RNA splicing
5	0045893	biological_process	positive regulation of DNA-templated transcription
5	0071005	cellular_component	U2-type precatalytic spliceosome
5	0071011	cellular_component	precatalytic spliceosome
5	1903241	biological_process	U2-type prespliceosome assembly
5	1990935	molecular_function	splicing factor binding
6	0000398	biological_process	mRNA splicing, via spliceosome
6	0003677	molecular_function	DNA binding
6	0003723	molecular_function	RNA binding
6	0005515	molecular_function	protein binding
6	0005634	cellular_component	nucleus
6	0005654	cellular_component	nucleoplasm
6	0005681	cellular_component	spliceosomal complex
6	0005684	cellular_component	U2-type spliceosomal complex
6	0005686	cellular_component	U2 snRNP
6	0005689	cellular_component	U12-type spliceosomal complex
6	0006397	biological_process	mRNA processing
6	0008270	molecular_function	zinc ion binding
6	0008380	biological_process	RNA splicing
6	0016363	cellular_component	nuclear matrix
6	0016607	cellular_component	nuclear speck
6	0045893	biological_process	positive regulation of DNA-templated transcription
6	0046872	molecular_function	metal ion binding
6	0048863	biological_process	stem cell differentiation
6	0071005	cellular_component	U2-type precatalytic spliceosome
6	0071011	cellular_component	precatalytic spliceosome
6	1903241	biological_process	U2-type prespliceosome assembly
A	0000389	biological_process	mRNA 3'-splice site recognition
A	0000398	biological_process	mRNA splicing, via spliceosome
A	0003723	molecular_function	RNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005681	cellular_component	spliceosomal complex
A	0005684	cellular_component	U2-type spliceosomal complex
A	0005686	cellular_component	U2 snRNP
A	0006396	biological_process	RNA processing
A	0006397	biological_process	mRNA processing
A	0008380	biological_process	RNA splicing
A	0016607	cellular_component	nuclear speck
A	0045292	biological_process	mRNA cis splicing, via spliceosome
A	0071004	cellular_component	U2-type prespliceosome
A	0071005	cellular_component	U2-type precatalytic spliceosome
A	0071013	cellular_component	catalytic step 2 spliceosome
A	1903241	biological_process	U2-type prespliceosome assembly
B	0000245	biological_process	spliceosomal complex assembly
B	0000389	biological_process	mRNA 3'-splice site recognition
B	0000398	biological_process	mRNA splicing, via spliceosome
B	0003676	molecular_function	nucleic acid binding
B	0003723	molecular_function	RNA binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005681	cellular_component	spliceosomal complex
B	0005684	cellular_component	U2-type spliceosomal complex
B	0005686	cellular_component	U2 snRNP
B	0006397	biological_process	mRNA processing
B	0008270	molecular_function	zinc ion binding
B	0008380	biological_process	RNA splicing
B	0010976	biological_process	positive regulation of neuron projection development
B	0016607	cellular_component	nuclear speck
B	0046872	molecular_function	metal ion binding
B	0071004	cellular_component	U2-type prespliceosome
B	0071005	cellular_component	U2-type precatalytic spliceosome
B	0071013	cellular_component	catalytic step 2 spliceosome
B	1903241	biological_process	U2-type prespliceosome assembly
C	0000375	biological_process	RNA splicing, via transesterification reactions
C	0000389	biological_process	mRNA 3'-splice site recognition
C	0000398	biological_process	mRNA splicing, via spliceosome
C	0003676	molecular_function	nucleic acid binding
C	0003723	molecular_function	RNA binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005681	cellular_component	spliceosomal complex
C	0005684	cellular_component	U2-type spliceosomal complex
C	0005686	cellular_component	U2 snRNP
C	0006397	biological_process	mRNA processing
C	0008270	molecular_function	zinc ion binding
