Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

7DNZ

Cryo-EM structure of the human ABCB6 (Hemin and GSH-bound)

Functional Information from GO Data
ChainGOidnamespacecontents
A0000139cellular_componentGolgi membrane
A0005524molecular_functionATP binding
A0005576cellular_componentextracellular region
A0005654cellular_componentnucleoplasm
A0005739cellular_componentmitochondrion
A0005740cellular_componentmitochondrial envelope
A0005741cellular_componentmitochondrial outer membrane
A0005764cellular_componentlysosome
A0005765cellular_componentlysosomal membrane
A0005768cellular_componentendosome
A0005774cellular_componentvacuolar membrane
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005794cellular_componentGolgi apparatus
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006778biological_processporphyrin-containing compound metabolic process
A0006779biological_processporphyrin-containing compound biosynthetic process
A0006785biological_processheme B biosynthetic process
A0006878biological_processintracellular copper ion homeostasis
A0006879biological_processintracellular iron ion homeostasis
A0007420biological_processbrain development
A0015439molecular_functionABC-type heme transporter activity
A0015562molecular_functionefflux transmembrane transporter activity
A0015886biological_processheme transport
A0016020cellular_componentmembrane
A0016887molecular_functionATP hydrolysis activity
A0020037molecular_functionheme binding
A0031901cellular_componentearly endosome membrane
A0031902cellular_componentlate endosome membrane
A0032585cellular_componentmultivesicular body membrane
A0033013biological_processtetrapyrrole metabolic process
A0033162cellular_componentmelanosome membrane
A0035351biological_processheme transmembrane transport
A0036020cellular_componentendolysosome membrane
A0042168biological_processheme metabolic process
A0043190cellular_componentATP-binding cassette (ABC) transporter complex
A0043588biological_processskin development
A0046906molecular_functiontetrapyrrole binding
A0055085biological_processtransmembrane transport
A0070062cellular_componentextracellular exosome
A0098849biological_processcellular detoxification of cadmium ion
A0140359molecular_functionABC-type transporter activity
A1903232biological_processmelanosome assembly
B0000139cellular_componentGolgi membrane
B0005524molecular_functionATP binding
B0005576cellular_componentextracellular region
B0005654cellular_componentnucleoplasm
B0005739cellular_componentmitochondrion
B0005740cellular_componentmitochondrial envelope
B0005741cellular_componentmitochondrial outer membrane
B0005764cellular_componentlysosome
B0005765cellular_componentlysosomal membrane
B0005768cellular_componentendosome
B0005774cellular_componentvacuolar membrane
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0005794cellular_componentGolgi apparatus
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006778biological_processporphyrin-containing compound metabolic process
B0006779biological_processporphyrin-containing compound biosynthetic process
B0006785biological_processheme B biosynthetic process
B0006878biological_processintracellular copper ion homeostasis
B0006879biological_processintracellular iron ion homeostasis
B0007420biological_processbrain development
B0015439molecular_functionABC-type heme transporter activity
B0015562molecular_functionefflux transmembrane transporter activity
B0015886biological_processheme transport
B0016020cellular_componentmembrane
B0016887molecular_functionATP hydrolysis activity
B0020037molecular_functionheme binding
B0031901cellular_componentearly endosome membrane
B0031902cellular_componentlate endosome membrane
B0032585cellular_componentmultivesicular body membrane
B0033013biological_processtetrapyrrole metabolic process
B0033162cellular_componentmelanosome membrane
B0035351biological_processheme transmembrane transport
B0036020cellular_componentendolysosome membrane
B0042168biological_processheme metabolic process
B0043190cellular_componentATP-binding cassette (ABC) transporter complex
B0043588biological_processskin development
B0046906molecular_functiontetrapyrrole binding
B0055085biological_processtransmembrane transport
B0070062cellular_componentextracellular exosome
B0098849biological_processcellular detoxification of cadmium ion
B0140359molecular_functionABC-type transporter activity
B1903232biological_processmelanosome assembly
Functional Information from PROSITE/UniProt
site_idPS00211
Number of Residues15
DetailsABC_TRANSPORTER_1 ABC transporters family signature. LSGGEKQRVAIARTI
ChainResidueDetails
ALEU727-ILE741

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues136
DetailsTOPO_DOM: Lumenal => ECO:0000305|PubMed:18279659, ECO:0000305|PubMed:21199866
ChainResidueDetails
AMET1-CYS26
BPHE285-ASN291
BASP397
BTHR521-ASP529
AARG94-TYR106
AASN169-GLN185
APHE285-ASN291
AASP397
ATHR521-ASP529
BMET1-CYS26
BARG94-TYR106
BASN169-GLN185

site_idSWS_FT_FI2
Number of Residues200
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
APHE27-ALA47
BPHE186-ALA206
ATYR73-GLY93
ALEU107-VAL127
APRO148-TRP168
APHE186-ALA206
BPHE27-ALA47
BTYR73-GLY93
BLEU107-VAL127
BPRO148-TRP168

site_idSWS_FT_FI3
Number of Residues1064
DetailsTOPO_DOM: Cytoplasmic => ECO:0000305
ChainResidueDetails
ALEU48-PRO72
BLYS313-ARG375
BLEU419-GLN499
BTYR551-ARG842
AGLU128-SER147
APRO207-LEU263
ALYS313-ARG375
ALEU419-GLN499
ATYR551-ARG842
BLEU48-PRO72
BGLU128-SER147
BPRO207-LEU263

site_idSWS_FT_FI4
Number of Residues240
DetailsTRANSMEM: Helical => ECO:0000255, ECO:0000255|PROSITE-ProRule:PRU00441
ChainResidueDetails
AVAL264-ILE284
BILE398-PHE418
BTHR500-VAL520
BTYR530-TYR550
ALEU292-LEU312
AGLY376-ALA396
AILE398-PHE418
ATHR500-VAL520
ATYR530-TYR550
BVAL264-ILE284
BLEU292-LEU312
BGLY376-ALA396

site_idSWS_FT_FI5
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:20823549, ECO:0007744|PDB:3NH9
ChainResidueDetails
BTYR599
BGLY623
ATYR599
AGLY623

site_idSWS_FT_FI6
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21199866
ChainResidueDetails
AASN6
BASN6

219869

PDB entries from 2024-05-15

PDB statisticsPDBj update infoContact PDBjnumon