7DX8

Trypsin-digested S protein of SARS-CoV-2 bound with PD of ACE2 in the conformation 2 (2 up RBD and 2 PD bound)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016020	cellular_component	membrane
A	0019031	cellular_component	viral envelope
A	0019064	biological_process	fusion of virus membrane with host plasma membrane
A	0039654	biological_process	fusion of virus membrane with host endosome membrane
A	0046813	biological_process	receptor-mediated virion attachment to host cell
A	0055036	cellular_component	virion membrane
A	0075509	biological_process	endocytosis involved in viral entry into host cell
B	0016020	cellular_component	membrane
B	0019031	cellular_component	viral envelope
B	0019064	biological_process	fusion of virus membrane with host plasma membrane
B	0039654	biological_process	fusion of virus membrane with host endosome membrane
B	0046813	biological_process	receptor-mediated virion attachment to host cell
B	0055036	cellular_component	virion membrane
B	0075509	biological_process	endocytosis involved in viral entry into host cell
C	0016020	cellular_component	membrane
C	0019031	cellular_component	viral envelope
C	0019064	biological_process	fusion of virus membrane with host plasma membrane
C	0039654	biological_process	fusion of virus membrane with host endosome membrane
C	0046813	biological_process	receptor-mediated virion attachment to host cell
C	0055036	cellular_component	virion membrane
C	0075509	biological_process	endocytosis involved in viral entry into host cell
D	0001618	molecular_function	virus receptor activity
D	0001817	biological_process	regulation of cytokine production
D	0002003	biological_process	angiotensin maturation
D	0003051	biological_process	angiotensin-mediated drinking behavior
D	0003081	biological_process	regulation of systemic arterial blood pressure by renin-angiotensin
D	0004175	molecular_function	endopeptidase activity
D	0004180	molecular_function	carboxypeptidase activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005737	cellular_component	cytoplasm
D	0005788	cellular_component	endoplasmic reticulum lumen
D	0005886	cellular_component	plasma membrane
D	0005929	cellular_component	cilium
D	0006508	biological_process	proteolysis
D	0008237	molecular_function	metallopeptidase activity
D	0008241	molecular_function	peptidyl-dipeptidase activity
D	0008270	molecular_function	zinc ion binding
D	0009986	cellular_component	cell surface
D	0015827	biological_process	tryptophan transport
D	0016020	cellular_component	membrane
D	0016324	cellular_component	apical plasma membrane
D	0019058	biological_process	viral life cycle
D	0019065	biological_process	receptor-mediated endocytosis of virus by host cell
D	0019229	biological_process	regulation of vasoconstriction
D	0022898	biological_process	regulation of transmembrane transporter activity
D	0030666	cellular_component	endocytic vesicle membrane
D	0031526	cellular_component	brush border membrane
D	0042127	biological_process	regulation of cell population proliferation
D	0042802	molecular_function	identical protein binding
D	0042995	cellular_component	cell projection
D	0045121	cellular_component	membrane raft
D	0046718	biological_process	symbiont entry into host cell
D	0046813	biological_process	receptor-mediated virion attachment to host cell
D	0046872	molecular_function	metal ion binding
D	0048662	biological_process	negative regulation of smooth muscle cell proliferation
D	0050727	biological_process	regulation of inflammatory response
D	0051957	biological_process	positive regulation of amino acid transport
D	0060135	biological_process	maternal process involved in female pregnancy
D	0060452	biological_process	positive regulation of cardiac muscle contraction
D	0061025	biological_process	membrane fusion
D	0070062	cellular_component	extracellular exosome
D	0070373	biological_process	negative regulation of ERK1 and ERK2 cascade
D	0097746	biological_process	blood vessel diameter maintenance
D	0098670	biological_process	entry receptor-mediated virion attachment to host cell
D	1903598	biological_process	positive regulation of gap junction assembly
D	1903779	biological_process	regulation of cardiac conduction
D	1905737	biological_process	positive regulation of L-proline import across plasma membrane
D	2000272	biological_process	negative regulation of signaling receptor activity
D	2000379	biological_process	positive regulation of reactive oxygen species metabolic process
E	0001618	molecular_function	virus receptor activity
E	0001817	biological_process	regulation of cytokine production
E	0002003	biological_process	angiotensin maturation
E	0003051	biological_process	angiotensin-mediated drinking behavior
E	0003081	biological_process	regulation of systemic arterial blood pressure by renin-angiotensin
E	0004175	molecular_function	endopeptidase activity
E	0004180	molecular_function	carboxypeptidase activity
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0005737	cellular_component	cytoplasm
E	0005788	cellular_component	endoplasmic reticulum lumen
E	0005886	cellular_component	plasma membrane
E	0005929	cellular_component	cilium
E	0006508	biological_process	proteolysis
E	0008237	molecular_function	metallopeptidase activity
E	0008241	molecular_function	peptidyl-dipeptidase activity
E	0008270	molecular_function	zinc ion binding
E	0009986	cellular_component	cell surface
E	0015827	biological_process	tryptophan transport
E	0016020	cellular_component	membrane
E	0016324	cellular_component	apical plasma membrane
E	0019058	biological_process	viral life cycle
E	0019065	biological_process	receptor-mediated endocytosis of virus by host cell
E	0019229	biological_process	regulation of vasoconstriction
E	0022898	biological_process	regulation of transmembrane transporter activity
E	0030666	cellular_component	endocytic vesicle membrane
E	0031526	cellular_component	brush border membrane
E	0042127	biological_process	regulation of cell population proliferation
E	0042802	molecular_function	identical protein binding
E	0042995	cellular_component	cell projection
E	0045121	cellular_component	membrane raft
E	0046718	biological_process	symbiont entry into host cell
E	0046813	biological_process	receptor-mediated virion attachment to host cell
E	0046872	molecular_function	metal ion binding
E	0048662	biological_process	negative regulation of smooth muscle cell proliferation
E	0050727	biological_process	regulation of inflammatory response
E	0051957	biological_process	positive regulation of amino acid transport
E	0060135	biological_process	maternal process involved in female pregnancy
E	0060452	biological_process	positive regulation of cardiac muscle contraction
E	0061025	biological_process	membrane fusion
E	0070062	cellular_component	extracellular exosome
E	0070373	biological_process	negative regulation of ERK1 and ERK2 cascade
E	0097746	biological_process	blood vessel diameter maintenance
E	0098670	biological_process	entry receptor-mediated virion attachment to host cell
E	1903598	biological_process	positive regulation of gap junction assembly
E	1903779	biological_process	regulation of cardiac conduction
E	1905737	biological_process	positive regulation of L-proline import across plasma membrane
E	2000272	biological_process	negative regulation of signaling receptor activity
E	2000379	biological_process	positive regulation of reactive oxygen species metabolic process

Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TAHHEMGHIQ

Chain	Residue	Details
D	THR371-GLN380

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1444
Details	TOPO_DOM: Extracellular => ECO:0000255

Chain	Residue	Details
D	GLN18-SER740
E	GLN18-SER740
C	GLN14-PRO1213

---

site_id	SWS_FT_FI2
Number of Residues	40
Details	TRANSMEM: Helical => ECO:0000255|PROSITE-ProRule:PRU01354

Chain	Residue	Details
D	ILE741-ILE761
E	ILE741-ILE761
C	TRP1214-LEU1234

---

site_id	SWS_FT_FI3
Number of Residues	86
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
D	PHE762-PHE805
E	PHE762-PHE805
C	CYS1235-THR1273

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU01355, ECO:0000305|PubMed:14754895, ECO:0000305|PubMed:27217402

Chain	Residue	Details
C	ARG685
D	GLU375
E	GLU375

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	ACT_SITE: Proton donor => ECO:0000255|PROSITE-ProRule:PRU01355, ECO:0000305|PubMed:14754895

Chain	Residue	Details
C	ARG815
D	HIS505
E	HIS505

---

site_id	SWS_FT_FI6
Number of Residues	6
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01355, ECO:0000269|PubMed:14754895, ECO:0000305|PubMed:19021774

Chain	Residue	Details
B	CYS1243
C	CYS1235
C	CYS1236
C	CYS1240
C	CYS1241
C	CYS1243
B	CYS1236
B	CYS1240
B	CYS1241
D	ARG169
D	TRP477
D	LYS481
E	ARG169
E	TRP477
E	LYS481

---

site_id	SWS_FT_FI7
Number of Residues	6
Details	BINDING: BINDING => ECO:0000305|PubMed:14754895

Chain	Residue	Details
B	CYS1248
B	CYS1250
B	CYS1253
B	CYS1254
C	CYS1247
C	CYS1248
C	CYS1250
C	CYS1253
C	CYS1254
D	ARG273
D	HIS345
D	TYR515
E	ARG273
E	HIS345
E	TYR515

---

site_id	SWS_FT_FI8
Number of Residues	6
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01355, ECO:0000269|PubMed:14754895

Chain	Residue	Details
C	ASN17
C	ASN1158
C	ASN1173
E	HIS378
E	GLU402
D	HIS374
D	HIS378
D	GLU402
E	HIS374

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0000305|PubMed:33436497, ECO:0000305|PubMed:33436498

Chain	Residue	Details
A	ASN717
A	ASN801
A	ASN1074
B	ASN61
B	ASN122
B	ASN717
B	ASN801
B	ASN1074
C	ASN61
C	ASN122
C	ASN717
C	ASN801
C	ASN1074
D	TYR781
E	TYR781

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000305|PubMed:33436497, ECO:0000305|PubMed:33436498

Chain	Residue	Details
C	ASN74
C	ASN149
C	ASN1194
A	ASN1194
B	ASN74
B	ASN149
B	ASN1194
D	SER783
E	SER783

---

site_id	SWS_FT_FI11
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000305|PubMed:14754895

Chain	Residue	Details
A	ASN616
A	ASN657
A	ASN1098
B	ASN165
B	ASN282
B	ASN331
B	ASN343
B	ASN616
B	ASN657
B	ASN1098
C	ASN165
C	ASN282
C	ASN331
C	ASN343
C	ASN616
C	ASN657
C	ASN1098
D	ASN53
D	ASN322
E	ASN53
E	ASN322

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:14754895, ECO:0000269|PubMed:15084671, ECO:0000269|PubMed:19901337

Chain	Residue	Details
B	ASN709
C	ASN234
C	ASN709
B	ASN234
D	ASN90
E	ASN90

---

site_id	SWS_FT_FI13
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:14754895

Chain	Residue	Details
D	ASN103
D	ASN432
E	ASN103
E	ASN432

---

site_id	SWS_FT_FI14
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:14754895, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19901337

Chain	Residue	Details
C	SER325
D	ASN546
E	ASN546

---

site_id	SWS_FT_FI15
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
C	ASN603
D	ASN690
E	ASN690

---

site_id	SWS_FT_FI16
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36876523

Chain	Residue	Details
A	THR678
B	THR678
C	THR676
C	THR678
D	LYS788
E	LYS788

---

site_id	SWS_FT_FI17
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942

Chain	Residue	Details
A	ASN1134
B	ASN1134
C	ASN1134

---