C	0008380	biological_process	RNA splicing
C	0016607	cellular_component	nuclear speck
C	0046872	molecular_function	metal ion binding
C	0071005	cellular_component	U2-type precatalytic spliceosome
C	0071013	cellular_component	catalytic step 2 spliceosome
C	1903241	biological_process	U2-type prespliceosome assembly
D	0000398	biological_process	mRNA splicing, via spliceosome
D	0000724	biological_process	double-strand break repair via homologous recombination
D	0003676	molecular_function	nucleic acid binding
D	0003723	molecular_function	RNA binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005681	cellular_component	spliceosomal complex
D	0005684	cellular_component	U2-type spliceosomal complex
D	0005686	cellular_component	U2 snRNP
D	0005694	cellular_component	chromosome
D	0006281	biological_process	DNA repair
D	0006325	biological_process	chromatin organization
D	0006397	biological_process	mRNA processing
D	0008380	biological_process	RNA splicing
D	0035861	cellular_component	site of double-strand break
D	0140463	molecular_function	chromatin-protein adaptor activity
D	0160004	molecular_function	poly-ADP-D-ribose modification-dependent protein binding
D	1903241	biological_process	U2-type prespliceosome assembly
D	1990166	biological_process	protein localization to site of double-strand break
E	0003676	molecular_function	nucleic acid binding
E	0003724	molecular_function	RNA helicase activity
E	0005524	molecular_function	ATP binding
F	0000398	biological_process	mRNA splicing, via spliceosome
F	0003723	molecular_function	RNA binding
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005681	cellular_component	spliceosomal complex
F	0005684	cellular_component	U2-type spliceosomal complex
F	0005686	cellular_component	U2 snRNP
F	0006397	biological_process	mRNA processing
F	0007283	biological_process	spermatogenesis
F	0008380	biological_process	RNA splicing
F	0016604	cellular_component	nuclear body
F	0016607	cellular_component	nuclear speck
F	0030532	cellular_component	small nuclear ribonucleoprotein complex
F	0030620	molecular_function	U2 snRNA binding
F	0071005	cellular_component	U2-type precatalytic spliceosome
F	0071007	cellular_component	U2-type catalytic step 2 spliceosome
F	0071013	cellular_component	catalytic step 2 spliceosome
F	1903241	biological_process	U2-type prespliceosome assembly
G	0000398	biological_process	mRNA splicing, via spliceosome
G	0001650	cellular_component	fibrillar center
G	0003676	molecular_function	nucleic acid binding
G	0003723	molecular_function	RNA binding
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005681	cellular_component	spliceosomal complex
G	0005684	cellular_component	U2-type spliceosomal complex
G	0005685	cellular_component	U1 snRNP
G	0005686	cellular_component	U2 snRNP
G	0006397	biological_process	mRNA processing
G	0008380	biological_process	RNA splicing
G	0016607	cellular_component	nuclear speck
G	0030619	molecular_function	U1 snRNA binding
G	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
G	0071005	cellular_component	U2-type precatalytic spliceosome
G	0071007	cellular_component	U2-type catalytic step 2 spliceosome
G	0071013	cellular_component	catalytic step 2 spliceosome
G	1903241	biological_process	U2-type prespliceosome assembly
a	0000245	biological_process	spliceosomal complex assembly
a	0000387	biological_process	spliceosomal snRNP assembly
a	0000398	biological_process	mRNA splicing, via spliceosome
a	0003723	molecular_function	RNA binding
a	0005515	molecular_function	protein binding
a	0005634	cellular_component	nucleus
a	0005654	cellular_component	nucleoplasm
a	0005681	cellular_component	spliceosomal complex
a	0005682	cellular_component	U5 snRNP
a	0005684	cellular_component	U2-type spliceosomal complex
