7D60
Cryo-EM Structure of human CALHM5 in the presence of rubidium red
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005261 | molecular_function | monoatomic cation channel activity |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0016020 | cellular_component | membrane |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| A | 0098655 | biological_process | monoatomic cation transmembrane transport |
| B | 0005261 | molecular_function | monoatomic cation channel activity |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0016020 | cellular_component | membrane |
| B | 0034220 | biological_process | monoatomic ion transmembrane transport |
| B | 0098655 | biological_process | monoatomic cation transmembrane transport |
| C | 0005261 | molecular_function | monoatomic cation channel activity |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0016020 | cellular_component | membrane |
| C | 0034220 | biological_process | monoatomic ion transmembrane transport |
| C | 0098655 | biological_process | monoatomic cation transmembrane transport |
| D | 0005261 | molecular_function | monoatomic cation channel activity |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0016020 | cellular_component | membrane |
| D | 0034220 | biological_process | monoatomic ion transmembrane transport |
| D | 0098655 | biological_process | monoatomic cation transmembrane transport |
| E | 0005261 | molecular_function | monoatomic cation channel activity |
| E | 0005886 | cellular_component | plasma membrane |
| E | 0016020 | cellular_component | membrane |
| E | 0034220 | biological_process | monoatomic ion transmembrane transport |
| E | 0098655 | biological_process | monoatomic cation transmembrane transport |
| F | 0005261 | molecular_function | monoatomic cation channel activity |
| F | 0005886 | cellular_component | plasma membrane |
| F | 0016020 | cellular_component | membrane |
| F | 0034220 | biological_process | monoatomic ion transmembrane transport |
| F | 0098655 | biological_process | monoatomic cation transmembrane transport |
| G | 0005261 | molecular_function | monoatomic cation channel activity |
| G | 0005886 | cellular_component | plasma membrane |
| G | 0016020 | cellular_component | membrane |
| G | 0034220 | biological_process | monoatomic ion transmembrane transport |
| G | 0098655 | biological_process | monoatomic cation transmembrane transport |
| H | 0005261 | molecular_function | monoatomic cation channel activity |
| H | 0005886 | cellular_component | plasma membrane |
| H | 0016020 | cellular_component | membrane |
| H | 0034220 | biological_process | monoatomic ion transmembrane transport |
| H | 0098655 | biological_process | monoatomic cation transmembrane transport |
| I | 0005261 | molecular_function | monoatomic cation channel activity |
| I | 0005886 | cellular_component | plasma membrane |
| I | 0016020 | cellular_component | membrane |
| I | 0034220 | biological_process | monoatomic ion transmembrane transport |
| I | 0098655 | biological_process | monoatomic cation transmembrane transport |
| J | 0005261 | molecular_function | monoatomic cation channel activity |
| J | 0005886 | cellular_component | plasma membrane |
| J | 0016020 | cellular_component | membrane |
| J | 0034220 | biological_process | monoatomic ion transmembrane transport |
| J | 0098655 | biological_process | monoatomic cation transmembrane transport |
| K | 0005261 | molecular_function | monoatomic cation channel activity |
| K | 0005886 | cellular_component | plasma membrane |
| K | 0016020 | cellular_component | membrane |
| K | 0034220 | biological_process | monoatomic ion transmembrane transport |
| K | 0098655 | biological_process | monoatomic cation transmembrane transport |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 462 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305 |
| Chain | Residue | Details |
| A | MET1-LYS15 | |
| E | ASN71-VAL99 | |
| F | MET1-LYS15 | |
| F | ASN71-VAL99 | |
| G | MET1-LYS15 | |
| G | ASN71-VAL99 | |
| H | MET1-LYS15 | |
| H | ASN71-VAL99 | |
| I | MET1-LYS15 | |
| I | ASN71-VAL99 | |
| J | MET1-LYS15 | |
| A | ASN71-VAL99 | |
