7D1X
Crystal structure of 7-alpha-hydroxyl bile acid sulfotransferase (Sult2a8)
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0008146 | molecular_function | sulfotransferase activity |
A | 0008202 | biological_process | steroid metabolic process |
A | 0016042 | biological_process | lipid catabolic process |
A | 0016740 | molecular_function | transferase activity |
A | 0030573 | biological_process | bile acid catabolic process |
A | 0050656 | molecular_function | 3'-phosphoadenosine 5'-phosphosulfate binding |
A | 0051923 | biological_process | sulfation |
B | 0005737 | cellular_component | cytoplasm |
B | 0005829 | cellular_component | cytosol |
B | 0008146 | molecular_function | sulfotransferase activity |
B | 0008202 | biological_process | steroid metabolic process |
B | 0016042 | biological_process | lipid catabolic process |
B | 0016740 | molecular_function | transferase activity |
B | 0030573 | biological_process | bile acid catabolic process |
B | 0050656 | molecular_function | 3'-phosphoadenosine 5'-phosphosulfate binding |
B | 0051923 | biological_process | sulfation |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 10 |
Details | binding site for residue CHD A 501 |
Chain | Residue |
A | TYR17 |
A | LYS238 |
A | TYR18 |
A | HIS48 |
A | ALA71 |
A | TRP77 |
A | PHE80 |
A | LYS138 |
A | TYR159 |
A | GLU237 |
site_id | AC2 |
Number of Residues | 18 |
Details | binding site for residue A3P A 502 |
Chain | Residue |
A | LYS44 |
A | SER45 |
A | GLY46 |
A | THR47 |
A | HIS48 |
A | TRP49 |
A | ARG121 |
A | SER129 |
A | TYR184 |
A | ILE218 |
A | PHE220 |
A | MET223 |
A | MET243 |
A | ARG244 |
A | LYS245 |
A | GLY246 |
A | HOH610 |
A | HOH621 |
site_id | AC3 |
Number of Residues | 5 |
Details | binding site for residue CHD B 501 |
Chain | Residue |
B | TYR18 |
B | HIS48 |
B | TRP77 |
B | PHE80 |
B | PHE134 |
site_id | AC4 |
Number of Residues | 16 |
Details | binding site for residue A3P B 502 |
Chain | Residue |
B | LYS44 |
B | SER45 |
B | GLY46 |
B | THR47 |
B | HIS48 |
B | TRP49 |
B | ARG121 |
B | SER129 |
B | TYR184 |
B | ILE218 |
B | PHE220 |
B | MET223 |
B | ILE242 |
B | MET243 |
B | ARG244 |
B | LYS245 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Proton acceptor => ECO:0000269|PubMed:29685090, ECO:0000269|PubMed:33872606 |
Chain | Residue | Details |
A | HIS48 | |
B | HIS48 |
site_id | SWS_FT_FI2 |
Number of Residues | 12 |
Details | BINDING: BINDING => ECO:0000269|PubMed:33872606 |
Chain | Residue | Details |
A | ARG121 | |
A | SER129 | |
A | TYR184 | |
A | ILE218 | |
A | ARG244 | |
B | LYS44 | |
B | ARG121 | |
B | SER129 | |
B | TYR184 | |
B | ILE218 | |
B | ARG244 | |
A | LYS44 |