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7CKW

Cryo-EM structure of Fenoldopam bound dopamine receptor DRD1-Gs signaling complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0002862biological_processnegative regulation of inflammatory response to antigenic stimulus
A0003091biological_processrenal water homeostasis
A0003924molecular_functionGTPase activity
A0003925molecular_functionG protein activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005834cellular_componentheterotrimeric G-protein complex
A0005886cellular_componentplasma membrane
A0007165biological_processsignal transduction
A0007186biological_processG protein-coupled receptor signaling pathway
A0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
A0007190biological_processactivation of adenylate cyclase activity
A0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
A0007608biological_processsensory perception of smell
A0010856molecular_functionadenylate cyclase activator activity
A0016020cellular_componentmembrane
A0019001molecular_functionguanyl nucleotide binding
A0031683molecular_functionG-protein beta/gamma-subunit complex binding
A0031748molecular_functionD1 dopamine receptor binding
A0032588cellular_componenttrans-Golgi network membrane
A0046872molecular_functionmetal ion binding
A0046907biological_processintracellular transport
A0048589biological_processdevelopmental growth
A0050796biological_processregulation of insulin secretion
A0050890biological_processcognition
A0060348biological_processbone development
A0060789biological_processhair follicle placode formation
A0070062cellular_componentextracellular exosome
A0070527biological_processplatelet aggregation
A0071377biological_processcellular response to glucagon stimulus
A0071380biological_processcellular response to prostaglandin E stimulus
A0071870biological_processcellular response to catecholamine stimulus
A0071880biological_processadenylate cyclase-activating adrenergic receptor signaling pathway
A0120162biological_processpositive regulation of cold-induced thermogenesis
B0001750cellular_componentphotoreceptor outer segment
B0003924molecular_functionGTPase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005765cellular_componentlysosomal membrane
B0005829cellular_componentcytosol
B0005834cellular_componentheterotrimeric G-protein complex
B0005886cellular_componentplasma membrane
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
B0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
B0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
B0007265biological_processRas protein signal transduction
B0008283biological_processcell population proliferation
B0016020cellular_componentmembrane
B0030159molecular_functionsignaling receptor complex adaptor activity
B0044877molecular_functionprotein-containing complex binding
B0045202cellular_componentsynapse
B0050909biological_processsensory perception of taste
B0051020molecular_functionGTPase binding
B0060041biological_processretina development in camera-type eye
B0070062cellular_componentextracellular exosome
B0071380biological_processcellular response to prostaglandin E stimulus
B0071870biological_processcellular response to catecholamine stimulus
B0097381cellular_componentphotoreceptor disc membrane
B1903561cellular_componentextracellular vesicle
G0005515molecular_functionprotein binding
G0005834cellular_componentheterotrimeric G-protein complex
G0005886cellular_componentplasma membrane
G0007165biological_processsignal transduction
G0007186biological_processG protein-coupled receptor signaling pathway
G0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
G0016020cellular_componentmembrane
G0031681molecular_functionG-protein beta-subunit binding
G0048144biological_processfibroblast proliferation
G0070062cellular_componentextracellular exosome
G0071380biological_processcellular response to prostaglandin E stimulus
G0071870biological_processcellular response to catecholamine stimulus
R0001588molecular_functiondopamine neurotransmitter receptor activity, coupled via Gs
R0001659biological_processtemperature homeostasis
R0001661biological_processconditioned taste aversion
R0001662biological_processbehavioral fear response
R0001764biological_processneuron migration
R0001932biological_processregulation of protein phosphorylation
R0001963biological_processsynaptic transmission, dopaminergic
R0001965molecular_functionG-protein alpha-subunit binding
R0001975biological_processresponse to amphetamine
R0004930molecular_functionG protein-coupled receptor activity
R0004952molecular_functiondopamine neurotransmitter receptor activity
R0005515molecular_functionprotein binding
R0005634cellular_componentnucleus
R0005783cellular_componentendoplasmic reticulum
R0005789cellular_componentendoplasmic reticulum membrane
R0005886cellular_componentplasma membrane
R0005929cellular_componentcilium
R0006606biological_processprotein import into nucleus
R0006936biological_processmuscle contraction
R0007186biological_processG protein-coupled receptor signaling pathway
R0007187biological_processG protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
R0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
R0007190biological_processactivation of adenylate cyclase activity
R0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
R0007212biological_processdopamine receptor signaling pathway
R0007416biological_processsynapse assembly
R0007612biological_processlearning
R0007613biological_processmemory
R0007617biological_processmating behavior
R0007625biological_processgrooming behavior
R0007626biological_processlocomotory behavior
R0007628biological_processadult walking behavior
R0007631biological_processfeeding behavior
R0008306biological_processassociative learning
R0008542biological_processvisual learning
R0009410biological_processresponse to xenobiotic stimulus
R0012505cellular_componentendomembrane system
R0014002biological_processastrocyte development
R0015872biological_processdopamine transport
R0016020cellular_componentmembrane
R0016477biological_processcell migration
R0019226biological_processtransmission of nerve impulse
R0019228biological_processneuronal action potential
R0021542biological_processdentate gyrus development
R0021756biological_processstriatum development
R0021766biological_processhippocampus development
R0021853biological_processcerebral cortex GABAergic interneuron migration
R0030335biological_processpositive regulation of cell migration
R0030425cellular_componentdendrite
R0030432biological_processperistalsis
R0032795molecular_functionheterotrimeric G-protein binding
R0035106biological_processoperant conditioning
R0035240molecular_functiondopamine binding
R0035249biological_processsynaptic transmission, glutamatergic
R0042053biological_processregulation of dopamine metabolic process
R0042220biological_processresponse to cocaine
R0042311biological_processvasodilation
R0042417biological_processdopamine metabolic process
R0042711biological_processmaternal behavior
R0042734cellular_componentpresynaptic membrane
R0042995cellular_componentcell projection
R0043197cellular_componentdendritic spine
R0043268biological_processpositive regulation of potassium ion transport
R0043410biological_processpositive regulation of MAPK cascade
R0045202cellular_componentsynapse
R0045211cellular_componentpostsynaptic membrane
R0046323biological_processglucose import
R0046959biological_processhabituation
R0046960biological_processsensitization
R0048148biological_processbehavioral response to cocaine
R0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
R0051584biological_processregulation of dopamine uptake involved in synaptic transmission
R0051968biological_processpositive regulation of synaptic transmission, glutamatergic
R0060134biological_processprepulse inhibition
R0060158biological_processphospholipase C-activating dopamine receptor signaling pathway
R0060170cellular_componentciliary membrane
R0060291biological_processlong-term synaptic potentiation
R0060292biological_processlong-term synaptic depression
R0071870biological_processcellular response to catecholamine stimulus
R0071880biological_processadenylate cyclase-activating adrenergic receptor signaling pathway
R0097648cellular_componentG protein-coupled receptor complex
R0097730cellular_componentnon-motile cilium
R0098978cellular_componentglutamatergic synapse
R0098982cellular_componentGABA-ergic synapse
R0099010biological_processmodification of postsynaptic structure
R0099171biological_processpresynaptic modulation of chemical synaptic transmission
R1990763molecular_functionarrestin family protein binding
R2001224biological_processpositive regulation of neuron migration
Functional Information from PROSITE/UniProt
site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
BLEU70-SER84
BILE157-ILE171
BLEU285-ALA299