a	0005685	cellular_component	U1 snRNP
a	0005686	cellular_component	U2 snRNP
a	0005687	cellular_component	U4 snRNP
a	0005689	cellular_component	U12-type spliceosomal complex
a	0005737	cellular_component	cytoplasm
a	0005829	cellular_component	cytosol
a	0006397	biological_process	mRNA processing
a	0008380	biological_process	RNA splicing
a	0030532	cellular_component	small nuclear ribonucleoprotein complex
a	0034709	cellular_component	methylosome
a	0034715	cellular_component	pICln-Sm protein complex
a	0034719	cellular_component	SMN-Sm protein complex
a	0036261	biological_process	7-methylguanosine cap hypermethylation
a	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
a	0070062	cellular_component	extracellular exosome
a	0071005	cellular_component	U2-type precatalytic spliceosome
a	0071007	cellular_component	U2-type catalytic step 2 spliceosome
a	0071011	cellular_component	precatalytic spliceosome
a	0071013	cellular_component	catalytic step 2 spliceosome
a	1903241	biological_process	U2-type prespliceosome assembly
b	0000387	biological_process	spliceosomal snRNP assembly
b	0000398	biological_process	mRNA splicing, via spliceosome
b	0003723	molecular_function	RNA binding
b	0005515	molecular_function	protein binding
b	0005634	cellular_component	nucleus
b	0005654	cellular_component	nucleoplasm
b	0005681	cellular_component	spliceosomal complex
b	0005682	cellular_component	U5 snRNP
b	0005683	cellular_component	U7 snRNP
b	0005684	cellular_component	U2-type spliceosomal complex
b	0005685	cellular_component	U1 snRNP
b	0005686	cellular_component	U2 snRNP
b	0005687	cellular_component	U4 snRNP
b	0005689	cellular_component	U12-type spliceosomal complex
b	0005737	cellular_component	cytoplasm
b	0005829	cellular_component	cytosol
b	0006397	biological_process	mRNA processing
b	0008380	biological_process	RNA splicing
b	0030532	cellular_component	small nuclear ribonucleoprotein complex
b	0034709	cellular_component	methylosome
b	0034715	cellular_component	pICln-Sm protein complex
b	0034719	cellular_component	SMN-Sm protein complex
b	0036261	biological_process	7-methylguanosine cap hypermethylation
b	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
b	0071005	cellular_component	U2-type precatalytic spliceosome
b	0071007	cellular_component	U2-type catalytic step 2 spliceosome
b	0071013	cellular_component	catalytic step 2 spliceosome
b	0120114	cellular_component	Sm-like protein family complex
b	1903241	biological_process	U2-type prespliceosome assembly
c	0000245	biological_process	spliceosomal complex assembly
c	0000387	biological_process	spliceosomal snRNP assembly
c	0000398	biological_process	mRNA splicing, via spliceosome
c	0003723	molecular_function	RNA binding
c	0005515	molecular_function	protein binding
c	0005634	cellular_component	nucleus
c	0005654	cellular_component	nucleoplasm
c	0005681	cellular_component	spliceosomal complex
c	0005682	cellular_component	U5 snRNP
c	0005683	cellular_component	U7 snRNP
c	0005684	cellular_component	U2-type spliceosomal complex
c	0005685	cellular_component	U1 snRNP
c	0005686	cellular_component	U2 snRNP
c	0005687	cellular_component	U4 snRNP
c	0005689	cellular_component	U12-type spliceosomal complex
c	0005697	cellular_component	telomerase holoenzyme complex
c	0005737	cellular_component	cytoplasm
c	0005829	cellular_component	cytosol
c	0006397	biological_process	mRNA processing
c	0008380	biological_process	RNA splicing
c	0030532	cellular_component	small nuclear ribonucleoprotein complex
c	0034709	cellular_component	methylosome
c	0034715	cellular_component	pICln-Sm protein complex
c	0034719	cellular_component	SMN-Sm protein complex
c	0036261	biological_process	7-methylguanosine cap hypermethylation
c	0043229	cellular_component	intracellular organelle
c	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