| J | ASN71-VAL99 | |
| K | MET1-LYS15 | |
| K | ASN71-VAL99 | |
| B | MET1-LYS15 | |
| B | ASN71-VAL99 | |
| C | MET1-LYS15 | |
| C | ASN71-VAL99 | |
| D | MET1-LYS15 | |
| D | ASN71-VAL99 | |
| E | MET1-LYS15 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 231 |
| Details | TRANSMEM: Helical; Name=S1 => ECO:0000269|PubMed:33298887, ECO:0007744|PDB:7D60 |
| Chain | Residue | Details |
| A | THR16-VAL37 | |
| J | THR16-VAL37 | |
| K | THR16-VAL37 | |
| B | THR16-VAL37 | |
| C | THR16-VAL37 | |
| D | THR16-VAL37 | |
| E | THR16-VAL37 | |
| F | THR16-VAL37 | |
| G | THR16-VAL37 | |
| H | THR16-VAL37 | |
| I | THR16-VAL37 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 561 |
| Details | TOPO_DOM: Extracellular => ECO:0000305 |
| Chain | Residue | Details |
| A | ALA38-THR45 | |
| E | SER130-SER174 | |
| F | ALA38-THR45 | |
| F | SER130-SER174 | |
| G | ALA38-THR45 | |
| G | SER130-SER174 | |
| H | ALA38-THR45 | |
| H | SER130-SER174 | |
| I | ALA38-THR45 | |
| I | SER130-SER174 | |
| J | ALA38-THR45 | |
| A | SER130-SER174 | |
| J | SER130-SER174 | |
| K | ALA38-THR45 | |
| K | SER130-SER174 | |
| B | ALA38-THR45 | |
| B | SER130-SER174 | |
| C | ALA38-THR45 | |
| C | SER130-SER174 | |
| D | ALA38-THR45 | |
| D | SER130-SER174 | |
| E | ALA38-THR45 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 264 |
| Details | TRANSMEM: Helical; Name=S2 => ECO:0000269|PubMed:33298887, ECO:0007744|PDB:7D60 |
| Chain | Residue | Details |
| A | GLU46-ASN70 | |
| J | GLU46-ASN70 | |
| K | GLU46-ASN70 | |
| B | GLU46-ASN70 | |
| C | GLU46-ASN70 | |
| D | GLU46-ASN70 | |
| E | GLU46-ASN70 | |
| F | GLU46-ASN70 | |
| G | GLU46-ASN70 | |
| H | GLU46-ASN70 | |
| I | GLU46-ASN70 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 319 |
| Details | TRANSMEM: Helical; Name=S3 => ECO:0000269|PubMed:33298887, ECO:0007744|PDB:7D60 |
| Chain | Residue | Details |
| A | LEU100-MET129 | |
| J | LEU100-MET129 | |
| K | LEU100-MET129 | |
| B | LEU100-MET129 | |
| C | LEU100-MET129 | |
| D | LEU100-MET129 | |
| E | LEU100-MET129 | |
| F | LEU100-MET129 | |
| G | LEU100-MET129 | |
| H | LEU100-MET129 | |
| I | LEU100-MET129 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 275 |
| Details | TRANSMEM: Helical; Name=S4 => ECO:0000269|PubMed:33298887, ECO:0007744|PDB:7D60 |
| Chain | Residue | Details |
| A | LEU175-TYR200 | |
| J | LEU175-TYR200 | |
| K | LEU175-TYR200 | |
| B | LEU175-TYR200 | |
| C | LEU175-TYR200 | |
| D | LEU175-TYR200 | |
| E | LEU175-TYR200 | |
| F | LEU175-TYR200 | |
| G | LEU175-TYR200 | |
| H | LEU175-TYR200 | |
| I | LEU175-TYR200 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 33 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:33298887, ECO:0007744|PDB:7D60 |
| Chain | Residue | Details |
| A | LYS15 | |
| D | LYS15 | |
| D | GLN102 | |
| D | ARG202 | |
| E | LYS15 | |
| E | GLN102 | |
| E | ARG202 | |
| F | LYS15 | |
| F | GLN102 | |
| F | ARG202 | |
| G | LYS15 | |
| A | GLN102 | |
| G | GLN102 | |
| G | ARG202 | |
| H | LYS15 | |
| H | GLN102 | |
| H | ARG202 | |
| I | LYS15 | |
| I | GLN102 | |
| I | ARG202 | |
| J | LYS15 | |
| J | GLN102 | |
| A | ARG202 | |
| J | ARG202 | |
| K | LYS15 | |
| K | GLN102 | |
| K | ARG202 | |
| B | LYS15 | |
| B | GLN102 | |
| B | ARG202 | |
| C | LYS15 | |
| C | GLN102 | |
| C | ARG202 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 22 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:33298887 |
| Chain | Residue | Details |
| A | ARG32 | |
| E | VAL37 | |
| F | ARG32 | |
| F | VAL37 | |
| G | ARG32 | |
| G | VAL37 | |
| H | ARG32 | |
| H | VAL37 | |
| I | ARG32 | |
| I | VAL37 | |
| J | ARG32 | |
| A | VAL37 | |
| J | VAL37 | |
| K | ARG32 | |
| K | VAL37 | |
| B | ARG32 | |
| B | VAL37 | |
| C | ARG32 | |
| C | VAL37 | |
| D | ARG32 | |
| D | VAL37 | |
| E | ARG32 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 11 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:33298887, ECO:0007744|PDB:7D61 |
| Chain | Residue | Details |
| A | ASN121 | |
| J | ASN121 | |
| K | ASN121 | |
| B | ASN121 | |
| C | ASN121 | |
| D | ASN121 | |
| E | ASN121 | |
| F | ASN121 | |
| G | ASN121 | |
| H | ASN121 | |
| I | ASN121 |
