7DWB

Human Pannexin1 model

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006812	biological_process	monoatomic cation transport
A	0015267	molecular_function	channel activity
A	0032732	biological_process	positive regulation of interleukin-1 production
B	0006812	biological_process	monoatomic cation transport
B	0015267	molecular_function	channel activity
B	0032732	biological_process	positive regulation of interleukin-1 production
C	0006812	biological_process	monoatomic cation transport
C	0015267	molecular_function	channel activity
C	0032732	biological_process	positive regulation of interleukin-1 production
D	0006812	biological_process	monoatomic cation transport
D	0015267	molecular_function	channel activity
D	0032732	biological_process	positive regulation of interleukin-1 production
E	0006812	biological_process	monoatomic cation transport
E	0015267	molecular_function	channel activity
E	0032732	biological_process	positive regulation of interleukin-1 production
F	0006812	biological_process	monoatomic cation transport
F	0015267	molecular_function	channel activity
F	0032732	biological_process	positive regulation of interleukin-1 production
G	0006812	biological_process	monoatomic cation transport
G	0015267	molecular_function	channel activity
G	0032732	biological_process	positive regulation of interleukin-1 production

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	560
Details	TRANSMEM: Helical => ECO:0000255|PROSITE-ProRule:PRU00351

Chain	Residue	Details
A	ILE41-GLY61
A	LYS107-TRP127
A	LEU226-SER246
A	LEU275-LEU295
B	ILE41-GLY61
B	LYS107-TRP127
B	LEU226-SER246
B	LEU275-LEU295
C	ILE41-GLY61
C	LYS107-TRP127
C	LEU226-SER246
C	LEU275-LEU295
D	ILE41-GLY61
D	LYS107-TRP127
D	LEU226-SER246
D	LEU275-LEU295
E	ILE41-GLY61
E	LYS107-TRP127
E	LEU226-SER246
E	LEU275-LEU295
F	ILE41-GLY61
F	LYS107-TRP127
F	LEU226-SER246
F	LEU275-LEU295
G	ILE41-GLY61
G	LYS107-TRP127
G	LEU226-SER246
G	LEU275-LEU295

---

site_id	SWS_FT_FI2
Number of Residues	497
Details	TOPO_DOM: Extracellular => ECO:0000255

Chain	Residue	Details
A	THR62-HIS106
A	SER247-LYS274
B	THR62-HIS106
B	SER247-LYS274
C	THR62-HIS106
C	SER247-LYS274
D	THR62-HIS106
D	SER247-LYS274
E	THR62-HIS106
E	SER247-LYS274
F	THR62-HIS106
F	SER247-LYS274
G	THR62-HIS106
G	SER247-LYS274

---

site_id	SWS_FT_FI3
Number of Residues	1589
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
A	ARG128-LEU217
A	ALA296-CYS434
B	ARG128-LEU217
B	ALA296-CYS434
C	ARG128-LEU217
C	ALA296-CYS434
D	ARG128-LEU217
D	ALA296-CYS434
E	ARG128-LEU217
E	ALA296-CYS434
F	ARG128-LEU217
F	ALA296-CYS434
G	ARG128-LEU217
G	ALA296-CYS434

---

site_id	SWS_FT_FI4
Number of Residues	7
Details	SITE: Cleavage; by CASP3 or CASP7 => ECO:0000269|PubMed:20944749

Chain	Residue	Details
C	ASP384
D	ASP384
E	ASP384
F	ASP384
G	ASP384
A	ASP384
B	ASP384

---

site_id	SWS_FT_FI5
Number of Residues	14
Details	MOD_RES: S-nitrosocysteine => ECO:0000250|UniProtKB:Q9JIP4

Chain	Residue	Details
D	CYS355
E	CYS40
E	CYS355
F	CYS40
F	CYS355
G	CYS40
G	CYS355
A	CYS355
B	CYS40
B	CYS355
C	CYS40
C	CYS355
D	CYS40
A	CYS40

---

site_id	SWS_FT_FI6
Number of Residues	7
Details	MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:30814251

Chain	Residue	Details
A	TYR207
B	TYR207
C	TYR207
D	TYR207
E	TYR207
F	TYR207
G	TYR207

---

site_id	SWS_FT_FI7
Number of Residues	7
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17715132, ECO:0000269|PubMed:30918116, ECO:0000269|PubMed:32494015, ECO:0000269|PubMed:33947837

Chain	Residue	Details
A	ASN263
B	ASN263
C	ASN263
D	ASN263
E	ASN263
F	ASN263
G	ASN263

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