c	0071005	cellular_component	U2-type precatalytic spliceosome
c	0071007	cellular_component	U2-type catalytic step 2 spliceosome
c	0071011	cellular_component	precatalytic spliceosome
c	0071013	cellular_component	catalytic step 2 spliceosome
c	1903241	biological_process	U2-type prespliceosome assembly
d	0000245	biological_process	spliceosomal complex assembly
d	0000387	biological_process	spliceosomal snRNP assembly
d	0000398	biological_process	mRNA splicing, via spliceosome
d	0003723	molecular_function	RNA binding
d	0005515	molecular_function	protein binding
d	0005634	cellular_component	nucleus
d	0005654	cellular_component	nucleoplasm
d	0005681	cellular_component	spliceosomal complex
d	0005682	cellular_component	U5 snRNP
d	0005683	cellular_component	U7 snRNP
d	0005684	cellular_component	U2-type spliceosomal complex
d	0005685	cellular_component	U1 snRNP
d	0005686	cellular_component	U2 snRNP
d	0005687	cellular_component	U4 snRNP
d	0005689	cellular_component	U12-type spliceosomal complex
d	0005737	cellular_component	cytoplasm
d	0005829	cellular_component	cytosol
d	0006397	biological_process	mRNA processing
d	0008380	biological_process	RNA splicing
d	0030532	cellular_component	small nuclear ribonucleoprotein complex
d	0034709	cellular_component	methylosome
d	0034719	cellular_component	SMN-Sm protein complex
d	0036261	biological_process	7-methylguanosine cap hypermethylation
d	0043186	cellular_component	P granule
d	0043229	cellular_component	intracellular organelle
d	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
d	0071004	cellular_component	U2-type prespliceosome
d	0071005	cellular_component	U2-type precatalytic spliceosome
d	0071007	cellular_component	U2-type catalytic step 2 spliceosome
d	0071011	cellular_component	precatalytic spliceosome
d	0071013	cellular_component	catalytic step 2 spliceosome
d	0097526	cellular_component	spliceosomal tri-snRNP complex
d	1903241	biological_process	U2-type prespliceosome assembly
e	0000243	cellular_component	commitment complex
e	0000387	biological_process	spliceosomal snRNP assembly
e	0000398	biological_process	mRNA splicing, via spliceosome
e	0003723	molecular_function	RNA binding
e	0005515	molecular_function	protein binding
e	0005634	cellular_component	nucleus
e	0005654	cellular_component	nucleoplasm
e	0005681	cellular_component	spliceosomal complex
e	0005682	cellular_component	U5 snRNP
e	0005683	cellular_component	U7 snRNP
e	0005684	cellular_component	U2-type spliceosomal complex
e	0005685	cellular_component	U1 snRNP
e	0005686	cellular_component	U2 snRNP
e	0005687	cellular_component	U4 snRNP
e	0005689	cellular_component	U12-type spliceosomal complex
e	0005697	cellular_component	telomerase holoenzyme complex
e	0005737	cellular_component	cytoplasm
e	0005829	cellular_component	cytosol
e	0006396	biological_process	RNA processing
e	0006397	biological_process	mRNA processing
e	0006479	biological_process	protein methylation
e	0008380	biological_process	RNA splicing
e	0016604	cellular_component	nuclear body
e	0019899	molecular_function	enzyme binding
e	0030532	cellular_component	small nuclear ribonucleoprotein complex
e	0034709	cellular_component	methylosome
e	0034715	cellular_component	pICln-Sm protein complex
e	0034719	cellular_component	SMN-Sm protein complex
e	0036261	biological_process	7-methylguanosine cap hypermethylation
e	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
e	0070034	molecular_function	telomerase RNA binding
e	0071005	cellular_component	U2-type precatalytic spliceosome
e	0071007	cellular_component	U2-type catalytic step 2 spliceosome
e	0071011	cellular_component	precatalytic spliceosome
e	0071013	cellular_component	catalytic step 2 spliceosome
e	0071208	molecular_function	histone pre-mRNA DCP binding
