7CMH
The LAT2-4F2hc complex in complex with tryptophan
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0006865 | biological_process | amino acid transport |
| B | 0003333 | biological_process | amino acid transmembrane transport |
| B | 0005515 | molecular_function | protein binding |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006865 | biological_process | amino acid transport |
| B | 0009925 | cellular_component | basal plasma membrane |
| B | 0015101 | molecular_function | organic cation transmembrane transporter activity |
| B | 0015171 | molecular_function | amino acid transmembrane transporter activity |
| B | 0015175 | molecular_function | neutral L-amino acid transmembrane transporter activity |
| B | 0015179 | molecular_function | L-amino acid transmembrane transporter activity |
| B | 0015180 | molecular_function | L-alanine transmembrane transporter activity |
| B | 0015187 | molecular_function | glycine transmembrane transporter activity |
| B | 0015190 | molecular_function | L-leucine transmembrane transporter activity |
| B | 0015297 | molecular_function | antiporter activity |
| B | 0015349 | molecular_function | thyroid hormone transmembrane transporter activity |
| B | 0015804 | biological_process | neutral amino acid transport |
| B | 0015807 | biological_process | L-amino acid transport |
| B | 0015816 | biological_process | glycine transport |
| B | 0015820 | biological_process | L-leucine transport |
| B | 0015827 | biological_process | tryptophan transport |
| B | 0015829 | biological_process | valine transport |
| B | 0016020 | cellular_component | membrane |
| B | 0016323 | cellular_component | basolateral plasma membrane |
| B | 0016324 | cellular_component | apical plasma membrane |
| B | 0019534 | molecular_function | toxin transmembrane transporter activity |
| B | 0022857 | molecular_function | transmembrane transporter activity |
| B | 0031528 | cellular_component | microvillus membrane |
| B | 0035524 | biological_process | proline transmembrane transport |
| B | 0042605 | molecular_function | peptide antigen binding |
| B | 0046982 | molecular_function | protein heterodimerization activity |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0070327 | biological_process | thyroid hormone transport |
| B | 0089718 | biological_process | amino acid import across plasma membrane |
| B | 0150104 | biological_process | transport across blood-brain barrier |
| B | 1902475 | biological_process | L-alpha-amino acid transmembrane transport |
| B | 1903801 | biological_process | L-leucine import across plasma membrane |
| B | 1904273 | biological_process | L-alanine import across plasma membrane |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 82 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:11121428, ECO:0000269|PubMed:30867591 |
| Chain | Residue | Details |
| A | THR102-TRP184 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Signal-anchor for type II membrane protein => ECO:0000269|PubMed:30867591 |
| Chain | Residue | Details |
| A | ALA185-ILE205 | |
| B | LEU150-PRO157 | |
| B | LYS211-ASP230 | |
| B | VAL288-GLY312 | |
| B | ASP383-THR386 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 424 |
| Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:11121428, ECO:0000269|PubMed:30867591 |
| Chain | Residue | Details |
| A | VAL206-ALA630 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | MET103 | |
| A | MET134 | |
| B | TYR253-LEU265 | |
| B | ARG339-PRO364 | |
| B | LEU409-ASN423 | |
| B | VAL467-PRO535 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q794F9 |
| Chain | Residue | Details |
| A | ASP106 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | LEU165 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 5 |
| Details | MOD_RES: Phosphoserine => ECO:0000305|PubMed:19065266 |
| Chain | Residue | Details |
| A | LEU406 | |
| A | ASP408 | |
| A | GLY410 | |
| A | LEU527 | |
| A | ARG531 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12754519, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973, ECO:0000269|PubMed:30867591, ECO:0000269|PubMed:33298890, ECO:0000269|PubMed:33758168, ECO:0000269|PubMed:34880232, ECO:0000269|PubMed:35352032, ECO:0007744|PDB:6IRS, ECO:0007744|PDB:7CMI, ECO:0007744|PDB:7DSK, ECO:0007744|PDB:7EPZ, ECO:0007744|PDB:7P9V |
| Chain | Residue | Details |
| A | GLN365 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12754519, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973, ECO:0000269|PubMed:30867591, ECO:0000269|PubMed:33298890, ECO:0000269|PubMed:33758168, ECO:0000269|PubMed:34880232, ECO:0000269|PubMed:35352032, ECO:0007744|PDB:6IRS, ECO:0007744|PDB:7CMI, ECO:0007744|PDB:7DSK, ECO:0007744|PDB:7EPZ, ECO:0007744|PDB:7P9V |
| Chain | Residue | Details |
| A | THR381 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:12754519, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19349973, ECO:0000269|PubMed:30867591, ECO:0000269|PubMed:33298890, ECO:0000269|PubMed:33758168, ECO:0000269|PubMed:34880232, ECO:0000269|PubMed:35352032, ECO:0007744|PDB:6IRS, ECO:0007744|PDB:7CMI, ECO:0007744|PDB:7DSK, ECO:0007744|PDB:7EPZ, ECO:0007744|PDB:7P9V |
| Chain | Residue | Details |
| A | LEU424 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973, ECO:0000269|PubMed:30867591, ECO:0000269|PubMed:33298890, ECO:0000269|PubMed:33758168, ECO:0000269|PubMed:34880232, ECO:0000269|PubMed:35352032, ECO:0007744|PDB:6IRS, ECO:0007744|PDB:7CMH, ECO:0007744|PDB:7DSK, ECO:0007744|PDB:7EPZ, ECO:0007744|PDB:7P9V |
| Chain | Residue | Details |
| A | ALA506 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) |
| Chain | Residue | Details |
| A | ILE147 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25114211 |
| Chain | Residue | Details |
| B | LEU424-PRO446 | |
| A | SER166 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=12 => ECO:0000269|PubMed:33298890, ECO:0007744|PDB:7CMH |
| Chain | Residue | Details |
| B | VAL447-GLY466 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:33298890, ECO:0007744|PDB:7CMI |
| Chain | Residue | Details |
| B | ILE53 | |
| B | GLY246 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:33298890, ECO:0007744|PDB:7CMH |
| Chain | Residue | Details |
| B | ASN134 | |
| B | ASN395 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 2 |
| Details | SITE: Important for substrate specificity => ECO:0000269|PubMed:34848541 |
| Chain | Residue | Details |
| B | ASN134 | |
| B | GLY246 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9QXW9 |
| Chain | Residue | Details |
| B | SER29 |
