7DTD
Voltage-gated sodium channel Nav1.1 and beta4
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001518 | cellular_component | voltage-gated sodium channel complex |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005248 | molecular_function | voltage-gated sodium channel activity |
| A | 0005261 | molecular_function | monoatomic cation channel activity |
| A | 0005272 | molecular_function | sodium channel activity |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006814 | biological_process | sodium ion transport |
| A | 0007628 | biological_process | adult walking behavior |
| A | 0008340 | biological_process | determination of adult lifespan |
| A | 0014704 | cellular_component | intercalated disc |
| A | 0016020 | cellular_component | membrane |
| A | 0016604 | cellular_component | nuclear body |
| A | 0019227 | biological_process | neuronal action potential propagation |
| A | 0019228 | biological_process | neuronal action potential |
| A | 0021675 | biological_process | nerve development |
| A | 0030018 | cellular_component | Z disc |
| A | 0030315 | cellular_component | T-tubule |
| A | 0030424 | cellular_component | axon |
| A | 0033268 | cellular_component | node of Ranvier |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| A | 0034702 | cellular_component | monoatomic ion channel complex |
| A | 0034706 | cellular_component | sodium channel complex |
| A | 0035725 | biological_process | sodium ion transmembrane transport |
| A | 0042391 | biological_process | regulation of membrane potential |
| A | 0043025 | cellular_component | neuronal cell body |
| A | 0043194 | cellular_component | axon initial segment |
| A | 0050884 | biological_process | neuromuscular process controlling posture |
| A | 0050966 | biological_process | detection of mechanical stimulus involved in sensory perception of pain |
| A | 0051649 | biological_process | establishment of localization in cell |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0086002 | biological_process | cardiac muscle cell action potential involved in contraction |
| A | 0086010 | biological_process | membrane depolarization during action potential |
| A | 0099505 | biological_process | regulation of presynaptic membrane potential |
| A | 0099508 | molecular_function | voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential |
| B | 0016020 | cellular_component | membrane |
Functional Information from PROSITE/UniProt
| site_id | PS00648 |
| Number of Residues | 15 |
| Details | RIBONUCLEASE_P Bacterial ribonuclease P protein component signature. IqrAyrRHLLKRtVK |
| Chain | Residue | Details |
| A | ILE1922-LYS1936 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1103 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305 |
| Chain | Residue | Details |
| A | MET1-SER128 | |
| A | GLY1480-VAL1542 | |
| A | LYS1591-ILE1602 | |
| A | LYS1651-ALA1669 | |
| A | LEU1786-LYS2009 | |
| A | ARG176-PRO189 | |
| A | PRO231-ASP249 | |
| A | VAL421-PRO768 | |
| A | ILE819-TRP832 | |
| A | TRP873-GLY888 | |
| A | LEU992-TRP1219 | |
| A | LYS1270-ALA1283 | |
| A | PHE1330-SER1346 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S1 of repeat I => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | LEU129-MET147 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 323 |
| Details | TOPO_DOM: Extracellular => ECO:0000305 |
| Chain | Residue | Details |
| A | SER148-THR154 | |
| A | ALA1303-GLY1310 | |
| A | ASN1367-VAL1418 | |
| A | ALA1441-LEU1457 | |
| A | GLU1561-THR1571 | |
| A | LEU1621-THR1633 | |
| A | GLY1688-THR1709 | |
| A | ILE1733-GLY1762 | |
| A | ASP208-SER213 | |
| A | MET270-THR367 | |
| A | ARG393-TYR399 | |
| A | GLU788-ASN798 | |
| A | GLU853-GLY854 | |
| A | GLY908-ASP936 | |
| A | ASP958-THR970 | |
| A | GLU1238-THR1250 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=S2 of repeat I => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | LYS155-ALA175 | |
| B | ASN71 | |
| B | ASN113 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 17 |
| Details | TRANSMEM: Helical; Name=S3 of repeat I => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | TRP190-VAL207 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 16 |
| Details | TRANSMEM: Helical; Name=S4 of repeat I => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | ALA214-ILE230 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=S5 of repeat I => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | VAL250-PHE269 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 87 |
| Details | INTRAMEM: Pore-forming => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | PHE368-LEU392 | |
| A | PHE937-TRP957 | |
| A | GLY1419-ALA1440 | |
| A | PHE1710-PRO1732 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=S6 of repeat I => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | MET400-ALA420 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S1 of repeat II => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | PHE769-MET787 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=S2 of repeat II => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | VAL799-LYS818 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=S3 of repeat II => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | ASN833-VAL852 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 17 |
| Details | TRANSMEM: Helical; Name=S4 of repeat II => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | LEU855-SER872 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S5 of repeat II => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | ALA889-VAL907 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=S6 of repeat II => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | VAL971-LEU991 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 17 |
| Details | TRANSMEM: Helical; Name=S1 of repeat III => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | PHE1220-PHE1237 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S2 of repeat III => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | MET1251-LEU1269 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S3 of repeat III => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | TRP1284-ASN1302 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S4 of repeat III => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | ALA1311-ARG1329 |
| site_id | SWS_FT_FI20 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=S5 of repeat III => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | ILE1347-VAL1366 |
| site_id | SWS_FT_FI21 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=S6 of repeat III => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | TYR1458-ILE1479 |
| site_id | SWS_FT_FI22 |
| Number of Residues | 17 |
| Details | TRANSMEM: Helical; Name=S1 of repeat IV => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | PHE1543-VAL1560 |
| site_id | SWS_FT_FI23 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S2 of repeat IV => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | ILE1572-LEU1590 |
| site_id | SWS_FT_FI24 |
| Number of Residues | 17 |
| Details | TRANSMEM: Helical; Name=S3 of repeat IV => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | GLY1603-PHE1620 |
| site_id | SWS_FT_FI25 |
| Number of Residues | 16 |
| Details | TRANSMEM: Helical; Name=S4 of repeat IV => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | LEU1634-ILE1650 |
| site_id | SWS_FT_FI26 |
| Number of Residues | 17 |
| Details | TRANSMEM: Helical; Name=S5 of repeat IV => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | LEU1670-PHE1687 |
| site_id | SWS_FT_FI27 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=S6 of repeat IV => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| A | ILE1763-ILE1785 |
| site_id | SWS_FT_FI28 |
| Number of Residues | 1 |
| Details | SITE: Key residue that permits the spider beta/delta-theraphotoxin-Pre1a to inhibit fast inactivation of the channel => ECO:0000269|PubMed:28428547 |
| Chain | Residue | Details |
| A | SER1574 |
| site_id | SWS_FT_FI29 |
| Number of Residues | 6 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P04774 |
| Chain | Residue | Details |
| A | SER470 | |
| A | SER523 | |
| A | SER525 | |
| A | SER550 | |
| A | SER607 | |
| A | SER730 |
| site_id | SWS_FT_FI30 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:A2APX8 |
| Chain | Residue | Details |
| A | SER551 |
| site_id | SWS_FT_FI31 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by PKC => ECO:0000250|UniProtKB:P04775 |
| Chain | Residue | Details |
| A | SER1516 |
| site_id | SWS_FT_FI32 |
| Number of Residues | 9 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN211 | |
| A | ASN284 | |
| A | ASN295 | |
| A | ASN301 | |
| A | ASN306 | |
| A | ASN338 | |
| A | ASN1378 | |
| A | ASN1392 | |
| A | ASN1403 |