e	0071209	molecular_function	U7 snRNA binding
e	0097526	cellular_component	spliceosomal tri-snRNP complex
e	1903241	biological_process	U2-type prespliceosome assembly
e	1990446	molecular_function	U1 snRNP binding
f	0000387	biological_process	spliceosomal snRNP assembly
f	0000398	biological_process	mRNA splicing, via spliceosome
f	0003723	molecular_function	RNA binding
f	0005515	molecular_function	protein binding
f	0005634	cellular_component	nucleus
f	0005654	cellular_component	nucleoplasm
f	0005681	cellular_component	spliceosomal complex
f	0005682	cellular_component	U5 snRNP
f	0005683	cellular_component	U7 snRNP
f	0005684	cellular_component	U2-type spliceosomal complex
f	0005685	cellular_component	U1 snRNP
f	0005686	cellular_component	U2 snRNP
f	0005687	cellular_component	U4 snRNP
f	0005689	cellular_component	U12-type spliceosomal complex
f	0005697	cellular_component	telomerase holoenzyme complex
f	0005737	cellular_component	cytoplasm
f	0005829	cellular_component	cytosol
f	0006397	biological_process	mRNA processing
f	0006479	biological_process	protein methylation
f	0008380	biological_process	RNA splicing
f	0030532	cellular_component	small nuclear ribonucleoprotein complex
f	0034709	cellular_component	methylosome
f	0034719	cellular_component	SMN-Sm protein complex
f	0036261	biological_process	7-methylguanosine cap hypermethylation
f	0043229	cellular_component	intracellular organelle
f	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
f	0070034	molecular_function	telomerase RNA binding
f	0070990	molecular_function	snRNP binding
f	0071004	cellular_component	U2-type prespliceosome
f	0071005	cellular_component	U2-type precatalytic spliceosome
f	0071007	cellular_component	U2-type catalytic step 2 spliceosome
f	0071013	cellular_component	catalytic step 2 spliceosome
f	0071204	cellular_component	histone pre-mRNA 3'end processing complex
f	0071208	molecular_function	histone pre-mRNA DCP binding
f	1903241	biological_process	U2-type prespliceosome assembly
f	1990446	molecular_function	U1 snRNP binding
f	1990447	molecular_function	U2 snRNP binding
g	0000243	cellular_component	commitment complex
g	0000245	biological_process	spliceosomal complex assembly
g	0000387	biological_process	spliceosomal snRNP assembly
g	0000398	biological_process	mRNA splicing, via spliceosome
g	0003723	molecular_function	RNA binding
g	0005515	molecular_function	protein binding
g	0005634	cellular_component	nucleus
g	0005654	cellular_component	nucleoplasm
g	0005681	cellular_component	spliceosomal complex
g	0005682	cellular_component	U5 snRNP
g	0005684	cellular_component	U2-type spliceosomal complex
g	0005685	cellular_component	U1 snRNP
g	0005686	cellular_component	U2 snRNP
g	0005687	cellular_component	U4 snRNP
g	0005689	cellular_component	U12-type spliceosomal complex
g	0005737	cellular_component	cytoplasm
g	0005829	cellular_component	cytosol
g	0006396	biological_process	RNA processing
g	0006397	biological_process	mRNA processing
g	0008380	biological_process	RNA splicing
g	0030532	cellular_component	small nuclear ribonucleoprotein complex
g	0034709	cellular_component	methylosome
g	0034715	cellular_component	pICln-Sm protein complex
g	0034719	cellular_component	SMN-Sm protein complex
g	0036261	biological_process	7-methylguanosine cap hypermethylation
g	0043229	cellular_component	intracellular organelle
g	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
g	0071005	cellular_component	U2-type precatalytic spliceosome
g	0071007	cellular_component	U2-type catalytic step 2 spliceosome
g	0071011	cellular_component	precatalytic spliceosome
g	0071013	cellular_component	catalytic step 2 spliceosome
g	0097526	cellular_component	spliceosomal tri-snRNP complex
g	1903241	biological_process	U2-type prespliceosome assembly