site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASIlNLCVISVDRYWaI
ChainResidueDetails
RALA109-ILE125

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues70
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
RMET1-ARG23
RGLY88-CYS96
RHIS164-ARG192
RSER300-THR312
AASP223
AASN292
ASER366

site_idSWS_FT_FI2
Number of Residues25
DetailsTRANSMEM: Helical; Name=1 => ECO:0000255
ChainResidueDetails
RILE24-ILE49

site_idSWS_FT_FI3
Number of Residues189
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
RARG50-ASN60
RASP120-LYS138
RARG219-LYS272
RARG338-THR446

site_idSWS_FT_FI4
Number of Residues26
DetailsTRANSMEM: Helical; Name=2 => ECO:0000255
ChainResidueDetails
RPHE61-ALA87

site_idSWS_FT_FI5
Number of Residues22
DetailsTRANSMEM: Helical; Name=3 => ECO:0000255
ChainResidueDetails
RASN97-VAL119

site_idSWS_FT_FI6
Number of Residues24
DetailsTRANSMEM: Helical; Name=4 => ECO:0000255
ChainResidueDetails
RALA139-TRP163

site_idSWS_FT_FI7
Number of Residues25
DetailsTRANSMEM: Helical; Name=5 => ECO:0000255
ChainResidueDetails
RTHR193-TYR218

site_idSWS_FT_FI8
Number of Residues26
DetailsTRANSMEM: Helical; Name=6 => ECO:0000255
ChainResidueDetails
RTHR273-GLY299

site_idSWS_FT_FI9
Number of Residues24
DetailsTRANSMEM: Helical; Name=7 => ECO:0000255
ChainResidueDetails
RPHE313-PHE337

site_idSWS_FT_FI10
Number of Residues2
DetailsLIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:10618483
ChainResidueDetails
RCYS347
RCYS351

site_idSWS_FT_FI11
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
RASN5

219869

PDB entries from 2024-05-15

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