Functional Information from PROSITE/UniProt

site_id	PS00039
Number of Residues	9
Details	DEAD_ATP_HELICASE DEAD-box subfamily ATP-dependent helicases signature. VLDEADRmF

Chain	Residue	Details
E	VAL527-PHE535

---

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. FVCSATH

Chain	Residue	Details
3	PHE287-HIS293

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00541

Chain	Residue	Details
E	ALA416
6	CYS72
6	CYS75
6	CYS85
f	ARG112
6	CYS26
6	CYS30
6	CYS33
6	CYS46
6	CYS49
6	CYS58
6	CYS61

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q62780

Chain	Residue	Details
E	SER199
3	LYS1171

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
E	LYS263
E	LYS776
C	SER295

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332

Chain	Residue	Details
E	TYR294
F	SER255
a	LYS8

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332

Chain	Residue	Details
E	SER295
E	SER296
C	SER369

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
E	SER346
E	SER929
1	LYS562

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
E	SER804
D	SER453

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q569Z5

Chain	Residue	Details
E	LYS904
D	SER494
D	SER521
D	SER529

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	LIPID: N-myristoyl glycine => ECO:0000269|PubMed:25255805

Chain	Residue	Details
E	GLY2
D	SER607
2	SER436

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25218447, ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:28112733

Chain	Residue	Details
E	LYS186
A	LYS131
A	LYS424
A	LYS499

---

site_id	SWS_FT_FI11
Number of Residues	5
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
D	SER557
E	LYS325
E	LYS779
E	LYS908
E	LYS916

---

site_id	SWS_FT_FI12
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18318008, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
D	SER579
2	LYS280
2	LYS492
2	LYS543
2	LYS770
2	LYS790
2	LYS843
2	LYS857

---

site_id	SWS_FT_FI13
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:21406692

Chain	Residue	Details
D	SER597
D	SER600

---

site_id	SWS_FT_FI14
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18318008, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
D	SER616
D	SER676

---

site_id	SWS_FT_FI15
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18318008, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
D	SER624

---

site_id	SWS_FT_FI16
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:20068231

Chain	Residue	Details
D	THR633

---

site_id	SWS_FT_FI17
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18318008, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
D	SER642

---

site_id	SWS_FT_FI18
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
D	SER702

---

site_id	SWS_FT_FI19
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
D	SER713
D	SER714
1	THR278
1	THR303
1	THR313

---

site_id	SWS_FT_FI20
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
D	SER721

---

site_id	SWS_FT_FI21
Number of Residues	1
Details	MOD_RES: Phosphoserine; by CK2 => ECO:0000269|PubMed:35597237

Chain	Residue	Details
D	SER748

---

site_id	SWS_FT_FI22
Number of Residues	3
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
D	LYS429
D	LYS430

---

site_id	SWS_FT_FI23
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:23186163

Chain	Residue	Details
1	THR296

---

site_id	SWS_FT_FI24
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:17081983

Chain	Residue	Details
1	THR299

---

site_id	SWS_FT_FI25
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
1	SER322

---

site_id	SWS_FT_FI26
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
1	THR326

---

site_id	SWS_FT_FI27
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231

Chain	Residue	Details
1	THR328

---

site_id	SWS_FT_FI28
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163

Chain	Residue	Details
1	SER332

---

site_id	SWS_FT_FI29
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:21406692

Chain	Residue	Details
1	THR341

---

site_id	SWS_FT_FI30
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692

Chain	Residue	Details
1	SER344

---

site_id	SWS_FT_FI31
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:21406692

Chain	Residue	Details
1	SER349

---

site_id	SWS_FT_FI32
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163

Chain	Residue	Details
1	THR350
1	THR436

---

site_id	SWS_FT_FI33
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
1	THR354

---

site_id	SWS_FT_FI34
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163

Chain	Residue	Details
1	SER400

---

site_id	SWS_FT_FI35
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by DYRK1A => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163

Chain	Residue	Details
1	THR434

---

site_id	SWS_FT_FI36
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
1	SER488

---

site_id	SWS_FT_FI37
Number of Residues	1
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733

Chain	Residue	Details
1	LYS214

---

site_id	SWS_FT_FI38
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
1	LYS430

---

site_id	SWS_FT_FI39
Number of Residues	1
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:25114211, ECO:0007744|PubMed:25218447, ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:28112733

Chain	Residue	Details
1	LYS413

---